mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HGF
Gene summary
Basic gene Info.Gene symbolHGF
Gene namehepatocyte growth factor (hepapoietin A; scatter factor)
SynonymsDFNB39|F-TCF|HGFB|HPTA|SF
CytomapUCSC genome browser: 7q21.1
Type of geneprotein-coding
RefGenesNM_000601.4,
NM_001010931.1,NM_001010932.1,NM_001010933.1,NM_001010934.1,
Descriptionfibroblast-derived tumor cytotoxic factorhepatocyte growth factorhepatopoeitin-Ahepatopoietin-Alung fibroblast-derived mitogen
Modification date20141222
dbXrefs MIM : 142409
HGNC : HGNC
Ensembl : ENSG00000019991
HPRD : 00799
Vega : OTTHUMG00000023804
ProteinUniProt: P14210
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HGF
BioGPS: 3082
PathwayNCI Pathway Interaction Database: HGF
KEGG: HGF
REACTOME: HGF
Pathway Commons: HGF
ContextiHOP: HGF
ligand binding site mutation search in PubMed: HGF
UCL Cancer Institute: HGF
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling20655899
GO:0030335positive regulation of cell migration21245381
GO:0035729cellular response to hepatocyte growth factor stimulus21245381
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic process20655899
GO:0048012hepatocyte growth factor receptor signaling pathway21245381
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation21245381
GO:0050918positive chemotaxis21245381
GO:0060326cell chemotaxis21245381
GO:0060665regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling14517989
GO:0090201negative regulation of release of cytochrome c from mitochondria20655899
GO:1901299negative regulation of hydrogen peroxide-mediated programmed cell death20655899
GO:2000573positive regulation of DNA biosynthetic process2531289


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Ligand binding site mutations for HGF
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
P180R178QSKCM2
R126R126TBRCA1
W188,G186P187SCOAD1
K60K60QCOAD1
Y619G618SCOAD1
R630R630PHNSC1
W188,G186P187SHNSC1
K78R76MLUAD1
A698P700TLUAD1
E662A661DLUAD1
G616W617CLUAD1
K78R76SLUAD1
G185G185RLUAD1
Q173N175SLUAD1
S135S135ILUAD1
R134R134HLUSC1
Y136Y136CLUSC1
Q173E174KSKCM1
G79G79ESKCM1
V200,Y198E199KSKCM1
R181R181PSKCM1
E183E183KSKCM1
R181R181QSKCM1
K58A56VUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for HGF from My Cancer Genome.
Hepatocyte growth factor (HGF) is a gene that encodes a protein that is involved in cell growth, motility, and morphogenesis. The protein, also known as hepatocyte growth factor, functions through the activation of a tyrosine kinase signaling pathway. Missense mutations, nonsense mutations, silent mutations, and frameshift insertions are observed in cancers such as lung cancer, parathyroid cancer, and skin cancer.Related Pathways: Receptor tyrosine kinase/growth factor signaling. Modified: December 4, 2015

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Protein structure related information for HGF
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
Y198E199K-1.6116232
V200E199K-1.6116232
Q173N175S-1.5675696
R126R126T-1.4569576
P180R178Q-1.2023212
W188P187S-1.1474085
G186P187S-1.1474085
Y136Y136C-1.1312223
K60K60Q-1.0916223
R134R134H-1.0411222
E183E183K-0.98577368
K58A56V-0.9630841
Q173E174K-0.93862602
K78R76S-0.88831407
G616W617C-0.88022956
R181R181Q-0.82727978
R630R630P-0.81257381
A698P700T-0.78968249
E662A661D-0.71343089
Y619G618S-0.6709706
R181R181P-0.57837053
K78R76M-0.53464982
G79G79E-0.50201384
G185G185R-0.42219738
S135S135I-0.329821
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HGF from PDB
PDB IDPDB titlePDB structure
1BHTNK1 FRAGMENT OF HUMAN HEPATOCYTE GROWTH FACTOR

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Differential gene expression and gene-gene network for HGF
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HGF and the right PPI network was created from samples without mutations in the LBS of HGF. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for HGF
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C2239176Carcinoma, Hepatocellular57Biomarker
umls:C0023903Liver Neoplasms20AlteredExpression, Biomarker, Therapeutic
umls:C0023890Liver Cirrhosis14AlteredExpression, Biomarker, Therapeutic
umls:C0007137Carcinoma, Squamous Cell11AlteredExpression, Biomarker, Therapeutic
umls:C0034069Pulmonary Fibrosis11Biomarker
umls:C0162557Liver Failure, Acute9Biomarker, Therapeutic
umls:C0151744Myocardial Ischemia7Biomarker, Therapeutic
umls:C0023893Liver Cirrhosis, Experimental7Therapeutic
umls:C0027819Neuroblastoma4Biomarker
umls:C0023467Leukemia, Myeloid, Acute3Biomarker
umls:C0878544Cardiomyopathies3Biomarker, Therapeutic
umls:C0042373Vascular Diseases2Biomarker, Therapeutic
umls:C0004763Barrett Esophagus1Biomarker
umls:C0023904Liver Neoplasms, Experimental1Biomarker
umls:C0027626Neoplasm Invasiveness1Biomarker
umls:C0027659Neoplasms, Experimental1Therapeutic
umls:C0030305Pancreatitis1Therapeutic
umls:C0030567Parkinson Disease1Therapeutic
umls:C0035126Reperfusion Injury1Biomarker
umls:C0040053Thrombosis1Biomarker
umls:C0043254Wounds, Penetrating1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HGF
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02264O2-Sulfo-Glucuronic AcidSmall molecule
ExperimentalDB03959N,O6-Disulfo-GlucosamineSmall molecule
InvestigationalDB05030XL880Small molecule
InvestigationalDB05434ABT-510Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HGF go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
EPEHEPES1bhtAE183 G185 G186 W188 Y198 V200
MPO3-(N-MORPHOLINO)PROPANESULFONIC ACID5csqAE183 W188 Y198
MPO3-(N-MORPHOLINO)PROPANESULFONIC ACID5csqBE183 W188 Y198
NHECHES5ct1BE183 W188 Y198
54O3-HYDROXYPROPANE-1-SULFONIC ACID5ct3BE183 W188 Y198
EP13-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]PROPANE-1-SULFONICACID5cs3BE183 W188 Y198 V200
CXS3-CYCLOHEXYL-1-PROPYLSULFONIC ACID5ct2AE183 W188 Y198 V200
CXS3-CYCLOHEXYL-1-PROPYLSULFONIC ACID5ct2BE183 W188 Y198 V200
IIIPeptide ligand (ILE,VAL,GLY,GLY,TYR,PRO,TRP,TRP,MET)4o3tAG616 Y619 R630 A698
SGNN,O6-DISULFO-GLUCOSAMINE1gmoGG79
SGNN,O6-DISULFO-GLUCOSAMINE1gmnAK58 K60
SO4SULFATE1bhtAK60
IDS2-O-SULFO-ALPHA-L-IDOPYRANURONIC ACID1gmnAK60
IDS2-O-SULFO-ALPHA-L-IDOPYRANURONIC ACID1gmoAK60
SGNN,O6-DISULFO-GLUCOSAMINE1gmoBK60
IDS2-O-SULFO-ALPHA-L-IDOPYRANURONIC ACID1gmoBK60
SGNN,O6-DISULFO-GLUCOSAMINE1gmoCK60
IDS2-O-SULFO-ALPHA-L-IDOPYRANURONIC ACID1gmoCK60
SGNN,O6-DISULFO-GLUCOSAMINE1gmoFK60
SGNN,O6-DISULFO-GLUCOSAMINE1gmoGK60
SGNN,O6-DISULFO-GLUCOSAMINE3mkpAK60
SGNN,O6-DISULFO-GLUCOSAMINE3mkpCK60
SGNN,O6-DISULFO-GLUCOSAMINE1gmnAK78 G79
SGNN,O6-DISULFO-GLUCOSAMINE1gmoBK78 G79
SGNN,O6-DISULFO-GLUCOSAMINE1gmoCK78 G79
SGNN,O6-DISULFO-GLUCOSAMINE1gmoFK78 G79
SGNN,O6-DISULFO-GLUCOSAMINE1gmoBP180 R181
SO4SULFATE1gmoAQ173
SO4SULFATE1gmoFQ173
