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mutLBSgeneDB |
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| Gene summary for GSTA2 |
 Gene summary |
| Basic gene Info. | Gene symbol | GSTA2 |
| Gene name | glutathione S-transferase alpha 2 | |
| Synonyms | GST2|GSTA2-2|GTA2|GTH2 | |
| Cytomap | UCSC genome browser: 6p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000846.4, | |
| Description | GST HA subunit 2GST class-alpha member 2GST-gammaS-(hydroxyalkyl)glutathione lyase A2glutathione S-alkyltransferase A2glutathione S-aralkyltransferase A2glutathione S-aryltransferase A2glutathione S-transferase A2liver GST2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138360 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000244067 | ||
| HPRD : 00709 | ||
| Vega : OTTHUMG00000016263 | ||
| Protein | UniProt: P09210 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSTA2 | |
| BioGPS: 2939 | ||
| Pathway | NCI Pathway Interaction Database: GSTA2 | |
| KEGG: GSTA2 | ||
| REACTOME: GSTA2 | ||
| Pathway Commons: GSTA2 | ||
| Context | iHOP: GSTA2 | |
| ligand binding site mutation search in PubMed: GSTA2 | ||
| UCL Cancer Institute: GSTA2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for GSTA2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | F220 | R221S | HNSC | 2 | F220 | R221S | BLCA | 1 | V55 | V55E | LUAD | 1 | P56 | V58A | LUAD | 1 | L107 | L107F | SKCM | 1 | F30 | E32D | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GSTA2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | F30 | E32D | -1.6778572 | F220 | R221S | -1.4098483 | P56 | V58A | -1.3042336 | L107 | L107F | -0.98076172 | V55 | V55E | -0.94567296 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GSTA2 from PDB |
| PDB ID | PDB title | PDB structure | 2WJU | Glutathione transferase A2-2 in complex with glutathione |  |
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| Differential gene expression and gene-gene network for GSTA2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GSTA2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0023893 | Liver Cirrhosis, Experimental | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GSTA2 |
| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00143 | Glutathione | Small molecule |  |
| Approved|vet_approved | DB00608 | Chloroquine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GSTA2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ASD | ANDROST-4-ENE-3,17-DIONE | 2vct | B | L107 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vct | C | L107 | ASD | ANDROST-4-ENE-3,17-DIONE | 2vct | A | L107 F220 | GSH | GLUTATHIONATE(1-) | 2wju | B | V55 F220 | GSH | GLUTATHIONATE(1-) | 2wju | C | V55 F220 | GSH | GLUTATHIONATE(1-) | 2wju | D | V55 F220 | GSH | GLUTATHIONATE(1-) | 2wju | E | V55 F220 | GSH | GLUTATHIONATE(1-) | 2wju | H | V55 F220 | GSH | GLUTATHIONATE(1-) | 4acs | D | V55 F220 | GSH | GLUTATHIONATE(1-) | 2wju | A | V55 P56 F220 | GSH | GLUTATHIONATE(1-) | 2wju | F | V55 P56 F220 | GSH | GLUTATHIONATE(1-) | 2wju | G | V55 P56 F220 | GSH | GLUTATHIONATE(1-) | 4acs | A | V55 P56 F220 | GSH | GLUTATHIONATE(1-) | 4acs | B | V55 P56 F220 | GSH | GLUTATHIONATE(1-) | 4acs | C | V55 P56 F220 |
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| Conservation information for LBS of GSTA2 |
| Multiple alignments for P09210 in multiple species |
| LBS | AA sequence | # species | Species |
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