mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for HMGCR

Gene summary

Basic gene Info.	Gene symbol	HMGCR
	Gene name	3-hydroxy-3-methylglutaryl-CoA reductase
	Synonyms	LDLCQ3
	Cytomap	UCSC genome browser: 5q13.3-q14
	Type of gene	protein-coding
	RefGenes	NM_000859.2, NM_001130996.1,
	Description	3-hydroxy-3-methylglutaryl CoA reductase (NADPH)3-hydroxy-3-methylglutaryl-Coenzyme A reductaseHMG-CoA reductasehydroxymethylglutaryl-CoA reductase
	Modification date	20141207
dbXrefs	MIM : 142910
	HGNC : HGNC
	Ensembl : ENSG00000113161
	HPRD : 00836
	Vega : OTTHUMG00000102069
Protein	UniProt: P04035 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_HMGCR
	BioGPS: 3156
Pathway	NCI Pathway Interaction Database: HMGCR
	KEGG: HMGCR
	REACTOME: HMGCR
	Pathway Commons: HMGCR
Context	iHOP: HMGCR
	ligand binding site mutation search in PubMed: HMGCR
	UCL Cancer Institute: HMGCR
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0051262	protein tetramerization	10698924

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Ligand binding site mutations for HMGCR

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
R590	R590C	COAD	1
H752	A753S	COAD	1
D767	Q766R	HNSC	1
F628	R630L	LUAD	1
S661	G663C	LUSC	1
A751	A751T	STAD	1
E528	C527Y	UCEC	1
V683	V683I	UCEC	1
K42	K42T	UCEC	1
V256	K257E	UCEC	1
A751	N750S	UCEC	1
S852	S852P	UCEC	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for HMGCR

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
A751	N750S	0.10782571
V683	V683I	-1.1501713
K42	K42T	-0.9060143
V256	K257E	-0.66384717
A751	A751T	-0.62864224
H752	A753S	-0.59131925
R590	R590C	-0.51924415
F628	R630L	-0.37551781
D767	Q766R	-0.3146852
S852	S852P	-0.20577229
E528	C527Y	-0.17541207
S661	G663C	-0.154599

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HMGCR from PDB

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Differential gene expression and gene-gene network for HMGCR

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of HMGCR and the right PPI network was created from samples without mutations in the LBS of HMGCR. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for HMGCR

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0020443	Hypercholesterolemia	14	AlteredExpression, Biomarker, GeneticVariation
umls:C2239176	Carcinoma, Hepatocellular	5	Biomarker
umls:C0022661	Kidney Failure, Chronic	2	Biomarker
umls:C0242216	Gallstones	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for HMGCR

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Nutraceutical	DB00157	NADH	Small molecule
Approved	DB00175	Pravastatin	Small molecule
Approved\|investigational	DB00227	Lovastatin	Small molecule
Withdrawn	DB00439	Cerivastatin	Small molecule
Approved	DB00641	Simvastatin	Small molecule
Approved	DB01076	Atorvastatin	Small molecule
Approved	DB01095	Fluvastatin	Small molecule
Approved	DB01098	Rosuvastatin	Small molecule
Nutraceutical	DB01992	Coenzyme A	Small molecule
Experimental	DB03169	(S)-Hmg-Coa	Small molecule
Experimental	DB03461	2'-Monophosphoadenosine 5'-Diphosphoribose	Small molecule
Experimental	DB04377	3-Hydroxy-3-Methyl-Glutaric Acid	Small molecule
Experimental	DB04447	1,4-Dithiothreitol	Small molecule
Investigational	DB05317	TAK-475	Small molecule
Investigational	DB05342	SP-01A	Small molecule
Experimental	DB06693	Mevastatin	Small molecule
Experimental	DB06846	7-[3-(4-FLUORO-PHENYL)-1-ISOPROPYL-1H-INDOL-2-YL]-3,5-DIHYDROXY-HEPTANOIC ACID	Small molecule
Approved	DB08860	Pitavastatin	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HMGCR go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	A	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	B	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	C	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	D	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	A	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	B	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	C	A751
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	D	A751
114		COMPACTIN	1hw8	A	A751
114		COMPACTIN	1hw8	C	A751
114		COMPACTIN	1hw8	D	A751
SIM		SIMVASTATIN ACID	1hw9	B	A751
SIM		SIMVASTATIN ACID	1hw9	C	A751
117		ATORVASTATIN	1hwk	B	A751
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	A	A751
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	D	A751
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	B	A751
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	C	A751
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	D	A751
114		COMPACTIN	1hw8	B	A751 H752
SIM		SIMVASTATIN ACID	1hw9	A	A751 H752
SIM		SIMVASTATIN ACID	1hw9	D	A751 H752
115		FLUVASTATIN	1hwi	A	A751 H752
