|
mutLBSgeneDB |
| |
| |
| |
| |
| |
| |
|
| Gene summary for APCS |
 Gene summary |
| Basic gene Info. | Gene symbol | APCS |
| Gene name | amyloid P component, serum | |
| Synonyms | HEL-S-92n|PTX2|SAP | |
| Cytomap | UCSC genome browser: 1q21-q23 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001639.3, | |
| Description | 9.5S alpha-1-glycoproteinepididymis secretory sperm binding protein Li 92npentaxin-relatedserum amyloid P-component | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 104770 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132703 | ||
| HPRD : 00101 | ||
| Vega : OTTHUMG00000022741 | ||
| Protein | UniProt: P02743 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_APCS | |
| BioGPS: 325 | ||
| Pathway | NCI Pathway Interaction Database: APCS | |
| KEGG: APCS | ||
| REACTOME: APCS | ||
| Pathway Commons: APCS | ||
| Context | iHOP: APCS | |
| ligand binding site mutation search in PubMed: APCS | ||
| UCL Cancer Institute: APCS | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0044869 | negative regulation by host of viral exo-alpha-sialidase activity | 23544079 | GO:0044871 | negative regulation by host of viral glycoprotein metabolic process | 23544079 | GO:0045087 | innate immune response | 23544079 | GO:0045656 | negative regulation of monocyte differentiation | 14607961 | GO:0046597 | negative regulation of viral entry into host cell | 23544079 | GO:0048525 | negative regulation of viral process | 23544079 | GO:1903016 | negative regulation of exo-alpha-sialidase activity | 23544079 | GO:1903019 | negative regulation of glycoprotein metabolic process | 23544079 |
| Top |
| Ligand binding site mutations for APCS |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D157 | Y159C | HNSC | 1 | Y93 | S91C | LUAD | 1 | K98 | H97Q | LUAD | 1 | K98 | T100I | LUAD | 1 | S120 | S121L | LUSC | 1 | E118 | E118V | OV | 1 | S181 | D180E | OV | 1 | S120 | S121L | SKCM | 1 | E210 | E210K | SKCM | 1 | D157 | D157N | SKCM | 1 | Q167 | F169S | UCEC | 1 | K162 | G160E | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Top |
| Protein structure related information for APCS |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
 |
| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S120 | S121L | 0.35949818 | E210 | E210K | -1.0307416 | Q167 | F169S | -0.87855821 | D157 | Y159C | -0.87117141 | K98 | T100I | -0.77979788 | D157 | D157N | -0.74484373 | E118 | E118V | -0.71426961 | K98 | H97Q | -0.59112364 | Y93 | S91C | -0.52790446 | K162 | G160E | -0.48641223 | S181 | D180E | -0.37697513 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for APCS from PDB |
| Top |
| Differential gene expression and gene-gene network for APCS |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Top |
| Top |
| Phenotype information for APCS |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C2239176 | Carcinoma, Hepatocellular | 2 | Biomarker |
| umls:C1956346 | Coronary Artery Disease | 2 | Biomarker |
| umls:C0018801 | Heart Failure | 1 | Biomarker |
| umls:C0023903 | Liver Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
| Top |
| Pharmacological information for APCS |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
 |
| Gene-centered drug-gene interaction network |
 |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB01651 | Methyl 4,6-O-[(1r)-1-Carboxyethylidene]-Beta-D-Galactopyranoside | Small molecule |  |
| Experimental | DB07579 | BIS-1,2-{[(Z)-2-CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBAMOYL}-ETHANE | Small molecule |  |
| Experimental | DB07580 | BIS-1,2-{[(Z)-2CARBOXY-2-METHYL-1,3-DIOXANE]-5-YLOXYCARBONYL}-PIPERAZINE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
 |
| Ligands binding to mutated ligand binding site of APCS go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
| Top |
| Conservation information for LBS of APCS |
| Multiple alignments for P02743 in multiple species |
| LBS | AA sequence | # species | Species | D157 | LGQEQDSYGGK | 1 | Homo sapiens | D157 | LGQEQDNYGGG | 1 | Mus musculus | D157 | LGQEQDTYGGG | 1 | Rattus norvegicus | D157 | LGQEQDSYGGG | 1 | Bos taurus | D164 | YGGKFDRSQSF | 1 | Homo sapiens | D164 | YGGGFQRSQSF | 1 | Mus musculus | D164 | YGGGFDKTQSF | 1 | Rattus norvegicus | D164 | YGGGFDKNQSF | 1 | Bos taurus | D77 | NTQGRDNELLV | 1 | Homo sapiens | D77 | SVKGRDNELLI | 1 | Mus musculus | D77 | SVNSRDNELLI | 1 | Rattus norvegicus | D77 | NIHSKDNELLV | 1 | Bos taurus | E118 | ICVSWESSSGI | 1 | Homo sapiens | E118 | LCTTWESSSGI | 1 | Mus musculus | E118 | FCTSWESSSGI | 1 | Rattus norvegicus | E118 | ICTSWESSTGI | 1 | Bos taurus | E155 | IVLGQEQDSYG | 2 | Homo sapiens, Bos taurus | E155 | IVLGQEQDNYG | 1 | Mus musculus | E155 | IVLGQEQDTYG | 1 | Rattus norvegicus | E210 | QALNYEIRGYV | 1 | Homo sapiens | E210 | QALNYEINGYV | 1 | Mus musculus | E210 | RALNYEINGYV | 1 | Rattus norvegicus | E210 | QALKYEIKGYV | 1 | Bos taurus | F163 | SYGGKFDRSQS | 1 | Homo sapiens | F163 | NYGGGFQRSQS | 1 | Mus musculus | F163 | TYGGGFDKTQS | 1 | Rattus norvegicus | F163 | SYGGGFDKNQS | 1 | Bos taurus | I211 | ALNYEINGYVV | 2 | Mus musculus, Rattus norvegicus | I211 | ALNYEIRGYVI | 1 | Homo sapiens | I211 | ALKYEIKGYVI | 1 | Bos taurus | K162 | DSYGGKFDRSQ | 1 | Homo sapiens | K162 | DNYGGGFQRSQ | 1 | Mus musculus | K162 | DTYGGGFDKTQ | 1 | Rattus norvegicus | K162 | DSYGGGFDKNQ | 1 | Bos taurus | K98 | YIGRHKVTSKV | 1 | Homo sapiens | K98 | YIGQSKVTVRG | 1 | Mus musculus | K98 | YIGNSKVTVRG | 1 | Rattus norvegicus | K98 | YIGKTKVTVRA | 1 | Bos taurus | L81 | RDNELLVYKER | 1 | Homo sapiens | L81 | RDNELLIYKEK | 1 | Mus musculus | L81 | RDNELLIYKDK | 1 | Rattus norvegicus | L81 | KDNELLVFKNG | 1 | Bos taurus | N51 | EKPLQNFTLCF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N51 | EKPLKNLTLCL | 1 | Bos taurus | N78 | TQGRDNELLVY | 1 | Homo sapiens | N78 | VKGRDNELLIY | 1 | Mus musculus | N78 | VNSRDNELLIY | 1 | Rattus norvegicus | N78 | IHSKDNELLVF | 1 | Bos taurus | Q156 | VLGQEQDSYGG | 2 | Homo sapiens, Bos taurus | Q156 | VLGQEQDNYGG | 1 | Mus musculus | Q156 | VLGQEQDTYGG | 1 | Rattus norvegicus | Q167 | KFDRSQSFVGE | 1 | Homo sapiens | Q167 | GFQRSQSFVGE | 1 | Mus musculus | Q167 | GFDKTQSFVGE | 1 | Rattus norvegicus | Q167 | GFDKNQSFMGE | 1 | Bos taurus | Q50 | LEKPLQNFTLC | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Q50 | LEKPLKNLTLC | 1 | Bos taurus | R212 | LNYEINGYVVI | 2 | Mus musculus, Rattus norvegicus | R212 | LNYEIRGYVII | 1 | Homo sapiens | R212 | LKYEIKGYVIV | 1 | Bos taurus | S120 | VSWESSSGIAE | 1 | Homo sapiens | S120 | TTWESSSGIVE | 1 | Mus musculus | S120 | TSWESSSGIAE | 1 | Rattus norvegicus | S120 | TSWESSTGIAE | 1 | Bos taurus | S166 | GKFDRSQSFVG | 1 | Homo sapiens | S166 | GGFQRSQSFVG | 1 | Mus musculus | S166 | GGFDKTQSFVG | 1 | Rattus norvegicus | S166 | GGFDKNQSFMG | 1 | Bos taurus | S181 | LYMWDSVLPPE | 1 | Homo sapiens | S181 | LYMWDYVLTPQ | 1 | Mus musculus | S181 | LYMWDSVLTPE | 1 | Rattus norvegicus | S181 | LYMWDSVLSPE | 1 | Bos taurus | V182 | YMWDSVLPPEN | 1 | Homo sapiens | V182 | YMWDYVLTPQD | 1 | Mus musculus | V182 | YMWDSVLTPEN | 1 | Rattus norvegicus | V182 | YMWDSVLSPEE | 1 | Bos taurus | Y209 | WQALNYEIRGY | 1 | Homo sapiens | Y209 | WQALNYEINGY | 1 | Mus musculus | Y209 | WRALNYEINGY | 1 | Rattus norvegicus | Y209 | WQALKYEIKGY | 1 | Bos taurus | Y83 | NELLVYKERVG | 1 | Homo sapiens | Y83 | NELLIYKEKVG | 1 | Mus musculus | Y83 | NELLIYKDKVG | 1 | Rattus norvegicus | Y83 | NELLVFKNGIG | 1 | Bos taurus | Y93 | GEYSLYIGRHK | 1 | Homo sapiens | Y93 | GEYSLYIGQSK | 1 | Mus musculus | Y93 | GQYSLYIGNSK | 1 | Rattus norvegicus | Y93 | GEYSLYIGKTK | 1 | Bos taurus |
 |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |