mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

Download

 Statistics

Help

About Us
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HSD11B1
Gene summary
Basic gene Info.Gene symbolHSD11B1
Gene namehydroxysteroid (11-beta) dehydrogenase 1
Synonyms11-DH|11-beta-HSD1|CORTRD2|HDL|HSD11|HSD11B|HSD11L|SDR26C1
CytomapUCSC genome browser: 1q32-q41
Type of geneprotein-coding
RefGenesNM_001206741.1,
NM_005525.3,NM_181755.2,
Descriptioncorticosteroid 11-beta-dehydrogenase isozyme 1short chain dehydrogenase/reductase family 26C, member 1
Modification date20141207
dbXrefs MIM : 600713
HGNC : HGNC
Ensembl : ENSG00000117594
HPRD : 07042
Vega : OTTHUMG00000036481
ProteinUniProt: P28845
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HSD11B1
BioGPS: 3290
PathwayNCI Pathway Interaction Database: HSD11B1
KEGG: HSD11B1
REACTOME: HSD11B1
Pathway Commons: HSD11B1
ContextiHOP: HSD11B1
ligand binding site mutation search in PubMed: HSD11B1
UCL Cancer Institute: HSD11B1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


Top
Ligand binding site mutations for HSD11B1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
S67E69KSKCM2
G45G45VBRCA1
S125S125CBRCA1
A226A226ELUSC1
H232H232YSKCM1
T92T92PSKCM1
G45G45ESKCM1
G45G45RSKCM1
L126L128IUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


Top
Protein structure related information for HSD11B1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L126L128I-1.0932091
T92T92P-0.84352177
S125S125C-0.69339202
G45G45E-0.57810524
G45G45V-0.45518337
G45G45R-0.43217011
H232H232Y-0.40659101
S67E69K-0.25753842
A226A226E-0.22325675
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HSD11B1 from PDB
PDB IDPDB titlePDB structure
1XU7Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1

Top
Differential gene expression and gene-gene network for HSD11B1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HSD11B1 and the right PPI network was created from samples without mutations in the LBS of HSD11B1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Top

Top
Phenotype information for HSD11B1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0028754Obesity27Biomarker, GeneticVariation
umls:C0020538Hypertension13Biomarker, GeneticVariation
umls:C1291245Cortisone reductase deficiency8Biomarker, GeneticVariation
umls:C0311277Obesity, Abdominal3Biomarker
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0011853Diabetes Mellitus, Experimental1Biomarker
umls:C0020456Hyperglycemia1Biomarker
umls:C0021655Insulin Resistance1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Top
Pharmacological information for HSD11B1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
NutraceuticalDB00157NADHSmall molecule
Approved|vet_approvedDB00635PrednisoneSmall molecule
ExperimentalDB02329CarbenoxoloneSmall molecule
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule
ExperimentalDB038142-(N-Morpholino)-Ethanesulfonic AcidSmall molecule
ExperimentalDB04652(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONESmall molecule
InvestigationalDB05064INCB13739Small molecule
ExperimentalDB06992(3,3-dimethylpiperidin-1-yl)(6-(3-fluoro-4-methylphenyl)pyridin-2-yl)methanoneSmall molecule
ExperimentalDB07017(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-oneSmall molecule
ExperimentalDB07049(2R)-1-[(4-tert-butylphenyl)sulfonyl]-2-methyl-4-(4-nitrophenyl)piperazineSmall molecule
ExperimentalDB070562-(6-{[(3-chloro-2-methylphenyl)sulfonyl]amino}pyridin-2-yl)-N,N-diethylacetamideSmall molecule
ExperimentalDB07310(5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-oneSmall molecule
ExperimentalDB07316N-{1-[(1-carbamoylcyclopropyl)methyl]piperidin-4-yl}-N-cyclopropyl-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideSmall molecule
ExperimentalDB07619N-cyclopropyl-N-(trans-4-pyridin-3-ylcyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamideSmall molecule
ExperimentalDB076241-{[(3R)-3-methyl-4-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}sulfonyl)piperazin-1-yl]methyl}cyclopropanecarboxamideSmall molecule
ExperimentalDB07866(5S)-2-(cyclooctylamino)-5-methyl-5-propyl-1,3-thiazol-4(5H)-oneSmall molecule
ExperimentalDB082772-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDESmall molecule
ExperimentalDB08280(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDESmall molecule
ExperimentalDB08771(5R)-2-[(2-fluorophenyl)amino]-5-(1-methylethyl)-1,3-thiazol-4(5H)-oneSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HSD11B1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CBOCARBENOXOLONE2belBA226
CBOCARBENOXOLONE2belCA226
CBOCARBENOXOLONE2belDA226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwCA226
ZMG(R)-2-(2-FLUOROPHENYLAMINO)-5-ISOPROPYLTHIAZOL-4(5H)-ONE2rbeBA226
H11(5S)-2-(CYCLOOCTYLAMINO)-5-METHYL-5-PROPYL-1,3-THIAZOL-4(5H)-ONE3byzAA226
H11(5S)-2-(CYCLOOCTYLAMINO)-5-METHYL-5-PROPYL-1,3-THIAZOL-4(5H)-ONE3byzBA226
H11(5S)-2-(CYCLOOCTYLAMINO)-5-METHYL-5-PROPYL-1,3-THIAZOL-4(5H)-ONE3byzCA226
A21(5S)-2-{[(1S)-1-(2-FLUOROPHENYL)ETHYL]AMINO}-5-METHYL-5-(TRIFLUOROMETHYL)-1,3-THIAZOL-4(5H)-ONE3bzuAA226
A21(5S)-2-{[(1S)-1-(2-FLUOROPHENYL)ETHYL]AMINO}-5-METHYL-5-(TRIFLUOROMETHYL)-1,3-THIAZOL-4(5H)-ONE3bzuCA226
3CZ(2R)-1-[(4-TERT-BUTYLPHENYL)SULFONYL]-2-METHYL-4-(4-NITROPHENYL)PIPERAZINE3czrAA226
D4N1-{[(3R)-3-METHYL-4-({4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)PIPERAZIN-1-YL]METHYL}CYCLOPROPANECARBOXAMIDE3d4nAA226
33T3-CHLORO-4-({(2R)-4-[4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL]-2-METHYLPIPERAZIN-1-YL}SULFONYL)BENZAMIDE3h6kCA226
21T4-[4-(2-ADAMANTYLCARBAMOYL)-5-TERT-BUTYL-PYRAZOL-1- YL]BENZOIC ACID4p38BA226
1EN3-[1-(4-CHLOROPHENYL)CYCLOPROPYL]-8-(2-FLUOROPHENOXY) [1,2,4]TRIAZOLO[4,3-A]PYRIDINE4ijvBA226
