mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IGF1R
Gene summary
Basic gene Info.Gene symbolIGF1R
Gene nameinsulin-like growth factor 1 receptor
SynonymsCD221|IGFIR|IGFR|JTK13
CytomapUCSC genome browser: 15q26.3
Type of geneprotein-coding
RefGenesNM_000875.4,
NM_001291858.1,NM_152452.1,
DescriptionIGF-I receptorinsulin-like growth factor I receptorsoluble IGF1R variant 1soluble IGF1R variant 2
Modification date20141222
dbXrefs MIM : 147370
HGNC : HGNC
Ensembl : ENSG00000140443
HPRD : 00932
Vega : OTTHUMG00000149851
ProteinUniProt: P08069
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IGF1R
BioGPS: 3480
PathwayNCI Pathway Interaction Database: IGF1R
KEGG: IGF1R
REACTOME: IGF1R
Pathway Commons: IGF1R
ContextiHOP: IGF1R
ligand binding site mutation search in PubMed: IGF1R
UCL Cancer Institute: IGF1R
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0043066negative regulation of apoptotic process12556535
GO:0046328regulation of JNK cascade12556535
GO:0046777protein autophosphorylation11162456
GO:0048009insulin-like growth factor receptor signaling pathway7679099
GO:0048015phosphatidylinositol-mediated signaling7692086
GO:0051262protein tetramerization1846292
GO:0051389inactivation of MAPKK activity12556535


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Ligand binding site mutations for IGF1R
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
E1043R1042CCOAD2
L1005R1003QCOAD1
R252R252HCOAD1
D1146E1145KCOAD1
A1051A1051SLUAD1
G1273G1273VLUAD1
L1174L1174MLUAD1
I1151K1150RPRAD1
W1178R1177CSTAD1
D1146,M1142A1144VSTAD1
N314R313CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Clinical information for IGF1R from My Cancer Genome.
Insulin-like growth factor 1 receptor (IGF1R) is a gene that encodes a protein that is a receptor tyrosine kinase that binds insulin-like growth factor. Missense mutations, nonsense mutations, silent mutations, frameshift deletions, and in-frame deletions are observed in cancers such as intestinal cancer, skin cancer, and stomach cancer. Related Pathways: Receptor tyrosine kinase/growth factor signaling. Modified: December 4, 2015

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Protein structure related information for IGF1R
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
G1273G1273V0.055519291
A1051A1051S-1.5794326
D1146E1145K-1.2893333
N314R313C-1.0668374
W1178R1177C-1.0376943
R252R252H-1.0344911
L1174L1174M-0.9766805
E1043R1042C-0.67064151
I1151K1150R-0.60213809
L1005R1003Q-0.36710019
M1142A1144V-0.13158656
D1146A1144V-0.13158656
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IGF1R from PDB
PDB IDPDB titlePDB structure
1K3AStructure of the Insulin-like Growth Factor 1 Receptor Kinase

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Differential gene expression and gene-gene network for IGF1R
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IGF1R and the right PPI network was created from samples without mutations in the LBS of IGF1R. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IGF1R
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1458155Breast Neoplasms22AlteredExpression, Biomarker, GeneticVariation, PostTranslationalModification
umls:C2239176Carcinoma, Hepatocellular15Biomarker, GeneticVariation
umls:C1849157Insulin-Like Growth Factor I, Resistance To9Biomarker, GeneticVariation
umls:C0206686Adrenocortical Carcinoma4Biomarker
umls:C0030567Parkinson Disease2Biomarker
umls:C0002395Alzheimer Disease2Biomarker, GeneticVariation
