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mutLBSgeneDB |
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| Gene summary for GSTM2 |
 Gene summary |
| Basic gene Info. | Gene symbol | GSTM2 |
| Gene name | glutathione S-transferase mu 2 (muscle) | |
| Synonyms | GST4|GSTM|GSTM2-2|GTHMUS | |
| Cytomap | UCSC genome browser: 1p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000848.3, NM_001142368.1, | |
| Description | GST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2glutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-transferase 4glutathione S-transferase M1glutathione S-transferase M2 (m | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138380 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000213366 | ||
| HPRD : 00710 | ||
| Vega : OTTHUMG00000011638 | ||
| Protein | UniProt: P28161 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSTM2 | |
| BioGPS: 2946 | ||
| Pathway | NCI Pathway Interaction Database: GSTM2 | |
| KEGG: GSTM2 | ||
| REACTOME: GSTM2 | ||
| Pathway Commons: GSTM2 | ||
| Context | iHOP: GSTM2 | |
| ligand binding site mutation search in PubMed: GSTM2 | ||
| UCL Cancer Institute: GSTM2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006749 | glutathione metabolic process | 16549767 | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum | 17023043 | GO:0018916 | nitrobenzene metabolic process | 2034681 | GO:0042178 | xenobiotic catabolic process | 16549767 | GO:0060315 | negative regulation of ryanodine-sensitive calcium-release channel activity | 17023043 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity | 17023043 | GO:0070458 | cellular detoxification of nitrogen compound | 2034681 | GO:0071313 | cellular response to caffeine | 22406107 |
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| Ligand binding site mutations for GSTM2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | Y116 | P118L | LUAD | 1 | M105 | D106N | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GSTM2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | Y116 | P118L | -1.0720531 | M105 | D106N | -0.57201192 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GSTM2 from PDB |
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| Differential gene expression and gene-gene network for GSTM2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GSTM2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 2 | Biomarker |
| umls:C2609414 | Acute Kidney Injury | 1 | Biomarker |
| umls:C0013080 | Down Syndrome | 1 | Biomarker |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| umls:C0524851 | Neurodegenerative Diseases | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GSTM2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00143 | Glutathione | Small molecule |  |
| Experimental | DB02458 | Glutathione S-(2,4 Dinitrobenzene) | Small molecule |  |
| Experimental | DB03310 | Oxidized Glutathione Disulfide | Small molecule |  |
| Experimental | DB04701 | S-METHYL-GLUTATHIONE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GSTM2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GSO | L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE | 2c4j | A | Y116 | GSO | L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE | 2c4j | C | Y116 | GSO | L-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE | 2c4j | D | Y116 |
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| Conservation information for LBS of GSTM2 |
| Multiple alignments for P28161 in multiple species |
| LBS | AA sequence | # species | Species | A112 | NRMVLARLCYN | 2 | Mus musculus, Rattus norvegicus | A112 | SRMQLAKLCYD | 1 | Homo sapiens | F209 | LPRPVFTKMAV | 1 | Homo sapiens | F209 | LPRPMFTKMAT | 1 | Mus musculus | F209 | LPRPLFTKMAI | 1 | Rattus norvegicus | G12 | YWDIRGLAHAI | 2 | Mus musculus, Rattus norvegicus | G12 | YWNIRGLAHSI | 1 | Homo sapiens | I10 | LGYWDIRGLAH | 2 | Mus musculus, Rattus norvegicus | I10 | LGYWNIRGLAH | 1 | Homo sapiens | K50 | QWLNEKFKLGL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L13 | WDIRGLAHAIR | 2 | Mus musculus, Rattus norvegicus | L13 | WNIRGLAHSIR | 1 | Homo sapiens | L60 | LDFPNLPYLID | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | M105 | LENQLMDNRMV | 2 | Mus musculus, Rattus norvegicus | M105 | LENQFMDSRMQ | 1 | Homo sapiens | M35 | EKRYTMGDAPD | 2 | Mus musculus, Rattus norvegicus | M35 | EKKYTMGDAPD | 1 | Homo sapiens | N59 | GLDFPNLPYLI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P61 | DFPNLPYLIDG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q72 | SHKITQSNAIL | 2 | Mus musculus, Rattus norvegicus | Q72 | THKITQSNAIL | 1 | Homo sapiens | R108 | QLMDNRMVLAR | 2 | Mus musculus, Rattus norvegicus | R108 | QFMDSRMQLAK | 1 | Homo sapiens | R166 | YDVLERNQVFE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R43 | APDYDRSQWLN | 1 | Homo sapiens | R43 | APDYDQSQWLN | 1 | Mus musculus | R43 | APDFDRSQWLN | 1 | Rattus norvegicus | S73 | HKITQSNAILR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T210 | PRPVFTKMAVW | 1 | Homo sapiens | T210 | PRPMFTKMATW | 1 | Mus musculus | T210 | PRPLFTKMAIW | 1 | Rattus norvegicus | W46 | YDRSQWLNEKF | 1 | Homo sapiens | W46 | YDQSQWLNEKF | 1 | Mus musculus | W46 | FDRSQWLNEKF | 1 | Rattus norvegicus | W8 | MTLGYWDIRGL | 2 | Mus musculus, Rattus norvegicus | W8 | MTLGYWNIRGL | 1 | Homo sapiens | Y116 | LAKLCYDPDFE | 1 | Homo sapiens | Y116 | LARLCYNADFE | 1 | Mus musculus | Y116 | LARLCYNPDFE | 1 | Rattus norvegicus | Y7 | PMTLGYWDIRG | 2 | Mus musculus, Rattus norvegicus | Y7 | PMTLGYWNIRG | 1 | Homo sapiens |
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