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mutLBSgeneDB |
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| Gene summary for HSPA2 |
 Gene summary |
| Basic gene Info. | Gene symbol | HSPA2 |
| Gene name | heat shock 70kDa protein 2 | |
| Synonyms | HSP70-2|HSP70-3 | |
| Cytomap | UCSC genome browser: 14q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021979.3, | |
| Description | heat shock 70kD protein 2heat shock-related 70 kDa protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 140560 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126803 | ||
| HPRD : 07174 | ||
| Protein | UniProt: P54652 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HSPA2 | |
| BioGPS: 3306 | ||
| Pathway | NCI Pathway Interaction Database: HSPA2 | |
| KEGG: HSPA2 | ||
| REACTOME: HSPA2 | ||
| Pathway Commons: HSPA2 | ||
| Context | iHOP: HSPA2 | |
| ligand binding site mutation search in PubMed: HSPA2 | ||
| UCL Cancer Institute: HSPA2 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042026 | protein refolding | 21231916 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
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| Ligand binding site mutations for HSPA2 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | V263 | A262T | COAD | 1 | G342 | G341V | LUAD | 1 | T229,G227 | D228V | LUAD | 1 | I165 | T166M | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HSPA2 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | V263 | A262T | -0.66071476 | I165 | T166M | -0.16710205 | G342 | G341V | -0.082404413 | G227 | D228V | -0.068245181 | T229 | D228V | -0.068245181 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HSPA2 from PDB |
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| Differential gene expression and gene-gene network for HSPA2 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HSPA2 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0009375 | Colonic Neoplasms | 1 | Biomarker |
| umls:C0151744 | Myocardial Ischemia | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HSPA2 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HSPA2 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 3i33 | A | G342 |
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| Conservation information for LBS of HSPA2 |
| Multiple alignments for P54652 in multiple species |
| LBS | AA sequence | # species | Species | A226 | EVKSTAGDTHL | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | A226 | EVKATAGDTHL | 1 | Arabidopsis thaliana | D153 | PAYFNDSQRQA | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | D209 | GGGTFDVSILT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | D209 | GGGTFDVSLLT | 1 | Arabidopsis thaliana | E119 | TFFPEEISSMV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | E119 | QFAAEEISSMV | 1 | Arabidopsis thaliana | G227 | VKSTAGDTHLG | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G227 | VKATAGDTHLG | 1 | Arabidopsis thaliana | G257 | HKKDIGPNKRA | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | G257 | NKKDISGDARA | 1 | Arabidopsis thaliana | G257 | HKKDIAPNKRA | 1 | Bos taurus | G342 | IVLVGGSTRIP | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | G342 | VVLVGGSTRIP | 1 | Arabidopsis thaliana | I165 | KDAGTITGLNV | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I165 | KDAGVIAGLNV | 1 | Arabidopsis thaliana | I173 | LNVLRIINEPT | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | I346 | GGSTRIPKIQK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | I346 | GGSTRIPKVQQ | 1 | Arabidopsis thaliana | K160 | QRQATKDAGTI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | K160 | QRQATKDAGVI | 1 | Arabidopsis thaliana | K274 | ACERAKRTLSS | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | L171 | TGLNVLRIINE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | L171 | AGLNVLRIINE | 1 | Arabidopsis thaliana | M123 | EEISSMVLTKM | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | M123 | EEISSMVLIKM | 1 | Arabidopsis thaliana | N238 | GEDFDNRMVSH | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | N238 | GEDFDNRMVNH | 1 | Arabidopsis thaliana | N238 | GEDFDNSMVSH | 1 | Bos taurus | Q157 | NDSQRQATKDA | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | R156 | FNDSQRQATKD | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | R172 | GLNVLRIINEP | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | R267 | AVRRLRTACER | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R267 | ALRRLRTACER | 1 | Arabidopsis thaliana | R275 | CERAKRTLSSS | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R275 | CERAKRTLSST | 1 | Arabidopsis thaliana | R345 | VGGSTRIPKIQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R345 | VGGSTRIPKVQ | 1 | Arabidopsis thaliana | R50 | FTDTERLIGDA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | R50 | FTDSERLIGDA | 1 | Arabidopsis thaliana | S122 | PEEISSMVLTK | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S122 | AEEISSMVLIK | 1 | Arabidopsis thaliana | S242 | DNRMVSHLAEE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S242 | DNRMVNHFVQE | 1 | Arabidopsis thaliana | S242 | DNSMVSHLAEE | 1 | Bos taurus | S278 | AKRTLSSSTQA | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | S278 | AKRTLSSTAQT | 1 | Arabidopsis thaliana | S343 | VLVGGSTRIPK | 5 | Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus | T126 | SSMVLTKMKEI | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T126 | SSMVLIKMREI | 1 | Arabidopsis thaliana | T225 | FEVKSTAGDTH | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T225 | FEVKATAGDTH | 1 | Arabidopsis thaliana | T229 | STAGDTHLGGE | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | T229 | ATAGDTHLGGE | 1 | Arabidopsis thaliana | V170 | ITGLNVLRIIN | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V170 | IAGLNVLRIIN | 1 | Arabidopsis thaliana | V241 | FDNRMVSHLAE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | V241 | FDNRMVNHFVQ | 1 | Arabidopsis thaliana | V241 | FDNSMVSHLAE | 1 | Bos taurus | V263 | PNKRAVRRLRT | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | V263 | GDARALRRLRT | 1 | Arabidopsis thaliana | Y150 | ITVPAYFNDSQ | 4 | Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus | Y150 | VTVPAYFNDSQ | 1 | Arabidopsis thaliana |
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