115		FLUVASTATIN	1hwi	B	A751 H752
115		FLUVASTATIN	1hwi	C	A751 H752
115		FLUVASTATIN	1hwi	D	A751 H752
116		CERIVASTATIN	1hwj	A	A751 H752
116		CERIVASTATIN	1hwj	B	A751 H752
116		CERIVASTATIN	1hwj	C	A751 H752
116		CERIVASTATIN	1hwj	D	A751 H752
117		ATORVASTATIN	1hwk	A	A751 H752
117		ATORVASTATIN	1hwk	C	A751 H752
117		ATORVASTATIN	1hwk	D	A751 H752
FBI		ROSUVASTATIN	1hwl	A	A751 H752
FBI		ROSUVASTATIN	1hwl	B	A751 H752
FBI		ROSUVASTATIN	1hwl	C	A751 H752
FBI		ROSUVASTATIN	1hwl	D	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	A	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	B	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	C	A751 H752
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	B	A751 H752
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	C	A751 H752
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	D	A751 H752
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	A	A751 H752
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	B	A751 H752
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	C	A751 H752
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	D	A751 H752
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	A	A751 H752
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	B	A751 H752
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	C	A751 H752
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	D	A751 H752
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	A	A751 H752
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	B	A751 H752
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	C	A751 H752
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	A	A751 H752
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	B	A751 H752
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	C	A751 H752
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	A	A751 H752
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	C	A751 H752
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	D	A751 H752
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	A	A751 H752
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	B	A751 H752
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	C	A751 H752
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	D	A751 H752
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	A	A751 H752
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	C	A751 H752
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	D	A751 H752
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	A	A751 H752
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	B	A751 H752
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	C	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	A	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	B	A751 H752
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	C	A751 H752
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	A	A751 H752
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	B	A751 H752
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	C	A751 H752
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	D	A751 H752
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	A	A751 H752
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	B	A751 H752
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	A	A751 H752 S852
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	B	A751 H752 S852
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	C	A751 H752 S852
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	D	A751 H752 S852
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	D	A751 H752 S852
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	D	A751 H752 S852
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	B	A751 H752 S852
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	D	A751 H752 S852
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	D	A751 H752 S852
COA		COENZYME A	1dq8	A	E528
COA		COENZYME A	1dq8	B	E528
COA		COENZYME A	1dqa	A	E528
COA		COENZYME A	1dqa	B	E528
COA		COENZYME A	1dqa	D	E528
ADP		ADP	1hw8	A	E528
ADP		ADP	1hw9	C	E528
ADP		ADP	1hwi	B	E528
ADP		ADP	1hwj	A	E528
ADP		ADP	1hwj	B	E528
ADP		ADP	1hwj	C	E528
ADP		ADP	1hwl	A	E528
ADP		ADP	1hwl	B	E528
ADP		ADP	1hwl	C	E528
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	A	E528 R590
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	B	E528 R590
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	C	E528 R590
HMG		(3S)-3-HYDROXY-3-METHYLGLUTARYL-COA(5-)	1dq9	D	E528 R590
ADP		ADP	1hw8	D	F628
ADP		ADP	1hw9	B	F628
ADP		ADP	1hw9	D	F628
ADP		ADP	1hwi	B	F628
ADP		ADP	1hwi	D	F628
ADP		ADP	1hwj	B	F628
ADP		ADP	1hwj	C	F628
ADP		ADP	1hwj	D	F628
ADP		ADP	1hwk	A	F628
ADP		ADP	1hwk	B	F628
ADP		ADP	1hwk	D	F628
COA		COENZYME A	1dq8	A	H752 S852
COA		COENZYME A	1dq8	B	H752 S852
COA		COENZYME A	1dq8	C	H752 S852
COA		COENZYME A	1dq8	D	H752 S852
COA		COENZYME A	1dqa	A	H752 S852
COA		COENZYME A	1dqa	B	H752 S852
COA		COENZYME A	1dqa	C	H752 S852
COA		COENZYME A	1dqa	D	H752 S852
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	A	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	B	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	C	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dq8	D	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	A	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	B	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	C	R590
MAH		3-HYDROXY-3-METHYLGLUTARIC ACID	1dqa	D	R590
SIM		SIMVASTATIN ACID	1hw9	D	R590
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	A	R590
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	B	R590
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	C	R590
7HI		(3R,5R)-7-[3-(BIPHENYL-4-YLCARBAMOYL)-2-ETHYL-5,6,7,8-TETRAHYDROCYCLOHEPTA[B]PYRROL-1(4H)-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd5	D	R590
NAP		NADP ZWITTERION	1dqa	A	R590 F628 S661 D767
NAP		NADP ZWITTERION	1dqa	B	R590 F628 S661 D767
NAP		NADP ZWITTERION	1dqa	C	R590 F628 S661 D767
NAP		NADP ZWITTERION	1dqa	D	R590 F628 S661 D767
114		COMPACTIN	1hw8	B	R590 S661
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	A	R590 S661
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	A	R590 S661
114		COMPACTIN	1hw8	D	R590 S661 V683
116		CERIVASTATIN	1hwj	B	R590 S661 V683
117		ATORVASTATIN	1hwk	A	R590 S661 V683
117		ATORVASTATIN	1hwk	B	R590 S661 V683
117		ATORVASTATIN	1hwk	C	R590 S661 V683
117		ATORVASTATIN	1hwk	D	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	A	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	B	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	D	R590 S661 V683
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	A	R590 S661 V683
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	B	R590 S661 V683
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	C	R590 S661 V683
HR2		(3R,5R)-7-[3-(4-FLUOROPHENYL)-1-ISOPROPYL-8-OXO-7-PHENYL-1,4,5,6,7,8-HEXAHYDROPYRROLO[2,3-C]AZEPIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6b	D	R590 S661 V683
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	A	R590 S661 V683
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	B	R590 S661 V683
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	A	R590 S661 V683
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	B	R590 S661 V683
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	C	R590 S661 V683
RIE		(3R,5R)-7-[1-(4-FLUOROPHENYL)-4-(1-METHYLETHYL)-3-{METHYL[(1R)-1-PHENYLETHYL]CARBAMOYL}-1H-PYRAZOL-5-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2r4f	D	R590 S661 V683
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	A	R590 S661 V683
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	B	R590 S661 V683
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	C	R590 S661 V683
RID		(3R,5R)-7-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-4-(MORPHOLIN-4-YLSULFONYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3bgl	D	R590 S661 V683
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	B	R590 S661 V683
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	D	R590 S661 V683
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	B	R590 S661 V683
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	C	R590 S661 V683
4HI		(3R,5R)-7-[4-(BENZYLCARBAMOYL)-2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccw	D	R590 S661 V683
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	A	R590 S661 V683
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	B	R590 S661 V683
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	C	R590 S661 V683
5HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-{[(1S)-2-HYDROXY-1-PHENYLETHYL]CARBAMOYL}-5-(1-METHYLETHYL)-1H-IMIDAZOL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3ccz	D	R590 S661 V683
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	B	R590 S661 V683
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	D	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	A	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	B	R590 S661 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	D	R590 S661 V683
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	A	R590 S661 V683
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	B	R590 S661 V683
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	C	R590 S661 V683