umls:C0015934Fetal Growth Retardation2Biomarker, GeneticVariation
umls:C0235833Hernias, Diaphragmatic, Congenital2Biomarker
umls:C0024115Lung Diseases2Biomarker
umls:C0007621Cell Transformation, Neoplastic1Biomarker
umls:C0014170Endometrial Neoplasms1Biomarker
umls:C0018273Growth Disorders1Biomarker
umls:C0752347Lewy Body Disease1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C0035229Respiratory Insufficiency1Biomarker
umls:C0037286Skin Neoplasms1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IGF1R
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
Approved|investigationalDB00030Insulin HumanBiotech
ApprovedDB00046Insulin LisproBiotech
ApprovedDB00047Insulin GlargineBiotech
ApprovedDB00071Insulin PorkBiotech
Approved|investigationalDB01277MecaserminBiotech
ExperimentalDB04395Phosphoaminophosphonic Acid-Adenylate EsterSmall molecule
InvestigationalDB05023ATL1101Small molecule
InvestigationalDB05184XL228Small molecule
InvestigationalDB05759IMC-A12Biotech
InvestigationalDB05897rhIGFBP-3Small molecule
InvestigationalDB05900INSM-18Small molecule
ExperimentalDB07156(4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dioneSmall molecule
ExperimentalDB074743-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IGF1R go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0AA1051 I1151 L1174
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0BA1051 I1151 L1174
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0CA1051 I1151 L1174
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0DA1051 I1151 L1174
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0AD1146 G1273
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0BD1146 G1273
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0CD1146 G1273
CCX3-CYANO-1H-INDOLE-7-CARBOXYLIC ACID {1-[4-(5-CYANO-1H-INDOL-3-YL)-BUTYL]-PIPERIDIN-4-YL}-AMIDE3lw0DD1146 G1273
7413-CYANOQUINOLINE3f5pBL1005
PDR3-(4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-5,6-DIMETHOXY-1-METHYL-1H-PYRROLO[3,2-B]PYRIDINE3lvpBL1005
ANPAMP-PNP1jqhAL1005 M1142
ANPAMP-PNP1jqhBL1005 M1142
ANPAMP-PNP1jqhCL1005 M1142
575(4Z)-6-BROMO-4-({[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)ISOQUINOLINE-1,3(2H,4H)-DIONE2zm3AL1005 M1142
575(4Z)-6-BROMO-4-({[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)ISOQUINOLINE-1,3(2H,4H)-DIONE2zm3BL1005 M1142
575(4Z)-6-BROMO-4-({[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)ISOQUINOLINE-1,3(2H,4H)-DIONE2zm3CL1005 M1142
575(4Z)-6-BROMO-4-({[4-(PYRROLIDIN-1-YLMETHYL)PHENYL]AMINO}METHYLIDENE)ISOQUINOLINE-1,3(2H,4H)-DIONE2zm3DL1005 M1142
7413-CYANOQUINOLINE3f5pAL1005 M1142
7413-CYANOQUINOLINE3f5pCL1005 M1142
7413-CYANOQUINOLINE3f5pDL1005 M1142
7413-CYANOQUINOLINE3f5pEL1005 M1142
7413-CYANOQUINOLINE3f5pFL1005 M1142
7413-CYANOQUINOLINE3f5pGL1005 M1142
7413-CYANOQUINOLINE3f5pHL1005 M1142
7413-CYANOQUINOLINE3f5pIL1005 M1142
7413-CYANOQUINOLINE3f5pJL1005 M1142
7413-CYANOQUINOLINE3f5pKL1005 M1142
7413-CYANOQUINOLINE3f5pML1005 M1142
7413-CYANOQUINOLINE3f5pLL1005 M1142
7413-CYANOQUINOLINE3f5pRL1005 M1142
7413-CYANOQUINOLINE3f5pSL1005 M1142
7413-CYANOQUINOLINE3f5pTL1005 M1142
PDR3-(4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-5,6-DIMETHOXY-1-METHYL-1H-PYRROLO[3,2-B]PYRIDINE3lvpAL1005 M1142
PDR3-(4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-5,6-DIMETHOXY-1-METHYL-1H-PYRROLO[3,2-B]PYRIDINE3lvpCL1005 M1142
PDR3-(4-CHLORO-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)-5,6-DIMETHOXY-1-METHYL-1H-PYRROLO[3,2-B]PYRIDINE3lvpDL1005 M1142
