mutLBSgeneDB
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mutLBSgeneDB
mutated Ligand Binding Site gene DataBase
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 Gene summary |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples. |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples |
K697 | D698G | COAD | 3 | L116 | T118A | BLCA | 1 | K697 | D698N | COAD | 1 | E189 | S188L | HNSC | 1 | Y609 | Y609H | KIRC | 1 | F834 | G836W | LUAD | 1 | K697 | D698A | OV | 1 | G339 | G339R | SKCM | 1 | M371 | F372Y | SKCM | 1 | H332 | P330H | STAD | 1 | G144 | H146Q | STAD | 1 | T316 | F317C | UCEC | 1 | S138 | S137R | UCEC | 1 | I304 | V305L | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
| Protein structure of wild type (WT) and mutant type (MT) of IDE |
| Wild type IDE |
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| Mutant type IDE |
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| Free energy of binding of drugs to wild type and mutant tpye of IDE |
| Gene symbol | Drug name | Free energy of binding (kcal/mol) of wild type | Free energy of binding (kcal/mol) of mutant type |
IDE | Bacitracin | -9.6 | -8.4 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change |
E189 | S188L | 0.29217145 | K697 | D698A | 0.26220341 | K697 | D698N | 0.14760209 | K697 | D698G | 0.081807496 | L116 | T118A | -1.4807808 | H332 | P330H | -1.0083762 | Y609 | Y609H | -0.93072671 | M371 | F372Y | -0.8082259 | G339 | G339R | -0.79612599 | T316 | F317C | -0.77417487 | I304 | V305L | -0.74582583 | G144 | H146Q | -0.55150065 | F834 | G836W | -0.31672351 | S138 | S137R | -0.23426768 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for IDE from PDB |
| PDB ID | PDB title | PDB structure |
2G47 | Crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-40) |  |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0002395 | Alzheimer Disease | 22 | Biomarker, GeneticVariation |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
| Gene-centered drug-gene interaction network |
| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|investigational | DB00030 | Insulin Human | Biotech |  |
| Approved | DB00071 | Insulin Pork | Biotech |  |
| Approved|vet_approved | DB00626 | Bacitracin | Small molecule |  |
| Gene-centered ligand-gene interaction network |
| Ligands binding to mutated ligand binding site of IDE go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
III | | Peptide ligand (LYS,LEU,VAL,PHE,PHE,ALA,GLU,ASP) | 2g47 | A | E189 | III | | Peptide ligand (LYS,LEU,VAL,PHE,PHE,ALA,GLU,ASP) | 2g47 | B | E189 | III | | Peptide ligand (GLN,ARG,LEU,ALA,ASN,PHE,LEU,VAL,HIS,SER,SER,ASN) | 2g48 | A | E189 | III | | Peptide ligand (PHE,VAL,GLN,TRP,LEU,MET,ASN) | 2g49 | A | E189 | III | | Peptide ligand (PHE,VAL,GLN,TRP,LEU,MET) | 2g49 | B | E189 | III | | Peptide ligand (GLU,ALA,LEU,TYR,LEU,VAL,CYS,GLY) | 2g54 | A | E189 | ZN | | ZINC(2+) | 2g54 | A | E189 | III | | Peptide ligand (GLU,ALA,LEU,TYR,LEU,VAL,CYS) | 2g54 | B | E189 | ZN | | ZINC(2+) | 2g54 | B | E189 | III | | Peptide ligand (VAL,GLU,ALA,LEU,TYR,LEU,VAL,CYS,GLY,GLU,ARG,GLY,PHE,PHE) | 2g56 | A | E189 | III | | Peptide ligand (ALA,ALA,ALA,ALA,ALA,ALA,ALA) | 2jbu | A | E189 | III | | Peptide ligand (ALA,ALA,ALA,ALA,ALA,ALA,ALA) | 2jbu | B | E189 | ZN | | ZINC(2+) | 2jg4 | A | E189 | ZN | | ZINC(2+) | 2jg4 | B | E189 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS,LEU,CYS,GLY,SER,HIS,LEU,VAL,GLU,ALA,LEU,TYR,LEU,VAL) | 2wby | A | E189 | ZN | | ZINC(2+) | 2wby | A | E189 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS,LEU,CYS,GLY,SER,HIS,LEU,VAL,GLU,ALA,LEU,TYR,LEU,VAL,CYS) | 2wby | B | E189 | ZN | | ZINC(2+) | 2wby | B | E189 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS,LEU,CYS,GLY,SER,HIS,LEU,VAL,GLU,ALA,LEU,TYR,LEU,VAL,CYS,GLY) | 2wc0 | A | E189 | ZN | | ZINC(2+) | 2wc0 | A | E189 | ZN | | ZINC(2+) | 2wc0 | B | E189 | III | | Peptide ligand (LYS,LEU,VAL,PHE,PHE,ALA,GLU) | 2wk3 | A | E189 | ZN | | ZINC(2+) | 2wk3 | A | E189 | III | | Peptide ligand (LYS,LEU,VAL,PHE,PHE,ALA,GLU) | 2wk3 | B | E189 | ZN | | ZINC(2+) | 2wk3 | B | E189 | ZN | | ZINC(2+) | 2ypu | A | E189 | ZN | | ZINC(2+) | 2ypu | B | E189 | ZN | | ZINC(2+) | 3cww | A | E189 | ZN | | ZINC(2+) | 3cww | B | E189 | ZN | | ZINC(2+) | 3e4a | A | E189 | ZN | | ZINC(2+) | 3e4a | B | E189 | ZN | | ZINC(2+) | 3e4z | A | E189 | ZN | | ZINC(2+) | 3e4z | B | E189 | ZN | | ZINC(2+) | 3e50 | A | E189 | ZN | | ZINC(2+) | 3e50 | B | E189 | III | | Peptide ligand (LYS,ARG,SER,ARG,GLN,VAL) | 3h44 | A | E189 | ZN | | ZINC(2+) | 3h44 | A | E189 | III | | Peptide ligand (SER,ARG,GLN,VAL) | 3h44 | B | E189 | ZN | | ZINC(2+) | 3h44 | B | E189 | III | | Peptide ligand (LEU,ALA,ASN,PHE,LEU) | 3hgz | A | E189 | ZN | | ZINC(2+) | 3hgz | A | E189 | III | | Peptide ligand (LEU,ALA,ASN,PHE,LEU) | 3hgz | B | E189 | ZN | | ZINC(2+) | 3hgz | B | E189 | ZN | | ZINC(2+) | 3n56 | A | E189 | ZN | | ZINC(2+) | 3n56 | B | E189 | ZN | | ZINC(2+) | 3n57 | A | E189 | ZN | | ZINC(2+) | 3n57 | B | E189 | ZN | | ZINC(2+) | 3ofi | A | E189 | ZN | | ZINC(2+) | 3ofi | B | E189 | ZN | | ZINC(2+) | 3qz2 | A | E189 | ZN | | ZINC(2+) | 3qz2 | B | E189 | ZN | | ZINC(2+) | 4dtt | A | E189 | ZN | | ZINC(2+) | 4dtt | B | E189 | I41 | | COMPOUND 41367 | 4dtt | B | E189 | ZN | | ZINC(2+) | 4dwk | A | E189 | ZN | | ZINC(2+) | 4dwk | B | E189 | ZN | | ZINC(2+) | 4iof | A | E189 | ZN | | ZINC(2+) | 4gs8 | A | E189 | ZN | | ZINC(2+) | 4gs8 | B | E189 | ZN | | ZINC(2+) | 4gsc | A | E189 | ZN | | ZINC(2+) | 4gsc | B | E189 | ZN | | ZINC(2+) | 4gse | A | E189 | ZN | | ZINC(2+) | 4gse | B | E189 | ZN | | ZINC(2+) | 4gsf | A | E189 | ZN | | ZINC(2+) | 4gsf | B | E189 | ZN | | ZINC(2+) | 4ifh | A | E189 | ZN | | ZINC(2+) | 4ifh | B | E189 | 1EF | | N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4- OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)-4- METHYLBENZAMIDE | 4ifh | B | E189 | ZN | | ZINC(2+) | 4lte | A | E189 | ZN | | ZINC(2+) | 4lte | B | E189 | ZN | | ZINC(2+) | 4qld | A | E189 | III | | Peptide ligand (PHE,GLN,THR,LYS,ARG,SER,LYS) | 4qld | B | E189 | ZN | | ZINC(2+) | 4qld | B | E189 | ZN | | ZINC(2+) | 4m1c | A | E189 | ZN | | ZINC(2+) | 4m1c | B | E189 | ZN | | ZINC(2+) | 4q5z | A | E189 | ZN | | ZINC(2+) | 4q5z | B | E189 | ZN | | ZINC(2+) | 4q5z | C | E189 | ZN | | ZINC(2+) | 4q5z | D | E189 | ZN | | ZINC(2+) | 4q5z | E | E189 | ZN | | ZINC(2+) | 4q5z | F | E189 | ZN | | ZINC(2+) | 4q5z | H | E189 | ZN | | ZINC(2+) | 4qia | A | E189 | ZN | | ZINC(2+) | 4qia | B | E189 | ZN | | ZINC(2+) | 4ral | A | E189 | III | | Peptide ligand (PHE,GLN,THR,LYS,ARG,SER,LYS) | 4ral | B | E189 | ZN | | ZINC(2+) | 4ral | B | E189 | ZN | | ZINC(2+) | 4pes | A | E189 | ZN | | ZINC(2+) | 4pes | B | E189 | ZN | | ZINC(2+) | 4pf7 | A | E189 | ZN | | ZINC(2+) | 4pf7 | B | E189 | ZN | | ZINC(2+) | 4pf9 | A | E189 | ZN | | ZINC(2+) | 4pf9 | B | E189 | ZN | | ZINC(2+) | 4pfc | A | E189 | ZN | | ZINC(2+) | 4pfc | B | E189 | ZN | | ZINC(2+) | 4re9 | A | E189 | 3M9 | | 4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2- YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-5-YL}METHYL) BENZAMIDE | 4re9 | A | E189 | ZN | | ZINC(2+) | 4re9 | B | E189 | ZN | | ZINC(2+) | 4nxo | A | E189 | ZN | | ZINC(2+) | 4nxo | B | E189 | III | | Peptide ligand (ARG,LEU,ALA,ASN,PHE,LEU,VAL,HIS,SER,SER,ASN,ASN,PHE) | 2g48 | B | E189 F834 | III | | Peptide ligand (HIS,LEU,VAL,GLU,ALA,LEU,TYR,LEU,VAL,CYS,GLY,GLU,ARG,GLY,PHE) | 2g56 | B | E189 F834 | OBD | | 4-METHYL-N-({1-[(2S)-1-(NAPHTHALEN-2-YL)-4-NITROSO-4- OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL)BENZAMIDE | 4gse | B | E189 F834 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS,THR,SER,ILE,CYS,SER,LEU,TYR,GLN,LEU,GLU) | 4q5z | A | E189 H332 G339 Y609 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS,LEU,CYS,GLY,SER,HIS,LEU,VAL,GLU,ALA,LEU,TYR,LEU,VAL,CYS,GLY) | 2wc0 | B | E189 K697 | III | | Peptide ligand (PHE,GLN,THR,LYS,ARG,SER,LYS) | 4qld | A | G144 E189 | III | | Peptide ligand (ALA,ALA,ALA) | 2jbu | B | G339 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS,THR,SER,ILE,CYS,SER,LEU,TYR,GLN,LEU,GLU,ASN,TYR,CYS) | 2wc0 | B | G339 | I41 | | COMPOUND 41367 | 2ypu | B | G339 | III | | Peptide ligand (ALA,ALA,ALA) | 3e4a | A | G339 | III | | Peptide ligand (ALA,SER,LEU,ALA) | 3h44 | B | G339 | III | | Peptide ligand (LYS,CYS) | 3hgz | A | G339 | I41 | | COMPOUND 41367 | 4dtt | B | G339 | MGW | METHYL N-(CARBOXYMETHYL)-N-(2-PHENYLETHYL)GLYCYL-L- HISTIDINATE | ((S)-2-[2-(CARBOXYMETHYL-PHENETHYL-AMINO)-ACETYLAMINO]- 3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4gsc | B | G339 | III | | Peptide ligand (PRO,MET,GLY) | 4qld | A | G339 | III | | Peptide ligand (ALA,PRO,MET) | 4qld | B | G339 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS) | 4q5z | F | G339 | 33K | | N-BENZYL-N-(CARBOXYMETHYL)GLYCYL-L-HISTIDINE | 4qia | A | G339 | 33K | | N-BENZYL-N-(CARBOXYMETHYL)GLYCYL-L-HISTIDINE | 4qia | B | G339 | III | | Peptide ligand (ALA,ALA,ALA) | 4pes | B | G339 | III | | Peptide ligand (VAL,VAL,SER,HIS,PHE) | 3e50 | B | G339 M371 Y609 | III | | Peptide ligand (ASP,ALA,GLU) | 2g47 | A | G339 Y609 | III | | Peptide ligand (ASP,ALA,GLU) | 2g47 | B | G339 Y609 | III | | Peptide ligand (LYS,CYS,ASN,THR) | 2g48 | B | G339 Y609 | III | | Peptide ligand (HIS,SER,GLN,GLY) | 2g49 | A | G339 Y609 | III | | Peptide ligand (HIS,SER,GLN) | 2g49 | B | G339 Y609 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS) | 2g54 | A | G339 Y609 | III | | Peptide ligand (PHE,VAL,ASN,GLN,HIS) | 2g54 | B | G339 Y609 | III | | Peptide ligand (PHE,VAL,ASN,GLN) | 2g56 | A | G339 Y609 | III | | Peptide ligand (PHE,VAL,ASN,GLN) | 2g56 | B | G339 Y609 | III | | Peptide ligand (ALA,ALA,ALA) | 2jbu | A | G339 Y609 | III | | Peptide ligand (ASP,ALA,GLU) | 2wk3 | A | G339 Y609 | III | | Peptide ligand (ASP,ALA,GLU) | 2wk3 | B | G339 Y609 | III | | Peptide ligand (ALA,PRO,PRO) | 3cww | A | G339 Y609 | III | | Peptide ligand (ALA,PRO,PRO,ALA) | 3cww | B | G339 Y609 | III | | Peptide ligand (ALA,ALA,ALA) | 3e4a | B | G339 Y609 | III | | Peptide ligand (ALA,TYR,ARG) | 3e4z | A | G339 Y609 | III | | Peptide ligand (ALA,TYR,ARG) | 3e4z | B | G339 Y609 | III | | Peptide ligand (VAL,VAL,SER,HIS,PHE) | 3e50 | A | G339 Y609 | III | | Peptide ligand (ALA,SER,LEU,ALA) | 3h44 | A | G339 Y609 | III | | Peptide ligand (LYS,CYS,ASN,CYS,ALA) | 3hgz | B | G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL) | 4q5z | B | G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN) | 4q5z | E | G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL,GLU) | 4q5z | G | G339 Y609 | III | | Peptide ligand (ALA,PRO,MET,GLY) | 4ral | A | G339 Y609 | III | | Peptide ligand (ALA,PRO,MET) | 4ral | B | G339 Y609 | III | | Peptide ligand (ALA,ALA,ALA) | 4pes | A | G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS) | 4q5z | H | H332 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS,THR,SER,ILE,CYS,SER,LEU,TYR,GLN,LEU,GLU,ASN,TYR,CYS) | 2wby | B | H332 G339 | MGK | METHYL N-(CARBOXYMETHYL)-N-(3-PHENYLPROPYL)GLYCYL-L- HISTIDINATE | ((S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPYL)-AMINO]- ACETYLAMINO}-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4dwk | A | H332 G339 | MGK | METHYL N-(CARBOXYMETHYL)-N-(3-PHENYLPROPYL)GLYCYL-L- HISTIDINATE | ((S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPYL)-AMINO]- ACETYLAMINO}-3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4dwk | B | H332 G339 | MGJ | N-(CARBOXYMETHYL)-N-(3-PHENYLPROPYL)GLYCYL-N-METHYL-L- HISTIDINAMIDE | [{[(S)-2-(1H-IMIDAZOL-4-YL)-1-METHYLCARBAMOYL- ETHYLCARBAMOYL]-METHYL}-(3-PHENYL-PROPYL)-AMINO]- ACETIC ACID | 4gs8 | B | H332 G339 | MGH | METHYL N-(CARBOXYMETHYL)-N-(3-PHENYLPROPANOYL)GLYCYL-D- HISTIDINATE | (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]- ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4gsf | B | H332 G339 | 2QW | | (2S)-2-AMINO-N-{(1S)-1-CYCLOHEXYL-2-[(4-METHYLPHENYL) AMINO]-2-OXOETHYL}-4-(METHYLSELANYL)BUTANAMIDE | 4pf7 | A | H332 G339 | 2QW | | (2S)-2-AMINO-N-{(1S)-1-CYCLOHEXYL-2-[(4-METHYLPHENYL) AMINO]-2-OXOETHYL}-4-(METHYLSELANYL)BUTANAMIDE | 4pf7 | B | H332 G339 | 2Q6 | | METHYL [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-AMINO-2- OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO) PHENYL]PENTYL}OXY)PHENYL]-3-(QUINOLIN-3-YL) PROPYL]CARBAMATE | 4pf9 | A | H332 G339 | III | | Peptide ligand (LYS,CYS,ASN,THR,ALA,THR) | 2g48 | A | H332 G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS,THR,SER,ILE,CYS,SER,LEU,TYR,GLN,LEU,GLU,ASN,TYR,CYS) | 2wby | A | H332 G339 Y609 | III | | Peptide ligand (GLY,ILE,VAL,GLU,GLN,CYS,CYS,THR,SER,ILE,CYS,SER,LEU,TYR,GLN,LEU,GLU,ASN,TYR,CYS) | 2wc0 | A | H332 G339 Y609 | I41 | | COMPOUND 41367 | 2ypu | A | H332 G339 Y609 | III | | Peptide ligand (SER,LEU,ARG) | 3n57 | A | H332 G339 Y609 | III | | Peptide ligand (SER,LEU,ARG) | 3n57 | B | H332 G339 Y609 | III | | Peptide ligand (MET,GLN,ILE) | 3ofi | A | H332 G339 Y609 | III | | Peptide ligand (MET,GLN,ILE) | 3ofi | B | H332 G339 Y609 | I41 | | COMPOUND 41367 | 4dtt | A | H332 G339 Y609 | MGJ | N-(CARBOXYMETHYL)-N-(3-PHENYLPROPYL)GLYCYL-N-METHYL-L- HISTIDINAMIDE | [{[(S)-2-(1H-IMIDAZOL-4-YL)-1-METHYLCARBAMOYL- ETHYLCARBAMOYL]-METHYL}-(3-PHENYL-PROPYL)-AMINO]- ACETIC ACID | 4gs8 | A | H332 G339 Y609 | MGW | METHYL N-(CARBOXYMETHYL)-N-(2-PHENYLETHYL)GLYCYL-L- HISTIDINATE | ((S)-2-[2-(CARBOXYMETHYL-PHENETHYL-AMINO)-ACETYLAMINO]- 3-(1H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4gsc | A | H332 G339 Y609 | MGH | METHYL N-(CARBOXYMETHYL)-N-(3-PHENYLPROPANOYL)GLYCYL-D- HISTIDINATE | (S)-2-{2-[CARBOXYMETHYL-(3-PHENYL-PROPIONYL)-AMINO]- ACETYLAMINO}-3-(3H-IMIDAZOL-4-YL)-PROPIONIC ACID METHYL ESTER | 4gsf | A | H332 G339 Y609 | 2PJ | | TERT-BUTYL [(2S)-2-(2,5-DIFLUOROPHENYL)-3-(QUINOLIN-3- YL)PROPYL]CARBAMATE | 4pes | A | I304 | 2PJ | | TERT-BUTYL [(2S)-2-(2,5-DIFLUOROPHENYL)-3-(QUINOLIN-3- YL)PROPYL]CARBAMATE | 4pes | B | I304 | 2Q6 | | METHYL [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-AMINO-2- OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO) PHENYL]PENTYL}OXY)PHENYL]-3-(QUINOLIN-3-YL) PROPYL]CARBAMATE | 4pf9 | B | I304 H332 G339 Y609 | 2QX | | METHYL [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-AMINO-2- OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO) PHENYL]PENTYL}-2-FLUOROPHENYL)-3-(QUINOLIN-3-YL) PROPYL]CARBAMATE | 4pfc | A | I304 H332 G339 Y609 | III | | Peptide ligand (PHE,DFF,LYS,FUM) | 4lte | A | I304 T316 | III | | Peptide ligand (PHE,DFF,LYS,FUM) | 4lte | B | I304 T316 | QIX | | N~2~-[(2R)-4-(HYDROXYAMINO)-2-(2-NAPHTHYLMETHYL)-4-OXOBUTANOYL]-L-ARGINYLGLYCYLGLYCINAMIDE | 3e4a | A | L116 E189 | QIX | | N~2~-[(2R)-4-(HYDROXYAMINO)-2-(2-NAPHTHYLMETHYL)-4-OXOBUTANOYL]-L-ARGINYLGLYCYLGLYCINAMIDE | 3e4a | B | L116 E189 | III | | Peptide ligand (LEU,VAL,ASP,THR,LEU,GLN) | 3e4z | A | S138 E189 | III | | Peptide ligand (LEU,VAL,ASP,THR,LEU,GLN) | 3e4z | B | S138 E189 | III | | Peptide ligand (ASP,SER,HIS,THR,GLN) | 3e50 | B | S138 E189 | I41 | | COMPOUND 41367 | 4dtt | A | S138 E189 | III | | Peptide ligand (PHE,GLN,THR,LYS,ARG,SER,LYS) | 4ral | A | S138 E189 | 2H7 | | 4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2- YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL) BENZAMIDE | 4nxo | A | S138 E189 | 2H7 | | 4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2- YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-4-YL}METHYL) BENZAMIDE | 4nxo | B | S138 E189 | 2QX | | METHYL [(2S)-2-(5-{5-[4-({(2S)-2-[(3S)-3-AMINO-2- OXOPIPERIDIN-1-YL]-2-CYCLOHEXYLACETYL}AMINO) PHENYL]PENTYL}-2-FLUOROPHENYL)-3-(QUINOLIN-3-YL) PROPYL]CARBAMATE | 4pfc | B | T316 H332 G339 Y609 |