4YQ4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S, 3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7jAA226
NAPNADP ZWITTERION3d5qDG45 S67
NDPNADPH1xu7AG45 S67 T92
NDPNADPH1xu7BG45 S67 T92
NDPNADPH1xu7CG45 S67 T92
NDPNADPH1xu7DG45 S67 T92
NDPNADPH1xu9AG45 S67 T92
NDPNADPH1xu9BG45 S67 T92
NDPNADPH1xu9CG45 S67 T92
NDPNADPH1xu9DG45 S67 T92
NAPNADP ZWITTERION2belAG45 S67 T92
NAPNADP ZWITTERION2belBG45 S67 T92
NAPNADP ZWITTERION2belCG45 S67 T92
NAPNADP ZWITTERION2belDG45 S67 T92
NAPNADP ZWITTERION2iltAG45 S67 T92
NAPNADP ZWITTERION2irwBG45 S67 T92
NAPNADP ZWITTERION2irwCG45 S67 T92
NAPNADP ZWITTERION2irwDG45 S67 T92
NAPNADP ZWITTERION2irwEG45 S67 T92
NAPNADP ZWITTERION2irwFG45 S67 T92
NAPNADP ZWITTERION2irwGG45 S67 T92
NAPNADP ZWITTERION2irwHG45 S67 T92
NDPNADPH2rbeAG45 S67 T92
NDPNADPH2rbeBG45 S67 T92
NDPNADPH2rbeCG45 S67 T92
NDPNADPH2rbeDG45 S67 T92
NDPNADPH3byzAG45 S67 T92
NDPNADPH3byzBG45 S67 T92
NDPNADPH3byzCG45 S67 T92
NDPNADPH3byzDG45 S67 T92
NAPNADP ZWITTERION3bzuAG45 S67 T92
NAPNADP ZWITTERION3bzuBG45 S67 T92
NAPNADP ZWITTERION3bzuCG45 S67 T92
NAPNADP ZWITTERION3ch6AG45 S67 T92
NAPNADP ZWITTERION3ch6BG45 S67 T92
NAPNADP ZWITTERION3ch6DG45 S67 T92
NAPNADP ZWITTERION3ch6EG45 S67 T92
NAPNADP ZWITTERION3czrAG45 S67 T92
NAPNADP ZWITTERION3czrBG45 S67 T92
NAPNADP ZWITTERION3d3eAG45 S67 T92
NAPNADP ZWITTERION3d3eBG45 S67 T92
NAPNADP ZWITTERION3d3eCG45 S67 T92
NAPNADP ZWITTERION3d3eDG45 S67 T92
NAPNADP ZWITTERION3d4nAG45 S67 T92
NAPNADP ZWITTERION3d4nBG45 S67 T92
NAPNADP ZWITTERION3d4nCG45 S67 T92
NAPNADP ZWITTERION3d4nDG45 S67 T92
NAPNADP ZWITTERION3d5qAG45 S67 T92
NAPNADP ZWITTERION3d5qBG45 S67 T92
NAPNADP ZWITTERION3d5qCG45 S67 T92
NDPNADPH3ey4AG45 S67 T92
NDPNADPH3ey4BG45 S67 T92
NDPNADPH3ey4CG45 S67 T92
NDPNADPH3ey4DG45 S67 T92
NAPNADP ZWITTERION3fcoAG45 S67 T92
NAPNADP ZWITTERION3fcoBG45 S67 T92
NAPNADP ZWITTERION3frjAG45 S67 T92
NAPNADP ZWITTERION3frjBG45 S67 T92
NAPNADP ZWITTERION3h6kAG45 S67 T92
NAPNADP ZWITTERION3h6kBG45 S67 T92
NAPNADP ZWITTERION3h6kCG45 S67 T92
NAPNADP ZWITTERION3h6kDG45 S67 T92
NAPNADP ZWITTERION3hfgAG45 S67 T92
NAPNADP ZWITTERION3hfgBG45 S67 T92
NAPNADP ZWITTERION3hfgDG45 S67 T92
NAPNADP ZWITTERION3oq1BG45 S67 T92
NAPNADP ZWITTERION3oq1CG45 S67 T92
NAPNADP ZWITTERION3oq1DG45 S67 T92
NAPNADP ZWITTERION3pdjAG45 S67 T92
NAPNADP ZWITTERION3pdjBG45 S67 T92
NDPNADPH3qqpAG45 S67 T92
NDPNADPH3qqpBG45 S67 T92
NDPNADPH3qqpCG45 S67 T92
NDPNADPH3qqpDG45 S67 T92
NAPNADP ZWITTERION3tfqAG45 S67 T92
NAPNADP ZWITTERION3tfqBG45 S67 T92
NAPNADP ZWITTERION3tfqDG45 S67 T92
NAPNADP ZWITTERION3tfqEG45 S67 T92
NAPNADP ZWITTERION4bb5AG45 S67 T92
NAPNADP ZWITTERION4bb5BG45 S67 T92
NAPNADP ZWITTERION4bb5CG45 S67 T92
NAPNADP ZWITTERION4bb5DG45 S67 T92
NAPNADP ZWITTERION4bb6AG45 S67 T92
NAPNADP ZWITTERION4bb6BG45 S67 T92
NAPNADP ZWITTERION4hfrAG45 S67 T92
NAPNADP ZWITTERION4hfrBG45 S67 T92
