mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTP1
Gene summary
Basic gene Info.Gene symbolGSTP1
Gene nameglutathione S-transferase pi 1
SynonymsDFN7|FAEES3|GST3|GSTP|HEL-S-22|PI
CytomapUCSC genome browser: 11q13
Type of geneprotein-coding
RefGenesNM_000852.3,
DescriptionGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase IIIglutathione S-transferase P
Modification date20141222
dbXrefs MIM : 134660
HGNC : HGNC
Ensembl : ENSG00000084207
HPRD : 00614
Vega : OTTHUMG00000137430
ProteinUniProt: P09211
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTP1
BioGPS: 2950
PathwayNCI Pathway Interaction Database: GSTP1
KEGG: GSTP1
REACTOME: GSTP1
Pathway Commons: GSTP1
ContextiHOP: GSTP1
ligand binding site mutation search in PubMed: GSTP1
UCL Cancer Institute: GSTP1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006469negative regulation of protein kinase activity16636664
GO:0006749glutathione metabolic process1540159
GO:0006805xenobiotic metabolic process1540159
GO:0009890negative regulation of biosynthetic process18962899
GO:0032691negative regulation of interleukin-1 beta production18962899
GO:0032720negative regulation of tumor necrosis factor production18962899
GO:0043407negative regulation of MAP kinase activity11408560
GO:0043508negative regulation of JUN kinase activity16636664
GO:0051771negative regulation of nitric-oxide synthase biosynthetic process18962899
GO:0070373negative regulation of ERK1 and ERK2 cascade11408560
GO:0071638negative regulation of monocyte chemotactic protein-1 production18962899
GO:2001237negative regulation of extrinsic apoptotic signaling pathway16636664


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Ligand binding site mutations for GSTP1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q148G146VBLCA1
S66T68SBRCA1
F193F193SSKCM1
Q65L63MSKCM1
P203N201DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for GSTP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F193F193S-1.7480326
Q65L63M-1.3965956
S66T68S-0.81762552
P203N201D-0.71787972
Q148G146V-0.68323057
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTP1 from PDB

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Differential gene expression and gene-gene network for GSTP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTP1 and the right PPI network was created from samples without mutations in the LBS of GSTP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for GSTP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0004096Asthma58Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms28AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C2239176Carcinoma, Hepatocellular25AlteredExpression, Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms24AlteredExpression, Biomarker, GeneticVariation
umls:C0007097Carcinoma24AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C0038356Stomach Neoplasms16Biomarker, GeneticVariation