SO4SULFATE1gmoHQ173
SO4SULFATE1gmoDR126 R134 S135 Y136
SO4SULFATE1gmoER126 R134 S135 Y136
SO4SULFATE1gmoBR126 S135 Y136
SO4SULFATE1gmoCR126 S135 Y136
SO4SULFATE1gmoFR126 S135 Y136
EPEHEPES5coeBR181 E183 G185 G186 W188 Y198
PIN2,2'-PIPERAZINE-1,4-DIYLBISETHANESULFONIC ACID5cs5BR181 E183 G185 G186 W188 Y198
6O5MB6053-(FURAN-2-YL)PROPANOIC ACID5cp9BR181 E183 W188 Y198
IIIPeptide ligand (ILE,ILE,GLY,GLY,CYS,PRO,TYR,TRP,MET,ASP,ARG,GLU,GLU,CYS)4o3uAY619 R630 E662 A698


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Conservation information for LBS of HGF
Multiple alignments for P14210 in multiple species
LBSAA sequence# speciesSpecies
A632GLLRVAHLYIM5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
A698PGRGCAIPNRP5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
C612PEKTTCSIYGW2Mus musculus, Rattus norvegicus
C612PEKTTCSVYGW2Canis lupus familiaris, Bos taurus
C612PEKTSCSVYGW1Homo sapiens
C669IGSGPCEGDYG3Homo sapiens, Mus musculus, Rattus norvegicus
C669IVSGPCEGDYG2Canis lupus familiaris, Bos taurus
C697VPGRGCAIPNR5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
D171SYRGKDLQENY5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
D672GPCEGDYGGPL5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
E183RNPRGEEGGPW5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
E184NPRGEEGGPWC5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
E662LCAGAEKIGSG2Mus musculus, Rattus norvegicus
E662ICAGAENIVSG2Canis lupus familiaris, Bos taurus
E662ICAGAEKIGSG1Homo sapiens
F162PHEHSFLPSSY5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
F190GGPWCFTSNPE5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G133CIIGKGGSYKG4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G133CIIGKGRSYKG1Homo sapiens
G169PSSYRGKDLQE5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G182CRNPRGEEGGP5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G185PRGEEGGPWCF5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G186RGEEGGPWCFT5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
G616TCSIYGWGYTG2Mus musculus, Rattus norvegicus
G616TCSVYGWGYTG2Canis lupus familiaris, Bos taurus
G616SCSVYGWGYTG1Homo sapiens
G667EKIGSGPCEGD3Homo sapiens, Mus musculus, Rattus norvegicus
G667ENIVSGPCEGD2Canis lupus familiaris, Bos taurus
G79CIRNKGLPFTC2Canis lupus familiaris, Bos taurus
G79CTRNKGLPFTC1Homo sapiens
G79CIRNRGFTFTC1Mus musculus
G79CIRNKGFPFTC1Rattus norvegicus
H551AWLGIHDVHGR2Homo sapiens, Bos taurus
H551AWLGIHDVHER2Mus musculus, Rattus norvegicus
H551AWLGIHDVHGK1Canis lupus familiaris
H633LLRVAHLYIMG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
I129YIRNCIIGKGG4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
I129YIRNCIIGKGR1Homo sapiens
I130IRNCIIGKGGS4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
I130IRNCIIGKGRS1Homo sapiens
I505PTQTTVGWMVS2Mus musculus, Rattus norvegicus
I505PTRTNVGWMVS2Canis lupus familiaris, Bos taurus
I505PTRTNIGWMVS1Homo sapiens
I59DPLLKIKTKKM2Canis lupus familiaris, Bos taurus
I59DPALKIKTKKV1Homo sapiens
I59DPLLKIKTKKV1Mus musculus
I59DPLVKIKTKKV1Rattus norvegicus
K170SSYRGKDLQEN5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
K58EDPLLKIKTKK3Mus musculus, Canis lupus familiaris, Bos taurus
K58IDPALKIKTKK1Homo sapiens
K58EDPLVKIKTKK1Rattus norvegicus
K60PLLKIKTKKMN2Canis lupus familiaris, Bos taurus
K60PALKIKTKKVN1Homo sapiens
K60PLLKIKTKKVN1Mus musculus
K60PLVKIKTKKVN1Rattus norvegicus
K62LKIKTKKMNTA2Canis lupus familiaris, Bos taurus
K62LKIKTKKVNTA1Homo sapiens
K62LKIKTKKVNSA1Mus musculus
K62VKIKTKKVNSA1Rattus norvegicus
K63KIKTKKVNSAD2Mus musculus, Rattus norvegicus
K63KIKTKKMNTAD2Canis lupus familiaris, Bos taurus
K63KIKTKKVNTAD1Homo sapiens
K78RCIRNKGLPFT2Canis lupus familiaris, Bos taurus
K78RCTRNKGLPFT1Homo sapiens
K78RCIRNRGFTFT1Mus musculus
K78RCIRNKGFPFT1Rattus norvegicus
L172YRGKDLQENYC5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
L629NADGLLRVAHL2Mus musculus, Rattus norvegicus
L629NYDGLLRVAHL1Homo sapiens
L629NFDGLLRVAHL1Canis lupus familiaris
L629NSDGLLRVAHL1Bos taurus
L634LRVAHLYIMGN5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
P164EHSFLPSSYRG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
P180NYCRNPRGEEG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
P668KIGSGPCEGDY3Homo sapiens, Mus musculus, Rattus norvegicus
P668NIVSGPCEGDY2Canis lupus familiaris, Bos taurus
Q173RGKDLQENYCR5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R126NKDYIRNCIIG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R134IIGKGGSYKGT4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R134IIGKGRSYKGT1Homo sapiens
R168LPSSYRGKDLQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R181YCRNPRGEEGG5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R197SNPEVRYEVCD5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
R630ADGLLRVAHLY2Mus musculus, Rattus norvegicus
R630YDGLLRVAHLY1Homo sapiens
R630FDGLLRVAHLY1Canis lupus familiaris
R630SDGLLRVAHLY1Bos taurus
R73DQCANRCIRNK2Canis lupus familiaris, Bos taurus
R73DQCANRCTRNK1Homo sapiens
R73DECANRCIRNR1Mus musculus
R73DECANRCIRNK1Rattus norvegicus
S135IGKGGSYKGTV4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
S135IGKGRSYKGTV1Homo sapiens
S611IPEKTTCSIYG2Mus musculus, Rattus norvegicus
S611IPEKTTCSVYG2Canis lupus familiaris, Bos taurus
S611IPEKTSCSVYG1Homo sapiens
S666AEKIGSGPCEG3Homo sapiens, Mus musculus, Rattus norvegicus
S666AENIVSGPCEG2Canis lupus familiaris, Bos taurus
T61LLKIKTKKMNT2Canis lupus familiaris, Bos taurus
T61ALKIKTKKVNT1Homo sapiens
T61LLKIKTKKVNS1Mus musculus
T61LVKIKTKKVNS1Rattus norvegicus
T620YGWGYTGLINA2Mus musculus, Rattus norvegicus
T620YGWGYTGLINY1Homo sapiens
T620YGWGYTGSINF1Canis lupus familiaris
T620YGWGYTGLINS1Bos taurus
V200EVRYEVCDIPQ5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
V614KTTCSIYGWGY2Mus musculus, Rattus norvegicus
V614KTTCSVYGWGY2Canis lupus familiaris, Bos taurus
V614KTSCSVYGWGY1Homo sapiens
V631DGLLRVAHLYI5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
V64IKTKKVNSADE2Mus musculus, Rattus norvegicus
V64IKTKKMNTADQ2Canis lupus familiaris, Bos taurus
V64IKTKKVNTADQ1Homo sapiens
W188EEGGPWCFTSN5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
Y136GKGGSYKGTVS4Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
Y136GKGRSYKGTVS1Homo sapiens
Y167FLPSSYRGKDL5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
Y198NPEVRYEVCDI5Homo sapiens, Mus musculus, Rattus norvegicus, Canis lupus familiaris, Bos taurus
Y615TTCSIYGWGYT2Mus musculus, Rattus norvegicus
Y615TTCSVYGWGYT2Canis lupus familiaris, Bos taurus
Y615TSCSVYGWGYT1Homo sapiens
Y619VYGWGYTGLIN2Homo sapiens, Bos taurus
Y619IYGWGYTGLIN2Mus musculus, Rattus norvegicus
Y619VYGWGYTGSIN1Canis lupus familiaris


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