mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KCNIP1
Gene summary
Basic gene Info.Gene symbolKCNIP1
Gene nameKv channel interacting protein 1
CytomapUCSC genome browser: 5q35.1
Type of geneprotein-coding
DescriptionA-type potassium channel modulatory protein 1Kv channel-interacting protein 1potassium channel interacting protein 1vesicle APC-binding protein
Modification date20141215
dbXrefs MIM : 604660
Ensembl : ENSG00000182132
HPRD : 06879
Vega : OTTHUMG00000130442
ProteinUniProt: Q9NZI2
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KCNIP1
BioGPS: 30820
PathwayNCI Pathway Interaction Database: KCNIP1
Pathway Commons: KCNIP1
ContextiHOP: KCNIP1
ligand binding site mutation search in PubMed: KCNIP1
UCL Cancer Institute: KCNIP1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for KCNIP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for KCNIP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KCNIP1 from PDB
PDB IDPDB titlePDB structure
2I2RCrystal structure of the KChIP1/Kv4.3 T1 complex

Differential gene expression and gene-gene network for KCNIP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KCNIP1 and the right PPI network was created from samples without mutations in the LBS of KCNIP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for KCNIP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for KCNIP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KCNIP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of KCNIP1
Multiple alignments for Q9NZI2 in multiple species
LBSAA sequence# speciesSpecies
D146TFNLYDINKDG3Homo sapiens, Mus musculus, Rattus norvegicus
D150YDINKDGYINK3Homo sapiens, Mus musculus, Rattus norvegicus
D194FFQKMDKNKDG3Homo sapiens, Mus musculus, Rattus norvegicus
D198MDKNKDGIVTL3Homo sapiens, Mus musculus, Rattus norvegicus
E157YINKEEMMDIV3Homo sapiens, Mus musculus, Rattus norvegicus
E205IVTLDEFLESC3Homo sapiens, Mus musculus, Rattus norvegicus
I200KNKDGIVTLDE3Homo sapiens, Mus musculus, Rattus norvegicus
N148NLYDINKDGYI3Homo sapiens, Mus musculus, Rattus norvegicus
N154KDGYINKEEMM3Homo sapiens, Mus musculus, Rattus norvegicus
N196QKMDKNKDGIV3Homo sapiens, Mus musculus, Rattus norvegicus
T202KDGIVTLDEFL3Homo sapiens, Mus musculus, Rattus norvegicus
Y152INKDGYINKEE3Homo sapiens, Mus musculus, Rattus norvegicus

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