umls:C0017638Glioma12Biomarker, GeneticVariation
umls:C0030567Parkinson Disease11Biomarker, GeneticVariation
umls:C0005695Urinary Bladder Neoplasms11Biomarker, GeneticVariation
umls:C0007131Carcinoma, Non-Small-Cell Lung11Biomarker, GeneticVariation
umls:C0282612Prostatic Intraepithelial Neoplasia9AlteredExpression, Biomarker
umls:C0019829Hodgkin Disease8Biomarker, GeneticVariation
umls:C0007134Carcinoma, Renal Cell7Biomarker
umls:C0029463Osteosarcoma6AlteredExpression, Biomarker, GeneticVariation
umls:C0032927Precancerous Conditions6Biomarker
umls:C0023904Liver Neoplasms, Experimental5Biomarker
umls:C0031117Peripheral Nervous System Diseases5Biomarker, GeneticVariation
umls:C0860207Drug-Induced Liver Injury4Biomarker, GeneticVariation
umls:C0023473Leukemia, Myelogenous, Chronic, BCR-ABL Positive3Biomarker, GeneticVariation
umls:C0400966Non-alcoholic Fatty Liver Disease3Biomarker
umls:C0004352Autistic Disorder3Biomarker
umls:C0236733Amphetamine-Related Disorders2Biomarker, GeneticVariation
umls:C0022658Kidney Diseases2Biomarker, GeneticVariation
umls:C0033941Psychoses, Substance-Induced2Biomarker, GeneticVariation
umls:C1261473Sarcoma2Biomarker
umls:C0002736Amyotrophic Lateral Sclerosis1AlteredExpression, Biomarker
umls:C0007273Carotid Artery Diseases1Biomarker, GeneticVariation
umls:C0042594Vestibular Diseases1Biomarker, GeneticVariation
umls:C0948089Acute Coronary Syndrome1Biomarker
umls:C2609414Acute Kidney Injury1Biomarker
umls:C0008625Chromosome Aberrations1Biomarker
umls:C0242656Disease Progression1Biomarker
umls:C0013182Drug Hypersensitivity1Biomarker
umls:C0151744Myocardial Ischemia1Biomarker
umls:C0027540Necrosis1Biomarker
umls:C0035234Respiratory Sounds1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for GSTP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
Approved|vet_approvedDB01242ClomipramineSmall molecule
ExperimentalDB01834(9r,10r)-9-(S-Glutathionyl)-10-Hydroxy-9,10-DihydrophenanthreneSmall molecule
ExperimentalDB01915S-HydroxycysteineSmall molecule
ExperimentalDB02633Cibacron BlueSmall molecule
ExperimentalDB03003Glutathione Sulfonic AcidSmall molecule
ExperimentalDB03686S-(P-Nitrobenzyl)GlutathioneSmall molecule
ExperimentalDB038142-(N-Morpholino)-Ethanesulfonic AcidSmall molecule
ExperimentalDB04077GlycerolSmall molecule
ExperimentalDB04132S-HexylglutathioneSmall molecule
ApprovedDB04339CarbocisteineSmall molecule
InvestigationalDB04972CanfosfamideSmall molecule
InvestigationalDB05460TLK-199Small molecule
ExperimentalDB07849S-NONYL-CYSTEINESmall molecule
ExperimentalDB08370S-(4-BROMOBENZYL)CYSTEINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
GTXS-HEXYLGLUTATHIONE2j9hAQ65 S66
GTXS-HEXYLGLUTATHIONE2j9hBQ65 S66


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Conservation information for LBS of GSTP1
Multiple alignments for P09211 in multiple species
