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mutLBSgeneDB |
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| Gene summary for DNAJB1 |
 Gene summary |
| Basic gene Info. | Gene symbol | DNAJB1 |
| Gene name | DnaJ (Hsp40) homolog, subfamily B, member 1 | |
| Synonyms | HSPF1|Hdj1|Hsp40|RSPH16B|Sis1 | |
| Cytomap | UCSC genome browser: 19p13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001300914.1, NM_006145.2, | |
| Description | dnaJ homolog subfamily B member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604572 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132002 | ||
| HPRD : 05198 | ||
| Vega : OTTHUMG00000183289 | ||
| Protein | UniProt: P25685 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_DNAJB1 | |
| BioGPS: 3337 | ||
| Pathway | NCI Pathway Interaction Database: DNAJB1 | |
| KEGG: DNAJB1 | ||
| REACTOME: DNAJB1 | ||
| Pathway Commons: DNAJB1 | ||
| Context | iHOP: DNAJB1 | |
| ligand binding site mutation search in PubMed: DNAJB1 | ||
| UCL Cancer Institute: DNAJB1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0032781 | positive regulation of ATPase activity | 23921388 | GO:0070389 | chaperone cofactor-dependent protein refolding | 18620420 | GO:0090084 | negative regulation of inclusion body assembly | 21231916 |
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| Ligand binding site mutations for DNAJB1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | I185 | I185V | HNSC | 1 | H166 | H166Q | LUAD | 1 | H166 | V164A | LUSC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for DNAJB1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | H166 | V164A | -1.2785588 | I185 | I185V | -1.1227392 | H166 | H166Q | -0.30551512 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for DNAJB1 from PDB |
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| Differential gene expression and gene-gene network for DNAJB1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for DNAJB1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for DNAJB1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of DNAJB1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | III | Peptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL) | 3agy | A | H166 I185 | III | Peptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP) | 3agy | B | H166 I185 | III | Peptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP) | 3agz | B | H166 I185 | III | Peptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP) | 3agz | A | I185 |
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| Conservation information for LBS of DNAJB1 |
| Multiple alignments for P25685 in multiple species |
| LBS | AA sequence | # species | Species | D225 | FPKEGDQTSN- | 3 | Homo sapiens, Mus musculus, Bos taurus | D225 | YKNQGDYNPQT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | D225 | FAGEGDEKPD- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E214 | KRGWKEGTKIT | 2 | Mus musculus, Bos taurus | E214 | KKGWKEGTKIT | 1 | Homo sapiens | E214 | KPGWKAGTKIT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E214 | KPGWKAGTKIK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F220 | GTKITFPKEGD | 3 | Homo sapiens, Mus musculus, Bos taurus | F220 | GTKITYKNQGD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F220 | GTKIKFAGEGD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F237 | PADIVFVLKDK | 3 | Homo sapiens, Mus musculus, Bos taurus | F237 | RKTLQFVIQEK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F237 | VQDIQFVLAEK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G215 | RGWKEGTKITF | 2 | Mus musculus, Bos taurus | G215 | KGWKEGTKITF | 1 | Homo sapiens | G215 | PGWKAGTKITY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G215 | PGWKAGTKIKF | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G224 | TFPKEGDQTSN | 3 | Homo sapiens, Mus musculus, Bos taurus | G224 | TYKNQGDYNPQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G224 | KFAGEGDEKPD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H166 | DPPVTHDLRVS | 3 | Homo sapiens, Mus musculus, Bos taurus | H166 | EETVQVNLPVS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H166 | NEVITRPLNVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H187 | KMKISHKRLNP | 3 | Homo sapiens, Mus musculus, Bos taurus | H187 | SFKIGRK--GP | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H187 | KMKISRHIIDA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I185 | TKKMKISHKRL | 3 | Homo sapiens, Mus musculus, Bos taurus | I185 | KKSFKIGRK-- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I185 | TKKMKISRHII | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I203 | RNEDKILTIEV | 3 | Homo sapiens, Mus musculus, Bos taurus | I203 | KT---QIDIQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I203 | KA-DRILEIKV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I218 | KEGTKITFPKE | 3 | Homo sapiens, Mus musculus, Bos taurus | I218 | KAGTKITYKNQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I218 | KAGTKIKFAGE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I235 | NIPADIVFVLK | 3 | Homo sapiens, Mus musculus, Bos taurus | I235 | GRRKTLQFVIQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I235 | GTVQDIQFVLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K181 | YSGCTKKMKIS | 3 | Homo sapiens, Mus musculus, Bos taurus | K181 | FVGKKKSFKIG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K181 | FTGCTKKMKIS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K182 | SGCTKKMKISH | 3 | Homo sapiens, Mus musculus, Bos taurus | K182 | VGKKKSFKIGR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K182 | TGCTKKMKISR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K184 | CTKKMKISHKR | 3 | Homo sapiens, Mus musculus, Bos taurus | K184 | KKKSFKIGRK- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K184 | CTKKMKISRHI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K213 | VKRGWKEGTKI | 2 | Mus musculus, Bos taurus | K213 | VKKGWKEGTKI | 1 | Homo sapiens | K213 | LKPGWKAGTKI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K213 | VKPGWKAGTKI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K217 | WKEGTKITFPK | 3 | Homo sapiens, Mus musculus, Bos taurus | K217 | WKAGTKITYKN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K217 | WKAGTKIKFAG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K306 | GLPLPKTPEKR | 3 | Homo sapiens, Mus musculus, Bos taurus | K306 | GMPTPKNPSQR | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K306 | GMPLPKNPSQR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M183 | GCTKKMKISHK | 3 | Homo sapiens, Mus musculus, Bos taurus | M183 | GKKKSFKIGRK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M183 | GCTKKMKISRH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S186 | KKMKISHKRLN | 3 | Homo sapiens, Mus musculus, Bos taurus | S186 | KSFKIGRK--G | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S186 | KKMKISRHIID | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T216 | GWKEGTKITFP | 3 | Homo sapiens, Mus musculus, Bos taurus | T216 | GWKAGTKITYK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T216 | GWKAGTKIKFA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T219 | EGTKITFPKEG | 3 | Homo sapiens, Mus musculus, Bos taurus | T219 | AGTKITYKNQG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T219 | AGTKIKFAGEG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W212 | EVKRGWKEGTK | 2 | Mus musculus, Bos taurus | W212 | EVKKGWKEGTK | 1 | Homo sapiens | W212 | QLKPGWKAGTK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W212 | KVKPGWKAGTK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) |
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