mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for ANXA4
Gene summary
Basic gene Info.Gene symbolANXA4
Gene nameannexin A4
CytomapUCSC genome browser: 2p13
Type of geneprotein-coding
Description35-beta calcimedinP32.5PAP-IIPP4-Xannexin IV (placental anticoagulant protein II)annexin-4carbohydrate-binding protein p33/p41chromobindin-4endonexin Iepididymis secretory protein Li 274lipocortin IVplacental anticoagulant protein IIproliferat
Modification date20141207
dbXrefs MIM : 106491
Ensembl : ENSG00000196975
HPRD : 00112
Vega : OTTHUMG00000129649
ProteinUniProt: P09525
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_ANXA4
BioGPS: 307
PathwayNCI Pathway Interaction Database: ANXA4
Pathway Commons: ANXA4
ContextiHOP: ANXA4
ligand binding site mutation search in PubMed: ANXA4
UCL Cancer Institute: ANXA4
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0006357regulation of transcription from RNA polymerase II promoter20237821
GO:0032088negative regulation of NF-kappaB transcription factor activity20237821

Ligand binding site mutations for ANXA4
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for ANXA4
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ANXA4 from PDB
PDB IDPDB titlePDB structure

Differential gene expression and gene-gene network for ANXA4
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of ANXA4 and the right PPI network was created from samples without mutations in the LBS of ANXA4. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for ANXA4
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0007134Carcinoma, Renal Cell4Biomarker
umls:C2239176Carcinoma, Hepatocellular1Biomarker
umls:C0023467Leukemia, Myeloid, Acute1Biomarker
umls:C0023903Liver Neoplasms1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0032927Precancerous Conditions1Biomarker
umls:C0033578Prostatic Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for ANXA4
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ANXA4 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CACALCIUM(2+)2zocAG101 G103 D143
CACALCIUM(2+)2zocBG101 G103 D143
CACALCIUM(2+)2zocAG187 E227
CACALCIUM(2+)2zocBG187 E227

Conservation information for LBS of ANXA4
Multiple alignments for P09525 in multiple species
LBSAA sequence# speciesSpecies
A102RAMKGAGTDEG2Homo sapiens, Mus musculus
A102RSLRGAVTDHK1Arabidopsis thaliana
A102KAMKGAGTDEG1Bos taurus
D143DDIRSDTSFMF2Homo sapiens, Bos taurus
D143EDIESEASGNH1Arabidopsis thaliana
D143EDICSDTSFMF1Mus musculus
D302SFIKGDTSGDY3Homo sapiens, Mus musculus, Bos taurus
D302NAVHSDTTSHY1Arabidopsis thaliana
E183LYEAGEKKWGT2Homo sapiens, Bos taurus
E183LKSAVARKHKS1Arabidopsis thaliana
E183LYEAGEKRWGT1Mus musculus
E227QSIKSETSGSF3Homo sapiens, Mus musculus, Bos taurus
E227KAIRDETRGNF1Arabidopsis thaliana
E233TSGSFEDALLA3Homo sapiens, Mus musculus, Bos taurus
E233TRGNFEHVLLT1Arabidopsis thaliana
G101RRAMKGAGTDE2Homo sapiens, Mus musculus
G101KRSLRGAVTDH1Arabidopsis thaliana
G101RKAMKGAGTDE1Bos taurus
G103AMKGAGTDEGC3Homo sapiens, Mus musculus, Bos taurus
G103SLRGAVTDHKA1Arabidopsis thaliana
G182DLYEAGEKKWG2Homo sapiens, Bos taurus
G182TLKSAVARKHK1Arabidopsis thaliana
G182ELYEAGEKRWG1Mus musculus
G187GEKKWGTDEVK2Homo sapiens, Bos taurus
G187VARKHKSDDQT1Arabidopsis thaliana
G187GEKRWGTDEVK1Mus musculus
G262SMKGLGTDDNT2Homo sapiens, Mus musculus
G262SMKGLGTDDTA1Arabidopsis thaliana
G262SMKGLGTDDDT1Bos taurus
G29RKAMKGLGTDE3Homo sapiens, Mus musculus, Bos taurus
G29FKAFKGRGCDT1Arabidopsis thaliana
K185EAGEKKWGTDE2Homo sapiens, Bos taurus
K185SAVARKHKSDD1Arabidopsis thaliana
K185EAGEKRWGTDE1Mus musculus
K225IEQSIKSETSG3Homo sapiens, Mus musculus, Bos taurus
K225LGKAIRDETRG1Arabidopsis thaliana
L261KSMKGLGTDDN2Homo sapiens, Mus musculus
L261KSMKGLGTDDT1Arabidopsis thaliana
L261KSMKGLGTDDD1Bos taurus
M27TLRKAMKGLGT3Homo sapiens, Mus musculus, Bos taurus
M27QLFKAFKGRGC1Arabidopsis thaliana
M99ELRRAMKGAGT2Homo sapiens, Mus musculus
M99ILKRSLRGAVT1Arabidopsis thaliana
S229IKSETSGSFED3Homo sapiens, Mus musculus, Bos taurus
S229IRDETRGNFEH1Arabidopsis thaliana
T228SIKSETSGSFE3Homo sapiens, Mus musculus, Bos taurus
T228AIRDETRGNFE1Arabidopsis thaliana

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas