mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HRAS
Gene summary
Basic gene Info.Gene symbolHRAS
Gene nameHarvey rat sarcoma viral oncogene homolog
SynonymsC-BAS/HAS|C-H-RAS|C-HA-RAS1|CTLO|H-RASIDX|HAMSV|HRAS1|RASH1|p21ras
CytomapUCSC genome browser: 11p15.5
Type of geneprotein-coding
RefGenesNM_001130442.1,
NM_005343.2,NM_176795.3,
DescriptionGTP- and GDP-binding peptide BGTPase HRasHa-Ras1 proto-oncoproteinHarvey rat sarcoma viral oncoproteinRas family small GTP binding protein H-Rasc-has/bas p21 proteinc-ras-Ki-2 activated oncogenep19 H-RasIDX proteintransformation gene: oncogene HAM
Modification date20141222
dbXrefs MIM : 190020
HGNC : HGNC
Ensembl : ENSG00000174775
HPRD : 01813
Vega : OTTHUMG00000131919
ProteinUniProt: P01112
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HRAS
BioGPS: 3265
PathwayNCI Pathway Interaction Database: HRAS
KEGG: HRAS
REACTOME: HRAS
Pathway Commons: HRAS
ContextiHOP: HRAS
ligand binding site mutation search in PubMed: HRAS
UCL Cancer Institute: HRAS
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0001934positive regulation of protein phosphorylation22065586
GO:0007050cell cycle arrest9054499
GO:0007093mitotic cell cycle checkpoint9054499
GO:0007265Ras protein signal transduction23027131
GO:0008284positive regulation of cell proliferation9765203
GO:0008285negative regulation of cell proliferation9054499
GO:0010629negative regulation of gene expression23027131
GO:0030335positive regulation of cell migration23027131
GO:0032855positive regulation of Rac GTPase activity23027131
GO:0034259negative regulation of Rho GTPase activity23027131
GO:0043406positive regulation of MAP kinase activity23027131
GO:0043410positive regulation of MAPK cascade9765203
GO:0045740positive regulation of DNA replication9765203
GO:0045944positive regulation of transcription from RNA polymerase II promoter22065586
GO:0046330positive regulation of JNK cascade22065586
GO:0070374positive regulation of ERK1 and ERK2 cascade22065586
GO:0090303positive regulation of wound healing23027131
GO:0090398cellular senescence9054499
GO:1900029positive regulation of ruffle assembly23027131
GO:2000251positive regulation of actin cytoskeleton reorganization23027131
GO:2000630positive regulation of miRNA metabolic process23027131


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Ligand binding site mutations for HRAS

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
Q61Q61RTHCA9
Q61Q61KTHCA3
G13G13VHNSC2
G12G12SHNSC2
G12G12DHNSC2
D33D33NBLCA1
D92E91KBLCA1
Y137R135QCOAD1
G60G60SCOAD1
G15G15DCOAD1
G13G13RHNSC1
A11A11DHNSC1
G12G12AHNSC1
G12G12CHNSC1
Q61Q61LHNSC1
L120L120VKIRC1
Q61Q61LLUAD1
G13G13CLUSC1
Q61Q61RLUSC1
Q61Q61KLUSC1
G13G13RLUSC1
G13G13VLUSC1
G13G13DSKCM1
Q61Q61KSKCM1
A59A59TUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for HRAS from My Cancer Genome.
Three different human RAS genes have been identified: KRAS (homologous to the oncogene from the Kirsten rat sarcoma virus), HRAS (homologous to the oncogene from the Harvey rat sarcoma virus), and NRAS (first isolated from a human neuroblastoma). The different RAS genes are highly homologous but functionally distinct; the degree of redundancy remains a topic of investigation (reviewed in Pylayeva-Gupta et al. 2011). RAS proteins are small GTPases that cycle between inactive guanosine diphosphate–bound and active guanosine triphosphate–bound forms. RAS proteins are central mediators downstream of growth factor receptor signaling and therefore are critical for cell proliferation, survival, and differentiation. RAS proteins can activate several downstream effectors, including the PI3K-AKT-mTOR pathway, which is involved in cell survival, and the RAS-RAF-MEK-ERK pathway, which is involved in cell proliferation.Specific RAS genes are recurrently mutated in different malignancies. HRAS mutations are particularly common in salivary gland, urinary tract, upper aerodigestive tract, cervical, and thyroid (for reviews see Karnoub and Weinberg 2008and Schubbert, Shannon, and Bollag 2007).Espinosa, A.V., Gilbert, J., Fagin, J. 2015. HRAS. My Cancer Genomehttps://www.mycancergenome.org/content/gene/hras/ (Updated December 2015)

