mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for GSTZ1
Gene summary
Basic gene Info.Gene symbolGSTZ1
Gene nameglutathione S-transferase zeta 1
CytomapUCSC genome browser: 14q24.3
Type of geneprotein-coding
DescriptionS-(hydroxyalkyl)glutathione lyaseglutathione S-alkyltransferaseglutathione S-aralkyltransferaseglutathione S-aryltransferaseglutathione transferase zeta 1maleylacetoacetate isomerasemaleylacetone isomerase
Modification date20141207
dbXrefs MIM : 603758
Ensembl : ENSG00000100577
HPRD : 04785
Vega : OTTHUMG00000171551
ProteinUniProt: O43708
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_GSTZ1
BioGPS: 2954
PathwayNCI Pathway Interaction Database: GSTZ1
Pathway Commons: GSTZ1
ContextiHOP: GSTZ1
ligand binding site mutation search in PubMed: GSTZ1
UCL Cancer Institute: GSTZ1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006749glutathione metabolic process10739172

Ligand binding site mutations for GSTZ1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for GSTZ1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for GSTZ1 from PDB

Differential gene expression and gene-gene network for GSTZ1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of GSTZ1 and the right PPI network was created from samples without mutations in the LBS of GSTZ1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for GSTZ1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0042594Vestibular Diseases1Biomarker, GeneticVariation
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C0005695Urinary Bladder Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for GSTZ1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00143GlutathioneSmall molecule
ExperimentalDB044471,4-DithiothreitolSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of GSTZ1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of GSTZ1
Multiple alignments for O43708 in multiple species
LBSAA sequence# speciesSpecies
C16YFRSSCSWRVR3Homo sapiens, Mus musculus, Rattus norvegicus
C16YWRSSCAHRVR2Arabidopsis thaliana, Arabidopsis thaliana
C16YWRSSCSWRVR1Caenorhabditis elegans
C16YWPSSCSWRVR1Drosophila melanogaster
L116QPLQNLSVLKQ3Homo sapiens, Mus musculus, Rattus norvegicus
L116QPHQNMALFRY1Arabidopsis thaliana
L116QPHQNLAVIRY1Arabidopsis thaliana
L116QPLHNLKVLQL1Caenorhabditis elegans
L116QPLQNVSVLDH1Drosophila melanogaster
N115IQPLQNLSVLK3Homo sapiens, Mus musculus, Rattus norvegicus
N115IQPHQNMALFR1Arabidopsis thaliana
N115IQPHQNLAVIR1Arabidopsis thaliana
N115IQPLHNLKVLQ1Caenorhabditis elegans
N115IQPLQNVSVLD1Drosophila melanogaster
N172VPQVANA-ERF2Homo sapiens, Mus musculus
N172APQIHAAFNRF1Arabidopsis thaliana
N172APQIHGAINRF1Arabidopsis thaliana
N172PPLIYSA-NRF1Caenorhabditis elegans
N172VPQVRNA-RRY1Drosophila melanogaster
N172APQVANA-ERF1Rattus norvegicus
P60PMGTVPALVDG2Arabidopsis thaliana, Arabidopsis thaliana
P60PMKQVPALKID2Mus musculus, Rattus norvegicus
