mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ERO1L

Gene summary

Basic gene Info.	Gene symbol	ERO1L
	Gene name	ERO1-like (S. cerevisiae)
	Synonyms	ERO1-alpha\|ERO1A\|ERO1LA
	Cytomap	UCSC genome browser: 14q22.1
	Type of gene	protein-coding
	RefGenes	NM_014584.1,
	Description	ERO1-LERO1-L-alphaERO1-like protein alphaendoplasmic oxidoreductin-1-like proteinoxidoreductin-1-L-alpha
	Modification date	20141222
dbXrefs	MIM : 615435
	HGNC : HGNC
	HPRD : 13278
Protein	UniProt: Q96HE7 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ERO1L
	BioGPS: 30001
Pathway	NCI Pathway Interaction Database: ERO1L
	KEGG: ERO1L
	REACTOME: ERO1L
	Pathway Commons: ERO1L
Context	iHOP: ERO1L
	ligand binding site mutation search in PubMed: ERO1L
	UCL Cancer Institute: ERO1L
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0051085	chaperone mediated protein folding requiring cofactor	11707400

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Ligand binding site mutations for ERO1L

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
M389	I388T	COAD	1
W197	W197R	LUAD	1
R187	R187H	UCEC	1
A196	D195Y	UCEC	1
Y204	E205K	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ERO1L

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
A196	D195Y	0.14229752
R187	R187H	-2.0063818
W197	W197R	-1.6011792
M389	I388T	-1.4352531
Y204	E205K	-0.94612976

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ERO1L from PDB

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Differential gene expression and gene-gene network for ERO1L

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ERO1L and the right PPI network was created from samples without mutations in the LBS of ERO1L. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ERO1L

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0017661	Glomerulonephritis, IGA	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ERO1L

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ERO1L go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
FAD		FAD	3ahq	A	R187 A196 W197 Y204 M389
FAD		FAD	3ahr	A	R187 W197 Y204 M389

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Conservation information for LBS of ERO1L

Multiple alignments for Q96HE7 in multiple species

LBS	AA sequence	# species	Species
A196	YKGPDAWKIWN	2	Homo sapiens, Bos taurus
A196	YKGPDAWRIWS	2	Mus musculus, Rattus norvegicus
A196	YGGKQAGQIWS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A196	YGGEQSSQIWS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A196	YGGEQSAQIWS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A196	YTGPSARRIWD	1	Arabidopsis thaliana
A196	YKGADTWRIWN	1	Xenopus tropicalis
A196	YSGPHSTRIWE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A196	YAGDGAKQVWD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
A256	ISGLHASINVH	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A256	VSGFHASIGTH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A256	ISGLHASIGTH	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A256	ISGLHASIATH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A256	ISGLHSSISMH	1	Arabidopsis thaliana
A256	ISGLHASINIH	1	Xenopus tropicalis
A256	LSGMHSSISTH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A256	VSGMHASISTH	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
C397	VGCFKCRLWGK	4	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus
C397	VQCDRCRLWGK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
C397	VHCDRCRMWGK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
C397	VGCEKCRLWGK	1	Arabidopsis thaliana
C397	VGCLKCRLWGK	1	Bos taurus
C397	VGCERCRLWGK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C397	VGCDKCRLWGK	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
H255	LISGLHASINV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H255	LVSGFHASIGT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H255	LISGLHASIGT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H255	LISGLHASIAT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H255	LISGLHSSISM	1	Arabidopsis thaliana
H255	LISGLHASINI	1	Xenopus tropicalis
H255	VLSGMHSSIST	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H255	IVSGMHASIST	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I199	PDAWKIWNVIY	2	Homo sapiens, Bos taurus
I199	PDAWRIWSVIY	2	Mus musculus, Rattus norvegicus
I199	KQAGQIWSTIY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I199	EQSSQIWSSIY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I199	EQSAQIWSAIY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I199	PSARRIWDSIY	1	Arabidopsis thaliana
I199	ADTWRIWNSIY	1	Xenopus tropicalis
I199	PHSTRIWEMIY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I199	DGAKQVWDAIY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
I258	GLHASINVHLS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I258	GFHASIGTHLS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I258	GLHASIGTHLS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
I258	GLHASIATHLS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
I258	GLHSSISMHIA	1	Arabidopsis thaliana
I258	GLHASINIHLC	1	Xenopus tropicalis
I258	GMHSSISTHLC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I258	GMHASISTHLC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
L262	SINVHLSARYL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L262	SIGTHLSKEYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L262	SIGTHLSNEHL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L262	SIATHLSNDYL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L262	SISMHIAADYL	1	Arabidopsis thaliana
L262	SINIHLCANYL	1	Xenopus tropicalis
L262	SISTHLCHGYL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L262	SISTHLCWDFL	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
M389	NISRIMDCVGC	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M389	NVTKIMDCVQC	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
M389	NVTKIMDCVHC	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
M389	NISALMDCVGC	1	Arabidopsis thaliana
M389	NISKIMDCVGC	1	Xenopus tropicalis
M389	TVSALMDCVGC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M389	NISRLMDCVGC	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
N259	LHASINVHLSA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N259	FHASIGTHLSK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N259	LHASIGTHLSN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N259	LHASIATHLSN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N259	LHSSISMHIAA	1	Arabidopsis thaliana
N259	LHASINIHLCA	1	Xenopus tropicalis
N259	MHSSISTHLCH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N259	MHASISTHLCW	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R187	LLNPERYTGYK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R187	TANPERFTGYG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R187	VANPERFTGYG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R187	QLNPERYTGYT	1	Arabidopsis thaliana
R187	LKNPERYTGYK	1	Xenopus tropicalis
R187	LENPERFTGYS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R187	LRNPERFTGYA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R287	TEFQQRFDGIL	3	Homo sapiens, Mus musculus, Bos taurus
R287	DLFMARIGNF-	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R287	ELFMTRVGNF-	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R287	ELFMARVGNH-	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R287	ELMYDRILRH-	1	Arabidopsis thaliana
R287	AEFQKRFDATL	1	Xenopus tropicalis
R287	TEFQQRFDGVL	1	Rattus norvegicus
R287	QCFQEKVLNY-	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R287	SCYINRLHKF-	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
R300	GEGPRRLKNLY	3	Homo sapiens, Rattus norvegicus, Bos taurus
R300	---PDRVTNMY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R300	---PDRVSNIY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R300	---PDRVANIY	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R300	---PDRVRNMY	1	Arabidopsis thaliana
R300	GEGPKRLKNLY	1	Xenopus tropicalis
R300	GEGPRRLRNLY	1	Mus musculus
R300	---PERLENLY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R300	---PERISNLY	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
S252	FYRLISGLHAS	7	Homo sapiens, Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
S252	FYRLVSGFHAS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S252	LYKLISGLHSS	1	Arabidopsis thaliana
S252	FYRVLSGMHSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S252	FYKIVSGMHAS	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
T189	NPERYTGYKGP	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T189	NPERFTGYGGE	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T189	NPERFTGYGGK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T189	NPERYTGYTGP	1	Arabidopsis thaliana
T189	NPERYTGYKGA	1	Xenopus tropicalis
T189	NPERFTGYSGP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T189	NPERFTGYAGD	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W197	KGPDAWKIWNV	2	Homo sapiens, Bos taurus
W197	KGPDAWRIWSV	2	Mus musculus, Rattus norvegicus
W197	GGKQAGQIWST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W197	GGEQSSQIWSS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W197	GGEQSAQIWSA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W197	TGPSARRIWDS	1	Arabidopsis thaliana
W197	KGADTWRIWNS	1	Xenopus tropicalis
W197	SGPHSTRIWEM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W197	AGDGAKQVWDA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
W200	DAWKIWNVIYE	2	Homo sapiens, Bos taurus
W200	DAWRIWSVIYE	2	Mus musculus, Rattus norvegicus
W200	QAGQIWSTIYQ	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W200	QSSQIWSSIYK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
W200	QSAQIWSAIYK	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
W200	SARRIWDSIYS	1	Arabidopsis thaliana
W200	DTWRIWNSIYE	1	Xenopus tropicalis
W200	HSTRIWEMIYN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W200	GAKQVWDAIYR	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y188	LNPERYTGYKG	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y188	ANPERFTGYGG	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y188	LNPERYTGYTG	1	Arabidopsis thaliana
Y188	KNPERYTGYKG	1	Xenopus tropicalis
Y188	ENPERFTGYSG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y188	RNPERFTGYAG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y191	ERYTGYKGPDA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y191	ERFTGYGGEQS	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y191	ERFTGYGGKQA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y191	ERYTGYTGPSA	1	Arabidopsis thaliana
Y191	ERYTGYKGADT	1	Xenopus tropicalis
Y191	ERFTGYSGPHS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y191	ERFTGYAGDGA	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y204	IWNVIYEENCF	2	Homo sapiens, Bos taurus
Y204	IWSVIYEENCF	2	Mus musculus, Rattus norvegicus
Y204	IWSTIYQDNCF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y204	IWSSIYKENCF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y204	IWSAIYKENCF	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y204	IWDSIYSENCP	1	Arabidopsis thaliana
Y204	IWNSIYEENCF	1	Xenopus tropicalis
Y204	IWEMIYNQ-CL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y204	VWDAIYRENCF	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Y248	EKRAFYRLISG	5	Homo sapiens, Xenopus tropicalis, Mus musculus, Rattus norvegicus, Bos taurus
Y248	AKDAFYRLVSG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y248	AKDAFYRLISG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Y248	AKDVFYRLISG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Y248	EKKVLYKLISG	1	Arabidopsis thaliana
Y248	EQRVFYRVLSG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y248	EKRVFYKIVSG	1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)