8HI		(3R,5R)-7-{3-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-4-PHENYL-5-[(4-SULFAMOYLPHENYL)CARBAMOYL]-1H-PYRROL-2-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cda	D	R590 S661 V683
114		COMPACTIN	1hw8	A	R590 V683
114		COMPACTIN	1hw8	C	R590 V683
SIM		SIMVASTATIN ACID	1hw9	A	R590 V683
SIM		SIMVASTATIN ACID	1hw9	B	R590 V683
SIM		SIMVASTATIN ACID	1hw9	C	R590 V683
115		FLUVASTATIN	1hwi	A	R590 V683
115		FLUVASTATIN	1hwi	B	R590 V683
115		FLUVASTATIN	1hwi	C	R590 V683
115		FLUVASTATIN	1hwi	D	R590 V683
116		CERIVASTATIN	1hwj	A	R590 V683
116		CERIVASTATIN	1hwj	C	R590 V683
116		CERIVASTATIN	1hwj	D	R590 V683
FBI		ROSUVASTATIN	1hwl	A	R590 V683
FBI		ROSUVASTATIN	1hwl	B	R590 V683
FBI		ROSUVASTATIN	1hwl	C	R590 V683
FBI		ROSUVASTATIN	1hwl	D	R590 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q1l	C	R590 V683
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	C	R590 V683
HR1		(3R,5R)-7-[1-(4-FLUOROPHENYL)-3-ISOPROPYL-4-OXO-5-PHENYL-4,5-DIHYDRO-3H-PYRROLO[2,3-C]QUINOLIN-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	2q6c	D	R590 V683
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	A	R590 V683
3HI		(3R,5R)-7-[2-(4-FLUOROPHENYL)-4-[(2-HYDROXYPHENYL)CARBAMOYL]-5-(1-METHYLETHYL)-3-PHENYL-1H-PYRROL-1-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cct	C	R590 V683
6HI		(3R,5R)-7-{2-[(4-FLUOROBENZYL)CARBAMOYL]-4-(4-FLUOROPHENYL)-1-(1-METHYLETHYL)-1H-IMIDAZOL-5-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cd0	C	R590 V683
882		(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID	3cd7	C	R590 V683
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	A	R590 V683
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	B	R590 V683
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	C	R590 V683
9HI		(3R,5R)-7-{3-[(4-CARBAMOYLPHENYL)SULFAMOYL]-4,5-BIS(4-FLUOROPHENYL)-2-(1-METHYLETHYL)-1H-PYRROL-1-YL}-3,5-DIHYDROXYHEPTANOIC ACID	3cdb	D	R590 V683

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Conservation information for LBS of HMGCR

Multiple alignments for P04035 in multiple species

LBS	AA sequence	# species	Species
A564	EGCLVASTNRG	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana
A564	EGCLVASAMRG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A564	EGALVASTNRG	1	Drosophila melanogaster
A564	EGALVASTMRG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A654	SRSGDAMGMNM	2	Homo sapiens, Bos taurus
A654	CSTGDAMGMNM	2	Arabidopsis thaliana, Arabidopsis thaliana
A654	TTTGDAMGMNM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A654	AITGDAMGMNM	1	Drosophila melanogaster
A654	SRTGDAMGMNM	1	Mus musculus
A654	SKTGDAMGMNM	1	Rattus norvegicus
A654	TSTGDAMGMNM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A751	IGGYNAHAANI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A751	VGGFNAHAANL	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A751	IGGNNAHAANM	1	Drosophila melanogaster
A751	VGGFNAHAANI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A751	LGGFNAHASNI	1	Arabidopsis thaliana
A751	LGGFNAHSSNI	1	Arabidopsis thaliana
A826	LGVQGACKDNP	3	Homo sapiens, Mus musculus, Rattus norvegicus
A826	LGVRGAHATRP	1	Drosophila melanogaster
A826	LGVQGACRDNP	1	Bos taurus
A826	LGVRGAHMTSP	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A826	LGVKGASTESP	1	Arabidopsis thaliana
A826	LGVKGSNNEKP	1	Arabidopsis thaliana
A826	LGVRGPHATAP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A826	LGVRGPHPTEP	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A856	LSLMAALAAGH	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A856	LSLMSAIAAGQ	2	Arabidopsis thaliana, Arabidopsis thaliana
A856	LSLMAALVNSD	1	Drosophila melanogaster
A856	LSLCSALASGH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A856	LSLCAALAAGH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A856	LSLCSALAAGH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C561	ATTEGCLVAST	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana
C561	ATTEGALVAST	2	Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
C561	ATTEGCLVASA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D653	QSRSGDAMGMN	2	Homo sapiens, Bos taurus
D653	RTTTGDAMGMN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D653	VAITGDAMGMN	1	Drosophila melanogaster
D653	QSRTGDAMGMN	1	Mus musculus
D653	QSKTGDAMGMN	1	Rattus norvegicus
D653	CTSTGDAMGMN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D653	CCSTGDAMGMN	1	Arabidopsis thaliana
D653	ACSTGDAMGMN	1	Arabidopsis thaliana
D690	GNYCTDKKPAA	7	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D690	GNFCCDKKPAA	1	Drosophila melanogaster
D690	GNFCSDKKPAA	1	Arabidopsis thaliana
D690	GNYCSDKKASA	1	Arabidopsis thaliana
