mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTM2
Gene summary
Basic gene Info.Gene symbolGSTM2
Gene nameglutathione S-transferase mu 2 (muscle)
SynonymsGST4|GSTM|GSTM2-2|GTHMUS
CytomapUCSC genome browser: 1p13.3
Type of geneprotein-coding
RefGenesNM_000848.3,
NM_001142368.1,
DescriptionGST class-mu 2GST, muscleS-(hydroxyalkyl)glutathione lyase M2glutathione S-alkyltransferase M2glutathione S-aralkyltransferase M2glutathione S-aryltransferase M2glutathione S-transferase 4glutathione S-transferase M1glutathione S-transferase M2 (m
Modification date20141207
dbXrefs MIM : 138380
HGNC : HGNC
Ensembl : ENSG00000213366
HPRD : 00710
Vega : OTTHUMG00000011638
ProteinUniProt: P28161
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTM2
BioGPS: 2946
PathwayNCI Pathway Interaction Database: GSTM2
KEGG: GSTM2
REACTOME: GSTM2
Pathway Commons: GSTM2
ContextiHOP: GSTM2
ligand binding site mutation search in PubMed: GSTM2
UCL Cancer Institute: GSTM2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006749glutathione metabolic process16549767
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum17023043
GO:0018916nitrobenzene metabolic process2034681
GO:0042178xenobiotic catabolic process16549767
GO:0060315negative regulation of ryanodine-sensitive calcium-release channel activity17023043
GO:0060316positive regulation of ryanodine-sensitive calcium-release channel activity17023043
GO:0070458cellular detoxification of nitrogen compound2034681
GO:0071313cellular response to caffeine22406107


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Ligand binding site mutations for GSTM2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Y116P118LLUAD1
M105D106NSKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GSTM2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y116P118L-1.0720531
M105D106N-0.57201192
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTM2 from PDB

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Differential gene expression and gene-gene network for GSTM2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTM2 and the right PPI network was created from samples without mutations in the LBS of GSTM2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GSTM2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007131Carcinoma, Non-Small-Cell Lung2Biomarker
umls:C2609414Acute Kidney Injury1Biomarker
umls:C0013080Down Syndrome1Biomarker
umls:C0860207Drug-Induced Liver Injury1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker
umls:C0524851Neurodegenerative Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GSTM2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
ExperimentalDB02458Glutathione S-(2,4 Dinitrobenzene)Small molecule
ExperimentalDB03310Oxidized Glutathione DisulfideSmall molecule
ExperimentalDB04701S-METHYL-GLUTATHIONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTM2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GSOL-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE2c4jAY116
GSOL-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE2c4jCY116
GSOL-GAMMA-GLUTAMYL-S-[(2S)-2-HYDROXY-2-PHENYLETHYL]-L-CYSTEINYLGLYCINE2c4jDY116


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Conservation information for LBS of GSTM2
Multiple alignments for P28161 in multiple species
LBSAA sequence# speciesSpecies
A112NRMVLARLCYN2Mus musculus, Rattus norvegicus
A112SRMQLAKLCYD1Homo sapiens
F209LPRPVFTKMAV1Homo sapiens
F209LPRPMFTKMAT1Mus musculus
F209LPRPLFTKMAI1Rattus norvegicus
G12YWDIRGLAHAI2Mus musculus, Rattus norvegicus
G12YWNIRGLAHSI1Homo sapiens
I10LGYWDIRGLAH2Mus musculus, Rattus norvegicus
I10LGYWNIRGLAH1Homo sapiens
K50QWLNEKFKLGL3Homo sapiens, Mus musculus, Rattus norvegicus
L13WDIRGLAHAIR2Mus musculus, Rattus norvegicus
L13WNIRGLAHSIR1Homo sapiens
L60LDFPNLPYLID3Homo sapiens, Mus musculus, Rattus norvegicus
M105LENQLMDNRMV2Mus musculus, Rattus norvegicus
M105LENQFMDSRMQ1Homo sapiens
M35EKRYTMGDAPD2Mus musculus, Rattus norvegicus
M35EKKYTMGDAPD1Homo sapiens
N59GLDFPNLPYLI3Homo sapiens, Mus musculus, Rattus norvegicus
P61DFPNLPYLIDG3Homo sapiens, Mus musculus, Rattus norvegicus
Q72SHKITQSNAIL2Mus musculus, Rattus norvegicus
Q72THKITQSNAIL1Homo sapiens
R108QLMDNRMVLAR2Mus musculus, Rattus norvegicus
R108QFMDSRMQLAK1Homo sapiens
R166YDVLERNQVFE3Homo sapiens, Mus musculus, Rattus norvegicus
R43APDYDRSQWLN1Homo sapiens
R43APDYDQSQWLN1Mus musculus
R43APDFDRSQWLN1Rattus norvegicus
S73HKITQSNAILR3Homo sapiens, Mus musculus, Rattus norvegicus
T210PRPVFTKMAVW1Homo sapiens
T210PRPMFTKMATW1Mus musculus
T210PRPLFTKMAIW1Rattus norvegicus
W46YDRSQWLNEKF1Homo sapiens
W46YDQSQWLNEKF1Mus musculus
W46FDRSQWLNEKF1Rattus norvegicus
W8MTLGYWDIRGL2Mus musculus, Rattus norvegicus
W8MTLGYWNIRGL1Homo sapiens
Y116LAKLCYDPDFE1Homo sapiens
Y116LARLCYNADFE1Mus musculus
Y116LARLCYNPDFE1Rattus norvegicus
Y7PMTLGYWDIRG2Mus musculus, Rattus norvegicus
Y7PMTLGYWNIRG1Homo sapiens


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