LBSAA sequence# speciesSpecies
A23MRMLLADQGQS3Mus musculus, Mus musculus, Bos taurus
A23LRMLLADQGQS2Homo sapiens, Macaca mulatta
A23TRMLLADQGQS1Rattus norvegicus
C102VEDLRCKYISL1Homo sapiens
C102VEDLRCKYGTL1Rattus norvegicus
C102VEDLRGKYVTL1Mus musculus
C102VEDLRGKYGTM1Mus musculus
C102VEDLRCKYVSL1Bos taurus
C102VEDLRCKYLSL1Macaca mulatta
D99NDGVEDLRCKY4Homo sapiens, Rattus norvegicus, Bos taurus, Macaca mulatta
D99NDGVEDLRGKY2Mus musculus, Mus musculus
E198FLSSPEHVNRP2Mus musculus, Mus musculus
E198FLASPEYVNLP1Homo sapiens
E198FLSSPDHLNRP1Rattus norvegicus
E198FLASPEHMNRP1Bos taurus
E198FLASPEHVNLP1Macaca mulatta
E31GQSWKEEVVTI3Rattus norvegicus, Mus musculus, Mus musculus
E31GQSWKEEVVTV1Homo sapiens
E31GQSWKEEVVAM1Bos taurus
E31GQSWKEEVVTM1Macaca mulatta
E86GKDQQEAALVD2Homo sapiens, Bos taurus
E86GKDQKEAALVD1Rattus norvegicus
E86GKNQREAAQMD1Mus musculus
E86GKNQREAAQVD1Mus musculus
E86GKDQREAALVD1Macaca mulatta
E98VNDGVEDLRCK4Homo sapiens, Rattus norvegicus, Bos taurus, Macaca mulatta
E98VNDGVEDLRGK2Mus musculus, Mus musculus
F143QGGKTFIVGDQ2Homo sapiens, Macaca mulatta
F143QGGKAFIVGDQ2Mus musculus, Mus musculus
F143QGGKAFIVGNQ1Rattus norvegicus
F143KGGQAFIVGDQ1Bos taurus
F193PKLKAFLASPE3Homo sapiens, Bos taurus, Macaca mulatta
F193PKIKAFLSSPE2Mus musculus, Mus musculus
F193PKIKAFLSSPD1Rattus norvegicus
F9YTVVYFPVRGR2Homo sapiens, Macaca mulatta
F9YTIVYFPVRGR2Rattus norvegicus, Mus musculus
F9YTIVYFPSPGR1Mus musculus
F9YTIVYFPVQGR1Bos taurus
G13YFPVRGRCAAL2Homo sapiens, Macaca mulatta
G13YFPVRGRCEAT1Rattus norvegicus
G13YFPVRGRCEAM1Mus musculus
G13YFPSPGRCEAM1Mus musculus
G13YFPVQGRCEAM1Bos taurus
G206NRPINGNGKQ4Rattus norvegicus, Mus musculus, Mus musculus, Bos taurus
G206NLPINGNGKQ2Homo sapiens, Macaca mulatta
G51ASCLYGQLPKF3Homo sapiens, Bos taurus, Macaca mulatta
G51PTCLYGQLPKF2Mus musculus, Mus musculus
G51STCLYGQLPKF1Rattus norvegicus
G78LGRTLGLYGKD3Homo sapiens, Bos taurus, Macaca mulatta
G78LGRSLGLYGKN2Mus musculus, Mus musculus
G78LGRSLGLYGKD1Rattus norvegicus
I105LRCKYISLIYT1Homo sapiens
I105LRCKYGTLIYT1Rattus norvegicus
I105LRGKYVTLIYT1Mus musculus
I105LRGKYGTMIYR1Mus musculus
I105LRCKYVSLIYT1Bos taurus
I105LRCKYLSLIYT1Macaca mulatta
I149IVGDQISFADY5Homo sapiens, Mus musculus, Mus musculus, Bos taurus, Macaca mulatta
I149IVGNQISFADY1Rattus norvegicus
K30QGQSWKEEVVT5Homo sapiens, Rattus norvegicus, Mus musculus, Mus musculus, Macaca mulatta
K30QGQSWKEEVVA1Bos taurus
K45QEGSLKASCLY2Homo sapiens, Macaca mulatta
K45MQGLLKPTCLY2Mus musculus, Mus musculus
K45LQGSLKSTCLY1Rattus norvegicus
K45LQGPLKASCLY1Bos taurus
K82LGLYGKDQQEA2Homo sapiens, Bos taurus
K82LGLYGKNQREA2Mus musculus, Mus musculus
K82LGLYGKDQKEA1Rattus norvegicus
K82LGLYGKDQREA1Macaca mulatta
L53CLYGQLPKFQD3Homo sapiens, Bos taurus, Macaca mulatta
L53CLYGQLPKFED3Rattus norvegicus, Mus musculus, Mus musculus
N205VNLPINGNGKQ2Homo sapiens, Macaca mulatta
