mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IDH1
Gene summary
Basic gene Info.Gene symbolIDH1
Gene nameisocitrate dehydrogenase 1 (NADP+), soluble
SynonymsHEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD
CytomapUCSC genome browser: 2q33.3
Type of geneprotein-coding
RefGenesNM_001282386.1,
NM_001282387.1,NM_005896.3,
DescriptionNADP(+)-specific ICDHNADP-dependent isocitrate dehydrogenase, cytosolicNADP-dependent isocitrate dehydrogenase, peroxisomalepididymis luminal protein 216epididymis secretory protein Li 26isocitrate dehydrogenase [NADP] cytoplasmicoxalosuccinate deca
Modification date20141222
dbXrefs MIM : 147700
HGNC : HGNC
Ensembl : ENSG00000138413
HPRD : 00984
Vega : OTTHUMG00000132943
ProteinUniProt: O75874
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IDH1
BioGPS: 3417
PathwayNCI Pathway Interaction Database: IDH1
KEGG: IDH1
REACTOME: IDH1
Pathway Commons: IDH1
ContextiHOP: IDH1
ligand binding site mutation search in PubMed: IDH1
UCL Cancer Institute: IDH1
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0006102isocitrate metabolic process10521434
GO:00061032-oxoglutarate metabolic process19935646


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Ligand binding site mutations for IDH1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R132R132HGBM13
R132R132CLAML12
R132R132CSKCM8
R132R132HLAML5
K72V71ACOAD3
R132R132GGBM2
R132R132LSKCM2
R132R132HBLCA1
M291M291IBLCA1
R132R132CBRCA1
R132R132CCOAD1
R132I130MCOAD1
K126K126RCOAD1
T327T325MCOAD1
R100R100LCOAD1
T311T311ACOAD1
R132I130VCOAD1
W124G123RCOAD1
R100I99TCOAD1
R132R132GLAML1
R132R132SLAML1
A111,R109E110DLUAD1
R109R109KLUAD1
D375D375YLUAD1
R132R132HPRAD1
R314R314LSTAD1
I113I113VUCEC1
R82E84AUCEC1
R119R119WUCEC1
S94W92RUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for IDH1 from My Cancer Genome.
Isocitrate dehydrogenase 1 (NADP+), soluble (IDH1) is a gene that encodes an epigenetic modifier, a NADP(+)-dependent enzyme that catalyzes oxidative decarboxylation of isocitrate (Gene 2013). Wild type IDH1 converts isocitrate to α-ketoglutarate, a step in the Krebs cycle, an important metabolic pathway that affects many other cellular biochemical processes (Shih et al. 2012).IDH1 is frequently mutated in glioma and acute myeloid leukemia, myelodysplastic syndromes, and other cancer types (Rohle et al. 2013; Walter et al. 2013). Mutations generally involve point mutations at the R132 residue of the protein, although a synonymous variant (G105G) has been found to be prognostically relevant in AML. Mutations in IDH1 and IDH2 result in deleterious “gain of function”: instead of converting isocitrate to α-ketoglutarate, mutated IDH1 or IDH2 converts isocitrate to 2-hydroxyglutarate (Shih et al. 2012; Yang et al. 2012). 2-hydroxyglutarate inhibits other proteins involved in epigenetic regulation (Shih et al. 2012).Wheeler, S., Seegmiller, A., Vnencak-Jones, C.L., Strickland, S.A., Kim, A.S. 2015. IDH1. My Cancer Genome https://www.mycancergenome.org/content/gene/idh1/ (Updated December 2015)

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Protein structure related information for IDH1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
K72V71A-1.5743637
R132R132G-1.5097508
R132R132H-1.387074
R132R132S-1.3629487
I113I113V-1.3137581
R109R109K-1.2467285
R132R132C-1.1768947
R100I99T-1.1231947
R119R119W-1.0700551
T311T311A-1.0462065
R82E84A-0.95252446
R109E110D-0.86362544
A111E110D-0.86362544
R132R132L-0.78647418
S94W92R-0.76240196
R132I130V-0.65758142
T327T325M-0.65238638
R132I130M-0.56083848
K126K126R-0.54102242
R314R314L-0.51493611
W124G123R-0.47746297
R100R100L-0.3729573
M291M291I-0.24266491
D375D375Y-0.1983698
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IDH1 from PDB
PDB IDPDB titlePDB structure
1T09Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex NADP

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Differential gene expression and gene-gene network for IDH1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types
IDH1_COAD_DE

