mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HINT1
Gene summary
Basic gene Info.Gene symbolHINT1
Gene namehistidine triad nucleotide binding protein 1
SynonymsHINT|NMAN|PKCI-1|PRKCNH1
CytomapUCSC genome browser: 5q31.2
Type of geneprotein-coding
RefGenesNM_005340.6,
NR_024610.2,NR_024611.2,NR_073488.1,
Descriptionadenosine 5'-monophosphoramidasehistidine triad nucleotide-binding protein 1protein kinase C inhibitor 1protein kinase C-interacting protein 1
Modification date20141207
dbXrefs MIM : 601314
HGNC : HGNC
HPRD : 03204
ProteinUniProt: P49773
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HINT1
BioGPS: 3094
PathwayNCI Pathway Interaction Database: HINT1
KEGG: HINT1
REACTOME: HINT1
Pathway Commons: HINT1
ContextiHOP: HINT1
ligand binding site mutation search in PubMed: HINT1
UCL Cancer Institute: HINT1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0009154purine ribonucleotide catabolic process16835243


Top
Ligand binding site mutations for HINT1
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
F19G20ELUAD1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for HINT1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
F19G20E-0.98117924
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HINT1 from PDB

Top
Differential gene expression and gene-gene network for HINT1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HINT1 and the right PPI network was created from samples without mutations in the LBS of HINT1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for HINT1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0036341Schizophrenia4Biomarker, GeneticVariation
umls:C0242287Isaacs Syndrome2Biomarker, GeneticVariation
umls:C2932678Inherited Peripheral Neuropathy1Biomarker
umls:C0026848Muscular Diseases1Biomarker
umls:C1861063TOBACCO ADDICTION, SUSCEPTIBILITY TO1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for HINT1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|nutraceuticalDB00131Adenosine monophosphateSmall molecule
ExperimentalDB01972Guanosine-5'-MonophosphateSmall molecule
ExperimentalDB021625'-O-(N-Ethyl-Sulfamoyl)AdenosineSmall molecule
ExperimentalDB02183Adenosine-5'-DitungstateSmall molecule
ExperimentalDB033498-Bromo-Adenosine-5'-MonophosphateSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HINT1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
AP2ADENOSINE 5'-METHYLENEDIPHOSPHATE1av5BF19
ADWADENOSINE-5'-DITUNGSTATE1kpeBF19
AMPAMP1kpfAF19
AMPAMP3tw2AF19
KAA5'-O-[N-(L-LYSYL)SULFAMOYL]ADENOSINE4eqeBF19
A5A'5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE4eqgBF19
WSA5'-O-[(L-TRYPTOPHYLAMINO)SULFONYL]ADENOSINE4eqhBF19


Top
Conservation information for LBS of HINT1
Multiple alignments for P49773 in multiple species
LBSAA sequence# speciesSpecies
D43CLAFHDISPQA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D43ALAFHDVSPQA1Caenorhabditis elegans
F19GGDTIFGKIIR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F19ANDTLFGKIIR1Caenorhabditis elegans
F41DRCLAFHDISP3Homo sapiens, Mus musculus, Rattus norvegicus
F41DEALAFHDVSP1Caenorhabditis elegans
F41DQCLAFHDISP1Bos taurus
G105EGSDGGQSVYH2Homo sapiens, Bos taurus
G105EGADGGQSVYH2Mus musculus, Rattus norvegicus
G105NGKDGAQSVFH1Caenorhabditis elegans
H112SVYHVHLHVLG2Homo sapiens, Bos taurus
H112SVYHIHLHVLG2Mus musculus, Rattus norvegicus
H112SVFHLHLHVLG1Caenorhabditis elegans
H114YHVHLHVLGGR2Homo sapiens, Bos taurus
H114YHIHLHVLGGR2Mus musculus, Rattus norvegicus
H114FHLHLHVLGGR1Caenorhabditis elegans
H42RCLAFHDISPQ3Homo sapiens, Mus musculus, Rattus norvegicus
H42EALAFHDVSPQ1Caenorhabditis elegans
H42QCLAFHDISPQ1Bos taurus
I44LAFHDISPQAP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I44LAFHDVSPQAP1Caenorhabditis elegans
L53APTHFLVIPKK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L53APIHFLVIPKR1Caenorhabditis elegans
N99YRMVVNEGSDG2Homo sapiens, Bos taurus
N99YRMVVNEGADG2Mus musculus, Rattus norvegicus
N99YRVVVNNGKDG1Caenorhabditis elegans
Q106GSDGGQSVYHV2Homo sapiens, Bos taurus
Q106GADGGQSVYHI2Mus musculus, Rattus norvegicus
Q106GKDGAQSVFHL1Caenorhabditis elegans
S107SDGGQSVYHVH2Homo sapiens, Bos taurus
S107ADGGQSVYHIH2Mus musculus, Rattus norvegicus
S107KDGAQSVFHLH1Caenorhabditis elegans
S45AFHDISPQAPT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S45AFHDVSPQAPI1Caenorhabditis elegans
V108DGGQSVYHVHL2Homo sapiens, Bos taurus
V108DGGQSVYHIHL2Mus musculus, Rattus norvegicus
V108DGAQSVFHLHL1Caenorhabditis elegans


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas