mutLBSgeneDB |
Gene summary for HNRNPK |
Gene summary |
Basic gene Info. | Gene symbol | HNRNPK |
Gene name | heterogeneous nuclear ribonucleoprotein K | |
Synonyms | CSBP|HNRPK|TUNP | |
Cytomap | UCSC genome browser: 9q21.32-q21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_002140.3, NM_031262.2,NM_031263.2, | |
Description | dC-stretch binding proteintransformation upregulated nuclear protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 600712 | |
HGNC : HGNC | ||
Ensembl : ENSG00000165119 | ||
HPRD : 02834 | ||
Vega : OTTHUMG00000020107 | ||
Protein | UniProt: P61978 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HNRNPK | |
BioGPS: 3190 | ||
Pathway | NCI Pathway Interaction Database: HNRNPK | |
KEGG: HNRNPK | ||
REACTOME: HNRNPK | ||
Pathway Commons: HNRNPK | ||
Context | iHOP: HNRNPK | |
ligand binding site mutation search in PubMed: HNRNPK | ||
UCL Cancer Institute: HNRNPK | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for HNRNPK |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R414 | R414C | COAD | 1 | R433 | R433W | STAD | 1 | R433 | R433Q | STAD | 1 | R433 | R433L | STAD | 1 | R433 | I435V | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for HNRNPK |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R433 | R433Q | -1.2383982 | R433 | I435V | -1.1836698 | R414 | R414C | -1.0348227 | R433 | R433W | -0.91930197 | R433 | R433L | -0.63855015 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for HNRNPK from PDB |
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Differential gene expression and gene-gene network for HNRNPK |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for HNRNPK |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C1458155 | Breast Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for HNRNPK |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of HNRNPK go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of HNRNPK |
Multiple alignments for P61978 in multiple species |
LBS | AA sequence | # species | Species | A399 | IPKDLAGSIIG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | E425 | SIKIDEPLEGS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G400 | PKDLAGSIIGK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G404 | AGSIIGKGGQR | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G406 | SIIGKGGQRIK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | G407 | IIGKGGQRIKQ | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | H415 | IKQIRHESGAS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I410 | KGGQRIKQIRH | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I421 | ESGASIKIDEP | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I423 | GASIKIDEPLE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | I58 | NAGAVIGKGGK | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K396 | QVTIPKDLAGS | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K405 | GSIIGKGGQRI | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K411 | GGQRIKQIRHE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | K422 | SGASIKIDEPL | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R414 | RIKQIRHESGA | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | R433 | EGSEDRIITIT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S401 | KDLAGSIIGKG | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S420 | HESGASIKIDE | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus | S459 | SVKQYSG-KFF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S459 | SVKQYADVEGF | 1 | Bos taurus | Y458 | NSVKQYSG-KF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y458 | NSVKQYADVEG | 1 | Bos taurus |
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