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IDH1 and the right PPI network was created from samples without mutations in the LBS of IDH1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

* In COAD


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Phenotype information for IDH1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0017638Glioma246Biomarker, GeneticVariation
umls:C0028945Oligodendroglioma32Biomarker, GeneticVariation
umls:C0345905Intrahepatic cholangiocarcinoma5Biomarker
umls:C1961102Precursor Cell Lymphoblastic Leukemia-Lymphoma5Biomarker, GeneticVariation
umls:C0014084Enchondromatosis3Biomarker
umls:C0018916Hemangioma2Biomarker, GeneticVariation
umls:C2239176Carcinoma, Hepatocellular2Biomarker
umls:C0936248Chondroma2Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs
166215R132HPathogenicSomatic-

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Pharmacological information for IDH1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB01727Isocitric AcidSmall molecule
ExperimentalDB034612'-Monophosphoadenosine 5'-DiphosphoriboseSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IDH1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
59D(7R)-1-(4-FLUOROBENZYL)-N-{3-[(1S)-1- HYDROXYETHYL]PHENYL}-7-METHYL-5-(1H-PYRROL-2- YLCARBONYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3- C]PYRIDINE-3-CARBOXAMIDE5de1AA111 I113 R119 W124 M291
59D(7R)-1-(4-FLUOROBENZYL)-N-{3-[(1S)-1- HYDROXYETHYL]PHENYL}-7-METHYL-5-(1H-PYRROL-2- YLCARBONYL)-4,5,6,7-TETRAHYDRO-1H-PYRAZOLO[4,3- C]PYRIDINE-3-CARBOXAMIDE5de1BI113 R119 W124 K126 M291
NAPNADP ZWITTERION1t0lBK72 R82 T311 R314
NAPNADP ZWITTERION1t0lDK72 R82 T311 R314
NAPNADP ZWITTERION4kzoCK72 R82 T311 R314
NAPNADP ZWITTERION4l03AK72 R82 T311 R314
NAPNADP ZWITTERION4l03BK72 R82 T311 R314
NAPNADP ZWITTERION4l03CK72 R82 T311 R314
NAPNADP ZWITTERION4l06AK72 R82 T311 R314
NAPNADP ZWITTERION4l06CK72 R82 T311 R314
NAPNADP ZWITTERION4l06FK72 R82 T311 R314
NAPNADP ZWITTERION4umxAK72 R82 T311 R314
NAPNADP ZWITTERION1t09AK72 R82 T311 R314 T327
NAPNADP ZWITTERION1t0lAK72 R82 T311 R314 T327
NAPNADP ZWITTERION1t0lCK72 R82 T311 R314 T327
NAPNADP ZWITTERION3masAK72 R82 T311 R314 T327
NAPNADP ZWITTERION3masBK72 R82 T311 R314 T327
NDPNADPH4i3kAK72 R82 T311 R314 T327
NDPNADPH4i3kBK72 R82 T311 R314 T327
NDPNADPH4i3lAK72 R82 T311 R314 T327
NDPNADPH4i3lBK72 R82 T311 R314 T327
NAPNADP ZWITTERION4kzoAK72 R82 T311 R314 T327
NAPNADP ZWITTERION4kzoBK72 R82 T311 R314 T327
NAPNADP ZWITTERION4l06BK72 R82 T311 R314 T327
NAPNADP ZWITTERION4l06DK72 R82 T311 R314 T327
NAPNADP ZWITTERION4l06EK72 R82 T311 R314 T327
NAPNADP ZWITTERION4l04CK72 R82 T311 R314 T327
NAPNADP ZWITTERION4l04EK72 R82 T311 R314 T327
NAPNADP ZWITTERION4umxBK72 R82 T311 R314 T327
NAPNADP ZWITTERION4umyAK72 R82 T311 R314 T327
NAPNADP ZWITTERION4umyBK72 R82 T311 R314 T327
