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mutLBSgeneDB |
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| Gene summary for HTR1B |
 Gene summary |
| Basic gene Info. | Gene symbol | HTR1B |
| Gene name | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | |
| Synonyms | 5-HT1B|5-HT1DB|HTR1D2|HTR1DB|S12 | |
| Cytomap | UCSC genome browser: 6q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000863.1, | |
| Description | 5-HT-1B5-HT-1D-beta5-hydroxytryptamine receptor 1Bserotonin 1D beta receptorserotonin receptor 1B | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 182131 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000135312 | ||
| HPRD : 01634 | ||
| Vega : OTTHUMG00000015066 | ||
| Protein | UniProt: P28222 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HTR1B | |
| BioGPS: 3351 | ||
| Pathway | NCI Pathway Interaction Database: HTR1B | |
| KEGG: HTR1B | ||
| REACTOME: HTR1B | ||
| Pathway Commons: HTR1B | ||
| Context | iHOP: HTR1B | |
| ligand binding site mutation search in PubMed: HTR1B | ||
| UCL Cancer Institute: HTR1B | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0007198 | adenylate cyclase-inhibiting serotonin receptor signaling pathway | 1315531 | GO:0030818 | negative regulation of cAMP biosynthetic process | 8882600 | GO:0035690 | cellular response to drug | 1315531 | GO:0071312 | cellular response to alkaloid | 1315531 |
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| Ligand binding site mutations for HTR1B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L126 | S127L | COAD | 1 | L348 | L348Q | LUAD | 1 | S334 | L335I | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for HTR1B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | S334 | L335I | -0.79612442 | L348 | L348Q | -0.5296766 | L126 | S127L | -0.38701277 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for HTR1B from PDB |
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| Differential gene expression and gene-gene network for HTR1B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for HTR1B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0236736 | Cocaine-Related Disorders | 2 | Biomarker, Therapeutic |
| umls:C0004352 | Autistic Disorder | 1 | Biomarker, GeneticVariation |
| umls:C0236733 | Amphetamine-Related Disorders | 1 | Therapeutic |
| umls:C0020649 | Hypotension | 1 | Biomarker |
| umls:C0033975 | Psychotic Disorders | 1 | Biomarker |
| umls:C0036572 | Seizures | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for HTR1B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00216 | Eletriptan | Small molecule |  |
| Approved | DB00246 | Ziprasidone | Small molecule |  |
| Approved | DB00247 | Methysergide | Small molecule |  |
| Approved | DB00248 | Cabergoline | Small molecule |  |
| Approved|investigational | DB00268 | Ropinirole | Small molecule |  |
| Approved|investigational | DB00315 | Zolmitriptan | Small molecule |  |
| Approved | DB00320 | Dihydroergotamine | Small molecule |  |
| Approved | DB00321 | Amitriptyline | Small molecule |  |
| Approved|investigational | DB00334 | Olanzapine | Small molecule |  |
| Approved | DB00363 | Clozapine | Small molecule |  |
| Approved | DB00408 | Loxapine | Small molecule |  |
| Approved|investigational | DB00413 | Pramipexole | Small molecule |  |
| Approved | DB00543 | Amoxapine | Small molecule |  |
| Approved|investigational | DB00571 | Propranolol | Small molecule |  |
| Approved | DB00589 | Lisuride | Small molecule |  |
| Approved|investigational | DB00669 | Sumatriptan | Small molecule |  |
| Approved | DB00696 | Ergotamine | Small molecule |  |
| Approved|investigational | DB00714 | Apomorphine | Small molecule |  |
| Approved | DB00904 | Ondansetron | Small molecule |  |
| Approved|investigational | DB00918 | Almotriptan | Small molecule |  |
| Approved|investigational | DB00952 | Naratriptan | Small molecule |  |
| Approved | DB00953 | Rizatriptan | Small molecule |  |
| Approved | DB00960 | Pindolol | Small molecule |  |
| Approved|investigational | DB00998 | Frovatriptan | Small molecule |  |
| Approved|vet_approved|withdrawn | DB01186 | Pergolide | Small molecule |  |
| Approved|investigational | DB01200 | Bromocriptine | Small molecule |  |
| Approved | DB01224 | Quetiapine | Small molecule |  |
| Approved|investigational | DB01238 | Aripiprazole | Small molecule |  |
| Approved|investigational | DB01359 | Penbutolol | Small molecule |  |
| Approved|vet_approved | DB01392 | Yohimbine | Small molecule |  |
| Investigational | DB04884 | Dapoxetine | Small molecule |  |
| Investigational | DB05743 | MAP-0004 | Small molecule |  |
| Investigational | DB06096 | NXN-188 | Small molecule |  |
| Approved | DB06216 | Asenapine | Small molecule |  |
| Approved | DB08807 | Bopindolol | Small molecule |  |
| Approved | DB09068 | Vortioxetine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of HTR1B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ERM | ERGOTAMINE | 4iar | A | L126 S334 L348 |
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| Conservation information for LBS of HTR1B |
| Multiple alignments for P28222 in multiple species |
| LBS | AA sequence | # species | Species | A216 | YSTVGAFYFPT | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | A216 | YSTVGAFYLPT | 2 | Mus musculus, Rattus norvegicus | A216 | YSATGSFFIPT | 1 | Caenorhabditis elegans | C133 | SDITCCTASIL | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | C133 | SDITCCTASIM | 2 | Mus musculus, Rattus norvegicus | C133 | ADILCSTASIW | 1 | Caenorhabditis elegans | C199 | EEVSECVVNTD | 2 | Homo sapiens, Pan troglodytes | C199 | NTVRQCTF-LD | 1 | Caenorhabditis elegans | C199 | EEMLDCFVNTD | 1 | Mus musculus | C199 | EEVLDCFVNTD | 1 | Rattus norvegicus | C199 | EEVSDCVVNTD | 1 | Canis lupus familiaris | D129 | FWLSSDITCCT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | D129 | VFVSADILCST | 1 | Caenorhabditis elegans | D129 | LWLSSDITCCT | 1 | Canis lupus familiaris | D352 | HLAIFDFFTWL | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | D352 | HMAIFDFFNWL | 2 | Mus musculus, Rattus norvegicus | D352 | NAHIEMFITWL | 1 | Caenorhabditis elegans | F330 | VCWLPFFIISL | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris | F330 | VCWAPFFTMYV | 1 | Caenorhabditis elegans | F331 | CWLPFFIISLV | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris | F331 | CWAPFFTMYVL | 1 | Caenorhabditis elegans | F351 | FHLAIFDFFTW | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | F351 | FHMAIFDFFNW | 2 | Mus musculus, Rattus norvegicus | F351 | PNAHIEMFITW | 1 | Caenorhabditis elegans | I130 | WLSSDITCCTA | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris | I130 | FVSADILCSTA | 1 | Caenorhabditis elegans | L126 | VCDFWLSSDIT | 4 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes | L126 | LCEVFVSADIL | 1 | Caenorhabditis elegans | L126 | VCDLWLSSDIT | 1 | Canis lupus familiaris | L348 | ACWFHLAIFDF | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | L348 | ACWFHMAIFDF | 2 | Mus musculus, Rattus norvegicus | L348 | -CSPNAHIEMF | 1 | Caenorhabditis elegans | S334 | PFFIISLVMPI | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris | S334 | PFFTMYVLVQF | 1 | Caenorhabditis elegans | T355 | IFDFFTWLGYL | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | T355 | IFDFFNWLGYL | 2 | Mus musculus, Rattus norvegicus | T355 | IEMFITWLGYS | 1 | Caenorhabditis elegans | V200 | EVSECVVNTDH | 2 | Homo sapiens, Pan troglodytes | V200 | TVRQCTF-LDL | 1 | Caenorhabditis elegans | V200 | EMLDCFVNTDH | 1 | Mus musculus | V200 | EVLDCFVNTDH | 1 | Rattus norvegicus | V200 | EVSDCVVNTDH | 1 | Canis lupus familiaris | V201 | VSECVVNTDHI | 2 | Homo sapiens, Pan troglodytes | V201 | VRQCTF-LDLP | 1 | Caenorhabditis elegans | V201 | MLDCFVNTDHV | 1 | Mus musculus | V201 | VLDCFVNTDHV | 1 | Rattus norvegicus | V201 | VSDCVVNTDHI | 1 | Canis lupus familiaris | W327 | AFIVCWLPFFI | 5 | Homo sapiens, Mus musculus, Rattus norvegicus, Pan troglodytes, Canis lupus familiaris | W327 | CFTVCWAPFFT | 1 | Caenorhabditis elegans | Y359 | FTWLGYLNSLI | 3 | Homo sapiens, Pan troglodytes, Canis lupus familiaris | Y359 | FNWLGYLNSLI | 2 | Mus musculus, Rattus norvegicus | Y359 | ITWLGYSNSAM | 1 | Caenorhabditis elegans |
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