mutLBSgeneDB |
Gene summary for HSPA8 |
Gene summary |
Basic gene Info. | Gene symbol | HSPA8 |
Gene name | heat shock 70kDa protein 8 | |
Synonyms | HEL-33|HEL-S-72p|HSC54|HSC70|HSC71|HSP71|HSP73|HSPA10|LAP-1|LAP1|NIP71 | |
Cytomap | UCSC genome browser: 11q24.1 | |
Type of gene | protein-coding | |
RefGenes | NM_006597.5, NM_153201.3, | |
Description | LPS-associated protein 1N-myristoyltransferase inhibitor protein 71constitutive heat shock protein 70epididymis luminal protein 33epididymis secretory sperm binding protein Li 72pheat shock 70kd protein 10heat shock cognate 71 kDa proteinheat shock | |
Modification date | 20141207 | |
dbXrefs | MIM : 600816 | |
HGNC : HGNC | ||
Ensembl : ENSG00000109971 | ||
HPRD : 07205 | ||
Vega : OTTHUMG00000166030 | ||
Protein | UniProt: P11142 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HSPA8 | |
BioGPS: 3312 | ||
Pathway | NCI Pathway Interaction Database: HSPA8 | |
KEGG: HSPA8 | ||
REACTOME: HSPA8 | ||
Pathway Commons: HSPA8 | ||
Context | iHOP: HSPA8 | |
ligand binding site mutation search in PubMed: HSPA8 | ||
UCL Cancer Institute: HSPA8 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0006200 | ATP catabolic process | 23921388 | GO:0042026 | protein refolding | 21231916 | GO:0045892 | negative regulation of transcription, DNA-templated | 10722728 | GO:1902904 | negative regulation of fibril organization | 23921388 |
Top |
Ligand binding site mutations for HSPA8 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | T204 | D206Y | COAD | 2 | G230 | D232E | BRCA | 1 | R272 | T273I | COAD | 1 | R342 | R342P | KIRC | 1 | T204,G202 | G203D | LUAD | 1 | G201 | D199N | LUAD | 1 | T37 | R36G | STAD | 1 | G230 | E231A | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for HSPA8 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | G230 | E231A | -1.4331387 | G201 | D199N | -1.3826663 | T37 | R36G | -0.91636719 | G202 | G203D | -0.72516321 | T204 | G203D | -0.72516321 | T204 | D206Y | -0.70937468 | R342 | R342P | -0.60494059 | G230 | D232E | -0.30936691 | R272 | T273I | -0.23232534 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for HSPA8 from PDB |
PDB ID | PDB title | PDB structure | 3LDQ | Crystal structure of HSC70/BAG1 in complex with small molecule inhibitor |
Top |
Differential gene expression and gene-gene network for HSPA8 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for HSPA8 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0001418 | Adenocarcinoma | 2 | Biomarker |
umls:C1846707 | Spinocerebellar Ataxia 17 | 2 | Biomarker |
umls:C0948089 | Acute Coronary Syndrome | 1 | Biomarker |
umls:C0007137 | Carcinoma, Squamous Cell | 1 | Biomarker |
umls:C0026640 | Mouth Neoplasms | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for HSPA8 |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB07045 | (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of HSPA8 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | 3BH | 8-AMINOADENOSINE | 3fzh | A | G201 G202 G230 R272 R342 | 3BK | 8-[(3,4-DICHLOROBENZYL)AMINO]ADENOSINE | 3fzk | A | G201 G202 G230 R272 R342 | 3P1 | 8-[(QUINOLIN-2-YLMETHYL)AMINO]ADENOSINE | 3ldq | A | G201 G202 G230 R272 R342 | 3F5 | ADENOSINE-DERIVED INHIBITOR (GRP78) | 3m3z | A | G201 G202 G230 R272 R342 | ADP | ADP | 4h5t | A | G201 G202 G230 R272 R342 | ATP | ATP | 3fzf | A | G201 G202 T204 G230 R272 R342 | GOL | GLYCEROL | 4h5r | A | T204 | GOL | GLYCEROL | 4h5r | B | T204 | 3GO | 5'-O-(4-CYANOBENZYL)-8-[(QUINOLIN-6-YLMETHYL)AMINO]ADENOSINE | 3fzm | A | T37 G201 G202 G230 R272 R342 | 3FD | 4-[[(2R,3S,4R,5R)-5-[6-AMINO-8-[(3,4-DICHLOROPHENYL)METHYLAMINO]PURIN-9-YL]-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXYMETHYL]BENZONITRILE | 3fzl | A | T37 G202 R272 R342 |