| Multiple alignments for P14735 in multiple species |
| LBS | AA sequence | # species | Species |
A140 | AGSSNAFTSGE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | A140 | NGISNAYTASN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A140 | NGDSNAYTDTD | 1 | Caenorhabditis elegans | A140 | GGSSNAYTASQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A140 | GGSTNAYTASE | 1 | Arabidopsis thaliana | A140 | GGSSNAATYPL | 1 | Drosophila melanogaster | A198 | NVMNDAWRLFQ | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | A198 | NLQSDSWRFWR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A198 | KVNEDFWRCLQ | 1 | Caenorhabditis elegans | A198 | NLQNDIWRIYQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A198 | NLLSDGWRIRQ | 1 | Arabidopsis thaliana | A198 | NLPSDLWRIKQ | 1 | Drosophila melanogaster | A479 | ENVRVAIVSKS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | A479 | NNFFAILAAHS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | A479 | -------IRKN | 1 | Caenorhabditis elegans | A479 | ENSRVTLISRS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | A479 | SNFRIFWESQK | 1 | Arabidopsis thaliana | A479 | SKSRIVIVSQS | 1 | Drosophila melanogaster | E111 | LSHFCEHMLFL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E111 | LAHFCEHLLFM | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E111 | LAHFCEHMLFL | 2 | Caenorhabditis elegans, Drosophila melanogaster | E111 | LAHFLEHMLFY | 1 | Arabidopsis thaliana | E182 | SCKDREVNAVD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E182 | ECKDREIRAVD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E182 | SATEREVCAVN | 1 | Caenorhabditis elegans | E182 | DSTDKEINAVN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E182 | DATMREIKAVD | 1 | Arabidopsis thaliana | E182 | SATEREINAVN | 1 | Drosophila melanogaster | E189 | NAVDSEHEKNV | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E189 | RAVDSEHCKNL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E189 | CAVNCEYLDKV | 1 | Caenorhabditis elegans | E189 | NAVNSENKKNL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E189 | KAVDSENQKNL | 1 | Arabidopsis thaliana | E189 | NAVNSEHEKNL | 1 | Drosophila melanogaster | E205 | RLFQLEKATGN | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E205 | RFWRLYSVLSN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E205 | RCLQVERSLSK | 1 | Caenorhabditis elegans | E205 | RIYQLDKSLTN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E205 | RIRQLQKHLSK | 1 | Arabidopsis thaliana | E205 | RIKQVNRHLAK | 1 | Drosophila melanogaster | E341 | HLIGHEGPGSL | 4 | Homo sapiens, Caenorhabditis elegans, Rattus norvegicus, Bos taurus | E341 | HLLGHEGEGSY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E341 | HLIGHEGSGSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E341 | HLIGHEGEGSL | 1 | Arabidopsis thaliana | E341 | HLIGHEGKGSI | 1 | Drosophila melanogaster | E365 | VGGQKEGARGF | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E365 | IAFNVSITEDA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | E365 | EADNHTIASGF | 1 | Caenorhabditis elegans | E365 | SAGGHTVSKGN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | E365 | SAGEGEWTLDY | 1 | Arabidopsis thaliana | E365 | MAGHQNTQNGF | 1 | Drosophila melanogaster | F115 | CEHMLFLGTKK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F115 | CEHLLFMGTKK | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F115 | CEHMLFLGTAK | 1 | Caenorhabditis elegans | F115 | CEHLLFMGSEK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F115 | LEHMLFYASEK | 1 | Arabidopsis thaliana | F115 | CEHMLFLGTEK | 1 | Drosophila melanogaster | F141 | GSSNAFTSGEH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F141 | GISNAYTASNN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F141 | GDSNAYTDTDH | 1 | Caenorhabditis elegans | F141 | GSSNAYTASQN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F141 | GSTNAYTASEE | 1 | Arabidopsis thaliana | F141 | GSSNAATYPLM | 1 | Drosophila melanogaster | F202 | DAWRLFQLEKA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F202 | DSWRFWRLYSV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F202 | DFWRCLQVERS | 1 | Caenorhabditis elegans | F202 | DIWRIYQLDKS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F202 | DGWRIRQLQKH | 1 | Arabidopsis thaliana | F202 | DLWRIKQVNRH | 1 | Drosophila melanogaster | F820 | ISEPCFNTLRT | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F820 | MKEPTFSILRT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F820 | IKNPAYTILRT | 1 | Caenorhabditis elegans | F820 | IHEPCFDTLRT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F820 | AKQATFHQLRT | 1 | Arabidopsis thaliana | F820 | LSEPCYDCLRT | 1 | Drosophila melanogaster | F834 | LGYIVFSGPRR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | F834 | LGYIVFTLVRQ | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | F834 | LGYNVSTESRL | 1 | Caenorhabditis elegans | F834 | LGYVVFSSSLN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | F834 | LGYITALAQRN | 1 | Arabidopsis thaliana | F834 | LGYIVFSGVRK | 1 | Drosophila melanogaster | G144 | NAFTSGEHTNY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G144 | NAYTASNNTNY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G144 | NAYTDTDHTNY | 1 | Caenorhabditis elegans | G144 | NAYTASQNTNY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G144 | NAYTASEETNY | 1 | Arabidopsis thaliana | G144 | NAATYPLMTKY | 1 | Drosophila melanogaster | G219 | PFSKFGTGNKY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G219 | VFSKFNTGNIE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G219 | DYSKFAIGNKK | 1 | Caenorhabditis elegans | G219 | PYHKFSTGNIE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G219 | PYHKFSTGNMD | 1 | Arabidopsis thaliana | G219 | AYSKFGSGNKT | 1 | Drosophila melanogaster | G335 | PGHYLGHLIGH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G335 | PAEYVCHLLGH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G335 | PGDYIAHLIGH | 1 | Caenorhabditis elegans | G335 | PPRILSHLIGH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G335 | PSQYLGHLIGH | 1 | Arabidopsis thaliana | G335 | PDNYLTHLIGH | 1 | Drosophila melanogaster | G339 | LGHLIGHEGPG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G339 | VCHLLGHEGEG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G339 | IAHLIGHEGPG | 1 | Caenorhabditis elegans | G339 | LSHLIGHEGSG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G339 | LGHLIGHEGEG | 1 | Arabidopsis thaliana | G339 | LTHLIGHEGKG | 1 | Drosophila melanogaster | G361 | VNTLVGGQKEG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G361 | ATSLIAFNVSI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G361 | VISLEADNHTI | 1 | Caenorhabditis elegans | G361 | ANELSAGGHTV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G361 | ATGLSAGEGEW | 1 | Arabidopsis thaliana | G361 | CNDLMAGHQNT | 1 | Drosophila melanogaster | G362 | NTLVGGQKEGA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G362 | TSLIAFNVSIT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G362 | ISLEADNHTIA | 1 | Caenorhabditis elegans | G362 | NELSAGGHTVS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G362 | TGLSAGEGEWT | 1 | Arabidopsis thaliana | G362 | NDLMAGHQNTQ | 1 | Drosophila melanogaster | G432 | KERPRGYTSKI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G432 | KTPAYQYAHVV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | G432 | VKHTMEKASIL | 1 | Caenorhabditis elegans | G432 | AGSPSSTVSSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | G432 | KIPPMSYIVDI | 1 | Arabidopsis thaliana | G432 | KEQPENLVTHA | 1 | Drosophila melanogaster | H112 | SHFCEHMLFLG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | H112 | AHFCEHLLFMG | 2 | Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H112 | AHFCEHMLFLG | 2 | Caenorhabditis elegans, Drosophila melanogaster | H112 | AHFLEHMLFYA | 1 | Arabidopsis thaliana | H332 | KSNPGHYLGHL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | H332 | KCRPAEYVCHL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H332 | LSQPGDYIAHL | 1 | Caenorhabditis elegans | H332 | ESKPPRILSHL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H332 | DEAPSQYLGHL | 1 | Arabidopsis thaliana | H332 | KSGPDNYLTHL | 1 | Drosophila melanogaster | H336 | GHYLGHLIGHE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | H336 | AEYVCHLLGHE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H336 | GDYIAHLIGHE | 1 | Caenorhabditis elegans | H336 | PRILSHLIGHE | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H336 | SQYLGHLIGHE | 1 | Arabidopsis thaliana | H336 | DNYLTHLIGHE | 1 | Drosophila melanogaster | H679 | RAEQPHQHAMY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | H679 | DALEAYHRSNH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | H679 | AFSQPHDLSAH | 1 | Caenorhabditis elegans | H679 | LYEVPYSQMSN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | H679 | KFRQPYHQAMY | 1 | Arabidopsis thaliana | H679 | KAEQPYQHSIY | 1 | Drosophila melanogaster | I304 | KQLYKIVPIKD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I304 | RKICYVKPVKN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I304 | AKRIEIVPIQN | 1 | Caenorhabditis elegans | I304 | QKIIQVRPVKD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I304 | QILVKAIPIKQ | 1 | Arabidopsis thaliana | I304 | GQKVKIVPIKD | 1 | Drosophila melanogaster | I374 | GFMFFIINVDL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I374 | DADIIVVSTFL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I374 | GFGVFSVTMDL | 1 | Caenorhabditis elegans | I374 | GNAFFAVDIDL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I374 | DYSFFKVSIDL | 1 | Arabidopsis thaliana | I374 | GFGFFDIVVDL | 1 | Drosophila melanogaster | I832 | EQLGYIVFSGP | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I832 | EQLGYIVFTLV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I832 | EALGYNVSTES | 1 | Caenorhabditis elegans | I832 | EQLGYVVFSSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I832 | EQLGYITALAQ | 1 | Arabidopsis thaliana | I832 | EQLGYIVFSGV | 1 | Drosophila melanogaster | I849 | QGLRFIIQSE- | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I849 | INLNIFVQSE- | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | I849 | VYLHVIVQGP- | 1 | Caenorhabditis elegans | I849 | ANIRILIQSE- | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | I849 | YGVQFIIQSSV | 1 | Arabidopsis thaliana | I849 | NGIRIIVQSA- | 1 | Drosophila melanogaster | K192 | DSEHEKNVMND | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K192 | DSEHCKNLQSD | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K192 | NCEYLDKVNED | 1 | Caenorhabditis elegans | K192 | NSENKKNLQND | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K192 | DSENQKNLLSD | 1 | Arabidopsis thaliana | K192 | NSEHEKNLPSD | 1 | Drosophila melanogaster | K308 | KIVPIKDIRNL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K308 | YVKPVKNLRRL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K308 | EIVPIQNTGQV | 1 | Caenorhabditis elegans | K308 | QVRPVKDLKKL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K308 | KAIPIKQGHKL | 1 | Arabidopsis thaliana | K308 | KIVPIKDIRSL | 1 | Drosophila melanogaster | K364 | LVGGQKEGARG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K364 | LIAFNVSITED | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K364 | LEADNHTIASG | 1 | Caenorhabditis elegans | K364 | LSAGGHTVSKG | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K364 | LSAGEGEWTLD | 1 | Arabidopsis thaliana | K364 | LMAGHQNTQNG | 1 | Drosophila melanogaster | K436 | RGYTSKIAGIL | 2 | Homo sapiens, Bos taurus | K436 | YQYAHVVASKL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K436 | MEKASILAECL | 1 | Caenorhabditis elegans | K436 | SSTVSSLAKCL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K436 | MSYIVDIASNM | 1 | Arabidopsis thaliana | K436 | ENLVTHAVSSM | 1 | Drosophila melanogaster | K436 | RGYTSKIAGKL | 1 | Rattus norvegicus | K697 | EVAWTKDELKE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K697 | PHSWSNAELRE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | K697 | DNIWSKEQLLA | 1 | Caenorhabditis elegans | K697 | ERSWSTAEKLQ | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | K697 | DQTWPWTEELD | 1 | Arabidopsis thaliana | K697 | ENAWANMELLD | 1 | Drosophila melanogaster | L116 | EHMLFLGTKKY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L116 | EHLLFMGTKKY | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L116 | EHMLFLGTAKY | 1 | Caenorhabditis elegans | L116 | EHLLFMGSEKF | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L116 | EHMLFYASEKY | 1 | Arabidopsis thaliana | L116 | EHMLFLGTEKY | 1 | Drosophila melanogaster | L201 | NDAWRLFQLEK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L201 | SDSWRFWRLYS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L201 | EDFWRCLQVER | 1 | Caenorhabditis elegans | L201 | NDIWRIYQLDK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L201 | SDGWRIRQLQK | 1 | Arabidopsis thaliana | L201 | SDLWRIKQVNR | 1 | Drosophila melanogaster | L204 | WRLFQLEKATG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L204 | WRFWRLYSVLS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L204 | WRCLQVERSLS | 1 | Caenorhabditis elegans | L204 | WRIYQLDKSLT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L204 | WRIRQLQKHLS | 1 | Arabidopsis thaliana | L204 | WRIKQVNRHLA | 1 | Drosophila melanogaster | L359 | GWVNTLVGGQK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L359 | GLATSLIAFNV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | L359 | GWVISLEADNH | 1 | Caenorhabditis elegans | L359 | GWANELSAGGH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | L359 | GWATGLSAGEG | 1 | Arabidopsis thaliana | L359 | GWCNDLMAGHQ | 1 | Drosophila melanogaster | M371 | GARGFMFFIIN | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | M371 | ITEDADIIVVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M371 | IASGFGVFSVT | 1 | Caenorhabditis elegans | M371 | VSKGNAFFAVD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M371 | WTLDYSFFKVS | 1 | Arabidopsis thaliana | M371 | TQNGFGFFDIV | 1 | Drosophila melanogaster | M683 | PHQHAMYYLRL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | M683 | AYHRSNHVLTW | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | M683 | PHDLSAHFIDL | 1 | Caenorhabditis elegans | M683 | PYSQMSNYYNA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | M683 | PYHQAMYYCSL | 1 | Arabidopsis thaliana | M683 | PYQHSIYYLAL | 1 | Drosophila melanogaster | N139 | HAGSSNAFTSG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | N139 | HNGISNAYTAS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N139 | NNGDSNAYTDT | 1 | Caenorhabditis elegans | N139 | HGGSSNAYTAS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N139 | HGGSTNAYTAS | 1 | Arabidopsis thaliana | N139 | SGGSSNAATYP | 1 | Drosophila melanogaster | N193 | SEHEKNVMNDA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | N193 | SEHCKNLQSDS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N193 | CEYLDKVNEDF | 1 | Caenorhabditis elegans | N193 | SENKKNLQNDI | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N193 | SENQKNLLSDG | 1 | Arabidopsis thaliana | N193 | SEHEKNLPSDL | 1 | Drosophila melanogaster | N376 | MFFIINVDLTE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | N376 | DIIVVSTFLTE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | N376 | GVFSVTMDLST | 1 | Caenorhabditis elegans | N376 | AFFAVDIDLTD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | N376 | SFFKVSIDLTD | 1 | Arabidopsis thaliana | N376 | GFFDIVVDLTQ | 1 | Drosophila melanogaster | Q363 | TLVGGQKEGAR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q363 | SLIAFNVSITE | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q363 | SLEADNHTIAS | 1 | Caenorhabditis elegans | Q363 | ELSAGGHTVSK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q363 | GLSAGEGEWTL | 1 | Arabidopsis thaliana | Q363 | DLMAGHQNTQN | 1 | Drosophila melanogaster | Q677 | NFRAEQPHQHA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q677 | DYDALEAYHRS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q677 | NHAFSQPHDLS | 1 | Caenorhabditis elegans | Q677 | NLLYEVPYSQM | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q677 | NYKFRQPYHQA | 1 | Arabidopsis thaliana | Q677 | NFKAEQPYQHS | 1 | Drosophila melanogaster | Q680 | AEQPHQHAMYY | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Q680 | ALEAYHRSNHV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Q680 | FSQPHDLSAHF | 1 | Caenorhabditis elegans | Q680 | YEVPYSQMSNY | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Q680 | FRQPYHQAMYY | 1 | Arabidopsis thaliana | Q680 | AEQPYQHSIYY | 1 | Drosophila melanogaster | R429 | FKDKERPRGYT | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R429 | TRQKTPAYQYA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R429 | FDDVKHTMEKA | 1 | Caenorhabditis elegans | R429 | FKQAGSPSSTV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R429 | YQDKIPPMSYI | 1 | Arabidopsis thaliana | R429 | FKEKEQPENLV | 1 | Drosophila melanogaster | R431 | DKERPRGYTSK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R431 | QKTPAYQYAHV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R431 | DVKHTMEKASI | 1 | Caenorhabditis elegans | R431 | QAGSPSSTVSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R431 | DKIPPMSYIVD | 1 | Arabidopsis thaliana | R431 | EKEQPENLVTH | 1 | Drosophila melanogaster | R477 | RPENVRVAIVS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R477 | RPNNFFAILAA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R477 | ---------IR | 1 | Caenorhabditis elegans | R477 | VPENSRVTLIS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R477 | SPSNFRIFWES | 1 | Arabidopsis thaliana | R477 | VPSKSRIVIVS | 1 | Drosophila melanogaster | R824 | CFNTLRTKEQL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R824 | TFSILRTKEQL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R824 | AYTILRTNEAL | 1 | Caenorhabditis elegans | R824 | CFDTLRTKEQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R824 | TFHQLRTVEQL | 1 | Arabidopsis thaliana | R824 | CYDCLRTKEQL | 1 | Drosophila melanogaster | R847 | GIQGLRFIIQS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | R847 | PFINLNIFVQS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | R847 | GNVYLHVIVQG | 1 | Caenorhabditis elegans | R847 | GTANIRILIQS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | R847 | GIYGVQFIIQS | 1 | Arabidopsis thaliana | R847 | GANGIRIIVQS | 1 | Drosophila melanogaster | S128 | KENEYSQFLSE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S128 | DENEYRKYLES | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S128 | SEREYFKYLAA | 1 | Caenorhabditis elegans | S128 | DENEYSSYLSK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S128 | EEDSYSKYITE | 1 | Arabidopsis thaliana | S128 | HENGYTTYLSQ | 1 | Drosophila melanogaster | S138 | EHAGSSNAFTS | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S138 | SHNGISNAYTA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S138 | ANNGDSNAYTD | 1 | Caenorhabditis elegans | S138 | KHGGSSNAYTA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S138 | EHGGSTNAYTA | 1 | Arabidopsis thaliana | S138 | QSGGSSNAATY | 1 | Drosophila melanogaster | S143 | SNAFTSGEHTN | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S143 | SNAYTASNNTN | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S143 | SNAYTDTDHTN | 1 | Caenorhabditis elegans | S143 | SNAYTASQNTN | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S143 | TNAYTASEETN | 1 | Arabidopsis thaliana | S143 | SNAATYPLMTK | 1 | Drosophila melanogaster | S96 | DVHIGSLSDPP | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | S96 | DVHIGSQSNPR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | S96 | DVKVGHLMDPW | 1 | Caenorhabditis elegans | S96 | DVNIGAFEDPK | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | S96 | SVSVGSFSDPQ | 1 | Arabidopsis thaliana | S96 | SVQVGHMSDPT | 1 | Drosophila melanogaster | T142 | SSNAFTSGEHT | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T142 | ISNAYTASNNT | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T142 | DSNAYTDTDHT | 1 | Caenorhabditis elegans | T142 | SSNAYTASQNT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T142 | STNAYTASEET | 1 | Arabidopsis thaliana | T142 | SSNAATYPLMT | 1 | Drosophila melanogaster | T208 | QLEKATGNPKH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T208 | RLYSVLSNPKS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T208 | QVERSLSKPGH | 1 | Caenorhabditis elegans | T208 | QLDKSLTNTKH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T208 | QLQKHLSKEDH | 1 | Arabidopsis thaliana | T208 | QVNRHLAKPDH | 1 | Drosophila melanogaster | T220 | FSKFGTGNKYT | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T220 | FSKFNTGNIET | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T220 | YSKFAIGNKKT | 1 | Caenorhabditis elegans | T220 | YHKFSTGNIET | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T220 | YHKFSTGNMDT | 1 | Arabidopsis thaliana | T220 | YSKFGSGNKTT | 1 | Drosophila melanogaster | T316 | RNLYVTFPIPD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | T316 | RRLDIVFPIPG | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | T316 | GQVSIKFPFPD | 1 | Caenorhabditis elegans | T316 | KKLEISFTVPD | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | T316 | HKLGVSWPVTP | 1 | Arabidopsis thaliana | T316 | RSLTISFTTDD | 1 | Drosophila melanogaster | V360 | WVNTLVGGQKE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V360 | LATSLIAFNVS | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V360 | WVISLEADNHT | 1 | Caenorhabditis elegans | V360 | WANELSAGGHT | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V360 | WATGLSAGEGE | 1 | Arabidopsis thaliana | V360 | WCNDLMAGHQN | 1 | Drosophila melanogaster | V833 | QLGYIVFSGPR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V833 | QLGYIVFTLVR | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | V833 | ALGYNVSTESR | 1 | Caenorhabditis elegans | V833 | QLGYVVFSSSL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | V833 | QLGYITALAQR | 1 | Arabidopsis thaliana | V833 | QLGYIVFSGVR | 1 | Drosophila melanogaster | W199 | VMNDAWRLFQL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | W199 | LQSDSWRFWRL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | W199 | VNEDFWRCLQV | 1 | Caenorhabditis elegans | W199 | LQNDIWRIYQL | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | W199 | LLSDGWRIRQL | 1 | Arabidopsis thaliana | W199 | LPSDLWRIKQV | 1 | Drosophila melanogaster | Y150 | EHTNYYFDVSH | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y150 | NNTNYYFEVSH | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y150 | DHTNYSFEVRS | 1 | Caenorhabditis elegans | Y150 | QNTNYFFEVNH | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y150 | EETNYHFDVNA | 1 | Arabidopsis thaliana | Y150 | LMTKYHFHVAP | 1 | Drosophila melanogaster | Y302 | HLKQLYKIVPI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y302 | EVRKICYVKPV | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y302 | QLAKRIEIVPI | 1 | Caenorhabditis elegans | Y302 | HLQKIIQVRPV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y302 | HLQILVKAIPI | 1 | Arabidopsis thaliana | Y302 | RYGQKVKIVPI | 1 | Drosophila melanogaster | Y314 | DIRNLYVTFPI | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y314 | NLRRLDIVFPI | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y314 | NTGQVSIKFPF | 1 | Caenorhabditis elegans | Y314 | DLKKLEISFTV | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y314 | QGHKLGVSWPV | 1 | Arabidopsis thaliana | Y314 | DIRSLTISFTT | 1 | Drosophila melanogaster | Y609 | LNEYAYAAELA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y609 | LGEYSYPASLA | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y609 | IIEETYNARLA | 1 | Caenorhabditis elegans | Y609 | LKDVQYDAACA | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y609 | LNEYAYYAQVA | 1 | Arabidopsis thaliana | Y609 | LNEYLYDAELA | 1 | Drosophila melanogaster | Y831 | KEQLGYIVFSG | 4 | Homo sapiens, Drosophila melanogaster, Rattus norvegicus, Bos taurus | Y831 | KEQLGYIVFTL | 1 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | Y831 | NEALGYNVSTE | 1 | Caenorhabditis elegans | Y831 | KEQLGYVVFSS | 1 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | Y831 | VEQLGYITALA | 1 | Arabidopsis thaliana |