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Protein structure related information for HRAS
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G15G15D0.4538696
Q61Q61L0.20187714
D92E91K-1.3071576
Y137R135Q-1.2129187
L120L120V-1.0781264
D33D33N-1.0038855
A11A11D-0.95003866
G60G60S-0.72378086
A59A59T-0.59971783
G12G12A-0.52787992
G12G12S-0.4398267
Q61Q61K-0.36102568
G13G13D-0.3556049
G12G12D-0.35182111
G13G13C-0.30121522
G13G13V-0.21411651
G12G12C-0.19725542
G13G13R-0.14971428
Q61Q61R-0.11317789
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HRAS from PDB
PDB IDPDB titlePDB structure
1AA9HUMAN C-HA-RAS(1-171)(DOT)GDP, NMR, MINIMIZED AVERAGE STRUCTURE

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Differential gene expression and gene-gene network for HRAS
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types
HRAS_HNSC_DE
HRAS_THCA_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HRAS and the right PPI network was created from samples without mutations in the LBS of HRAS. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In HNSC

* In THCA


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Phenotype information for HRAS
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0587248Costello Syndrome53Biomarker, GeneticVariation
umls:C0007097Carcinoma41AlteredExpression, Biomarker, GeneticVariation
umls:C0007137Carcinoma, Squamous Cell30Biomarker, GeneticVariation
umls:C1458155Breast Neoplasms14AlteredExpression, Biomarker
umls:C2239176Carcinoma, Hepatocellular14Biomarker
umls:C0023903Liver Neoplasms13Biomarker
umls:C0030354Papilloma12Biomarker
umls:C0005695Urinary Bladder Neoplasms12Biomarker, GeneticVariation
umls:C0027819Neuroblastoma11Biomarker
umls:C0037286Skin Neoplasms11Biomarker
umls:C0040136Thyroid Neoplasms10Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms8Biomarker
umls:C0007138Carcinoma, Transitional Cell6Biomarker, GeneticVariation
umls:C0032927Precancerous Conditions5Biomarker
umls:C0038356Stomach Neoplasms4Biomarker, GeneticVariation
umls:C0018923Hemangiosarcoma4Biomarker
umls:C1275081Cardiofaciocutaneous syndrome4Biomarker, GeneticVariation
umls:C0028326Noonan Syndrome4Biomarker, GeneticVariation
umls:C0026640Mouth Neoplasms3Biomarker, GeneticVariation
umls:C0024668Mammary Neoplasms, Experimental3Biomarker
umls:C0206669Adenoma, Liver Cell3Biomarker
umls:C0023904Liver Neoplasms, Experimental3Biomarker
umls:C0265318Nevus, Sebaceous of Jadassohn2Biomarker, GeneticVariation
umls:C0004352Autistic Disorder2Biomarker, GeneticVariation
umls:C0040411Tongue Neoplasms2Biomarker
umls:C0007621Cell Transformation, Neoplastic2Biomarker
umls:C0027659Neoplasms, Experimental2Biomarker
umls:C0036631Seminoma1Biomarker, GeneticVariation
umls:C0010606Carcinoma, Adenoid Cystic1Biomarker
umls:C0242656Disease Progression1Biomarker
umls:C0024667Mammary Neoplasms, Animal1Biomarker
umls:C0027671Neoplastic Processes1Biomarker
umls:C0030849Penile Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for HRAS
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB02210Hexane-1,6-DiolSmall molecule
ExperimentalDB03226TrifluoroethanolSmall molecule
ExperimentalDB04137Guanosine-5'-TriphosphateSmall molecule
ExperimentalDB04315Guanosine-5'-DiphosphateSmall molecule
ExperimentalDB08751N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HRAS go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
RSF(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rslAA11 G12
GDPGUANOSINE-5'-DIPHOSPHATE1crpAA11 G12 G13 G15
GTPGTP521pAA11 G13 G15
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4g3xAA11 G13 G15 G60 L120
RSF(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rslAA59
MGMAGNESIUM(2+)1aa9AD33
MGMAGNESIUM(2+)1gnpAD33
CACALCIUM(2+)1lf0AD33
XY2N,N'-DIMETHYL-N-(ACETYL)-N'-(7-NITROBENZ-2-OXA-1,3-DIAZOL-4-YL)ETHYLENEDIAMINE2ce2XD33
CACALCIUM(2+)2rgaAD33
CACALCIUM(2+)2rgbAD33
CACALCIUM(2+)2rgcAD33
CACALCIUM(2+)2rgdAD33
CACALCIUM(2+)2rgeAD33
CACALCIUM(2+)3rryAD33
RSF(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rslAD33
RSF(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rslAD33
MGMAGNESIUM(2+)4k81DD33
DTUDITHIOERYTHRITOL4dlrAD92
DTTL-1,4-DITHIOTHREITOL4dlvAD92
DTUDITHIOERYTHRITOL4dlxAD92
DTTL-1,4-DITHIOTHREITOL4dlyAD92
RSF(3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rslAG12 G13
GDPGUANOSINE-5'-DIPHOSPHATE1aa9AG12 G13 G15
GDPGUANOSINE-5'-DIPHOSPHATE1crqAG12 G13 G15
GDPGUANOSINE-5'-DIPHOSPHATE1q21AG12 G13 G15
GDPGUANOSINE-5'-DIPHOSPHATE1wq1RG12 G13 G15
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1nvwQG12 G13 G15 A59 G60 Q61 L120
CAGGUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]2cl6XG12 G13 G15 D33 G60 Q61 L120
GDPGUANOSINE-5'-DIPHOSPHATE3lo5EG12 G13 G15 D33 L120
AGNPHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER1gnpAG12 G13 G15 G60
CAGGUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]1gnqAG12 G13 G15 G60
GTPGTP1nvxQG12 G13 G15 G60
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1p2uAG12 G13 G15 G60
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER721pAG12 G13 G15 G60
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1ctqAG12 G13 G15 G60 L120
CAGGUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]1gnrAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1iaqAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1iaqBG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1iaqCG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1lf0AG12 G13 G15 G60 L120
GTPGTP1nvuQG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1p2sAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1p2tAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1p2vAG12 G13 G15 G60 L120
GTPGTP1qraAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1zw6AG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER221pAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2cl0XG12 G13 G15 G60 L120
GTPGTP2cl7XG12 G13 G15 G60 L120
