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mutLBSgeneDB |
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| Gene summary for IFNB1 |
 Gene summary |
| Basic gene Info. | Gene symbol | IFNB1 |
| Gene name | interferon, beta 1, fibroblast | |
| Synonyms | IFB|IFF|IFNB | |
| Cytomap | UCSC genome browser: 9p21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002176.2, | |
| Description | IFN-betafibroblast interferoninterferon beta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 147640 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171855 | ||
| HPRD : 00972 | ||
| Vega : OTTHUMG00000019652 | ||
| Protein | UniProt: P01574 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IFNB1 | |
| BioGPS: 3456 | ||
| Pathway | NCI Pathway Interaction Database: IFNB1 | |
| KEGG: IFNB1 | ||
| REACTOME: IFNB1 | ||
| Pathway Commons: IFNB1 | ||
| Context | iHOP: IFNB1 | |
| ligand binding site mutation search in PubMed: IFNB1 | ||
| UCL Cancer Institute: IFNB1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0033141 | positive regulation of peptidyl-serine phosphorylation of STAT protein | 18035482 | GO:0035458 | cellular response to interferon-beta | 18035482 | GO:0043330 | response to exogenous dsRNA | 21266579 | GO:0045071 | negative regulation of viral genome replication | 19008854 | GO:0045581 | negative regulation of T cell differentiation | 20554961 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 18035482 | GO:0060337 | type I interferon signaling pathway | 18035482 | GO:2000552 | negative regulation of T-helper 2 cell cytokine production | 20554961 | GO:2001235 | positive regulation of apoptotic signaling pathway | 10918594 |
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| Ligand binding site mutations for IFNB1 |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | T103,N101 | E102K | LUAD | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for IFNB1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T103 | E102K | -0.80723756 | N101 | E102K | -0.80723756 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for IFNB1 from PDB |
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| Differential gene expression and gene-gene network for IFNB1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for IFNB1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0026769 | Multiple Sclerosis | 149 | Biomarker, GeneticVariation, Therapeutic |
| umls:C0025202 | Melanoma | 37 | AlteredExpression, Biomarker, GeneticVariation, Therapeutic |
| umls:C0019163 | Hepatitis B | 6 | Biomarker, Therapeutic |
| umls:C1458155 | Breast Neoplasms | 3 | Biomarker, Therapeutic |
| umls:C0006111 | Brain Diseases | 2 | Biomarker |
| umls:C0027819 | Neuroblastoma | 2 | Biomarker, Therapeutic |
| umls:C0003463 | Anus Neoplasms | 2 | Therapeutic |
| umls:C0206735 | Melanoma, Amelanotic | 1 | Therapeutic |
| umls:C0025205 | Melanoma, Experimental | 1 | Therapeutic |
| umls:C0036572 | Seizures | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for IFNB1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Experimental | DB02379 | Beta-D-Glucose | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of IFNB1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of IFNB1 |
| Multiple alignments for P01574 in multiple species |
| LBS | AA sequence | # species | Species | H114 | LANVYHQINHL | 1 | Homo sapiens | H114 | LDELHQQTVFL | 1 | Mus musculus | H114 | LDELHQQTELL | 1 | Rattus norvegicus | H118 | YHQINHLKTVL | 1 | Homo sapiens | H118 | HQQTVFLKTVL | 1 | Mus musculus | H118 | HQQTELLEIIL | 1 | Rattus norvegicus | N101 | SSTGWNETIVE | 2 | Homo sapiens, Rattus norvegicus | N101 | SSTGWNETIVV | 1 | Mus musculus | N107 | ETIVENLLANV | 1 | Homo sapiens | N107 | ETIVVRLLDEL | 1 | Mus musculus | N107 | ETIVESLLDEL | 1 | Rattus norvegicus | Q44 | QKLLWQLNGRL | 1 | Homo sapiens | Q44 | QELLEQLNGKI | 1 | Mus musculus | Q44 | QKLLRQLNGRL | 1 | Rattus norvegicus | T103 | TGWNETIVENL | 1 | Homo sapiens | T103 | TGWNETIVVRL | 1 | Mus musculus | T103 | TGWNETIVESL | 1 | Rattus norvegicus |
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