D767	IACGQDAAQNV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D767	LATGQDPAQNV	2	Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D767	IATGQDPAQNV	2	Arabidopsis thaliana, Arabidopsis thaliana
D767	LALGQDPAQNV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E528	MGACCENVIGY	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E528	LGQCCEMPVGY	2	Arabidopsis thaliana, Arabidopsis thaliana
E528	FGACCENVIGY	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E528	LNACCENVLGY	1	Drosophila melanogaster
E528	LNACCENVIGY	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E559	PMATTEGCLVA	8	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E559	PMATTEGALVA	2	Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F628	DSTSRFARLQK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F628	NSTSRFARLQH	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F628	DSTSRFGRLKD	1	Drosophila melanogaster
F628	NRSSRFARLQS	1	Arabidopsis thaliana
F628	NKSSRFARLQS	1	Arabidopsis thaliana
G560	MATTEGCLVAS	8	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G560	MATTEGALVAS	2	Drosophila melanogaster, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G652	FQSRSGDAMGM	2	Homo sapiens, Bos taurus
G652	FRTTTGDAMGM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G652	FVAITGDAMGM	1	Drosophila melanogaster
G652	FQSRTGDAMGM	1	Mus musculus
G652	LQSKTGDAMGM	1	Rattus norvegicus
G652	FCTSTGDAMGM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G652	FCCSTGDAMGM	1	Arabidopsis thaliana
G652	FACSTGDAMGM	1	Arabidopsis thaliana
G656	TGDAMGMNMIS	5	Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G656	TGDAMGMNMVS	3	Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana
G656	SGDAMGMNMIS	2	Homo sapiens, Bos taurus
G806	EIGTVGGGTNL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G806	EVGTIGGGTVL	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G806	EVGTVGGGTQL	2	Arabidopsis thaliana, Arabidopsis thaliana
G806	EVGTVGGGTGL	1	Drosophila melanogaster
G807	IGTVGGGTNLL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G807	VGTIGGGTVLE	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G807	VGTVGGGTQLA	2	Arabidopsis thaliana, Arabidopsis thaliana
G807	VGTVGGGTGLP	1	Drosophila melanogaster
G860	AALAAGHLVRS	3	Mus musculus, Rattus norvegicus, Bos taurus
G860	AALAAGHLVKS	1	Homo sapiens
G860	AALVNSDLVKS	1	Drosophila melanogaster
G860	SALASGHLVKS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G860	SAIAAGQLVRS	1	Arabidopsis thaliana
G860	SAIAAGQLVKS	1	Arabidopsis thaliana
G860	AALAAGHLVQS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G860	SALAAGHLVQS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H752	GGYNAHAANIV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H752	GGFNAHAANLV	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H752	GGNNAHAANMV	1	Drosophila melanogaster
H752	GGFNAHAANIV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H752	GGFNAHASNIV	1	Arabidopsis thaliana
H752	GGFNAHSSNIV	1	Arabidopsis thaliana
H861	ALAAGHLVRSH	3	Mus musculus, Rattus norvegicus, Bos taurus
H861	ALAAGHLVQSH	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H861	ALAAGHLVKSH	1	Homo sapiens
H861	ALVNSDLVKSH	1	Drosophila melanogaster
H861	ALASGHLVKSH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H861	AIAAGQLVRSH	1	Arabidopsis thaliana
H861	AIAAGQLVKSH	1	Arabidopsis thaliana
H866	HLVRSHMVHNR	2	Mus musculus, Rattus norvegicus
H866	HLVQSHMTHNR	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H866	HLVKSHMIHNR	1	Homo sapiens
H866	DLVKSHMRHNR	1	Drosophila melanogaster
H866	HLVRSHMIHNR	1	Bos taurus
H866	HLVKSHIGLNR	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H866	QLVRSHMKYNR	1	Arabidopsis thaliana
H866	QLVKSHMKYNR	1	Arabidopsis thaliana
H869	RSHMVHNRSKI	2	Mus musculus, Rattus norvegicus
H869	KSHMIHNRSKI	1	Homo sapiens
H869	KSHMRHNRSSI	1	Drosophila melanogaster
H869	RSHMIHNRSKI	1	Bos taurus
H869	KSHIGLNRSAL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H869	RSHMKYNRSSR	1	Arabidopsis thaliana
H869	KSHMKYNRSSR	1	Arabidopsis thaliana
H869	QSHMTHNRKPA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H869	QSHMTHNRKTN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H9	RLFRMHGLFVA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H9	RLFRAHGEFCA	1	Drosophila melanogaster
H9	----MIYKLAA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H9	------MDLRR	1	Arabidopsis thaliana
H9	-----MEDLRR	1	Arabidopsis thaliana
H9	KPIAYVSRFSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H9	KPFACTARFSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K42	FTGNNKICGWN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K42	TSSRHRPCHGW	1	Drosophila melanogaster
K42	FHDASGACHFF	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K42	RTSDDDHRRRA	1	Arabidopsis thaliana
K42	-----------	1	Arabidopsis thaliana
K42	TVFEKDNTKYI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K42	VIYSVDHTRYL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K691	NYCTDKKPAAI	7	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K691	NFCCDKKPAAI	1	Drosophila melanogaster
K691	NFCSDKKPAAV	1	Arabidopsis thaliana
K691	NYCSDKKASAV	1	Arabidopsis thaliana
K692	YCTDKKPAAIN	7	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K692	FCCDKKPAAIN	1	Drosophila melanogaster
K692	FCSDKKPAAVN	1	Arabidopsis thaliana
K692	YCSDKKASAVN	1	Arabidopsis thaliana
K704	IEGRGKSVVCE	3	Homo sapiens, Bos taurus, Arabidopsis thaliana
K704	IEGRGKTVVCE	2	Mus musculus, Rattus norvegicus
K704	IEGRGKSVVAE	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K704	IKGRGKRVVTE	1	Drosophila melanogaster
K704	IDGRGKSVIAE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K704	IEGRGKHVVCE	1	Arabidopsis thaliana
K722	VREVLKTTTEA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K722	LRSVLKTDAKT	1	Drosophila melanogaster
K722	VKSVLKTTVED	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K722	VNKVLKTSVAA	1	Arabidopsis thaliana
K722	VEKVLKTSVEA	1	Arabidopsis thaliana
K722	VRKVLKSDVSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K722	VKSVLKSDVSA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K735	EVNINKNLVGS	2	Homo sapiens, Bos taurus
K735	DVNINKNLVGS	2	Mus musculus, Rattus norvegicus
K735	ECNKLKNMGGS	1	Drosophila melanogaster
K735	KLNVDKNLIGS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K735	ELNMLKNLAGS	1	Arabidopsis thaliana
K735	ELNTLKNLVGS	1	Arabidopsis thaliana
K735	ELNIAKNLVGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K735	ELNISKNLVGS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L173	--LDALVECLV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L173	-----------	2	Arabidopsis thaliana, Arabidopsis thaliana
L173	--LDTIVEVLL	1	Drosophila melanogaster
L173	KACRNAAPPIL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L173	RLIQDHLLCIF	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L173	YLIRDYLFYIS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L562	TTEGCLVASTN	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana, Arabidopsis thaliana
L562	TTEGCLVASAM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L562	TTEGALVASTN	1	Drosophila melanogaster
L562	TTEGALVASTM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L853	AGELSLMAALA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L853	AGELSLCSALA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L853	AGELSLMSAIA	2	Arabidopsis thaliana, Arabidopsis thaliana
L853	AGELSLMAALV	1	Drosophila melanogaster
L853	AGELSLCAALA	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L857	SLMAALAAGHL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L857	SLMSAIAAGQL	2	Arabidopsis thaliana, Arabidopsis thaliana
L857	SLMAALVNSDL	1	Drosophila melanogaster
L857	SLCSALASGHL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L857	SLCAALAAGHL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L857	SLCSALAAGHL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L862	LAAGHLVRSHM	3	Mus musculus, Rattus norvegicus, Bos taurus
L862	LAAGHLVQSHM	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L862	LAAGHLVKSHM	1	Homo sapiens
L862	LVNSDLVKSHM	1	Drosophila melanogaster
L862	LASGHLVKSHI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L862	IAAGQLVRSHM	1	Arabidopsis thaliana
L862	IAAGQLVKSHM	1	Arabidopsis thaliana
M655	RSGDAMGMNMI	2	Homo sapiens, Bos taurus
M655	STGDAMGMNMV	2	Arabidopsis thaliana, Arabidopsis thaliana
M655	TTGDAMGMNMI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M655	ITGDAMGMNMV	1	Drosophila melanogaster
M655	RTGDAMGMNMI	1	Mus musculus
M655	KTGDAMGMNMI	1	Rattus norvegicus
M655	STGDAMGMNMI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M657	GDAMGMNMISK	7	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M657	GDAMGMNMVSK	3	Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana
M659	AMGMNMISKGT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M659	AMGMNMISKGV	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M659	AMGMNMVSKGV	2	Arabidopsis thaliana, Arabidopsis thaliana
M659	AMGMNMVSKGA	1	Drosophila melanogaster
N35	CMMSMNMFTGN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N35	SSMGGSATSSR	1	Drosophila melanogaster
N35	PYRNDCIFHDA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N35	SFRSYQPRTSD	1	Arabidopsis thaliana
N35	EISNVAV----	1	Arabidopsis thaliana
N35	SIPELANTVFE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N35	TLPSLDDVIYS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N392	-----------	2	Arabidopsis thaliana, Arabidopsis thaliana
N392	EETGINRERKV	1	Homo sapiens
N392	QEKDTENSAAV	1	Drosophila melanogaster
N392	EDPGANQERKV	1	Mus musculus
N392	EDPGVNQDRKV	1	Rattus norvegicus
N392	EETRKNRERKV	1	Bos taurus
N392	EEPEKKVVEKV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N392	KASTPVLTNKT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N392	QQKSATIEFSE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N529	GACCENVIGYM	6	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N529	NACCENVLGYV	1	Drosophila melanogaster
N529	NACCENVIGYM	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N529	GQCCEMPVGYI	1	Arabidopsis thaliana
N529	GQCCEMPVGYV	1	Arabidopsis thaliana
N567	LVASTNRGCRA	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N567	LVASTNRGCKA	2	Drosophila melanogaster, Arabidopsis thaliana
N567	LVASAMRGCKA	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N567	LVASTMRGCKA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N567	LVASTNRGFKA	1	Arabidopsis thaliana
N658	DAMGMNMISKG	7	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N658	DAMGMNMVSKG	3	Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana
N686	LAVSGNYCTDK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N686	VSVSGNYCTDK	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N686	ISLSGNFCCDK	1	Drosophila melanogaster
N686	ISVSGNYCTDK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N686	IGISGNFCSDK	1	Arabidopsis thaliana
N686	IGISGNYCSDK	1	Arabidopsis thaliana
N755	NAHAANIVTAI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N755	NAHAANMVTAV	1	Drosophila melanogaster
N755	NAHAANIVTAV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N755	NAHASNIVSAV	1	Arabidopsis thaliana
N755	NAHSSNIVSAV	1	Arabidopsis thaliana
N755	NAHAANLVTAV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N755	NAHAANLVTAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P477	KHI--PAYKLE	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P477	GGTHCPLHKIE	1	Drosophila melanogaster
P477	KKI--PLYALE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
P477	GVI--PSYSLE	1	Arabidopsis thaliana
P477	GTI--PSYSLE	1	Arabidopsis thaliana
P477	GKL--PLYALE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P477	GKL--PLYSLE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R4	--MLSRLFRMH	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R4	--MIGRLFRAH	1	Drosophila melanogaster
R4	---------MI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R4	-----------	1	Arabidopsis thaliana
R4	----------M	1	Arabidopsis thaliana
R4	LKQMAKPIAYV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R4	IVHLVKPFACT	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R568	VASTNRGCRAI	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R568	VASAMRGCKAI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R568	VASTNRGCKAL	1	Drosophila melanogaster
R568	VASTMRGCKAI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R568	VASTNRGCKAM	1	Arabidopsis thaliana
R568	VASTNRGFKAI	1	Arabidopsis thaliana
R571	TNRGCRAIGLG	2	Homo sapiens, Bos taurus
R571	TNRGCRAISLG	2	Mus musculus, Rattus norvegicus
R571	AMRGCKAINAG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R571	TNRGCKALSVR	1	Drosophila melanogaster
R571	TMRGCKAINAG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R571	TNRGCKAMFIS	1	Arabidopsis thaliana
R571	TNRGFKAIHLS	1	Arabidopsis thaliana
R590	ADGMTRGPVVR	3	Homo sapiens, Mus musculus, Bos taurus
R590	KDGMTRGPVVR	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R590	DVGMTRAPCVR	1	Drosophila melanogaster
R590	ADGMSRGPVVR	1	Rattus norvegicus
R590	RDQMSRGPCVA	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R590	KDGMTRAPVVR	1	Arabidopsis thaliana
R590	KDAMTRAPVVR	1	Arabidopsis thaliana
R627	FDSTSRFARLQ	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R627	FNSTSRFARLQ	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R627	FDSTSRFGRLK	1	Drosophila melanogaster
R627	FNRSSRFARLQ	1	Arabidopsis thaliana
R627	FNKSSRFARLQ	1	Arabidopsis thaliana
S15	GLFVASHPWEV	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S15	GEFCASHPWEV	1	Drosophila melanogaster
S15	YKLAARYPIQV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S15	MDLRRRPPKPP	1	Arabidopsis thaliana
S15	EDLRRRFP---	1	Arabidopsis thaliana
S15	SRFSAKRPIHI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S15	ARFSARYPIHV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S3	---MLSRLFRM	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S3	-----------	2	Arabidopsis thaliana, Arabidopsis thaliana
S3	---MIGRLFRA	1	Drosophila melanogaster
S3	----------M	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S3	GLKQMAKPIAY	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S3	TIVHLVKPFAC	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S565	GCLVASTNRGC	5	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Arabidopsis thaliana
S565	GCLVASAMRGC	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S565	GALVASTNRGC	1	Drosophila melanogaster
S565	GALVASTMRGC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S565	GCLVASTNRGF	1	Arabidopsis thaliana
S626	AFDSTSRFARL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S626	AFNSTSRFARL	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S626	EFDSTSRFGRL	1	Drosophila melanogaster
S626	VFNRSSRFARL	1	Arabidopsis thaliana
S626	IFNKSSRFARL	1	Arabidopsis thaliana
S651	RFQSRSGDAMG	2	Homo sapiens, Bos taurus
S651	RFRTTTGDAMG	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S651	RFVAITGDAMG	1	Drosophila melanogaster
S651	RFQSRTGDAMG	1	Mus musculus
S651	RLQSKTGDAMG	1	Rattus norvegicus
S651	RFCTSTGDAMG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S651	RFCCSTGDAMG	1	Arabidopsis thaliana
S651	RFACSTGDAMG	1	Arabidopsis thaliana
S661	GMNMISKGTEK	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S661	GMNMVSKGVQN	2	Arabidopsis thaliana, Arabidopsis thaliana
S661	GMNMISKGVEY	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S661	GMNMVSKGAEM	1	Drosophila melanogaster
S661	GMNMISKGVEH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S684	QILAVSGNYCT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S684	EVVSVSGNYCT	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S684	QIISLSGNFCC	1	Drosophila melanogaster
S684	QVISVSGNYCT	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S684	DVIGISGNFCS	1	Arabidopsis thaliana
S684	DVIGISGNYCS	1	Arabidopsis thaliana
S852	MAGELSLMAAL	5	Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
S852	LAGELSLMSAI	2	Arabidopsis thaliana, Arabidopsis thaliana
S852	MAGELSLCSAL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S852	LAGELSLCAAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S852	LAGELSLCSAL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S865	GHLVRSHMVHN	2	Mus musculus, Rattus norvegicus
S865	GHLVQSHMTHN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S865	GHLVKSHMIHN	1	Homo sapiens
S865	SDLVKSHMRHN	1	Drosophila melanogaster
S865	GHLVRSHMIHN	1	Bos taurus
S865	GHLVKSHIGLN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S865	GQLVRSHMKYN	1	Arabidopsis thaliana
S865	GQLVKSHMKYN	1	Arabidopsis thaliana
V13	MHGLFVASHPW	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V13	AHGEFCASHPW	1	Drosophila melanogaster
V13	MIYKLAARYPI	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V13	--MDLRRRPPK	1	Arabidopsis thaliana
V13	-MEDLRRRFP-	1	Arabidopsis thaliana
V13	YVSRFSAKRPI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V13	CTARFSARYPI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V256	--TQRVKMIMS	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V256	-----------	2	Arabidopsis thaliana, Arabidopsis thaliana
V256	--LQRVKLIMT	1	Drosophila melanogaster
V256	SRYFKVRYGTK	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V256	--FLNLSVVVI	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V256	--FLRSNVAII	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V683	MQILAVSGNYC	3	Homo sapiens, Mus musculus, Bos taurus
V683	MEVVSVSGNYC	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V683	MQIISLSGNFC	1	Drosophila melanogaster
V683	LQILAVSGNYC	1	Rattus norvegicus
V683	MQVISVSGNYC	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V683	MDVIGISGNFC	1	Arabidopsis thaliana
V683	MDVIGISGNYC	1	Arabidopsis thaliana
V720	KVVREVLKTTT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V720	ATLRSVLKTDA	1	Drosophila melanogaster
V720	DAVKSVLKTTV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V720	EIVNKVLKTSV	1	Arabidopsis thaliana
V720	EIVEKVLKTSV	1	Arabidopsis thaliana
V720	DVVRKVLKSDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V720	DVVKSVLKSDV	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V805	IEIGTVGGGTN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V805	IEVGTIGGGTV	3	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V805	IEVGTVGGGTQ	2	Arabidopsis thaliana, Arabidopsis thaliana
V805	LEVGTVGGGTG	1	Drosophila melanogaster
Y479	I--PAYKLETL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y479	THCPLHKIESV	1	Drosophila melanogaster
Y479	I--PLYALERV	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y479	I--PSYSLESR	1	Arabidopsis thaliana
Y479	I--PSYSLETK	1	Arabidopsis thaliana
Y479	L--PLYALEKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y479	L--PLYSLEKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)