NDPNADPH4hx5AG45 S67 T92
NDPNADPH4hx5BG45 S67 T92
NDPNADPH4hx5CG45 S67 T92
NDPNADPH4hx5DG45 S67 T92
NAPNADP ZWITTERION4c7kAG45 S67 T92
NAPNADP ZWITTERION4c7kBG45 S67 T92
NAPNADP ZWITTERION4c7kCG45 S67 T92
NAPNADP ZWITTERION4c7kDG45 S67 T92
NDPNADPH4k1lAG45 S67 T92
NDPNADPH4k1lBG45 S67 T92
NDPNADPH4k1lCG45 S67 T92
NDPNADPH4k1lDG45 S67 T92
NDPNADPH4p38AG45 S67 T92
NDPNADPH4p38BG45 S67 T92
NAPNADP ZWITTERION4ijuAG45 S67 T92
NAPNADP ZWITTERION4ijuBG45 S67 T92
NAPNADP ZWITTERION4ijuDG45 S67 T92
NAPNADP ZWITTERION4ijuEG45 S67 T92
NAPNADP ZWITTERION4ijvAG45 S67 T92
NAPNADP ZWITTERION4ijvBG45 S67 T92
NAPNADP ZWITTERION4ijvDG45 S67 T92
NAPNADP ZWITTERION4ijvEG45 S67 T92
NAPNADP ZWITTERION4ijwAG45 S67 T92
NAPNADP ZWITTERION4ijwBG45 S67 T92
NAPNADP ZWITTERION4ijwDG45 S67 T92
NAPNADP ZWITTERION4ijwEG45 S67 T92
NAPNADP ZWITTERION4c7jAG45 S67 T92
NAPNADP ZWITTERION4c7jBG45 S67 T92
NAPNADP ZWITTERION4c7jCG45 S67 T92
NAPNADP ZWITTERION4c7jDG45 S67 T92
NAPNADP ZWITTERION3bzuDG45 T92
311(3,3-DIMETHYLPIPERIDIN-1-YL)(6-(3-FLUORO-4-METHYLPHENYL)PYRIDIN-2-YL)METHANONE3ch6DL126
S053,4-DIHYDROQUINOLIN-1(2H)-YL[4-(1H-IMIDAZOL-5-YL)PIPERIDIN-1-YL]METHANONE3qqpBL126
14M{(3S)-1-[5-(CYCLOHEXYLCARBAMOYL)-6-(PROPYLSULFANYL) PYRIDIN-2-YL]PIPERIDIN-3-YL}ACETIC ACID4hfrAL126
14M{(3S)-1-[5-(CYCLOHEXYLCARBAMOYL)-6-(PROPYLSULFANYL) PYRIDIN-2-YL]PIPERIDIN-3-YL}ACETIC ACID4hfrBL126
SFF(4AS,8AR)-N-CYCLOHEXYL-4A,5,6,7,8,8A-HEXAHYDRO-4,1,2- BENZOXATHIAZIN-3-AMINE 1,1-DIOXIDE4k1lAL126
SFF(4AS,8AR)-N-CYCLOHEXYL-4A,5,6,7,8,8A-HEXAHYDRO-4,1,2- BENZOXATHIAZIN-3-AMINE 1,1-DIOXIDE4k1lBL126
SFF(4AS,8AR)-N-CYCLOHEXYL-4A,5,6,7,8,8A-HEXAHYDRO-4,1,2- BENZOXATHIAZIN-3-AMINE 1,1-DIOXIDE4k1lCL126
1EO(1S,4S)-4-[8-(2-FLUOROPHENOXY)[1,2,4]TRIAZOLO[4,3- A]PYRIDIN-3-YL]BICYCLO[2.2.1]HEPTAN-1-OL4ijuEL126
1EN3-[1-(4-CHLOROPHENYL)CYCLOPROPYL]-8-(2-FLUOROPHENOXY) [1,2,4]TRIAZOLO[4,3-A]PYRIDINE4ijvDL126
1EN3-[1-(4-CHLOROPHENYL)CYCLOPROPYL]-8-(2-FLUOROPHENOXY) [1,2,4]TRIAZOLO[4,3-A]PYRIDINE4ijvEL126
1EQ3-[1-(4-CHLOROPHENYL)CYCLOPROPYL]-8-CYCLOPROPYL[1,2, 4]TRIAZOLO[4,3-A]PYRIDINE4ijwDL126
CBOCARBENOXOLONE2belAL126 A226
NN12-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE2iltAL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwAL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwBL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwDL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwEL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwFL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwGL126 A226
NN4(1S,3R,4S,5S,7S)-4-{[2-(4-METHOXYPHENOXY)-2-METHYLPROPANOYL]AMINO}ADAMANTANE-1-CARBOXAMIDE2irwHL126 A226
ZMG(R)-2-(2-FLUOROPHENYLAMINO)-5-ISOPROPYLTHIAZOL-4(5H)-ONE2rbeDL126 A226
H11(5S)-2-(CYCLOOCTYLAMINO)-5-METHYL-5-PROPYL-1,3-THIAZOL-4(5H)-ONE3byzDL126 A226
A21(5S)-2-{[(1S)-1-(2-FLUOROPHENYL)ETHYL]AMINO}-5-METHYL-5-(TRIFLUOROMETHYL)-1,3-THIAZOL-4(5H)-ONE3bzuBL126 A226