NAPNADP ZWITTERION5de1AK72 R82 T311 R314 T327
NAPNADP ZWITTERION3mapAK72 R82 T311 R314 T327 D375
NAPNADP ZWITTERION3mapBK72 R82 T311 R314 T327 D375
NAPNADP ZWITTERION3marAK72 R82 T311 R314 T327 D375
NAPNADP ZWITTERION4l04AK72 R82 T311 R314 T327 D375
NAPNADP ZWITTERION4l04DK72 R82 T311 R314 T327 D375
NDPNADPH4xrxAK72 R82 T311 R314 T327 D375
NDPNADPH4xrxBK72 R82 T311 R314 T327 D375
NAPNADP ZWITTERION4l04BK72 T311 R314
CACALCIUM(2+)1t0lAR109
CACALCIUM(2+)1t0lBR109
CACALCIUM(2+)1t0lCR109
CACALCIUM(2+)1t0lDR109
CACALCIUM(2+)3inmAR109
CACALCIUM(2+)3inmBR109
CACALCIUM(2+)3inmCR109
CACALCIUM(2+)4kzoBR109
CACALCIUM(2+)4kzoCR109
CACALCIUM(2+)4l06AR109
CACALCIUM(2+)4l06CR109
CACALCIUM(2+)4l06DR109
CACALCIUM(2+)4l06ER109
CACALCIUM(2+)4l06FR109
CACALCIUM(2+)4l04AR109
CACALCIUM(2+)4l04CR109
CACALCIUM(2+)4l04DR109
CACALCIUM(2+)4l04ER109
CACALCIUM(2+)4l04FR109
NDPNADPH3inmCR82 T311 R314
NAPNADP ZWITTERION3marBR82 T311 R314 D375
NAPNADP ZWITTERION4l04FR82 T311 R314 D375
NDPNADPH3inmAR82 T311 R314 T327
NDPNADPH3inmBR82 T311 R314 T327
NAPNADP ZWITTERION5de1BR82 T311 R314 T327
NAPNADP ZWITTERION1t09BR82 T311 R314 T327 D375
ICTISOCITRIC ACID3mapAS94 R100
ICTISOCITRIC ACID3mapBS94 R100
ICTISOCITRIC ACID3masAS94 R100
ICTISOCITRIC ACID3masBS94 R100
1BX1-HYDROXY-6-(4-HYDROXYBENZYL)-4-METHYLPYRIDIN-2(1H)-ONE4i3kAS94 R100
1BZ6-BENZYL-1-HYDROXY-4-METHYLPYRIDIN-2(1H)-ONE4i3lAS94 R100
42V5-[(E)-(1-METHYL-5-OXO-2-THIOXOIMIDAZOLIDIN-4-YLIDENE) METHYL]PYRIDIN-2(1H)-ONE4xrxAS94 R100
AKG2-OXOGLUTARIC ACID3inmAS94 R100 R109
AKG2-OXOGLUTARIC ACID3inmBS94 R100 R109
AKG2-OXOGLUTARIC ACID3inmCS94 R100 R109
AKG2-OXOGLUTARIC ACID4kzoAS94 R100 R109
AKG2-OXOGLUTARIC ACID4kzoBS94 R100 R109
AKG2-OXOGLUTARIC ACID4kzoCS94 R100 R109
AKG2-OXOGLUTARIC ACID4l03BS94 R100 R109
ICTISOCITRIC ACID1t0lAS94 R100 R109 R132
ICTISOCITRIC ACID1t0lBS94 R100 R109 R132
ICTISOCITRIC ACID1t0lCS94 R100 R109 R132
ICTISOCITRIC ACID1t0lDS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l03AS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l03CS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06AS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06BS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06CS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06DS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06ES94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l06FS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04AS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04BS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04CS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04DS94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04ES94 R100 R109 R132
AKG2-OXOGLUTARIC ACID4l04FS94 R100 R109 R132
VVS2,6-BIS(1H-IMIDAZOL-1-YLMETHYL)-4-(2,4,4- TRIMETHYLPENTAN-2-YL)PHENOL4umxAW124 M291


