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mutLBSgeneDB |
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| Gene summary for CD209 |
 Gene summary |
| Basic gene Info. | Gene symbol | CD209 |
| Gene name | CD209 molecule | |
| Synonyms | CDSIGN|CLEC4L|DC-SIGN|DC-SIGN1 | |
| Cytomap | UCSC genome browser: 19p13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001144893.1, NM_001144894.1,NM_001144895.1,NM_001144896.1,NM_001144897.1, NM_001144899.1,NM_021155.3,NR_026692.1, | |
| Description | C-type lectin domain family 4 member LC-type lectin domain family 4, member LCD209 antigenHIV gpl20-binding proteindendritic cell-specific ICAM-3-grabbing non-integrin 1dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-in | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604672 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000090659 | ||
| HPRD : 05241 | ||
| Vega : OTTHUMG00000182530 | ||
| Protein | UniProt: Q9NNX6 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CD209 | |
| BioGPS: 30835 | ||
| Pathway | NCI Pathway Interaction Database: CD209 | |
| KEGG: CD209 | ||
| REACTOME: CD209 | ||
| Pathway Commons: CD209 | ||
| Context | iHOP: CD209 | |
| ligand binding site mutation search in PubMed: CD209 | ||
| UCL Cancer Institute: CD209 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042129 | regulation of T cell proliferation | 12456590 |
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| Ligand binding site mutations for CD209 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | E358 | A357T | GBM | 1 | N349,E347 | P348L | KIRC | 1 | G361 | N362I | SKCM | 1 | E358 | E358K | SKCM | 1 | D320 | D320Y | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for CD209 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | E358 | A357T | -0.84050702 | E358 | E358K | -0.79874857 | E347 | P348L | -0.52756026 | N349 | P348L | -0.52756026 | G361 | N362I | -0.21814523 | D320 | D320Y | -0.14237677 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for CD209 from PDB |
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| Differential gene expression and gene-gene network for CD209 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for CD209 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0019693 | HIV Infections | 19 | Biomarker, GeneticVariation |
| umls:C0011311 | Dengue | 11 | Biomarker, GeneticVariation |
| umls:C0041327 | Tuberculosis, Pulmonary | 6 | Biomarker, GeneticVariation |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for CD209 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of CD209 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | CA | CALCIUM(2+) | 1k9i | A | D320 | CA | CALCIUM(2+) | 1k9i | B | D320 | CA | CALCIUM(2+) | 1k9i | C | D320 | CA | CALCIUM(2+) | 1k9i | D | D320 | CA | CALCIUM(2+) | 1k9i | E | D320 | CA | CALCIUM(2+) | 1k9i | F | D320 | CA | CALCIUM(2+) | 1k9i | G | D320 | CA | CALCIUM(2+) | 1k9i | H | D320 | CA | CALCIUM(2+) | 1k9i | I | D320 | CA | CALCIUM(2+) | 1k9i | J | D320 | CA | CALCIUM(2+) | 1sl4 | A | D320 | CA | CALCIUM(2+) | 1sl5 | A | D320 | CA | CALCIUM(2+) | 2it5 | A | D320 | CA | CALCIUM(2+) | 2it6 | A | D320 | CA | CALCIUM(2+) | 2xr5 | A | D320 | CA | CALCIUM(2+) | 2xr6 | A | D320 | MAN | ALPHA-D-MANNOSE | 1k9i | A | E347 N349 | CA | CALCIUM(2+) | 1k9i | A | E347 N349 | CA | CALCIUM(2+) | 1k9i | B | E347 N349 | MAN | ALPHA-D-MANNOSE | 1k9i | C | E347 N349 | CA | CALCIUM(2+) | 1k9i | C | E347 N349 | MAN | ALPHA-D-MANNOSE | 1k9i | D | E347 N349 | CA | CALCIUM(2+) | 1k9i | D | E347 N349 | MAN | ALPHA-D-MANNOSE | 1k9i | E | E347 N349 | CA | CALCIUM(2+) | 1k9i | E | E347 N349 | CA | CALCIUM(2+) | 1k9i | F | E347 N349 | CA | CALCIUM(2+) | 1k9i | G | E347 N349 | MAN | ALPHA-D-MANNOSE | 1k9i | H | E347 N349 | CA | CALCIUM(2+) | 1k9i | H | E347 N349 | CA | CALCIUM(2+) | 1k9i | I | E347 N349 | CA | CALCIUM(2+) | 1k9i | J | E347 N349 | MAN | ALPHA-D-MANNOSE | 1sl4 | A | E347 N349 | CA | CALCIUM(2+) | 1sl4 | A | E347 N349 | FUC | ALPHA-L-FUCOPYRANOSE | 1sl5 | A | E347 N349 | CA | CALCIUM(2+) | 1sl5 | A | E347 N349 | MAN | ALPHA-D-MANNOSE | 2it5 | A | E347 N349 | CA | CALCIUM(2+) | 2it5 | A | E347 N349 | MAN | ALPHA-D-MANNOSE | 2it6 | A | E347 N349 | CA | CALCIUM(2+) | 2it6 | A | E347 N349 | MAN | ALPHA-D-MANNOSE | 2xr5 | A | E347 N349 | CA | CALCIUM(2+) | 2xr5 | A | E347 N349 | MAN | ALPHA-D-MANNOSE | 2xr6 | A | E347 N349 | CA | CALCIUM(2+) | 2xr6 | A | E347 N349 | MAN | ALPHA-D-MANNOSE | 2it6 | A | E358 | MAN | ALPHA-D-MANNOSE | 1k9i | A | G361 | MAN | ALPHA-D-MANNOSE | 1k9i | C | G361 | MAN | ALPHA-D-MANNOSE | 1k9i | D | G361 | MAN | ALPHA-D-MANNOSE | 1k9i | E | G361 | MAN | ALPHA-D-MANNOSE | 1k9i | H | G361 | MAN | ALPHA-D-MANNOSE | 1sl4 | A | G361 | AE9 | 2-AZIDOETHANOL | 2xr6 | A | N349 |
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| Conservation information for LBS of CD209 |
| Multiple alignments for Q9NNX6 in multiple species |
| LBS | AA sequence | # species | Species | D320 | WMGLSDLNQEG | 1 | Homo sapiens | D320 | WMGLSDLNKEG | 1 | Mus musculus | D320 | WMGLSDLNEEG | 1 | Pan troglodytes | D320 | WMGLSDLNHEG | 1 | Macaca mulatta | D355 | NVGEEDCAEFS | 2 | Homo sapiens, Pan troglodytes | D355 | NVGGQDCVEFR | 1 | Mus musculus | D355 | NIGEEDCAEFS | 1 | Macaca mulatta | D366 | GNGWNDDKCNL | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | D366 | DNGWNDAKCEQ | 1 | Mus musculus | D367 | NGWNDDKCNLA | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | D367 | NGWNDAKCEQR | 1 | Mus musculus | E324 | SDLNQEGTWQW | 1 | Homo sapiens | E324 | SDLNKEGEWYW | 1 | Mus musculus | E324 | SDLNEEGTWQW | 1 | Pan troglodytes | E324 | SDLNHEGTWQW | 1 | Macaca mulatta | E347 | YWNRGEPNNVG | 2 | Homo sapiens, Pan troglodytes | E347 | YWKKGQPNNVG | 1 | Mus musculus | E347 | YWNKGEPNNIG | 1 | Macaca mulatta | E353 | PNNVGEEDCAE | 2 | Homo sapiens, Pan troglodytes | E353 | PNNVGGQDCVE | 1 | Mus musculus | E353 | PNNIGEEDCAE | 1 | Macaca mulatta | E354 | NNVGEEDCAEF | 2 | Homo sapiens, Pan troglodytes | E354 | NNVGGQDCVEF | 1 | Mus musculus | E354 | NNIGEEDCAEF | 1 | Macaca mulatta | E358 | EEDCAEFSGNG | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | E358 | GQDCVEFRDNG | 1 | Mus musculus | F313 | SRSNRFTWMGL | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | F313 | SKKNSYTWMGL | 1 | Mus musculus | G361 | CAEFSGNGWND | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | G361 | CVEFRDNGWND | 1 | Mus musculus | K368 | GWNDDKCNLAK | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | K368 | GWNDAKCEQRK | 1 | Mus musculus | L371 | DDKCNLAKFWI | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | L371 | DAKCEQRKFWI | 1 | Mus musculus | N349 | NRGEPNNVGEE | 2 | Homo sapiens, Pan troglodytes | N349 | KKGQPNNVGGQ | 1 | Mus musculus | N349 | NKGEPNNIGEE | 1 | Macaca mulatta | N350 | RGEPNNVGEED | 2 | Homo sapiens, Pan troglodytes | N350 | KGQPNNVGGQD | 1 | Mus musculus | N350 | KGEPNNIGEED | 1 | Macaca mulatta | N365 | SGNGWNDDKCN | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | N365 | RDNGWNDAKCE | 1 | Mus musculus | S360 | DCAEFSGNGWN | 3 | Homo sapiens, Pan troglodytes, Macaca mulatta | S360 | DCVEFRDNGWN | 1 | Mus musculus | V351 | GEPNNVGEEDC | 2 | Homo sapiens, Pan troglodytes | V351 | GQPNNVGGQDC | 1 | Mus musculus | V351 | GEPNNIGEEDC | 1 | Macaca mulatta | W327 | NQEGTWQWVDG | 1 | Homo sapiens | W327 | NKEGEWYWLDG | 1 | Mus musculus | W327 | NEEGTWQWVDG | 1 | Pan troglodytes | W327 | NHEGTWQWVDG | 1 | Macaca mulatta |
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