mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for HTR1B
Gene summary
Basic gene Info.Gene symbolHTR1B
Gene name5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled
CytomapUCSC genome browser: 6q13
Type of geneprotein-coding
Description5-HT-1B5-HT-1D-beta5-hydroxytryptamine receptor 1Bserotonin 1D beta receptorserotonin receptor 1B
Modification date20141207
dbXrefs MIM : 182131
Ensembl : ENSG00000135312
HPRD : 01634
Vega : OTTHUMG00000015066
ProteinUniProt: P28222
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HTR1B
BioGPS: 3351
PathwayNCI Pathway Interaction Database: HTR1B
Pathway Commons: HTR1B
ContextiHOP: HTR1B
ligand binding site mutation search in PubMed: HTR1B
UCL Cancer Institute: HTR1B
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathway1315531
GO:0030818negative regulation of cAMP biosynthetic process8882600
GO:0035690cellular response to drug1315531
GO:0071312cellular response to alkaloid1315531

Ligand binding site mutations for HTR1B

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for HTR1B
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for HTR1B from PDB

Differential gene expression and gene-gene network for HTR1B
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of HTR1B and the right PPI network was created from samples without mutations in the LBS of HTR1B. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for HTR1B
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0236736Cocaine-Related Disorders2Biomarker, Therapeutic
umls:C0004352Autistic Disorder1Biomarker, GeneticVariation
umls:C0236733Amphetamine-Related Disorders1Therapeutic
umls:C0033975Psychotic Disorders1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for HTR1B
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00216EletriptanSmall molecule
ApprovedDB00246ZiprasidoneSmall molecule
ApprovedDB00247MethysergideSmall molecule
ApprovedDB00248CabergolineSmall molecule
Approved|investigationalDB00268RopiniroleSmall molecule
Approved|investigationalDB00315ZolmitriptanSmall molecule
ApprovedDB00320DihydroergotamineSmall molecule
ApprovedDB00321AmitriptylineSmall molecule
Approved|investigationalDB00334OlanzapineSmall molecule
ApprovedDB00363ClozapineSmall molecule
ApprovedDB00408LoxapineSmall molecule
Approved|investigationalDB00413PramipexoleSmall molecule
ApprovedDB00543AmoxapineSmall molecule
Approved|investigationalDB00571PropranololSmall molecule
ApprovedDB00589LisurideSmall molecule
Approved|investigationalDB00669SumatriptanSmall molecule
ApprovedDB00696ErgotamineSmall molecule
Approved|investigationalDB00714ApomorphineSmall molecule
ApprovedDB00904OndansetronSmall molecule
Approved|investigationalDB00918AlmotriptanSmall molecule
Approved|investigationalDB00952NaratriptanSmall molecule
ApprovedDB00953RizatriptanSmall molecule
ApprovedDB00960PindololSmall molecule
Approved|investigationalDB00998FrovatriptanSmall molecule
Approved|vet_approved|withdrawnDB01186PergolideSmall molecule
Approved|investigationalDB01200BromocriptineSmall molecule
ApprovedDB01224QuetiapineSmall molecule
Approved|investigationalDB01238AripiprazoleSmall molecule
Approved|investigationalDB01359PenbutololSmall molecule
Approved|vet_approvedDB01392YohimbineSmall molecule
InvestigationalDB04884DapoxetineSmall molecule
InvestigationalDB05743MAP-0004Small molecule
InvestigationalDB06096NXN-188Small molecule
ApprovedDB06216AsenapineSmall molecule
ApprovedDB08807BopindololSmall molecule
ApprovedDB09068VortioxetineSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of HTR1B go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of HTR1B
Multiple alignments for P28222 in multiple species
LBSAA sequence# speciesSpecies
A216YSTVGAFYFPT3Homo sapiens, Pan troglodytes, Canis lupus familiaris
A216YSTVGAFYLPT2Mus musculus, Rattus norvegicus
A216YSATGSFFIPT1Caenorhabditis elegans
C133SDITCCTASIL3Homo sapiens, Pan troglodytes, Canis lupus familiaris
C133SDITCCTASIM2Mus musculus, Rattus norvegicus
C133ADILCSTASIW1Caenorhabditis elegans
C199EEVSECVVNTD2Homo sapiens, Pan troglodytes
C199NTVRQCTF-LD1Caenorhabditis elegans
C199EEMLDCFVNTD1Mus musculus
C199EEVLDCFVNTD1Rattus norvegicus
C199EEVSDCVVNTD1Canis lupus familiaris
D129FWLSSDITCCT4Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes
D129VFVSADILCST1Caenorhabditis elegans
D129LWLSSDITCCT1Canis lupus familiaris
D352HLAIFDFFTWL3Homo sapiens, Pan troglodytes, Canis lupus familiaris
D352HMAIFDFFNWL2Mus musculus, Rattus norvegicus
D352NAHIEMFITWL1Caenorhabditis elegans
F330VCWLPFFIISL5Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
F330VCWAPFFTMYV1Caenorhabditis elegans
F331CWLPFFIISLV5Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
F331CWAPFFTMYVL1Caenorhabditis elegans
F351FHLAIFDFFTW3Homo sapiens, Pan troglodytes, Canis lupus familiaris
F351FHMAIFDFFNW2Mus musculus, Rattus norvegicus
F351PNAHIEMFITW1Caenorhabditis elegans
I130WLSSDITCCTA5Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
I130FVSADILCSTA1Caenorhabditis elegans
L126VCDFWLSSDIT4Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes
L126LCEVFVSADIL1Caenorhabditis elegans
L126VCDLWLSSDIT1Canis lupus familiaris
L348ACWFHLAIFDF3Homo sapiens, Pan troglodytes, Canis lupus familiaris
L348ACWFHMAIFDF2Mus musculus, Rattus norvegicus
L348-CSPNAHIEMF1Caenorhabditis elegans
S334PFFIISLVMPI5Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
S334PFFTMYVLVQF1Caenorhabditis elegans
T355IFDFFTWLGYL3Homo sapiens, Pan troglodytes, Canis lupus familiaris
T355IFDFFNWLGYL2Mus musculus, Rattus norvegicus
T355IEMFITWLGYS1Caenorhabditis elegans
V200EVSECVVNTDH2Homo sapiens, Pan troglodytes
V200TVRQCTF-LDL1Caenorhabditis elegans
V200EMLDCFVNTDH1Mus musculus
V200EVLDCFVNTDH1Rattus norvegicus
V200EVSDCVVNTDH1Canis lupus familiaris
V201VSECVVNTDHI2Homo sapiens, Pan troglodytes
V201VRQCTF-LDLP1Caenorhabditis elegans
V201MLDCFVNTDHV1Mus musculus
V201VLDCFVNTDHV1Rattus norvegicus
V201VSDCVVNTDHI1Canis lupus familiaris
W327AFIVCWLPFFI5Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris
W327CFTVCWAPFFT1Caenorhabditis elegans
Y359FTWLGYLNSLI3Homo sapiens, Pan troglodytes, Canis lupus familiaris
Y359FNWLGYLNSLI2Mus musculus, Rattus norvegicus
Y359ITWLGYSNSAM1Caenorhabditis elegans

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