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mutLBSgeneDB |
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| Gene summary for ANXA2 |
 Gene summary |
| Basic gene Info. | Gene symbol | ANXA2 |
| Gene name | annexin A2 | |
| Synonyms | ANX2|ANX2L4|CAL1H|HEL-S-270|LIP2|LPC2|LPC2D|P36|PAP-IV | |
| Cytomap | UCSC genome browser: 15q22.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001002857.1, NM_001002858.2,NM_001136015.2,NM_004039.2, | |
| Description | annexin IIannexin-2calpactin I heavy chaincalpactin I heavy polypeptidecalpactin-1 heavy chainchromobindin 8chromobindin-8epididymis secretory protein Li 270lipocortin IIplacental anticoagulant protein IVprotein I | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 151740 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000182718 | ||
| HPRD : 01061 | ||
| Vega : OTTHUMG00000132763 | ||
| Protein | UniProt: P07355 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANXA2 | |
| BioGPS: 302 | ||
| Pathway | NCI Pathway Interaction Database: ANXA2 | |
| KEGG: ANXA2 | ||
| REACTOME: ANXA2 | ||
| Pathway Commons: ANXA2 | ||
| Context | iHOP: ANXA2 | |
| ligand binding site mutation search in PubMed: ANXA2 | ||
| UCL Cancer Institute: ANXA2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0031340 | positive regulation of vesicle fusion | 2138016 | GO:0036035 | osteoclast development | 7961821 | GO:0043086 | negative regulation of catalytic activity | 3013422 | GO:0051290 | protein heterotetramerization | 23091277 |
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| Ligand binding site mutations for ANXA2 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T123,E125 | D124N | COAD | 2 | E6 | E6K | COAD | 1 | T123 | T123P | OV | 1 | M118 | S117F | SKCM | 1 | E53 | T55A | STAD | 1 | D162 | S161L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ANXA2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T123 | T123P | -1.21394 | M118 | S117F | -1.1631412 | E53 | T55A | -0.80617686 | D162 | S161L | -0.65254699 | E6 | E6K | -0.37644006 | T123 | D124N | -0.11946242 | E125 | D124N | -0.11946242 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ANXA2 from PDB |
| PDB ID | PDB title | PDB structure | 2HYV | Human Annexin A2 with heparin hexasaccharide bound |  |
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| Differential gene expression and gene-gene network for ANXA2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ANXA2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007137 | Carcinoma, Squamous Cell | 4 | Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 3 | Biomarker |
| umls:C0023903 | Liver Neoplasms | 2 | Biomarker |
| umls:C0029456 | Osteoporosis | 2 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0026640 | Mouth Neoplasms | 1 | Biomarker |
| umls:C0027626 | Neoplasm Invasiveness | 1 | Biomarker |
| umls:C0043094 | Weight Gain | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ANXA2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00031 | Tenecteplase | Biotech |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ANXA2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1xjl | A | E53 | CA | CALCIUM(2+) | 1xjl | B | E53 | CA | CALCIUM(2+) | 1xjl | B | M118 D162 | CA | CALCIUM(2+) | 1xjl | A | M118 T123 D162 | CA | CALCIUM(2+) | 1xjl | A | T123 E125 | CA | CALCIUM(2+) | 1xjl | B | T123 E125 |
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| Conservation information for LBS of ANXA2 |
| Multiple alignments for P07355 in multiple species |
| LBS | AA sequence | # species | Species | D162 | KDIISDTSGDF | 4 | Homo sapiens, Gallus gallus, Mus musculus, Canis lupus familiaris | D162 | KDIISDTSGEF | 1 | Rattus norvegicus | D162 | KDIVSDTSGDF | 1 | Bos taurus | D322 | YYIQQDTKGDY | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | D322 | YFIQQDTKGDY | 2 | Gallus gallus, Rattus norvegicus | D326 | QDTKGDYQKAL | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | D326 | QDTKGDYQRAL | 1 | Gallus gallus | E125 | GLGTDEDSLIE | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | E125 | GLGTDEDTLIE | 1 | Gallus gallus | E247 | ESIKKEVKGDL | 4 | Gallus gallus, Mus musculus, Canis lupus familiaris, Bos taurus | E247 | ESIRKEVKGDL | 2 | Homo sapiens, Rattus norvegicus | E253 | VKGDLENAFLN | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | E53 | TKGVDEVTIVN | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | E53 | TKGVDEVTIIN | 1 | Gallus gallus | E6 | MSTVHEILCKL | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | E6 | MSTVHEILSKL | 1 | Gallus gallus | E96 | LSGHLETVILG | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | E96 | LSGHLEAVILG | 1 | Gallus gallus | E96 | LSGHLETVMLG | 1 | Rattus norvegicus | G120 | KASMKGLGTDE | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G120 | KAAMKGLGTDE | 1 | Gallus gallus | G122 | SMKGLGTDEDS | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G122 | AMKGLGTDEDT | 1 | Gallus gallus | G202 | DLYDAGVKRKG | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | G202 | ELYDAGVKRKG | 3 | Gallus gallus, Rattus norvegicus, Mus musculus | G207 | GVKRKGTDVPK | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G280 | YDSMKGKGTRD | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G282 | SMKGKGTRDKV | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G325 | QQDTKGDYQKA | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G325 | QQDTKGDYQRA | 1 | Gallus gallus | G50 | AIKTKGVDEVT | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | G50 | AVKTKGVDEVT | 1 | Mus musculus | G93 | KSALSGHLETV | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | G93 | KSALSGHLEAV | 1 | Gallus gallus | H94 | SALSGHLETVI | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | H94 | SALSGHLEAVI | 1 | Gallus gallus | H94 | SALSGHLETVM | 1 | Rattus norvegicus | K10 | HEILCKLSLEG | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K10 | HEILSKLSLEG | 1 | Gallus gallus | K119 | LKASMKGLGTD | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K119 | LKAAMKGLGTD | 1 | Gallus gallus | K206 | AGVKRKGTDVP | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K249 | IKKEVKGDLEN | 4 | Gallus gallus, Mus musculus, Canis lupus familiaris, Bos taurus | K249 | IRKEVKGDLEN | 2 | Homo sapiens, Rattus norvegicus | K279 | LYDSMKGKGTR | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K281 | DSMKGKGTRDK | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K324 | IQQDTKGDYQK | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | K324 | IQQDTKGDYQR | 1 | Gallus gallus | K88 | LASALKSALSG | 3 | Homo sapiens, Canis lupus familiaris, Bos taurus | K88 | LSAALKSALSG | 1 | Gallus gallus | K88 | LPSAMKSALSG | 1 | Rattus norvegicus | K88 | LPSALKSALSG | 1 | Mus musculus | L11 | EILCKLSLEGD | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | L11 | EILSKLSLEGD | 1 | Gallus gallus | L121 | ASMKGLGTDED | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | L121 | AAMKGLGTDED | 1 | Gallus gallus | L13 | LCKLSLEGDHS | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | L13 | LSKLSLEGDHS | 1 | Gallus gallus | L8 | TVHEILCKLSL | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | L8 | TVHEILSKLSL | 1 | Gallus gallus | L91 | ALKSALSGHLE | 5 | Homo sapiens, Gallus gallus, Mus musculus, Canis lupus familiaris, Bos taurus | L91 | AMKSALSGHLE | 1 | Rattus norvegicus | M118 | ELKASMKGLGT | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | M118 | ELKAAMKGLGT | 1 | Gallus gallus | M278 | RLYDSMKGKGT | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | R205 | DAGVKRKGTDV | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | R245 | MLESIKKEVKG | 4 | Gallus gallus, Mus musculus, Canis lupus familiaris, Bos taurus | R245 | MLESIRKEVKG | 2 | Homo sapiens, Rattus norvegicus | S12 | ILCKLSLEGDH | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | S12 | ILSKLSLEGDH | 1 | Gallus gallus | S92 | LKSALSGHLET | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | S92 | LKSALSGHLEA | 1 | Gallus gallus | S92 | MKSALSGHLET | 1 | Rattus norvegicus | T123 | MKGLGTDEDSL | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | T123 | MKGLGTDEDTL | 1 | Gallus gallus | T283 | MKGKGTRDKVL | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | T323 | YIQQDTKGDYQ | 4 | Homo sapiens, Mus musculus, Canis lupus familiaris, Bos taurus | T323 | FIQQDTKGDYQ | 2 | Gallus gallus, Rattus norvegicus | V203 | LYDAGVKRKGT | 6 | Homo sapiens, Gallus gallus, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | V248 | SIKKEVKGDLE | 4 | Gallus gallus, Mus musculus, Canis lupus familiaris, Bos taurus | V248 | SIRKEVKGDLE | 2 | Homo sapiens, Rattus norvegicus | V51 | IKTKGVDEVTI | 5 | Homo sapiens, Gallus gallus, Rattus norvegicus, Canis lupus familiaris, Bos taurus | V51 | VKTKGVDEVTI | 1 | Mus musculus | Y327 | DTKGDYQKALL | 5 | Homo sapiens, Rattus norvegicus, Mus musculus, Canis lupus familiaris, Bos taurus | Y327 | DTKGDYQRALL | 1 | Gallus gallus |
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