P60PMKQVPTLKID1Homo sapiens
P60PAAKVPTFVVD1Caenorhabditis elegans
P60PMQKVPSLKID1Drosophila melanogaster
Q111IASGIQPLQNL2Mus musculus, Rattus norvegicus
Q111IAGGIQPLQNL1Homo sapiens
Q111VMSGIQPHQNM1Arabidopsis thaliana
Q111VLSGIQPHQNL1Arabidopsis thaliana
Q111VASGIQPLHNL1Caenorhabditis elegans
Q111ICSGIQPLQNV1Drosophila melanogaster
Q114GIQPLQNLSVL3Homo sapiens, Mus musculus, Rattus norvegicus
Q114GIQPHQNMALF1Arabidopsis thaliana
Q114GIQPHQNLAVI1Arabidopsis thaliana
Q114GIQPLHNLKVL1Caenorhabditis elegans
Q114GIQPLQNVSVL1Drosophila melanogaster
Q45D-RGQQFSKDF1Homo sapiens
Q45---GDQSDSDF1Arabidopsis thaliana
Q45---GDQFDSDF1Arabidopsis thaliana
Q45---SEEAKSKL1Caenorhabditis elegans
Q45TVSGHAYTDEY1Drosophila melanogaster
Q45D-GGQQFTEEF1Mus musculus
Q45D-GGQQFSEEF1Rattus norvegicus
Q58INPMGTVPALV2Arabidopsis thaliana, Arabidopsis thaliana
Q58LNPMKQVPALK2Mus musculus, Rattus norvegicus
Q58LNPMKQVPTLK1Homo sapiens
Q58INPAAKVPTFV1Caenorhabditis elegans
Q58VNPMQKVPSLK1Drosophila melanogaster
Q71DVVINDSFAII2Arabidopsis thaliana, Arabidopsis thaliana
Q71GITIHQSLAII1Homo sapiens
Q71GQVITESLAII1Caenorhabditis elegans
Q71GHTLCDSVAII1Drosophila melanogaster
Q71GITIVQSLAIM1Mus musculus
Q71GITIGQSLAIL1Rattus norvegicus
R13LYSYFRSSCSW3Homo sapiens, Mus musculus, Rattus norvegicus
R13LYSYWRSSCAH2Arabidopsis thaliana, Arabidopsis thaliana
R13LYSYWRSSCSW1Caenorhabditis elegans
R13LYSYWPSSCSW1Drosophila melanogaster
R175ANA-ERFKVDL3Homo sapiens, Mus musculus, Rattus norvegicus
R175HAAFNRFHINM1Arabidopsis thaliana
R175HGAINRFQINM1Arabidopsis thaliana
R175YSA-NRFNLDL1Caenorhabditis elegans
R175RNA-RRYKADL1Drosophila melanogaster
R19SSCSWRVRIAL4Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus
R19SSCAHRVRIAL2Arabidopsis thaliana, Arabidopsis thaliana
R19SSCSWRVRVAL1Drosophila melanogaster
S117PLQNLSVLKQV3Homo sapiens, Mus musculus, Rattus norvegicus
S117PHQNMALFRYL1Arabidopsis thaliana
S117PHQNLAVIRYI1Arabidopsis thaliana
S117PLHNLKVLQLL1Caenorhabditis elegans
S117PLQNVSVLDHI1Drosophila melanogaster
S14YSYFRSSCSWR3Homo sapiens, Mus musculus, Rattus norvegicus
S14YSYWRSSCAHR2Arabidopsis thaliana, Arabidopsis thaliana
S14YSYWRSSCSWR1Caenorhabditis elegans
S14YSYWPSSCSWR1Drosophila melanogaster
S15SYFRSSCSWRV3Homo sapiens, Mus musculus, Rattus norvegicus
S15SYWRSSCAHRV2Arabidopsis thaliana, Arabidopsis thaliana
S15SYWRSSCSWRV1Caenorhabditis elegans
S15SYWPSSCSWRV1Drosophila melanogaster
S72VVINDSFAIIM2Arabidopsis thaliana, Arabidopsis thaliana
S72ITIHQSLAIIE1Homo sapiens
S72QVITESLAIIE1Caenorhabditis elegans
S72HTLCDSVAIIH1Drosophila melanogaster
S72ITIVQSLAIME1Mus musculus
S72ITIGQSLAILE1Rattus norvegicus
V59NPMGTVPALVD2Arabidopsis thaliana, Arabidopsis thaliana
V59NPMKQVPALKI2Mus musculus, Rattus norvegicus
V59NPMKQVPTLKI1Homo sapiens
V59NPAAKVPTFVV1Caenorhabditis elegans
V59NPMQKVPSLKI1Drosophila melanogaster

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