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Conservation information for LBS of IDH1
Multiple alignments for O75874 in multiple species
LBSAA sequence# speciesSpecies
A111TVFREAIICKN4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A111TVFREPIICKN1Arabidopsis thaliana
A111TVFREPIVIPR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A111TVFREPILIKN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A258DMVAQAMKSEG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A258DMVAYALKSEG1Arabidopsis thaliana
A258DMVAQMIKSKG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A258DMVAQAIKSNG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A282QSDSVAQGYGS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A282QSDFLAQGFGS1Arabidopsis thaliana
A282QSDIVAQGFGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A282MSDVVAQAYGS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A307TVEAEAAHGTV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A307TFESEAAHGTV2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A307TIEAEAAHGTV1Arabidopsis thaliana
A308VEAEAAHGTVT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A308IEAEAAHGTVT1Arabidopsis thaliana
A308FESEAAHGTVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A308FESEAAHGTVQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A74VGVKCATITPD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
A74VGIKCATITPD2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A74VAIKCATITPD1Arabidopsis thaliana
C379KDLAACIKGLP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C379KDLALIIHG-S1Arabidopsis thaliana
C379KDLALAC---G1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C379KDLYLLSKS-P1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D252EHRLIDDMVAQ5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D252EHRLIDDMVAY1Arabidopsis thaliana
D252QHRLIDDMVAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D253HRLIDDMVAQA5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D253HRLIDDMVAYA1Arabidopsis thaliana
D253HRLIDDMVAQM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D275KNYDGDVQSDS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D275KNYDGDVQSDF1Arabidopsis thaliana
D275KNYDGDVQSDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D275KNYDGDVMSDV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D279GDVQSDSVAQG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D279GDVQSDFLAQG1Arabidopsis thaliana
D279GDVQSDIVAQG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D279GDVMSDVVAQA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D375GFMTKDLAACI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
D375GKMTKDLALII1Arabidopsis thaliana
D375GIMTKDLALAC1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D375GIMTKDLYLLS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E306KTVEAEAAHGT4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
E306KTIEAEAAHGT1Arabidopsis thaliana
E306KTFESEAAHGT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E306RTFESEAAHGT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G284DSVAQGYGSLG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G284DFLAQGFGSLG1Arabidopsis thaliana
G284DIVAQGFGSLG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G284DVVAQAYGSLG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G289GYGSLGMMTSV4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
G289GFGSLGLMTSV1Arabidopsis thaliana
G289GFGSLGLMTSI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G289AYGSLGLMTSV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G310AEAAHGTVTRH5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
G310SEAAHGTVTRH1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G310SEAAHGTVQRH1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G97WKSPNGTIRNI6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G97WRSPNGTIRNI1Arabidopsis thaliana
H309EAEAAHGTVTR5Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus
H309ESEAAHGTVTR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H309ESEAAHGTVQR1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H315GTVTRHYRMYQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
H315GTVTRHFRVHQ1Arabidopsis thaliana
H315GTVTRHYRKYQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H315GTVQRHYMQYL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I113FREAIICKNIP4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I113FREPIICKNVP1Arabidopsis thaliana
I113FREPIVIPRIP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I113FREPILIKNIP1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I215STKNTILKKYD7Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I76VKCATITPDEK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
I76IKCATITPDEA2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
I76IKCATITPDEG1Arabidopsis thaliana
K126VSGWVKPIIIG2Homo sapiens, Bos taurus
K126VTGWVKPIIIG2Mus musculus, Rattus norvegicus
K126VPGWTKPICIG1Arabidopsis thaliana
K126VPRWEKPIIIG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K126IPGWTNPICIG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K212LYLSTKNTILK6Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K212LFLSTKNTILK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K260VAQAMKSEGGF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
K260VAYALKSEGGY1Arabidopsis thaliana
K260VAQMIKSKGGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K260VAQAIKSNGGF1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
K72YNVGVKCATIT3Bos taurus, Mus musculus, Rattus norvegicus
K72HNVGVKCATIT1Homo sapiens
K72YNVAIKCATIT1Arabidopsis thaliana
K72YGVGIKCATIT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
K72NDVGIKCATIT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L120KNIPRLVSGWV2Homo sapiens, Bos taurus
L120KNIPRLVTGWV2Mus musculus, Rattus norvegicus
L120KNVPKLVPGWT1Arabidopsis thaliana
L120PRIPRLVPRWE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L120KNIPKYIPGWT1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L250WYEHRLIDDMV4Homo sapiens, Arabidopsis thaliana, Bos taurus, Rattus norvegicus
L250CYEHRLIDDMV1Mus musculus
L250HYEHRLIDDMV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L250WYQHRLIDDMV1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
L288QGYGSLGMMTS4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L288QGFGSLGLMTS2Arabidopsis thaliana, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L288QAYGSLGLMTS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M254RLIDDMVAQAM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