A21(5S)-2-{[(1S)-1-(2-FLUOROPHENYL)ETHYL]AMINO}-5-METHYL-5-(TRIFLUOROMETHYL)-1,3-THIAZOL-4(5H)-ONE3bzuDL126 A226
D3EN-CYCLOPROPYL-N-(TRANS-4-PYRIDIN-3-YLCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3d3eAL126 A226
D3EN-CYCLOPROPYL-N-(TRANS-4-PYRIDIN-3-YLCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3d3eBL126 A226
D3EN-CYCLOPROPYL-N-(TRANS-4-PYRIDIN-3-YLCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3d3eCL126 A226
D3EN-CYCLOPROPYL-N-(TRANS-4-PYRIDIN-3-YLCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3d3eDL126 A226
D4N1-{[(3R)-3-METHYL-4-({4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)PIPERAZIN-1-YL]METHYL}CYCLOPROPANECARBOXAMIDE3d4nBL126 A226
IIGN-CYCLOPROPYL-N-(CIS-4-CYCLOPROPYL-4-HYDROXYCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3fcoAL126 A226
IIGN-CYCLOPROPYL-N-(CIS-4-CYCLOPROPYL-4-HYDROXYCYCLOHEXYL)-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3fcoBL126 A226
A49N-{1-[(1-CARBAMOYLCYCLOPROPYL)METHYL]PIPERIDIN-4-YL}-N-CYCLOPROPYL-4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]BENZAMIDE3frjBL126 A226
17R(R)-1-(3-(1H-1,2,4-TRIAZOL-1-YL)PHENYLSULFONYL)-4-(4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL)-2-METHYLPIPERAZINE3hfgDL126 A226
3OQ3-(2-FLUOROETHYL)-4-({4-[(1R)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)BENZONITRILE3oq1AL126 A226
3OQ3-(2-FLUOROETHYL)-4-({4-[(1R)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)BENZONITRILE3oq1BL126 A226
3OQ3-(2-FLUOROETHYL)-4-({4-[(1R)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)BENZONITRILE3oq1CL126 A226
3OQ3-(2-FLUOROETHYL)-4-({4-[(1R)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)BENZONITRILE3oq1DL126 A226
3PJN-((1R,4S)-4-(3-AMINO-3-OXOPROPYL)-4-PHENYLCYCLOHEXYL)-N-CYCLOPROPYL-4-((S)-1,1,1-TRIFLUORO-2-HYDROXYPROPAN-2-YL)BENZAMIDE3pdjAL126 A226
S053,4-DIHYDROQUINOLIN-1(2H)-YL[4-(1H-IMIDAZOL-5-YL)PIPERIDIN-1-YL]METHANONE3qqpCL126 A226
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE4bb5AL126 A226
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE4bb5BL126 A226
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE4bb5CL126 A226
HD24-CYCLOPENTYL-N-[(1S,3R)-5-OXIDANYL-2- ADAMANTYL]-2-[[(3S)-OXOLAN-3-YL]AMINO]PYRIMIDINE-5- CARBOXAMIDE4bb5DL126 A226
HD16-(4-METHYLPIPERAZIN-1-YL)-N-[(1R,3S)-5- OXIDANYL-2-ADAMANTYL]-2-PROPYLSULFANYL-PYRIDINE-3- CARBOXAMIDE4bb6AL126 A226
HD16-(4-METHYLPIPERAZIN-1-YL)-N-[(1R,3S)-5- OXIDANYL-2-ADAMANTYL]-2-PROPYLSULFANYL-PYRIDINE-3- CARBOXAMIDE4bb6BL126 A226
19V4-[5-(4-TERT-BUTYLPIPERAZIN-1-YL)PYRIDIN-2-YL]-N-[(1R, 2S,3S,5S,7S)-5-CARBAMOYLTRICYCLO[3.3.1.1~3,7~]DEC-2- YL]-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXAMIDE4hx5AL126 A226
19V4-[5-(4-TERT-BUTYLPIPERAZIN-1-YL)PYRIDIN-2-YL]-N-[(1R, 2S,3S,5S,7S)-5-CARBAMOYLTRICYCLO[3.3.1.1~3,7~]DEC-2- YL]-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXAMIDE4hx5BL126 A226
