mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTA1
Gene summary
Basic gene Info.Gene symbolGSTA1
Gene nameglutathione S-transferase alpha 1
SynonymsGST2|GSTA1-1|GTH1
CytomapUCSC genome browser: 6p12.1
Type of geneprotein-coding
RefGenesNM_145740.3,
DescriptionGST HA subunit 1GST class-alpha member 1GST, class alpha, 1GST-epsilonS-(hydroxyalkyl)glutathione lyase A1glutathione S-alkyltransferase A1glutathione S-aryltransferase A1glutathione S-transferase 2glutathione S-transferase A1glutathione S-transf
Modification date20141222
dbXrefs MIM : 138359
HGNC : HGNC
HPRD : 00708
ProteinUniProt: P09210
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTA1
BioGPS: 2938
PathwayNCI Pathway Interaction Database: GSTA1
KEGG: GSTA1
REACTOME: GSTA1
Pathway Commons: GSTA1
ContextiHOP: GSTA1
ligand binding site mutation search in PubMed: GSTA1
UCL Cancer Institute: GSTA1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006749glutathione metabolic process11851347


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Ligand binding site mutations for GSTA1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L107L107VBLCA1
E210E210DCOAD1
V111V111IGBM1
R131R131HGBM1
E104,I106M105IHNSC1
T68T68ASTAD1
R131R131CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GSTA1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F30E32D-1.6778572
F220R221S-1.4098483
P56V58A-1.3042336
L107L107F-0.98076172
V55V55E-0.94567296
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTA1 from PDB

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Differential gene expression and gene-gene network for GSTA1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTA1 and the right PPI network was created from samples without mutations in the LBS of GSTA1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GSTA1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms1Biomarker, GeneticVariation
umls:C0400966Non-alcoholic Fatty Liver Disease1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GSTA1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
Approved|vet_approvedDB00608ChloroquineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTA1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
ASDANDROST-4-ENE-3,17-DIONE2vctBL107
ASDANDROST-4-ENE-3,17-DIONE2vctCL107
ASDANDROST-4-ENE-3,17-DIONE2vctAL107 F220
GSHGLUTATHIONATE(1-)2wjuBV55 F220
GSHGLUTATHIONATE(1-)2wjuCV55 F220
GSHGLUTATHIONATE(1-)2wjuDV55 F220
GSHGLUTATHIONATE(1-)2wjuEV55 F220
GSHGLUTATHIONATE(1-)2wjuHV55 F220
GSHGLUTATHIONATE(1-)4acsDV55 F220
GSHGLUTATHIONATE(1-)2wjuAV55 P56 F220
GSHGLUTATHIONATE(1-)2wjuFV55 P56 F220
GSHGLUTATHIONATE(1-)2wjuGV55 P56 F220
GSHGLUTATHIONATE(1-)4acsAV55 P56 F220
GSHGLUTATHIONATE(1-)4acsBV55 P56 F220
GSHGLUTATHIONATE(1-)4acsCV55 P56 F220


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Conservation information for LBS of GSTA1
Multiple alignments for P09210 in multiple species
LBSAA sequence# speciesSpecies


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