|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for DPP7 |
 Gene summary |
| Basic gene Info. | Gene symbol | DPP7 |
| Gene name | dipeptidyl-peptidase 7 | |
| Synonyms | DPP2|DPPII|QPP | |
| Cytomap | UCSC genome browser: 9q34.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_013379.2, | |
| Description | DPP IIcarboxytripeptidasedipeptidyl aminopeptidase IIdipeptidyl arylamidase IIdipeptidyl peptidase 2dipeptidyl peptidase IIdipeptidyl-peptidase IIquiescent cell proline dipeptidase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610537 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000176978 | ||
| HPRD : 07634 | ||
| Vega : OTTHUMG00000020977 | ||
| Protein | UniProt: Q9UHL4 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DPP7 | |
| BioGPS: 29952 | ||
| Pathway | NCI Pathway Interaction Database: DPP7 | |
| KEGG: DPP7 | ||
| REACTOME: DPP7 | ||
| Pathway Commons: DPP7 | ||
| Context | iHOP: DPP7 | |
| ligand binding site mutation search in PubMed: DPP7 | ||
| UCL Cancer Institute: DPP7 | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
| Top |
| Ligand binding site mutations for DPP7 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P188 | A187T | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for DPP7 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P188 | A187T | -0.2724887 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DPP7 from PDB |
| Top |
| Differential gene expression and gene-gene network for DPP7 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for DPP7 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0027540 | Necrosis | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for DPP7 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of DPP7 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | OPY | GSK237826A | 3n0t | A | P188 | OPY | GSK237826A | 3n0t | B | P188 | OPY | GSK237826A | 3n0t | C | P188 | OPY | GSK237826A | 3n0t | D | P188 |
| Top |
| Conservation information for LBS of DPP7 |
| Multiple alignments for Q9UHL4 in multiple species |
| LBS | AA sequence | # species | Species | D334 | YQSCADPTGCG | 2 | Mus musculus, Rattus norvegicus | D334 | YHSCADPTGCG | 1 | Homo sapiens | E453 | RASNSEDPPSV | 2 | Mus musculus, Rattus norvegicus | E453 | RASHPEDPASV | 1 | Homo sapiens | E78 | FYTGNEGDIWS | 2 | Mus musculus, Rattus norvegicus | E78 | FYTGNEGDVWA | 1 | Homo sapiens | G337 | CADPTGCGTGS | 2 | Mus musculus, Rattus norvegicus | G337 | CADPTGCGTGP | 1 | Homo sapiens | H443 | IQGGAHHLDLR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H451 | DLRASNSEDPP | 2 | Mus musculus, Rattus norvegicus | H451 | DLRASHPEDPA | 1 | Homo sapiens | M271 | FTVLAMMDYPY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P188 | LAASAPVLAVA | 1 | Homo sapiens | P188 | LAASAPVVAVA | 1 | Mus musculus | P188 | LAASAPVIAVA | 1 | Rattus norvegicus | S162 | IAFGGSYGGML | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T336 | SCADPTGCGTG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W347 | PDARAWDYQAC | 1 | Homo sapiens | W347 | SDARAWDYQAC | 1 | Mus musculus | W347 | SNARAWDYQAC | 1 | Rattus norvegicus | W420 | GDLDPWAGGGI | 2 | Mus musculus, Rattus norvegicus | W420 | GNLDPWAGGGI | 1 | Homo sapiens | Y163 | AFGGSYGGMLS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |