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mutLBSgeneDB |
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| Gene summary for HNRNPF |
 Gene summary |
| Basic gene Info. | Gene symbol | HNRNPF |
| Gene name | heterogeneous nuclear ribonucleoprotein F | |
| Synonyms | HNRPF|OK/SW-cl.23|mcs94-1 | |
| Cytomap | UCSC genome browser: 10q11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001098204.1, NM_001098205.1,NM_001098206.1,NM_001098207.1,NM_001098208.1, NM_004966.3, | |
| Description | HnRNP F proteinnucleolin-like protein mcs94-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601037 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169813 | ||
| HPRD : 03023 | ||
| Vega : OTTHUMG00000018029 | ||
| Protein | UniProt: P52597 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HNRNPF | |
| BioGPS: 3185 | ||
| Pathway | NCI Pathway Interaction Database: HNRNPF | |
| KEGG: HNRNPF | ||
| REACTOME: HNRNPF | ||
| Pathway Commons: HNRNPF | ||
| Context | iHOP: HNRNPF | |
| ligand binding site mutation search in PubMed: HNRNPF | ||
| UCL Cancer Institute: HNRNPF | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0043484 | regulation of RNA splicing | 20526337 |
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| Ligand binding site mutations for HNRNPF |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | R116 | R114W | UCEC | 2 | S54 | E56Q | BLCA | 1 | R355 | R355S | KICH | 1 | R294 | M293I | LUSC | 1 | F86 | S88F | SKCM | 1 | F360 | F360L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HNRNPF |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S54 | E56Q | -1.5017081 | R355 | R355S | -0.88827905 | F360 | F360L | -0.62594636 | F86 | S88F | -0.57077905 | R294 | M293I | -0.54439925 | R116 | R114W | -0.35342694 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HNRNPF from PDB |
| PDB ID | PDB title | PDB structure | 2HGL | NMR structure of the first qRRM domain of human hnRNP F |  |
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| Differential gene expression and gene-gene network for HNRNPF |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HNRNPF |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HNRNPF |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HNRNPF go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | NUC | Nucleic Acids | 2kg0 | A | R116 | NUC | Nucleic Acids | 2kg1 | A | R294 R355 F360 | NUC | Nucleic Acids | 2kfy | A | S54 F86 |
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| Conservation information for LBS of HNRNPF |
| Multiple alignments for P52597 in multiple species |
| LBS | AA sequence | # species | Species | D348 | AAMSKDRANMQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D74 | LALKKDRESMG | 3 | Bos taurus, Mus musculus, Rattus norvegicus | D74 | MALKKDRESMG | 1 | Homo sapiens | E330 | GRVTGEADVEF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E358 | QHRYIELFLNS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E84 | GHRYIEVFKSH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F120 | LRGLPFGCTKE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F184 | RYIEVFKSSQE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F360 | RYIELFLNSTT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | F86 | RYIEVFKSHRT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G117 | FVRLRGLPFGC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G17 | VVKLRGLPWSC | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G295 | CVHMRGLPYKA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | H172 | KALGKHKERIG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I151 | DPEGKITGEAF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I357 | MQHRYIELFLN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I83 | MGHRYIEVFKS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K14 | EGFVVKLRGLP | 2 | Homo sapiens, Bos taurus | K14 | EGYVVKLRGLP | 2 | Mus musculus, Rattus norvegicus | K150 | VDPEGKITGEA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K173 | ALGKHKERIGH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L118 | VRLRGLPFGCT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L18 | VKLRGLPWSCS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L296 | VHMRGLPYKAT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L359 | HRYIELFLNST | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | P19 | KLRGLPWSCSV | 2 | Homo sapiens, Bos taurus | P19 | KLRGLPWSCSI | 2 | Mus musculus, Rattus norvegicus | P297 | HMRGLPYKATE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Q53 | TREGRQSGEAF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R116 | GFVRLRGLPFG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R16 | FVVKLRGLPWS | 2 | Homo sapiens, Bos taurus | R16 | YVVKLRGLPWS | 2 | Mus musculus, Rattus norvegicus | R294 | HCVHMRGLPYK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R349 | AMSKDRANMQH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R355 | ANMQHRYIELF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R52 | YTREGRQSGEA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R75 | ALKKDRESMGH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R81 | ESMGHRYIEVF | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S54 | REGRQSGEAFV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V327 | GPDGRVTGEAD | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V85 | HRYIEVFKSHR | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | W20 | LRGLPWSCSVE | 2 | Homo sapiens, Bos taurus | W20 | LRGLPWSCSIE | 2 | Mus musculus, Rattus norvegicus | Y298 | MRGLPYKATEN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y356 | NMQHRYIELFL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y82 | SMGHRYIEVFK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus |
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