mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DPP7
Gene summary
Basic gene Info.Gene symbolDPP7
Gene namedipeptidyl-peptidase 7
CytomapUCSC genome browser: 9q34.3
Type of geneprotein-coding
DescriptionDPP IIcarboxytripeptidasedipeptidyl aminopeptidase IIdipeptidyl arylamidase IIdipeptidyl peptidase 2dipeptidyl peptidase IIdipeptidyl-peptidase IIquiescent cell proline dipeptidase
Modification date20141207
dbXrefs MIM : 610537
Ensembl : ENSG00000176978
HPRD : 07634
Vega : OTTHUMG00000020977
ProteinUniProt: Q9UHL4
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DPP7
BioGPS: 29952
PathwayNCI Pathway Interaction Database: DPP7
Pathway Commons: DPP7
ContextiHOP: DPP7
ligand binding site mutation search in PubMed: DPP7
UCL Cancer Institute: DPP7
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for DPP7

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DPP7
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DPP7 from PDB

Differential gene expression and gene-gene network for DPP7
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DPP7 and the right PPI network was created from samples without mutations in the LBS of DPP7. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DPP7
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DPP7

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DPP7 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of DPP7
Multiple alignments for Q9UHL4 in multiple species
LBSAA sequence# speciesSpecies
D334YQSCADPTGCG2Mus musculus, Rattus norvegicus
D334YHSCADPTGCG1Homo sapiens
E453RASNSEDPPSV2Mus musculus, Rattus norvegicus
E453RASHPEDPASV1Homo sapiens
E78FYTGNEGDIWS2Mus musculus, Rattus norvegicus
E78FYTGNEGDVWA1Homo sapiens
G337CADPTGCGTGS2Mus musculus, Rattus norvegicus
G337CADPTGCGTGP1Homo sapiens
H443IQGGAHHLDLR3Homo sapiens, Mus musculus, Rattus norvegicus
H451DLRASNSEDPP2Mus musculus, Rattus norvegicus
H451DLRASHPEDPA1Homo sapiens
M271FTVLAMMDYPY3Homo sapiens, Mus musculus, Rattus norvegicus
P188LAASAPVLAVA1Homo sapiens
P188LAASAPVVAVA1Mus musculus
P188LAASAPVIAVA1Rattus norvegicus
S162IAFGGSYGGML3Homo sapiens, Mus musculus, Rattus norvegicus
T336SCADPTGCGTG3Homo sapiens, Mus musculus, Rattus norvegicus
W347PDARAWDYQAC1Homo sapiens
W347SDARAWDYQAC1Mus musculus
W347SNARAWDYQAC1Rattus norvegicus
W420GDLDPWAGGGI2Mus musculus, Rattus norvegicus
W420GNLDPWAGGGI1Homo sapiens
Y163AFGGSYGGMLS3Homo sapiens, Mus musculus, Rattus norvegicus

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