GTPGTP2clcXG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rgaAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rgbAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rgcAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rgdAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rgeAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2rggAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3ddcAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3i3sRG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3k8yAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3k9lAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3k9lCG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3kkmAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3l8zAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3lbhAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3lbiAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3lbnAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3oiuAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rryAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs5AG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3tgpAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlsAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dltAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dluAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlvAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlwAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER5p21AG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER621pAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4g0nAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4xvqAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4xvrAG12 G13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1nvvQG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3l8yAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rrzAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs0AG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs2AG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs3AG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs4AG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rs7AG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rslAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3rsoAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlrAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlxAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlyAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4dlzAG12 G13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4nyiQG12 G13 G15 G60 Q61 L120
GDPGUANOSINE-5'-DIPHOSPHATE1lf5AG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1xcmAG12 G13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE1xd2AG12 G13 G15 L120
CAGGUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]2evwXG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3k9lBG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3k9nAG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3kknAG12 G13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE3lo5AG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4eflAG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4efnAG12 G13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE4q21AG12 G13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2lwiAG12 G13 G15 L120
AF3ALUMINIUM TRIFLUORIDE1wq1RG12 G13 G60 Q61
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER2lcfAG12 G13 L120
RSG(3S,3AR,6AS)-HEXAHYDROFURO[2,3-B]FURAN-3-OL3rsoAG13
GCP5'-GUANYLYLMETHYLENEBISPHOSPHONATE1jahAG13 G15
NEQN-ETHYLMALEIMIDE4us0RG13 G15
L71(3S)-3-[3-(AMINOMETHYL)PHENYL]-1- ETHYLPYRROLIDINE-2,5-DIONE4us1RG13 G15
L7S3-[(3R)-1-ETHYL-2,5-DIOXOPYRROLIDIN-3-YL] BENZAMIDE4us2RG13 G15
GTPGTP1plkAG13 G15 D33 A59 G60 Q61 L120
GTPGTP4k81FG13 G15 G60
GTPGTP4k81HG13 G15 G60
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1agpAG13 G15 G60 L120
DBGDABP-GPPNHP1cluAG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER1k8rAG13 G15 G60 L120
DBGDABP-GPPNHP1rvdAG13 G15 G60 L120
GTPGTP2c5lAG13 G15 G60 L120
GTPGTP2c5lBG13 G15 G60 L120
GTPGTP2uziRG13 G15 G60 L120
GTPGTP2vh5RG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3oivAG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER3oiwAG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER421pAG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER821pAG13 G15 G60 L120
GTPGTP4k81BG13 G15 G60 L120
GTPGTP4k81DG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4l9wAG13 G15 G60 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4nyjQG13 G15 G60 Q61 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4nymQG13 G15 G60 Q61 L120
GDPGUANOSINE-5'-DIPHOSPHATE1crrAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE1iozAG13 G15 L120
GCP5'-GUANYLYLMETHYLENEBISPHOSPHONATE1jaiAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE1xj0AG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE1zvqAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE2ce2XG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE2cldXG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE2q21AG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE2quzAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE2x1vAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE3kudAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE3lo5CG13 G15 L120
GNPPHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER4efmAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE4l9sAG13 G15 L120
GDPGUANOSINE-5'-DIPHOSPHATE1pllAG15 D33 G60
CAGGUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]1pljAG15 G60 L120
DTTL-1,4-DITHIOTHREITOL4dlyAQ61
DTUDITHIOERYTHRITOL4dlzAQ61
CACALCIUM(2+)3k8yAY137
CACALCIUM(2+)3l8zAY137
CACALCIUM(2+)3lbhAY137
CACALCIUM(2+)3lbiAY137
CACALCIUM(2+)3oiuAY137
CACALCIUM(2+)3oiwAY137
CACALCIUM(2+)4dltAY137
CACALCIUM(2+)4dluAY137
CACALCIUM(2+)4dlwAY137
CACALCIUM(2+)4g0nAY137


