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mutLBSgeneDB |
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| Gene summary for ANXA4 |
 Gene summary |
| Basic gene Info. | Gene symbol | ANXA4 |
| Gene name | annexin A4 | |
| Synonyms | ANX4|HEL-S-274|PIG28|ZAP36 | |
| Cytomap | UCSC genome browser: 2p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001153.3, | |
| Description | 35-beta calcimedinP32.5PAP-IIPP4-Xannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferat | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 106491 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196975 | ||
| HPRD : 00112 | ||
| Vega : OTTHUMG00000129649 | ||
| Protein | UniProt: P09525 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ANXA4 | |
| BioGPS: 307 | ||
| Pathway | NCI Pathway Interaction Database: ANXA4 | |
| KEGG: ANXA4 | ||
| REACTOME: ANXA4 | ||
| Pathway Commons: ANXA4 | ||
| Context | iHOP: ANXA4 | |
| ligand binding site mutation search in PubMed: ANXA4 | ||
| UCL Cancer Institute: ANXA4 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006357 | regulation of transcription from RNA polymerase II promoter | 20237821 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 20237821 |
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| Ligand binding site mutations for ANXA4 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D143 | R143C | SKCM | 2 | G101 | M101I | BRCA | 1 | E227 | K227T | COAD | 1 | G187 | G189E | LUAD | 1 | G103 | G105C | LUAD | 1 | L261 | S259L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ANXA4 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ANXA4 from PDB |
| PDB ID | PDB title | PDB structure | 2ZOC | " |  |
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| Differential gene expression and gene-gene network for ANXA4 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ANXA4 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007134 | Carcinoma, Renal Cell | 4 | Biomarker |
| umls:C0007097 | Carcinoma | 1 | Biomarker |
| umls:C2239176 | Carcinoma, Hepatocellular | 1 | Biomarker |
| umls:C0023467 | Leukemia, Myeloid, Acute | 1 | Biomarker |
| umls:C0023903 | Liver Neoplasms | 1 | Biomarker |
| umls:C0024667 | Mammary Neoplasms, Animal | 1 | Biomarker |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | Biomarker |
| umls:C0032927 | Precancerous Conditions | 1 | Biomarker |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ANXA4 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ANXA4 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 2zoc | A | G101 G103 D143 | CA | CALCIUM(2+) | 2zoc | B | G101 G103 D143 | CA | CALCIUM(2+) | 2zoc | A | G187 E227 | CA | CALCIUM(2+) | 2zoc | B | G187 E227 | CA | CALCIUM(2+) | 2zoc | B | L261 |
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| Conservation information for LBS of ANXA4 |
| Multiple alignments for P09525 in multiple species |
| LBS | AA sequence | # species | Species | A102 | RAMKGAGTDEG | 2 | Homo sapiens, Mus musculus | A102 | RSLRGAVTDHK | 1 | Arabidopsis thaliana | A102 | KAMKGAGTDEG | 1 | Bos taurus | D143 | DDIRSDTSFMF | 2 | Homo sapiens, Bos taurus | D143 | EDIESEASGNH | 1 | Arabidopsis thaliana | D143 | EDICSDTSFMF | 1 | Mus musculus | D302 | SFIKGDTSGDY | 3 | Homo sapiens, Mus musculus, Bos taurus | D302 | NAVHSDTTSHY | 1 | Arabidopsis thaliana | E183 | LYEAGEKKWGT | 2 | Homo sapiens, Bos taurus | E183 | LKSAVARKHKS | 1 | Arabidopsis thaliana | E183 | LYEAGEKRWGT | 1 | Mus musculus | E227 | QSIKSETSGSF | 3 | Homo sapiens, Mus musculus, Bos taurus | E227 | KAIRDETRGNF | 1 | Arabidopsis thaliana | E233 | TSGSFEDALLA | 3 | Homo sapiens, Mus musculus, Bos taurus | E233 | TRGNFEHVLLT | 1 | Arabidopsis thaliana | G101 | RRAMKGAGTDE | 2 | Homo sapiens, Mus musculus | G101 | KRSLRGAVTDH | 1 | Arabidopsis thaliana | G101 | RKAMKGAGTDE | 1 | Bos taurus | G103 | AMKGAGTDEGC | 3 | Homo sapiens, Mus musculus, Bos taurus | G103 | SLRGAVTDHKA | 1 | Arabidopsis thaliana | G182 | DLYEAGEKKWG | 2 | Homo sapiens, Bos taurus | G182 | TLKSAVARKHK | 1 | Arabidopsis thaliana | G182 | ELYEAGEKRWG | 1 | Mus musculus | G187 | GEKKWGTDEVK | 2 | Homo sapiens, Bos taurus | G187 | VARKHKSDDQT | 1 | Arabidopsis thaliana | G187 | GEKRWGTDEVK | 1 | Mus musculus | G262 | SMKGLGTDDNT | 2 | Homo sapiens, Mus musculus | G262 | SMKGLGTDDTA | 1 | Arabidopsis thaliana | G262 | SMKGLGTDDDT | 1 | Bos taurus | G29 | RKAMKGLGTDE | 3 | Homo sapiens, Mus musculus, Bos taurus | G29 | FKAFKGRGCDT | 1 | Arabidopsis thaliana | K185 | EAGEKKWGTDE | 2 | Homo sapiens, Bos taurus | K185 | SAVARKHKSDD | 1 | Arabidopsis thaliana | K185 | EAGEKRWGTDE | 1 | Mus musculus | K225 | IEQSIKSETSG | 3 | Homo sapiens, Mus musculus, Bos taurus | K225 | LGKAIRDETRG | 1 | Arabidopsis thaliana | L261 | KSMKGLGTDDN | 2 | Homo sapiens, Mus musculus | L261 | KSMKGLGTDDT | 1 | Arabidopsis thaliana | L261 | KSMKGLGTDDD | 1 | Bos taurus | M27 | TLRKAMKGLGT | 3 | Homo sapiens, Mus musculus, Bos taurus | M27 | QLFKAFKGRGC | 1 | Arabidopsis thaliana | M99 | ELRRAMKGAGT | 2 | Homo sapiens, Mus musculus | M99 | ILKRSLRGAVT | 1 | Arabidopsis thaliana | M99 | ELRKAMKGAGT | 1 | Bos taurus | S229 | IKSETSGSFED | 3 | Homo sapiens, Mus musculus, Bos taurus | S229 | IRDETRGNFEH | 1 | Arabidopsis thaliana | T228 | SIKSETSGSFE | 3 | Homo sapiens, Mus musculus, Bos taurus | T228 | AIRDETRGNFE | 1 | Arabidopsis thaliana |
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