M254RLIDDMVAYAL1Arabidopsis thaliana
M254RLIDDMVAQMI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M254RLIDDMVAQAI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
M291GSLGMMTSVLV2Homo sapiens, Bos taurus
M291GSLGMMTSVLI2Mus musculus, Rattus norvegicus
M291GSLGLMTSVLV1Arabidopsis thaliana
M291GSLGLMTSILV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
M291GSLGLMTSVLI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N101NGTIRNILGGT5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N101NGTIRNILNGT2Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N328QETSTNPIASI3Homo sapiens, Mus musculus, Rattus norvegicus
N328GETSTNSIASI1Arabidopsis thaliana
N328QETLTNPIASI1Bos taurus
N328EETSTNSIASI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N328KKTSTNSIASI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N96MWKSPNGTIRN6Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N96MWRSPNGTIRN1Arabidopsis thaliana
P118ICKNIPRLVSG2Homo sapiens, Bos taurus
P118ICKNIPRLVTG2Mus musculus, Rattus norvegicus
P118ICKNVPKLVPG1Arabidopsis thaliana
P118VIPRIPRLVPR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
P118LIKNIPKYIPG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q257DDMVAQAMKSE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q257DDMVAYALKSE1Arabidopsis thaliana
Q257DDMVAQMIKSK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q257DDMVAQAIKSN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Q277YDGDVQSDSVA4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Q277YDGDVQSDFLA1Arabidopsis thaliana
Q277YDGDVQSDIVA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Q277YDGDVMSDVVA1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R100PNGTIRNILGG5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R100PNGTIRNILNG2Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R109GGTVFREAIIC4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R109NGTVFREPIIC1Arabidopsis thaliana
R109GGTVFREPIVI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R109NGTVFREPILI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R119CKNIPRLVSGW2Homo sapiens, Bos taurus
R119CKNIPRLVTGW2Mus musculus, Rattus norvegicus
R119CKNVPKLVPGW1Arabidopsis thaliana
R119IPRIPRLVPRW1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R119IKNIPKYIPGW1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R132PIIIGRHAYGD4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R132PICIGRHAFGD2Arabidopsis thaliana, Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R132PIIIGRHAHGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R314HGTVTRHYRMY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R314HGTVTRHFRVH1Arabidopsis thaliana
R314HGTVTRHYRKY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R314HGTVQRHYMQY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
R82TPDEKRVEEFK4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
R82TPDEGRVTEFG1Arabidopsis thaliana
R82TPDEARVKEFN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R82TPDEARVKEYN1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S278DGDVQSDSVAQ4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S278DGDVQSDFLAQ1Arabidopsis thaliana
S278DGDVQSDIVAQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S278DGDVMSDVVAQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S280DVQSDSVAQGY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S280DVQSDFLAQGF1Arabidopsis thaliana
S280DVQSDIVAQGF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S280DVMSDVVAQAY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S94KQMWKSPNGTI4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
S94KQMWRSPNGTI1Arabidopsis thaliana
S94HKMWKSPNGTI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S94KKMWKSPNGTI1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T214LSTKNTILKKY7Homo sapiens, Arabidopsis thaliana, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T311EAAHGTVTRHY5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T311EAAHGTVTRHF1Arabidopsis thaliana
T311EAAHGTVQRHY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T313AHGTVTRHYRM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T313AHGTVTRHFRV1Arabidopsis thaliana
T313AHGTVTRHYRK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T313AHGTVQRHYMQ1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T327GQETSTNPIAS3Homo sapiens, Mus musculus, Rattus norvegicus
T327GGETSTNSIAS1Arabidopsis thaliana
T327GQETLTNPIAS1Bos taurus
T327GEETSTNSIAS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T327GKKTSTNSIAS1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T75GVKCATITPDE4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T75GIKCATITPDE2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T75AIKCATITPDE1Arabidopsis thaliana
T77KCATITPDEKR4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
T77KCATITPDEAR2Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T77KCATITPDEGR1Arabidopsis thaliana
V281VQSDSVAQGYG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
V281VQSDFLAQGFG1Arabidopsis thaliana
V281VQSDIVAQGFG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V281VMSDVVAQAYG1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
V312AAHGTVTRHYR5Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V312AAHGTVTRHFR1Arabidopsis thaliana
V312AAHGTVQRHYM1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W124RLVSGWVKPII2Homo sapiens, Bos taurus
W124RLVTGWVKPII2Mus musculus, Rattus norvegicus
W124KLVPGWTKPIC1Arabidopsis thaliana
W124RLVPRWEKPII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W124KYIPGWTNPIC1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
W267EGGFIWACKNY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
W267EGGYVWACKNY1Arabidopsis thaliana
W267KGGFIMALKNY1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
W267NGGFVWACKNY1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y139AYGDQYRATDF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y139AFGDQYRATDA1Arabidopsis thaliana
Y139AHGDQYKATDT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y139AFGDQYKSTDL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)
Y285SVAQGYGSLGM4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
Y285FLAQGFGSLGL1Arabidopsis thaliana
Y285IVAQGFGSLGL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y285VVAQAYGSLGL1Schizosaccharomyces pombe (strain 972 / ATCC 24843)


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