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Conservation information for LBS of HRAS
Multiple alignments for P01112 in multiple species
LBSAA sequence# speciesSpecies
A11LVVVGAGGVGK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
A146YIETSAKTRQG4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
A18GVGKSALTIQL4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
A59DILDTAGQEEY4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
A66QEEYSAMRDQY4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
A83FLCVFAINNTK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
C118LVGNKCDLAAR3Homo sapiens, Mus musculus, Rattus norvegicus
C118LVGNKCDLPAR1Gallus gallus
D105IKRVKDSDDVP4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D107RVKDSDDVPMV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D108VKDSDDVPMVL4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D119VGNKCDLAART3Homo sapiens, Mus musculus, Rattus norvegicus
D119VGNKCDLPART1Gallus gallus
D30QNHFVDEYDPT4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D33FVDEYDPTIED4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D38DPTIEDSYRKQ4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D54ETCLLDILDTA4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D57LLDILDTAGQE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
D92TKSFEDIHQYR4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E143GIPYIETSAKT4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E162YTLVREIRQHK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E34Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E31NHFVDEYDPTI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E37YDPTIEDSYRK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E62DTAGQEEYSAM4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E63TAGQEEYSAMR4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
E76YMRTGEGFLCV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
F28LIQNHFVDEYD4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
G12VVVGAGGVGKS4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
G13VVGAGGVGKSA4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
G15GAGGVGKSALT4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
G151AKTRQGVEDAF4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
G60ILDTAGQEEYS4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
H27QLIQNHFVDEY4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
I21KSALTIQLIQN4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
I24LTIQLIQNHFV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
I36EYDPTIEDSYR4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K101YREQIKRVKDS4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K117VLVGNKCDLAA3Homo sapiens, Mus musculus, Rattus norvegicus
K117VLVGNKCDLPA1Gallus gallus
K147IETSAKTRQGV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K16AGGVGKSALTI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K42EDSYRKQVVID4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K54Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
K88AINNTKSFEDI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
L120GNKCDLAARTV3Homo sapiens, Mus musculus, Rattus norvegicus
L120GNKCDLPARTV1Gallus gallus
L23ALTIQLIQNHF4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
L56CLLDILDTAGQ4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
L6MTEYKLVVVGA4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
M111SDDVPMVLVGN4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
M67EEYSAMRDQYM4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
N116MVLVGNKCDLA3Homo sapiens, Mus musculus, Rattus norvegicus
N116MVLVGNKCDLP1Gallus gallus
N85CVFAINNTKSF4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
N86VFAINNTKSFE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
P34VDEYDPTIEDS4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q150SAKTRQGVEDA4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q165VREIRQHKLRK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q25TIQLIQNHFVD4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q61LDTAGQEEYSA4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q70SAMRDQYMRTG4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q95FEDIHQYREQI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Q99HQYREQIKRVK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R102REQIKRVKDSD4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R149TSAKTRQGVED4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R41IEDSYRKQVVI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R73RDQYMRTGEGF4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
R97DIHQYREQIKR4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
S106KRVKDSDDVPM4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
S145PYIETSAKTRQ4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
S17GGVGKSALTIQ4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
S39PTIEDSYRKQV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
S89INNTKSFEDIH4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
T35DEYDPTIEDSY4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
T58LDILDTAGQEE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
T74DQYMRTGEGFL4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V103EQIKRVKDSDD4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V109KDSDDVPMVLV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V14VGAGGVGKSAL4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V29IQNHFVDEYDP4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V44SYRKQVVIDGE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
V7TEYKLVVVGAG4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y137DLARSYGIPYI4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y157VEDAFYTLVRE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y32HFVDEYDPTIE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y40TIEDSYRKQVV4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y64AGQEEYSAMRD4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y71AMRDQYMRTGE4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus
Y96EDIHQYREQIK4Homo sapiens, Mus musculus, Rattus norvegicus, Gallus gallus


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