mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for PILRB
Gene summary
Basic gene Info.Gene symbolPILRB
Gene namepaired immunoglobin-like type 2 receptor beta
CytomapUCSC genome browser: 7q22.1
Type of geneprotein-coding
Descriptionactivating receptor PILR-betaactivating receptor PILRbetacell surface receptor FDFACTcell surface receptor FDFACT1cell surface receptor FDFACT2paired immunoglobin-like receptor betapaired immunoglobulin-like receptor betapaired immunoglobulin-like
Modification date20141207
dbXrefs MIM : 605342
ProteinUniProt: Q9UKJ0
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PILRB
BioGPS: 29990
PathwayNCI Pathway Interaction Database: PILRB
Pathway Commons: PILRB
ContextiHOP: PILRB
ligand binding site mutation search in PubMed: PILRB
UCL Cancer Institute: PILRB
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for PILRB
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for PILRB
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for PILRB from PDB

Differential gene expression and gene-gene network for PILRB
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of PILRB and the right PPI network was created from samples without mutations in the LBS of PILRB. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for PILRB
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for PILRB
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of PILRB go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of PILRB
Multiple alignments for Q9UKJ0 in multiple species
LBSAA sequence# speciesSpecies
I142QQLQSIKGTKL1Homo sapiens
I142KFWQSLPGTQL1Mus musculus
I142KLWQSIPGTQL1Mus musculus
Q140GRQQLQSIKGT1Homo sapiens
Q140GIKFWQSLPGT1Mus musculus
Q140GMKLWQSIPGT1Mus musculus
R126SVYFCRVELDT1Homo sapiens
R126TWYFCRVFLQT1Mus musculus
R126AQYFSRVNLQS1Mus musculus
W59SFYFPWKLAKD2Mus musculus, Mus musculus
W59SFYYPWELAIV1Homo sapiens
Y33GPSYLYGVTQP1Homo sapiens
Y33NGGNDFGVNQP1Mus musculus
Y33NRKNGFGVNQP1Mus musculus

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