mutated Ligand Binding Site gene DataBase





About Us

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for DNAJB1
Gene summary
Basic gene Info.Gene symbolDNAJB1
Gene nameDnaJ (Hsp40) homolog, subfamily B, member 1
CytomapUCSC genome browser: 19p13.2
Type of geneprotein-coding
DescriptiondnaJ homolog subfamily B member 1dnaJ protein homolog 1heat shock 40 kDa protein 1human DnaJ protein 1radial spoke 16 homolog B
Modification date20141207
dbXrefs MIM : 604572
Ensembl : ENSG00000132002
HPRD : 05198
Vega : OTTHUMG00000183289
ProteinUniProt: P25685
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_DNAJB1
BioGPS: 3337
PathwayNCI Pathway Interaction Database: DNAJB1
Pathway Commons: DNAJB1
ContextiHOP: DNAJB1
ligand binding site mutation search in PubMed: DNAJB1
UCL Cancer Institute: DNAJB1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0032781positive regulation of ATPase activity23921388
GO:0070389chaperone cofactor-dependent protein refolding18620420
GO:0090084negative regulation of inclusion body assembly21231916

Ligand binding site mutations for DNAJB1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for DNAJB1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for DNAJB1 from PDB

Differential gene expression and gene-gene network for DNAJB1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of DNAJB1 and the right PPI network was created from samples without mutations in the LBS of DNAJB1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for DNAJB1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for DNAJB1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of DNAJB1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL)3agyAH166 I185
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)3agyBH166 I185
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)3agzBH166 I185
IIIPeptide ligand (GLY,PRO,THR,ILE,GLU,GLU,VAL,ASP)3agzAI185

Conservation information for LBS of DNAJB1
Multiple alignments for P25685 in multiple species
LBSAA sequence# speciesSpecies
D225FPKEGDQTSN-3Homo sapiens, Mus musculus, Bos taurus
D225YKNQGDYNPQT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D225FAGEGDEKPD-1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E214KRGWKEGTKIT2Mus musculus, Bos taurus
E214KKGWKEGTKIT1Homo sapiens
E214KPGWKAGTKIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E214KPGWKAGTKIK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F220GTKITFPKEGD3Homo sapiens, Mus musculus, Bos taurus
F220GTKITYKNQGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F220GTKIKFAGEGD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
F237PADIVFVLKDK3Homo sapiens, Mus musculus, Bos taurus
F237RKTLQFVIQEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F237VQDIQFVLAEK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G215RGWKEGTKITF2Mus musculus, Bos taurus
G215KGWKEGTKITF1Homo sapiens
G215PGWKAGTKITY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G215PGWKAGTKIKF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G224TFPKEGDQTSN3Homo sapiens, Mus musculus, Bos taurus
G224TYKNQGDYNPQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G224KFAGEGDEKPD1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H166DPPVTHDLRVS3Homo sapiens, Mus musculus, Bos taurus
H166EETVQVNLPVS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H166NEVITRPLNVS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H187KMKISHKRLNP3Homo sapiens, Mus musculus, Bos taurus
H187SFKIGRK--GP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H187KMKISRHIIDA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I185TKKMKISHKRL3Homo sapiens, Mus musculus, Bos taurus
I185KKSFKIGRK--1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I185TKKMKISRHII1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I203RNEDKILTIEV3Homo sapiens, Mus musculus, Bos taurus
I203KT---QIDIQL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I203KA-DRILEIKV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I218KEGTKITFPKE3Homo sapiens, Mus musculus, Bos taurus
I218KAGTKITYKNQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I218KAGTKIKFAGE1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I235NIPADIVFVLK3Homo sapiens, Mus musculus, Bos taurus
I235GRRKTLQFVIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I235GTVQDIQFVLA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K181YSGCTKKMKIS3Homo sapiens, Mus musculus, Bos taurus
K181FVGKKKSFKIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K181FTGCTKKMKIS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K182SGCTKKMKISH3Homo sapiens, Mus musculus, Bos taurus
K182VGKKKSFKIGR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K182TGCTKKMKISR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K184CTKKMKISHKR3Homo sapiens, Mus musculus, Bos taurus
K184KKKSFKIGRK-1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K184CTKKMKISRHI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K213VKRGWKEGTKI2Mus musculus, Bos taurus
K213VKKGWKEGTKI1Homo sapiens
K213LKPGWKAGTKI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K213VKPGWKAGTKI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K217WKEGTKITFPK3Homo sapiens, Mus musculus, Bos taurus
K217WKAGTKITYKN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K217WKAGTKIKFAG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K306GLPLPKTPEKR3Homo sapiens, Mus musculus, Bos taurus
K306GMPTPKNPSQR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K306GMPLPKNPSQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M183GCTKKMKISHK3Homo sapiens, Mus musculus, Bos taurus
M183GKKKSFKIGRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M183GCTKKMKISRH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S186KKMKISHKRLN3Homo sapiens, Mus musculus, Bos taurus
S186KSFKIGRK--G1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S186KKMKISRHIID1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T216GWKEGTKITFP3Homo sapiens, Mus musculus, Bos taurus
T216GWKAGTKITYK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T216GWKAGTKIKFA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T219EGTKITFPKEG3Homo sapiens, Mus musculus, Bos taurus
T219AGTKITYKNQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T219AGTKIKFAGEG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W212EVKRGWKEGTK2Mus musculus, Bos taurus
W212EVKKGWKEGTK1Homo sapiens
W212QLKPGWKAGTK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W212KVKPGWKAGTK1Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Copyright © 2016-Present - The University of Texas Health Science Center at Houston
Site Policies | State of Texas