19V4-[5-(4-TERT-BUTYLPIPERAZIN-1-YL)PYRIDIN-2-YL]-N-[(1R, 2S,3S,5S,7S)-5-CARBAMOYLTRICYCLO[3.3.1.1~3,7~]DEC-2- YL]-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXAMIDE4hx5CL126 A226
19V4-[5-(4-TERT-BUTYLPIPERAZIN-1-YL)PYRIDIN-2-YL]-N-[(1R, 2S,3S,5S,7S)-5-CARBAMOYLTRICYCLO[3.3.1.1~3,7~]DEC-2- YL]-3,4-DIHYDROQUINOXALINE-1(2H)-CARBOXAMIDE4hx5DL126 A226
DZL2-ETHYL-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-4- [(2R)-OXOLAN-2-YL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7kAL126 A226
DZL2-ETHYL-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-4- [(2R)-OXOLAN-2-YL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7kBL126 A226
DZL2-ETHYL-N-[(1S,3R)-5-OXIDANYL-2-ADAMANTYL]-4- [(2R)-OXOLAN-2-YL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7kCL126 A226
21T4-[4-(2-ADAMANTYLCARBAMOYL)-5-TERT-BUTYL-PYRAZOL-1- YL]BENZOIC ACID4p38AL126 A226
4YQ4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S, 3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7jBL126 A226
4YQ4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S, 3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7jCL126 A226
4YQ4-CYCLOPROPYL-2-(2-HYDROXYETHYLOXY)-N-[(1S, 3R)-5-OXIDANYL-2-ADAMANTYL]-1,3-THIAZOLE-5- CARBOXAMIDE4c7jDL126 A226
3PJN-((1R,4S)-4-(3-AMINO-3-OXOPROPYL)-4-PHENYLCYCLOHEXYL)-N-CYCLOPROPYL-4-((S)-1,1,1-TRIFLUORO-2-HYDROXYPROPAN-2-YL)BENZAMIDE3pdjBL126 A226 H232
T303-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE3d5qBS125 L126
T303-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE3d5qCS125 L126
T303-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE3d5qDS125 L126
352(5S)-2-{[(1S)-1-(4-FLUOROPHENYL)ETHYL]AMINO}-5-(1-HYDROXY-1-METHYLETHYL)-5-METHYL-1,3-THIAZOL-4(5H)-ONE3ey4AS125 L126
352(5S)-2-{[(1S)-1-(4-FLUOROPHENYL)ETHYL]AMINO}-5-(1-HYDROXY-1-METHYLETHYL)-5-METHYL-1,3-THIAZOL-4(5H)-ONE3ey4BS125 L126
352(5S)-2-{[(1S)-1-(4-FLUOROPHENYL)ETHYL]AMINO}-5-(1-HYDROXY-1-METHYLETHYL)-5-METHYL-1,3-THIAZOL-4(5H)-ONE3ey4CS125 L126
D4N1-{[(3R)-3-METHYL-4-({4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)PIPERAZIN-1-YL]METHYL}CYCLOPROPANECARBOXAMIDE3d4nCS125 L126 A226
D4N1-{[(3R)-3-METHYL-4-({4-[(1S)-2,2,2-TRIFLUORO-1-HYDROXY-1-METHYLETHYL]PHENYL}SULFONYL)PIPERAZIN-1-YL]METHYL}CYCLOPROPANECARBOXAMIDE3d4nDS125 L126 A226
T303-[1-(4-FLUOROPHENYL)CYCLOPROPYL]-4-(1-METHYLETHYL)-5-[4-(TRIFLUOROMETHOXY)PHENYL]-4H-1,2,4-TRIAZOLE3d5qAS125 L126 A226
352(5S)-2-{[(1S)-1-(4-FLUOROPHENYL)ETHYL]AMINO}-5-(1-HYDROXY-1-METHYLETHYL)-5-METHYL-1,3-THIAZOL-4(5H)-ONE3ey4DS125 L126 A226
33T3-CHLORO-4-({(2R)-4-[4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL]-2-METHYLPIPERAZIN-1-YL}SULFONYL)BENZAMIDE3h6kAS125 L126 A226
33T3-CHLORO-4-({(2R)-4-[4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL]-2-METHYLPIPERAZIN-1-YL}SULFONYL)BENZAMIDE3h6kBS125 L126 A226
33T3-CHLORO-4-({(2R)-4-[4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL]-2-METHYLPIPERAZIN-1-YL}SULFONYL)BENZAMIDE3h6kDS125 L126 A226
17R(R)-1-(3-(1H-1,2,4-TRIAZOL-1-YL)PHENYLSULFONYL)-4-(4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL)-2-METHYLPIPERAZINE3hfgAS125 L126 A226
17R(R)-1-(3-(1H-1,2,4-TRIAZOL-1-YL)PHENYLSULFONYL)-4-(4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL)-2-METHYLPIPERAZINE3hfgBS125 L126 A226
17R(R)-1-(3-(1H-1,2,4-TRIAZOL-1-YL)PHENYLSULFONYL)-4-(4-FLUORO-2-(TRIFLUOROMETHYL)PHENYL)-2-METHYLPIPERAZINE3hfgCS125 L126 A226
07M8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE3tfqAS125 L126 A226
07M8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE3tfqBS125 L126 A226
07M8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE3tfqDS125 L126 A226
07M8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE3tfqES125 L126 A226
NAPNADP ZWITTERION2irwAS67 T92
NAPNADP ZWITTERION3hfgCS67 T92
NAPNADP ZWITTERION3oq1AS67 T92


Top
Conservation information for LBS of HSD11B1
Multiple alignments for P28845 in multiple species
LBSAA sequence# speciesSpecies
A172VVSSLAGKVAY1Homo sapiens
A172VISSLAGKMTQ1Mus musculus
A172IISSMAGKMTQ1Rattus norvegicus
A223IDTETAMKAVS1Homo sapiens
A223IDTETAMKEIS1Mus musculus
A223IDTETALKETS1Rattus norvegicus
A226ETAMKAVSGIV1Homo sapiens
A226ETAMKEISGII1Mus musculus
A226ETALKETSGII1Rattus norvegicus
A42VIVTGASKGIG3Homo sapiens, Mus musculus, Rattus norvegicus
A65HVVLTARSEEG2Mus musculus, Rattus norvegicus
A65HVVVTARSKET1Homo sapiens
D259EEVYYDSSLWT1Homo sapiens
D259SEVYYDKSPLT1Mus musculus
D259DEVYYDKSSWT1Rattus norvegicus
G216TLCVLGLIDTE2Homo sapiens, Mus musculus
G216TLCVLGFIDTE1Rattus norvegicus
G41KVIVTGASKGI3Homo sapiens, Mus musculus, Rattus norvegicus
G45TGASKGIGREM3Homo sapiens, Mus musculus, Rattus norvegicus
G91AHYIAGTMEDM3Homo sapiens, Mus musculus, Rattus norvegicus
H120MLILNHITNTS1Homo sapiens
H120MLILNHITQTS1Mus musculus
H120MLILNHITQTT1Rattus norvegicus
H232VSGIVHMQAAP1Homo sapiens
H232ISGIINAQASP1Mus musculus
H232TSGIILSQAAP1Rattus norvegicus
I121LILNHITNTSL1Homo sapiens
I121LILNHITQTSL1Mus musculus
I121LILNHITQTTM1Rattus norvegicus
I218CVLGLIDTETA2Homo sapiens, Mus musculus
I218CVLGFIDTETA1Rattus norvegicus
I46GASKGIGREMA3Homo sapiens, Mus musculus, Rattus norvegicus
K187AYSASKFALDG1Homo sapiens
K187PYSASKFALDG1Mus musculus
K187SYSASKFALDG1Rattus norvegicus
K44VTGASKGIGRE3Homo sapiens, Mus musculus, Rattus norvegicus
L126ITNTSLNLFHD1Homo sapiens
L126ITQTSLSLFHD1Mus musculus
L126ITQTTMSLFHD1Rattus norvegicus
L171VVVSSLAGKVA1Homo sapiens
L171AVISSLAGKMT1Mus musculus
L171AIISSMAGKMT1Rattus norvegicus
L215ITLCVLGLIDT2Homo sapiens, Mus musculus
L215ITLCVLGFIDT1Rattus norvegicus
L217LCVLGLIDTET2Homo sapiens, Mus musculus
L217LCVLGFIDTET1Rattus norvegicus
L276PCRKILEFLYS1Homo sapiens
L276PGRKIMEFFSL1Mus musculus
L276PGRRIMEFLSL1Rattus norvegicus