Top |
Conservation information for LBS of HSPA8 |
Multiple alignments for P11142 in multiple species |
LBS | AA sequence | # species | Species | D366 | KSINPDEAVAY | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | E268 | LRTACERAKRT | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | F150 | TVPAYFNDSQR | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G201 | LIFDLGGGTFD | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G202 | IFDLGGGTFDV | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G230 | DTHLGGEDFDN | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G338 | DIVLVGGSTRI | 7 | Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G338 | DVVLVGGSTRI | 1 | Arabidopsis thaliana | G339 | IVLVGGSTRIP | 7 | Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | G339 | VVLVGGSTRIP | 1 | Arabidopsis thaliana | I343 | GGSTRIPKIQK | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | I343 | GGSTRIPKVQQ | 1 | Arabidopsis thaliana | I343 | GGSTRIPKVQR | 1 | Drosophila melanogaster | I343 | GGSTRIPKVQK | 1 | Caenorhabditis elegans | K271 | ACERAKRTLSS | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | K71 | TVFDAKRLIGR | 7 | Homo sapiens, Arabidopsis thaliana, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | K71 | TIFDAKRLIGR | 1 | Drosophila melanogaster | Q154 | YFNDSQRQATK | 7 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Bos taurus, Mus musculus, Rattus norvegicus | Q154 | YFNDSQRQGTK | 1 | Gallus gallus | R272 | CERAKRTLSSS | 7 | Homo sapiens, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | R272 | CERAKRTLSST | 1 | Arabidopsis thaliana | R342 | VGGSTRIPKIQ | 5 | Homo sapiens, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | R342 | VGGSTRIPKVQ | 3 | Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans | R72 | VFDAKRLIGRR | 6 | Homo sapiens, Arabidopsis thaliana, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | R72 | IFDAKRLIGRR | 1 | Drosophila melanogaster | R72 | VFDAKRLIGRK | 1 | Caenorhabditis elegans | R76 | KRLIGRRFDDA | 5 | Homo sapiens, Drosophila melanogaster, Bos taurus, Mus musculus, Rattus norvegicus | R76 | KRLIGRRFTDS | 1 | Arabidopsis thaliana | R76 | KRLIGRKFDDP | 1 | Caenorhabditis elegans | R76 | KRLIGRRFDDS | 1 | Gallus gallus | S275 | AKRTLSSSTQA | 6 | Homo sapiens, Drosophila melanogaster, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | S275 | AKRTLSSTAQT | 1 | Arabidopsis thaliana | S275 | AKRTLSSSSQA | 1 | Caenorhabditis elegans | S340 | VLVGGSTRIPK | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T13 | GIDLGTTYSCV | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T14 | IDLGTTYSCVG | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T204 | DLGGGTFDVSI | 6 | Homo sapiens, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T204 | DLGGGTFDVSL | 1 | Arabidopsis thaliana | T204 | DLGGGTFDVSV | 1 | Drosophila melanogaster | T226 | STAGDTHLGGE | 6 | Homo sapiens, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | T226 | ATAGDTHLGGE | 2 | Arabidopsis thaliana, Drosophila melanogaster | T37 | DQGNRTTPSYV | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y149 | VTVPAYFNDSQ | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus | Y15 | DLGTTYSCVGV | 8 | Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, Caenorhabditis elegans, Gallus gallus, Bos taurus, Mus musculus, Rattus norvegicus |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |