mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for SLC25A24
Gene summary
Basic gene Info.Gene symbolSLC25A24
Gene namesolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SynonymsAPC1|SCAMC-1
CytomapUCSC genome browser: 1p13.3
Type of geneprotein-coding
RefGenesNM_013386.4,
NM_213651.2,
Descriptioncalcium-binding mitochondrial carrier protein SCaMC-1calcium-binding transportermitochondrial ATP-Mg/Pi carrier protein 1mitochondrial Ca(2+)-dependent solute carrier protein 1short calcium-binding mitochondrial carrier 1small calcium-binding mitocho
Modification date20141207
dbXrefs MIM : 608744
HGNC : HGNC
Ensembl : ENSG00000085491
HPRD : 12290
Vega : OTTHUMG00000011013
ProteinUniProt: Q6NUK1
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_SLC25A24
BioGPS: 29957
PathwayNCI Pathway Interaction Database: SLC25A24
KEGG: SLC25A24
REACTOME: SLC25A24
Pathway Commons: SLC25A24
ContextiHOP: SLC25A24
ligand binding site mutation search in PubMed: SLC25A24
UCL Cancer Institute: SLC25A24
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for SLC25A24

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
D36,V38G37ABRCA1
D99D99YLUAD1
D99,N101K100RSTAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for SLC25A24
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
D99D99Y-1.0404982
D99K100R-0.98338562
N101K100R-0.98338562
V38G37A-0.90855659
D36G37A-0.90855659
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for SLC25A24 from PDB

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Differential gene expression and gene-gene network for SLC25A24
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of SLC25A24 and the right PPI network was created from samples without mutations in the LBS of SLC25A24. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for SLC25A24
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017661Glomerulonephritis, IGA1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for SLC25A24
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of SLC25A24 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)4n5xAD36 V38
CACALCIUM(2+)4zcuAD36 V38
CACALCIUM(2+)4zcuBD36 V38
CACALCIUM(2+)4zcuCD36 V38
CACALCIUM(2+)4zcvAD36 V38
CACALCIUM(2+)4zcvBD36 V38
CACALCIUM(2+)4zcvCD36 V38
CACALCIUM(2+)4zcvDD36 V38
CACALCIUM(2+)4n5xAD99 N101
CACALCIUM(2+)4zcuAD99 N101
CACALCIUM(2+)4zcuBD99 N101
CACALCIUM(2+)4zcuCD99 N101
CACALCIUM(2+)4zcvBD99 N101
CACALCIUM(2+)4zcvCD99 N101
CACALCIUM(2+)4zcvDD99 N101
CACALCIUM(2+)4zcvAN101


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Conservation information for LBS of SLC25A24
Multiple alignments for Q6NUK1 in multiple species
LBSAA sequence# speciesSpecies
D103DK-NNDGKIEA2Homo sapiens, Bos taurus
D103EEINCQSLLQG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D103DK-NEDGRVDA1Danio rerio
D103DK-NKDGKIES1Xenopus tropicalis
D103DK-NNDGKIEP1Mus musculus
D135ILQSIDVDGTM1Homo sapiens
D135FRHGY------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D135ILHSIDVDGTM1Danio rerio
D135ILKSMDADGTL1Xenopus tropicalis
D135ILQSIDSDGTM1Mus musculus
D135ILQSIDADGTM1Bos taurus
D137QSIDVDGTMTV1Homo sapiens
D137HGY--------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D137HSIDVDGTMTL1Danio rerio
D137KSMDADGTLTV1Xenopus tropicalis
D137QSIDSDGTMTV1Mus musculus
D137QSIDADGTMTV1Bos taurus
D32LFQALDRNGDG1Homo sapiens
D32ELSDITIQSVL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D32LFEKLDVNKDG1Danio rerio
D32LFHKLDVNKDG1Xenopus tropicalis
D32LFRALDRNGDG1Mus musculus
D32LFQKLDRNGDG1Bos taurus
D36LDRNGDGVVDI3Homo sapiens, Mus musculus, Bos taurus
D36ITIQSVLPCDY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D36LDVNKDGKVDV1Danio rerio
D36LDVNKDGKVDI1Xenopus tropicalis
D40GDGVVDIGELQ2Homo sapiens, Mus musculus
D40SVLPCDYSLFK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D40KDGKVDVSELK1Danio rerio
D40KDGKVDIVELQ1Xenopus tropicalis
D40GDGVVDISELQ1Bos taurus
D68IFTTGDVNKDG3Homo sapiens, Mus musculus, Bos taurus
D68-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D68IVTSGDTDKDE1Danio rerio
D68IVAAGDTNKDG1Xenopus tropicalis
D72GDVNKDGKLDF3Homo sapiens, Mus musculus, Bos taurus
D72-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D72GDTDKDEGLDF1Danio rerio
D72GDTNKDGHLDF1Xenopus tropicalis
D76KDGKLDFEEFM3Homo sapiens, Mus musculus, Bos taurus
D76-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D76KDEGLDFEEFS1Danio rerio
D76KDGHLDFGEFI1Xenopus tropicalis
D99AFKSLDK-NND3Homo sapiens, Mus musculus, Bos taurus
D99VFSPKEEINCQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D99TFKSLDK-NED1Danio rerio
D99AFTSLDK-NKD1Xenopus tropicalis
E107NDGKIEASEIV2Homo sapiens, Bos taurus
E107CQSLLQGPELK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E107EDGRVDAKEIQ1Danio rerio
E107KDGKIESAEIM1Xenopus tropicalis
E107NDGKIEPSEIV1Mus musculus
E110KIEASEIVQSL2Homo sapiens, Bos taurus
E110LLQGPELKTAL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E110RVDAKEIQQSL1Danio rerio
E110KIESAEIMNSL1Xenopus tropicalis
E110KIEPSEIVQSL1Mus musculus
E146TVDWNEWRDYF3Homo sapiens, Mus musculus, Bos taurus
E146------WKLHP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E146TLDWNEWREHF1Danio rerio
E146TVDWNEWRDHF1Xenopus tropicalis
E43VVDIGELQEGL1Homo sapiens
E43PCDYSLFKNNL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E43KVDVSELKTGL1Danio rerio
E43KVDIVELQEGL1Xenopus tropicalis
E43VVDIGELQQGL1Mus musculus
E43VVDISELQEGL1Bos taurus
E60LGQDAEEKIFT3Homo sapiens, Mus musculus, Bos taurus
E60-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E60MGKGEAQKIVT1Danio rerio
E60VGKGAEEKIVA1Xenopus tropicalis
E61GQDAEEKIFTT3Homo sapiens, Mus musculus, Bos taurus
E61-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E61GKGEAQKIVTS1Danio rerio
E61GKGAEEKIVAA1Xenopus tropicalis
E79KLDFEEFMKYL3Homo sapiens, Mus musculus, Bos taurus
E79-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E79GLDFEEFSKYL1Danio rerio
E79HLDFGEFIRYL1Xenopus tropicalis
I106NNDGKIEASEI2Homo sapiens, Bos taurus
I106NCQSLLQGPEL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I106NEDGRVDAKEI1Danio rerio
I106NKDGKIESAEI1Xenopus tropicalis
I106NNDGKIEPSEI1Mus musculus
K105-NNDGKIEASE2Homo sapiens, Bos taurus
K105INCQSLLQGPE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K105-NEDGRVDAKE1Danio rerio
K105-NKDGKIESAE1Xenopus tropicalis
K105-NNDGKIEPSE1Mus musculus
K74VNKDGKLDFEE3Homo sapiens, Mus musculus, Bos taurus
K74-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K74TDKDEGLDFEE1Danio rerio
K74TNKDGHLDFGE1Xenopus tropicalis
N101SLDK-NNDGKI3Homo sapiens, Mus musculus, Bos taurus
N101PKEEINCQSLL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N101SLDK-NEDGRV1Danio rerio
N101SLDK-NKDGKI1Xenopus tropicalis
N34QALDRNGDGVV1Homo sapiens
N34SDITIQSVLPC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N34EKLDVNKDGKV1Danio rerio
N34HKLDVNKDGKV1Xenopus tropicalis
N34RALDRNGDGVV1Mus musculus
N34QKLDRNGDGVV1Bos taurus
N70TTGDVNKDGKL3Homo sapiens, Mus musculus, Bos taurus
N70-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N70TSGDTDKDEGL1Danio rerio
N70AAGDTNKDGHL1Xenopus tropicalis
Q45DIGELQEGLRN1Homo sapiens
Q45DYSLFKNNLRV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q45DVSELKTGLAA1Danio rerio
Q45DIVELQEGLKA1Xenopus tropicalis
Q45DIGELQQGLQS1Mus musculus
Q45DISELQEGLKS1Bos taurus
Q57GIPLGQDAEEK3Homo sapiens, Mus musculus, Bos taurus
Q57RLP--------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q57GFSMGKGEAQK1Danio rerio
Q57GMAVGKGAEEK1Xenopus tropicalis
T139IDVDGTMTVDW1Homo sapiens
T139Y----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T139IDVDGTMTLDW1Danio rerio
T139MDADGTLTVDW1Xenopus tropicalis
T139IDSDGTMTVDW1Mus musculus
T139IDADGTMTVDW1Bos taurus
T141VDGTMTVDWNE1Homo sapiens
T141-----------1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T141VDGTMTLDWNE1Danio rerio
T141ADGTLTVDWNE1Xenopus tropicalis
T141SDGTMTVDWNE1Mus musculus
T141ADGTMTVDWNE1Bos taurus
V142DGTMTVDWNEW3Homo sapiens, Mus musculus, Bos taurus
V142----------W1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V142DGTMTLDWNEW1Danio rerio
V142DGTLTVDWNEW1Xenopus tropicalis
V38RNGDGVVDIGE2Homo sapiens, Mus musculus
V38IQSVLPCDYSL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V38VNKDGKVDVSE1Danio rerio
V38VNKDGKVDIVE1Xenopus tropicalis
V38RNGDGVVDISE1Bos taurus


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