N205VNRPINGNGKQ2Mus musculus, Mus musculus
N205LNRPINGNGKQ1Rattus norvegicus
N205MNRPINGNGKQ1Bos taurus
P10TVVYFPVRGRC2Homo sapiens, Macaca mulatta
P10TIVYFPVRGRC2Rattus norvegicus, Mus musculus
P10TIVYFPSPGRC1Mus musculus
P10TIVYFPVQGRC1Bos taurus
P203EHVNRPINGNG2Mus musculus, Mus musculus
P203EYVNLPINGNG1Homo sapiens
P203DHLNRPINGNG1Rattus norvegicus
P203EHMNRPINGNG1Bos taurus
P203EHVNLPINGNG1Macaca mulatta
P54LYGQLPKFQDG3Homo sapiens, Bos taurus, Macaca mulatta
P54LYGQLPKFEDG3Rattus norvegicus, Mus musculus, Mus musculus
Q148FIVGDQISFAD5Homo sapiens, Mus musculus, Mus musculus, Bos taurus, Macaca mulatta
Q148FIVGNQISFAD1Rattus norvegicus
Q27LADQGQSWKEE6Homo sapiens, Rattus norvegicus, Mus musculus, Mus musculus, Bos taurus, Macaca mulatta
Q40TIDTWMQGLLK2Mus musculus, Mus musculus
Q40TVETWQEGSLK1Homo sapiens
Q40TIDVWLQGSLK1Rattus norvegicus
Q40AMQSWLQGPLK1Bos taurus
Q40TMETWQEGSLK1Macaca mulatta
Q52SCLYGQLPKFQ3Homo sapiens, Bos taurus, Macaca mulatta
Q52TCLYGQLPKFE3Rattus norvegicus, Mus musculus, Mus musculus
Q65DLTLYQSNAIL4Rattus norvegicus, Mus musculus, Mus musculus, Bos taurus
Q65DLTLYQSNTIL1Homo sapiens
Q65DLTLYQSNTFL1Macaca mulatta
R14FPVRGRCAALR2Homo sapiens, Macaca mulatta
R14FPVRGRCEATR1Rattus norvegicus
R14FPVRGRCEAMR1Mus musculus
R14FPSPGRCEAMR1Mus musculus
R14FPVQGRCEAMR1Bos taurus
R187ARLSARPKIKA3Rattus norvegicus, Mus musculus, Mus musculus
R187GRLSARPKLKA1Homo sapiens
R187ARLNSRPKLKA1Bos taurus
R187ARLSARPKLKA1Macaca mulatta
S66LTLYQSNAILR4Rattus norvegicus, Mus musculus, Mus musculus, Bos taurus
S66LTLYQSNTILR1Homo sapiens
S66LTLYQSNTFLR1Macaca mulatta
T110ISLIYTNYEAG1Homo sapiens
T110GTLIYTNYENG1Rattus norvegicus
T110VTLIYTNYENG1Mus musculus
T110GTMIYRNYENG1Mus musculus
T110VSLIYTNYEAG1Bos taurus
T110LSLIYTNYEAG1Macaca mulatta
T35KEEVVTIDTWM2Mus musculus, Mus musculus
T35KEEVVTVETWQ1Homo sapiens
T35KEEVVTIDVWL1Rattus norvegicus
T35KEEVVAMQSWL1Bos taurus
T35KEEVVTMETWQ1Macaca mulatta
V11VVYFPVRGRCA2Homo sapiens, Macaca mulatta
V11IVYFPVRGRCE2Rattus norvegicus, Mus musculus
V11IVYFPSPGRCE1Mus musculus
V11IVYFPVQGRCE1Bos taurus
V36EEVVTIDTWMQ2Mus musculus, Mus musculus
V36EEVVTVETWQE1Homo sapiens
V36EEVVTIDVWLQ1Rattus norvegicus
V36EEVVAMQSWLQ1Bos taurus
V36EEVVTMETWQE1Macaca mulatta
W29DQGQSWKEEVV6Homo sapiens, Rattus norvegicus, Mus musculus, Mus musculus, Bos taurus, Macaca mulatta
W39VTIDTWMQGLL2Mus musculus, Mus musculus
W39VTVETWQEGSL1Homo sapiens
W39VTIDVWLQGSL1Rattus norvegicus
W39VAMQSWLQGPL1Bos taurus
W39VTMETWQEGSL1Macaca mulatta
Y109YISLIYTNYEA1Homo sapiens
Y109YGTLIYTNYEN1Rattus norvegicus
Y109YVTLIYTNYEN1Mus musculus
Y109YGTMIYRNYEN1Mus musculus
Y109YVSLIYTNYEA1Bos taurus
Y109YLSLIYTNYEA1Macaca mulatta
Y8PYTVVYFPVRG2Homo sapiens, Macaca mulatta
Y8PYTIVYFPVRG2Rattus norvegicus, Mus musculus
Y8PYTIVYFPSPG1Mus musculus
Y8PYTIVYFPVQG1Bos taurus


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