mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for HMBS

Gene summary

Basic gene Info.	Gene symbol	HMBS
	Gene name	hydroxymethylbilane synthase
	Synonyms	PBG-D\|PBGD\|PORC\|UPS
	Cytomap	UCSC genome browser: 11q23.3
	Type of gene	protein-coding
	RefGenes	NM_000190.3, NM_001024382.1,NM_001258208.1,NM_001258209.1,
	Description	porphobilinogen deaminaseporphyria, acute; Chester typepre-uroporphyrinogen synthaseuroporphyrinogen I synthaseuroporphyrinogen I synthetase
	Modification date	20141219
dbXrefs	MIM : 609806
	HGNC : HGNC
	Ensembl : ENSG00000256269
	HPRD : 01440
	Vega : OTTHUMG00000168295
Protein	UniProt: P08397 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HMBS
	BioGPS: 3145
Pathway	NCI Pathway Interaction Database: HMBS
	KEGG: HMBS
	REACTOME: HMBS
	Pathway Commons: HMBS
Context	iHOP: HMBS
	ligand binding site mutation search in PubMed: HMBS
	UCL Cancer Institute: HMBS
Assigned class in mutLBSgeneDB	C: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for HMBS

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
H268	V267M	COAD	1
A214	Y213H	COAD	1
A31	R32H	COAD	1
H207	I205S	GBM	1
H120	A122T	LUAD	1
A214	Y213H	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for HMBS

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
A31	R32H	-1.6096719
H207	I205S	-1.2204947
H120	A122T	-1.0596135
A214	Y213H	-0.93153784
H268	V267M	-0.88328524

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HMBS from PDB

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Differential gene expression and gene-gene network for HMBS

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of HMBS and the right PPI network was created from samples without mutations in the LBS of HMBS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for HMBS

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0162565	Porphyria, Acute Intermittent	143	AlteredExpression, Biomarker, GeneticVariation

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for HMBS

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Drug information targeting mutLBSgene (Approved drugs only)

Drug status

DrugBank ID

Name

Type

Drug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HMBS go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
DPM		DIPYRROMETHANE COFACTOR	3eq1	A	A214
SO4		SULFATE	3eq1	A	A31
SO4		SULFATE	3eq1	B	H120 H207 H268
SO4		SULFATE	3eq1	A	H120 H268

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Conservation information for LBS of HMBS

Multiple alignments for P08397 in multiple species

LBS	AA sequence	# species	Species
A189	SAIILATAGLQ	2	Homo sapiens, Bos taurus
A189	QATLLALAGLK	1	Arabidopsis thaliana
A189	HATLLALAGLK	1	Oryza sativa subsp. japonica
A189	KCIILATAGLV	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A189	KCIVLASAGLM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A189	QCIILASAGLM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A189	DCLVLAAAGLF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A189	SAIVLAVAGLQ	1	Mus musculus
A214	EECMYAVGQGA	3	Homo sapiens, Mus musculus, Bos taurus
A214	DEMLPAVAQGA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
A214	TIMLHAVGQGA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A214	DTMCYAVGQGA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A214	DTMYHAVGQGA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A214	PFVYYAVGQGA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A31	RKSQLARIQTD	3	Homo sapiens, Mus musculus, Bos taurus
A31	RGSPLALAQAY	1	Arabidopsis thaliana
A31	RGSPLALAQAH	1	Oryza sativa subsp. japonica
A31	RRSKLAVIQSE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
A31	RRSKLAVVQSE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A31	RKSKLAVIQSN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A31	RKSKLAVIQSE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C261	HLEGGCSVPVA	3	Homo sapiens, Mus musculus, Bos taurus
C261	TLEGGCSVPIG	3	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C261	TLDGSCRTPIA	1	Arabidopsis thaliana
C261	VLDGNCRTPIA	1	Oryza sativa subsp. japonica
C261	RLQGGCAIPIG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D99	VHSLKDLPTVL	2	Homo sapiens, Bos taurus
D99	VHSMKDVPTYL	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
D99	VHSLKDMPTLL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D99	VHSLKDMPTQL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D99	VHSLKDLPSEM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D99	VHSLKDVPTIL	1	Mus musculus
G218	YAVGQGALGVE	2	Homo sapiens, Bos taurus
G218	PAVAQGAIGIA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
G218	HAVGQGALGIE	2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G218	YAVGQGALAVE	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Mus musculus
G218	YAVGQGALGIE	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H120	PREDVRDAFIC	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
H120	KRENPHDAVVF	1	Homo sapiens
H120	KRVDPSDCLVM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H120	KRVDPTDALVM	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H120	KRVDPTDCLVM	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H120	KRSCPLDAIVF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H120	KRENPCDAVVF	1	Mus musculus
H120	KRESPYDAVVF	1	Bos taurus
H207	VGQILHPEECM	3	Homo sapiens, Mus musculus, Bos taurus
H207	VASILSLDEML	1	Arabidopsis thaliana
H207	ATSVLSVDEML	1	Oryza sativa subsp. japonica
H207	ITQRFDSTIML	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H207	ITQRFNADTMC	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H207	ITQRFHSDTMY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H207	IAQMLTAPFVY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H268	VPVAVHTAM--	1	Homo sapiens
H268	TPIAGYASK--	1	Arabidopsis thaliana
H268	TPIAAYASR--	1	Oryza sativa subsp. japonica
H268	VPIGVYSTF--	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H268	VPIGVVSNY--	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H268	VPIGVESKY--	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H268	IPIGVQTDVLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H268	VPVAVHTVM--	1	Mus musculus
H268	VPVAVHTAI--	1	Bos taurus
K98	VVHSLKDLPTV	2	Homo sapiens, Bos taurus
K98	AVHSMKDVPTY	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
K98	IVHSLKDMPTL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K98	IVHSLKDMPTQ	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
K98	LVHSLKDLPSE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K98	VVHSLKDVPTI	1	Mus musculus
L188	FSAIILATAGL	2	Homo sapiens, Bos taurus
L188	VQATLLALAGL	1	Arabidopsis thaliana
L188	VHATLLALAGL	1	Oryza sativa subsp. japonica
L188	CKCIILATAGL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L188	YKCIVLASAGL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L188	YQCIILASAGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L188	FDCLVLAAAGL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L188	FSAIVLAVAGL	1	Mus musculus
L30	TRKSQLARIQT	3	Homo sapiens, Mus musculus, Bos taurus
L30	TRGSPLALAQA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
L30	GRRSKLAVIQS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
L30	GRRSKLAVVQS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
L30	GRKSKLAVIQS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L30	TRKSKLAVIQS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N169	KSIRGNLNTRL	2	Mus musculus, Bos taurus
N169	RSIRGNLNTRL	1	Homo sapiens
N169	ENFRGNVQTRL	1	Arabidopsis thaliana
N169	VNFRGNVQTRL	1	Oryza sativa subsp. japonica
N169	ASVRGNIQTRL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N169	ESIRGNIQTRL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N169	ESVRGNIQTRL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N169	VDIRGNVGTRL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P208	GQILHPEECMY	3	Homo sapiens, Mus musculus, Bos taurus
P208	ASILSLDEMLP	1	Arabidopsis thaliana
P208	TSVLSVDEMLP	1	Oryza sativa subsp. japonica
P208	TQRFDSTIMLH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
P208	TQRFNADTMCY	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
P208	TQRFHSDTMYH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P208	AQMLTAPFVYY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q217	MYAVGQGALGV	2	Homo sapiens, Bos taurus
Q217	LPAVAQGAIGI	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
Q217	LHAVGQGALGI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Q217	CYAVGQGALGI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Q217	YHAVGQGALGI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q217	YYAVGQGALAV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q217	MYAVGQGALAV	1	Mus musculus
R149	GTSSLRRAAQL	2	Homo sapiens, Bos taurus
R149	GTSSVRRSAQL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R149	GTASLRRKSQI	1	Arabidopsis thaliana
R149	GSASLRRQSQI	1	Oryza sativa subsp. japonica
R149	GTSSIRRSAQL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R149	GTSSIRRRALL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R149	GTSSLRRVAQL	1	Mus musculus
R150	TSSLRRAAQLQ	2	Homo sapiens, Bos taurus
R150	TSSVRRSAQLK	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R150	TASLRRKSQIL	1	Arabidopsis thaliana
R150	SASLRRQSQIL	1	Oryza sativa subsp. japonica
R150	TSSIRRSAQLR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R150	TSSIRRRALLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R150	TSSLRRVAQLQ	1	Mus musculus
R173	GNLNTRLRKLD	3	Homo sapiens, Mus musculus, Bos taurus
R173	GNVQTRLSKLQ	1	Arabidopsis thaliana
R173	GNVQTRLRKLK	1	Oryza sativa subsp. japonica
R173	GNIQTRLKKLD	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R173	GNIQTRLAKLD	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R173	GNIQTRLQKLD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R173	GNVGTRLAKLD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R195	TAGLQRMGWHN	1	Homo sapiens
R195	LAGLKRLSMTE	1	Arabidopsis thaliana
R195	LAGLKRLNMAE	1	Oryza sativa subsp. japonica
R195	TAGLVRLGLES	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R195	SAGLMRSGLDS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R195	SAGLMRMGLEN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R195	AAGLFRLGLKD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R195	VAGLQRMGWQN	1	Mus musculus
R195	TAGLQRMGWQN	1	Bos taurus
R26	IRVGTRKSQLA	3	Homo sapiens, Mus musculus, Bos taurus
R26	IRIGTRGSPLA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
R26	LRIAGRRSKLA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
R26	VRIGGRRSKLA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
R26	LHIGGRKSKLA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R26	FPIGTRKSKLA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S146	SVVGTSSLRRA	2	Homo sapiens, Bos taurus
S146	SVVGTASLRRK	1	Arabidopsis thaliana
S146	SVVGSASLRRQ	1	Oryza sativa subsp. japonica
S146	SVVGTSSIRRS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S146	SVVGTSSVRRS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S146	GIVGTSSVRRS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S146	SVVGTSSIRRR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S146	SAVGTSSLRRV	1	Mus musculus
S147	VVGTSSLRRAA	2	Homo sapiens, Bos taurus
S147	VVGTASLRRKS	1	Arabidopsis thaliana
S147	VVGSASLRRQS	1	Oryza sativa subsp. japonica
S147	VVGTSSIRRSA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S147	VVGTSSVRRSA	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S147	IVGTSSVRRSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S147	VVGTSSIRRRA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S147	AVGTSSLRRVA	1	Mus musculus
S28	VGTRKSQLARI	3	Homo sapiens, Mus musculus, Bos taurus
S28	IGTRGSPLALA	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
S28	IAGRRSKLAVI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S28	IGGRRSKLAVV	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S28	IGGRKSKLAVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S28	IGTRKSKLAVI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S96	DLVVHSLKDLP	2	Homo sapiens, Bos taurus
S96	DIAVHSMKDVP	2	Arabidopsis thaliana, Oryza sativa subsp. japonica
S96	DLIVHSLKDMP	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S96	DMIVHSLKDMP	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S96	RILVHSLKDLP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S96	DLVVHSLKDVP	1	Mus musculus