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mutLBSgeneDB |
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| Gene summary for GSTZ1 |
 Gene summary |
| Basic gene Info. | Gene symbol | GSTZ1 |
| Gene name | glutathione S-transferase zeta 1 | |
| Synonyms | GSTZ1-1|MAAI|MAI | |
| Cytomap | UCSC genome browser: 14q24.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001513.3, NM_145870.2,NM_145871.2, | |
| Description | S-(hydroxyalkyl)glutathione lyaseglutathione S-alkyltransferaseglutathione S-aralkyltransferaseglutathione S-aryltransferaseglutathione transferase zeta 1maleylacetoacetate isomerasemaleylacetone isomerase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603758 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000100577 | ||
| HPRD : 04785 | ||
| Vega : OTTHUMG00000171551 | ||
| Protein | UniProt: O43708 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSTZ1 | |
| BioGPS: 2954 | ||
| Pathway | NCI Pathway Interaction Database: GSTZ1 | |
| KEGG: GSTZ1 | ||
| REACTOME: GSTZ1 | ||
| Pathway Commons: GSTZ1 | ||
| Context | iHOP: GSTZ1 | |
| ligand binding site mutation search in PubMed: GSTZ1 | ||
| UCL Cancer Institute: GSTZ1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006749 | glutathione metabolic process | 10739172 |
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| Ligand binding site mutations for GSTZ1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | N172 | A171T | COAD | 1 | R19 | V20I | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GSTZ1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | R19 | V20I | -0.3552691 | N172 | A171T | -0.34618294 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GSTZ1 from PDB |
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| Differential gene expression and gene-gene network for GSTZ1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GSTZ1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0042594 | Vestibular Diseases | 1 | Biomarker, GeneticVariation |
| umls:C0031117 | Peripheral Nervous System Diseases | 1 | Biomarker |
| umls:C0005695 | Urinary Bladder Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GSTZ1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00143 | Glutathione | Small molecule |  |
| Experimental | DB04447 | 1,4-Dithiothreitol | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GSTZ1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SO4 | SULFATE | 1fw1 | A | N172 | GSH | GLUTATHIONATE(1-) | 1fw1 | A | R19 |
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| Conservation information for LBS of GSTZ1 |
| Multiple alignments for O43708 in multiple species |
| LBS | AA sequence | # species | Species | C16 | YFRSSCSWRVR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | C16 | YWRSSCAHRVR | 2 | Arabidopsis thaliana, Arabidopsis thaliana | C16 | YWRSSCSWRVR | 1 | Caenorhabditis elegans | C16 | YWPSSCSWRVR | 1 | Drosophila melanogaster | L116 | QPLQNLSVLKQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L116 | QPHQNMALFRY | 1 | Arabidopsis thaliana | L116 | QPHQNLAVIRY | 1 | Arabidopsis thaliana | L116 | QPLHNLKVLQL | 1 | Caenorhabditis elegans | L116 | QPLQNVSVLDH | 1 | Drosophila melanogaster | N115 | IQPLQNLSVLK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N115 | IQPHQNMALFR | 1 | Arabidopsis thaliana | N115 | IQPHQNLAVIR | 1 | Arabidopsis thaliana | N115 | IQPLHNLKVLQ | 1 | Caenorhabditis elegans | N115 | IQPLQNVSVLD | 1 | Drosophila melanogaster | N172 | VPQVANA-ERF | 2 | Homo sapiens, Mus musculus | N172 | APQIHAAFNRF | 1 | Arabidopsis thaliana | N172 | APQIHGAINRF | 1 | Arabidopsis thaliana | N172 | PPLIYSA-NRF | 1 | Caenorhabditis elegans | N172 | VPQVRNA-RRY | 1 | Drosophila melanogaster | N172 | APQVANA-ERF | 1 | Rattus norvegicus | P60 | PMGTVPALVDG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | P60 | PMKQVPALKID | 2 | Mus musculus, Rattus norvegicus | P60 | PMKQVPTLKID | 1 | Homo sapiens | P60 | PAAKVPTFVVD | 1 | Caenorhabditis elegans | P60 | PMQKVPSLKID | 1 | Drosophila melanogaster | Q111 | IASGIQPLQNL | 2 | Mus musculus, Rattus norvegicus | Q111 | IAGGIQPLQNL | 1 | Homo sapiens | Q111 | VMSGIQPHQNM | 1 | Arabidopsis thaliana | Q111 | VLSGIQPHQNL | 1 | Arabidopsis thaliana | Q111 | VASGIQPLHNL | 1 | Caenorhabditis elegans | Q111 | ICSGIQPLQNV | 1 | Drosophila melanogaster | Q114 | GIQPLQNLSVL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q114 | GIQPHQNMALF | 1 | Arabidopsis thaliana | Q114 | GIQPHQNLAVI | 1 | Arabidopsis thaliana | Q114 | GIQPLHNLKVL | 1 | Caenorhabditis elegans | Q114 | GIQPLQNVSVL | 1 | Drosophila melanogaster | Q45 | D-RGQQFSKDF | 1 | Homo sapiens | Q45 | ---GDQSDSDF | 1 | Arabidopsis thaliana | Q45 | ---GDQFDSDF | 1 | Arabidopsis thaliana | Q45 | ---SEEAKSKL | 1 | Caenorhabditis elegans | Q45 | TVSGHAYTDEY | 1 | Drosophila melanogaster | Q45 | D-GGQQFTEEF | 1 | Mus musculus | Q45 | D-GGQQFSEEF | 1 | Rattus norvegicus | Q58 | INPMGTVPALV | 2 | Arabidopsis thaliana, Arabidopsis thaliana | Q58 | LNPMKQVPALK | 2 | Mus musculus, Rattus norvegicus | Q58 | LNPMKQVPTLK | 1 | Homo sapiens | Q58 | INPAAKVPTFV | 1 | Caenorhabditis elegans | Q58 | VNPMQKVPSLK | 1 | Drosophila melanogaster | Q71 | DVVINDSFAII | 2 | Arabidopsis thaliana, Arabidopsis thaliana | Q71 | GITIHQSLAII | 1 | Homo sapiens | Q71 | GQVITESLAII | 1 | Caenorhabditis elegans | Q71 | GHTLCDSVAII | 1 | Drosophila melanogaster | Q71 | GITIVQSLAIM | 1 | Mus musculus | Q71 | GITIGQSLAIL | 1 | Rattus norvegicus | R13 | LYSYFRSSCSW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R13 | LYSYWRSSCAH | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R13 | LYSYWRSSCSW | 1 | Caenorhabditis elegans | R13 | LYSYWPSSCSW | 1 | Drosophila melanogaster | R175 | ANA-ERFKVDL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R175 | HAAFNRFHINM | 1 | Arabidopsis thaliana | R175 | HGAINRFQINM | 1 | Arabidopsis thaliana | R175 | YSA-NRFNLDL | 1 | Caenorhabditis elegans | R175 | RNA-RRYKADL | 1 | Drosophila melanogaster | R19 | SSCSWRVRIAL | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus | R19 | SSCAHRVRIAL | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R19 | SSCSWRVRVAL | 1 | Drosophila melanogaster | S117 | PLQNLSVLKQV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S117 | PHQNMALFRYL | 1 | Arabidopsis thaliana | S117 | PHQNLAVIRYI | 1 | Arabidopsis thaliana | S117 | PLHNLKVLQLL | 1 | Caenorhabditis elegans | S117 | PLQNVSVLDHI | 1 | Drosophila melanogaster | S14 | YSYFRSSCSWR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S14 | YSYWRSSCAHR | 2 | Arabidopsis thaliana, Arabidopsis thaliana | S14 | YSYWRSSCSWR | 1 | Caenorhabditis elegans | S14 | YSYWPSSCSWR | 1 | Drosophila melanogaster | S15 | SYFRSSCSWRV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S15 | SYWRSSCAHRV | 2 | Arabidopsis thaliana, Arabidopsis thaliana | S15 | SYWRSSCSWRV | 1 | Caenorhabditis elegans | S15 | SYWPSSCSWRV | 1 | Drosophila melanogaster | S72 | VVINDSFAIIM | 2 | Arabidopsis thaliana, Arabidopsis thaliana | S72 | ITIHQSLAIIE | 1 | Homo sapiens | S72 | QVITESLAIIE | 1 | Caenorhabditis elegans | S72 | HTLCDSVAIIH | 1 | Drosophila melanogaster | S72 | ITIVQSLAIME | 1 | Mus musculus | S72 | ITIGQSLAILE | 1 | Rattus norvegicus | V59 | NPMGTVPALVD | 2 | Arabidopsis thaliana, Arabidopsis thaliana | V59 | NPMKQVPALKI | 2 | Mus musculus, Rattus norvegicus | V59 | NPMKQVPTLKI | 1 | Homo sapiens | V59 | NPAAKVPTFVV | 1 | Caenorhabditis elegans | V59 | NPMQKVPSLKI | 1 | Drosophila melanogaster |
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