L279KILEFLYSTSY1Homo sapiens
L279KIMEFFSLRYY1Mus musculus
L279RIMEFLSLRSY1Rattus norvegicus
L8FMKKYLLPILG1Homo sapiens
L8VMKNYLLPILV1Mus musculus
L8-MKKYLLPVLV1Rattus norvegicus
M179KVAYPMVAAYS1Homo sapiens
M179KMTQPMIAPYS1Mus musculus
M179KMTQPLIASYS1Rattus norvegicus
M233SGIVHMQAAPK1Homo sapiens
M233SGIINAQASPK1Mus musculus
M233SGIILSQAAPK1Rattus norvegicus
M286STSYNMDRFIN1Homo sapiens
M286LRYYNKDMFVS1Mus musculus
M286LRSYNRDLFVS1Rattus norvegicus
M93YIAGTMEDMTF2Homo sapiens, Mus musculus
M93YIAGTMEDMAF1Rattus norvegicus
N119DMLILNHITQT2Mus musculus, Rattus norvegicus
N119DMLILNHITNT1Homo sapiens
P178GKVAYPMVAAY1Homo sapiens
P178GKMTQPMIAPY1Mus musculus
P178GKMTQPLIASY1Rattus norvegicus
Q234GIVHMQAAPKE1Homo sapiens
Q234GIINAQASPKE1Mus musculus
Q234GIILSQAAPKE1Rattus norvegicus
R288SYNMDRFINK1Homo sapiens
R288YYNKDMFVSN1Mus musculus
R288SYNRDLFVSN1Rattus norvegicus
R66VVLTARSEEGL2Mus musculus, Rattus norvegicus
R66VVVTARSKETL1Homo sapiens
S125HITNTSLNLFH1Homo sapiens
S125HITQTSLSLFH1Mus musculus
S125HITQTTMSLFH1Rattus norvegicus
S169SIVVVSSLAGK1Homo sapiens
S169SIAVISSLAGK1Mus musculus
S169SIAIISSMAGK1Rattus norvegicus
S170IVVVSSLAGKV1Homo sapiens
S170IAVISSLAGKM1Mus musculus
S170IAIISSMAGKM1Rattus norvegicus
S22AYYYYSANEEF1Homo sapiens
S22AYYYYSTNEEF1Mus musculus
S22G-YYYSTNEEF1Rattus norvegicus
S261VYYDSSLWTTL1Homo sapiens
S261VYYDKSPLTPI1Mus musculus
S261VYYDKSSWTPL1Rattus norvegicus
S43IVTGASKGIGR3Homo sapiens, Mus musculus, Rattus norvegicus
S67VLTARSEEGLQ2Mus musculus, Rattus norvegicus
S67VVTARSKETLQ1Homo sapiens
T124NHITNTSLNLF1Homo sapiens
T124NHITQTSLSLF1Mus musculus
T124NHITQTTMSLF1Rattus norvegicus
T220LGLIDTETAMK2Homo sapiens, Mus musculus
T220LGFIDTETALK1Rattus norvegicus
T222LIDTETAMKAV1Homo sapiens
T222LIDTETAMKEI1Mus musculus
T222FIDTETALKET1Rattus norvegicus
T264DSSLWTTLLIR1Homo sapiens
T264DKSPLTPILLG1Mus musculus
T264DKSSWTPLLLG1Rattus norvegicus
T92HYIAGTMEDMT2Homo sapiens, Mus musculus
T92HYIAGTMEDMA1Rattus norvegicus
V168GSIVVVSSLAG1Homo sapiens
V168GSIAVISSLAG1Mus musculus
V168GSIAIISSMAG1Rattus norvegicus
V175SLAGKVAYPMV1Homo sapiens
V175SLAGKMTQPMI1Mus musculus
V175SMAGKMTQPLI1Rattus norvegicus
V180VAYPMVAAYSA1Homo sapiens
V180MTQPMIAPYSA1Mus musculus
V180MTQPLIASYSA1Rattus norvegicus
V227TAMKAVSGIVH1Homo sapiens
V227TAMKEISGIIN1Mus musculus
V227TALKETSGIIL1Rattus norvegicus
V231AVSGIVHMQAA1Homo sapiens
V231EISGIINAQAS1Mus musculus
V231ETSGIILSQAA1Rattus norvegicus
Y177AGKVAYPMVAA1Homo sapiens
Y177AGKMTQPMIAP1Mus musculus
Y177AGKMTQPLIAS1Rattus norvegicus
Y183PMVAAYSASKF1Homo sapiens
Y183PMIAPYSASKF1Mus musculus
Y183PLIASYSASKF1Rattus norvegicus
Y280ILEFLYSTSYN1Homo sapiens
Y280IMEFFSLRYYN1Mus musculus
Y280IMEFLSLRSYN1Rattus norvegicus
Y284LYSTSYNMDRF1Homo sapiens
Y284FSLRYYNKDMF1Mus musculus
Y284LSLRSYNRDLF1Rattus norvegicus


Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas