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mutLBSgeneDB |
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| Gene summary for HCK |
 Gene summary |
| Basic gene Info. | Gene symbol | HCK |
| Gene name | HCK proto-oncogene, Src family tyrosine kinase | |
| Synonyms | JTK9|p59Hck|p61Hck | |
| Cytomap | UCSC genome browser: 20q11-q12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001172129.1, NM_001172130.1,NM_001172131.1,NM_001172132.1,NM_001172133.1, NM_002110.3, | |
| Description | hematopoietic cell kinasehemopoietic cell kinasep59-HCK/p60-HCKtyrosine-protein kinase HCK | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 142370 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101336 | ||
| HPRD : 00796 | ||
| Vega : OTTHUMG00000032204 | ||
| Protein | UniProt: P08631 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HCK | |
| BioGPS: 3055 | ||
| Pathway | NCI Pathway Interaction Database: HCK | |
| KEGG: HCK | ||
| REACTOME: HCK | ||
| Pathway Commons: HCK | ||
| Context | iHOP: HCK | |
| ligand binding site mutation search in PubMed: HCK | ||
| UCL Cancer Institute: HCK | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0071801 | regulation of podosome assembly | 15998323 | GO:2000251 | positive regulation of actin cytoskeleton reorganization | 15998323 |
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| Ligand binding site mutations for HCK |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | G339 | G339V | BLCA | 1 | D399 | D399G | COAD | 1 | K290 | M292I | GBM | 1 | Y132 | A134T | HNSC | 1 | G339 | G339E | KIRC | 1 | G339 | G339E | LUAD | 1 | Y127 | Y127F | LUAD | 1 | I331 | I329M | LUSC | 1 | Y132 | A134T | SKCM | 1 | G271 | G271E | SKCM | 1 | E334 | E334K | SKCM | 1 | V276 | G274R | STAD | 1 | H93 | H93Q | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HCK |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | G339 | G339V | 0.71502423 | G339 | G339E | 0.68428214 | I331 | I329M | -1.4413612 | D399 | D399G | -1.3691743 | K290 | M292I | -0.98485006 | Y132 | A134T | -0.90617512 | H93 | H93Q | -0.84144605 | Y127 | Y127F | -0.81545307 | E334 | E334K | -0.63426966 | V276 | G274R | -0.21166667 | G271 | G271E | -0.14034252 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HCK from PDB |
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| Differential gene expression and gene-gene network for HCK |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HCK |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HCK |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01809 | 1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine | Small molecule |  |
| Experimental | DB01962 | Phosphonotyrosine | Small molecule |  |
| Experimental | DB04216 | Quercetin | Small molecule |  |
| Approved | DB06616 | Bosutinib | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HCK go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of HCK |
| Multiple alignments for P08631 in multiple species |
| LBS | AA sequence | # species | Species | A270 | EKKLGAGQFGE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A288 | KHTKVAVKTMK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A385 | RDLRAANILVS | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | A398 | LVCKIADFGLA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D343 | KGSLLDFLKSE | 2 | Mus musculus, Rattus norvegicus | D343 | KGSLLDFLKSD | 1 | Homo sapiens | D399 | VCKIADFGLAR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | D96 | AIHREDLSFQK | 2 | Mus musculus, Rattus norvegicus | D96 | AIHHEDLSFQK | 1 | Homo sapiens | E113 | LEESGEWWKAR | 2 | Homo sapiens, Rattus norvegicus | E113 | LEEAGEWWKAR | 1 | Mus musculus | E256 | EKDAWEIPRES | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E305 | EAFLAEANLMK | 2 | Mus musculus, Rattus norvegicus | E305 | EAFLAEANVMK | 1 | Homo sapiens | E334 | IFIVTEFMAKG | 2 | Mus musculus, Rattus norvegicus | E334 | IYIITEFMAKG | 1 | Homo sapiens | E519 | FYTATESQYQQ | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | E95 | EAIHREDLSFQ | 2 | Mus musculus, Rattus norvegicus | E95 | EAIHHEDLSFQ | 1 | Homo sapiens | F302 | MSVEAFLAEAN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | F335 | FIVTEFMAKGS | 2 | Mus musculus, Rattus norvegicus | F335 | YIITEFMAKGS | 1 | Homo sapiens | F400 | CKIADFGLARI | 2 | Mus musculus, Rattus norvegicus | F400 | CKIADFGLARV | 1 | Homo sapiens | G112 | VLEESGEWWKA | 2 | Homo sapiens, Rattus norvegicus | G112 | VLEEAGEWWKA | 1 | Mus musculus | G269 | MEKKLGAGQFG | 2 | Mus musculus, Rattus norvegicus | G269 | LEKKLGAGQFG | 1 | Homo sapiens | G271 | KKLGAGQFGEV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G339 | EFMAKGSLLDF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G401 | KIADFGLARII | 2 | Mus musculus, Rattus norvegicus | G401 | KIADFGLARVI | 1 | Homo sapiens | H93 | DYEAIHREDLS | 2 | Mus musculus, Rattus norvegicus | H93 | DYEAIHHEDLS | 1 | Homo sapiens | H94 | YEAIHREDLSF | 2 | Mus musculus, Rattus norvegicus | H94 | YEAIHHEDLSF | 1 | Homo sapiens | I331 | QEPIFIVTEFM | 2 | Mus musculus, Rattus norvegicus | I331 | KEPIYIITEFM | 1 | Homo sapiens | I92 | YDYEAIHREDL | 2 | Mus musculus, Rattus norvegicus | I92 | YDYEAIHHEDL | 1 | Homo sapiens | K101 | DLSFQKGDQMV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K116 | SGEWWKARSLA | 2 | Homo sapiens, Rattus norvegicus | K116 | AGEWWKARSLA | 1 | Mus musculus | K290 | TKVAVKTMKPG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L268 | QMEKKLGAGQF | 2 | Mus musculus, Rattus norvegicus | L268 | KLEKKLGAGQF | 1 | Homo sapiens | L320 | DKLVKLHAVVS | 2 | Mus musculus, Rattus norvegicus | L320 | DKLVKLHAVVT | 1 | Homo sapiens | L388 | RAANILVSASL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L402 | IADFGLARIIE | 2 | Mus musculus, Rattus norvegicus | L402 | IADFGLARVIE | 1 | Homo sapiens | M309 | AEANVMKTLQH | 1 | Homo sapiens | M309 | AEANLMKSLQH | 1 | Mus musculus | M309 | AEANLMKTLQH | 1 | Rattus norvegicus | M336 | IVTEFMAKGSL | 2 | Mus musculus, Rattus norvegicus | M336 | IITEFMAKGSL | 1 | Homo sapiens | N131 | GYIPSNYVARV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N386 | DLRAANILVSA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P129 | KEGYIPSNYVA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q524 | ESQYQQQP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R383 | IHRDLRAANIL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S111 | VVLEESGEWWK | 2 | Homo sapiens, Rattus norvegicus | S111 | VVLEEAGEWWK | 1 | Mus musculus | S130 | EGYIPSNYVAR | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S340 | FMAKGSLLDFL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | T333 | PIFIVTEFMAK | 2 | Mus musculus, Rattus norvegicus | T333 | PIYIITEFMAK | 1 | Homo sapiens | V276 | GQFGEVWMATY | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V289 | HTKVAVKTMKP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V318 | QHDKLVKLHAV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | W114 | EESGEWWKARS | 2 | Homo sapiens, Rattus norvegicus | W114 | EEAGEWWKARS | 1 | Mus musculus | W115 | ESGEWWKARSL | 2 | Homo sapiens, Rattus norvegicus | W115 | EAGEWWKARSL | 1 | Mus musculus | Y127 | TKKEGYIPSNY | 2 | Mus musculus, Rattus norvegicus | Y127 | TRKEGYIPSNY | 1 | Homo sapiens | Y132 | YIPSNYVARVN | 2 | Mus musculus, Rattus norvegicus | Y132 | YIPSNYVARVD | 1 | Homo sapiens | Y522 | ATESQYQQQP | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y87 | IVVALYDYEAI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y89 | VALYDYEAIHR | 2 | Mus musculus, Rattus norvegicus | Y89 | VALYDYEAIHH | 1 | Homo sapiens |
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