DYKN-{2-METHOXY-4-[(1-METHYLPIPERIDIN-4-YL)OXY] PHENYL}-4-(1H-PYRROLO[2,3-C]PYRIDIN-3-YL) PYRIMIDIN-2-AMINE4d2rAL1005 M1142
MQY(5S)-5-METHYL-1-(QUINOLIN-4-YLMETHYL)-3-{4-[(TRIFLUOROMETHYL)SULFONYL]PHENYL}IMIDAZOLIDINE-2,4-DIONE3o23AM1142 I1151


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Conservation information for LBS of IGF1R
Multiple alignments for P08069 in multiple species
LBSAA sequence# speciesSpecies
A1031T--RVAIKTVN4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A1031RFGPCAIKINV1Caenorhabditis elegans
A1031R--ECAIKTVN1Drosophila melanogaster
A1051EFLNEASVMKE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A1051NYLMEANIMKN1Caenorhabditis elegans
A1051NFLSEASVMKE1Drosophila melanogaster
D1086LMTRGDLKSYL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D1086MMDLGNLRDYL1Caenorhabditis elegans
D1086LMKKGDLKSYL1Drosophila melanogaster
D1135KFVHRDLAARN5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D1135KFCHRDLAARN1Caenorhabditis elegans
D1146CMVAEDFTVKI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D1146CMINRDETVKI1Caenorhabditis elegans
D1146CMVADDLTVKI1Drosophila melanogaster
D1153TVKIGDFGMTR5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D1153TVKIGDFGMAR1Caenorhabditis elegans
D1159FGMTRDIYETD5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
D1159FGMARDLFYHD1Caenorhabditis elegans
D1186PESLKDGVFTT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D1186PESLKDGKFDS1Caenorhabditis elegans
D1186PESLRDGVYSS1Drosophila melanogaster
D162WSLILDAVSNN3Homo sapiens, Mus musculus, Rattus norvegicus
D162WKHLITSSIND1Caenorhabditis elegans
D162WLEILAENETQ1Drosophila melanogaster
D162-----------1Bos taurus
E1015FGMVYEGVAKG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E1015FGKVYLGTGNN1Caenorhabditis elegans
E1015FGMVYEGILKS1Drosophila melanogaster
E1043AASMRERIEFL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E1043DPASTENLNYL1Caenorhabditis elegans
E1043NATDRERTNFL1Drosophila melanogaster
E1050IEFLNEASVMK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E1050LNYLMEANIMK1Caenorhabditis elegans
E1050TNFLSEASVMK1Drosophila melanogaster
E1080TLVIMELMTRG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E1080AMVVMEMMDLG1Caenorhabditis elegans
E1080ALVVMELMKKG1Drosophila melanogaster
E1118IQMAGEIADGM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
E1118HEWAAQICDGM1Caenorhabditis elegans
E1118YQMAIEIADGM1Drosophila melanogaster
E1271KDEM-EPSFQE2Mus musculus, Rattus norvegicus
E1271KEEM-EPGFRE1Homo sapiens
E1271AAEA-SPEFRD1Caenorhabditis elegans
E1271EPQCPNSQFKE1Drosophila melanogaster
E1271KDEM-EAGFRE1Bos taurus
F1010LGQGSFGMVYE5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
F1010CGEGSFGKVYL1Caenorhabditis elegans
F1047RERIEFLNEAS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F1047TENLNYLMEAN1Caenorhabditis elegans
F1047RERTNFLSEAS1Drosophila melanogaster
F1057SVMKEFNCHHV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F1057NIMKNFKTNFI1Caenorhabditis elegans
F1057SVMKEFDTYHV1Drosophila melanogaster
F1131LNANKFVHRDL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F1131LESLKFCHRDL1Caenorhabditis elegans
F1131LAAKKFVHRDL1Drosophila melanogaster
F1147MVAEDFTVKIG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
F1147MINRDETVKIG1Caenorhabditis elegans
F1147MVADDLTVKIG1Drosophila melanogaster
F1154VKIGDFGMTRD5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
F1154VKIGDFGMARD1Caenorhabditis elegans
F1189LKDGVFTTHSD3Mus musculus, Rattus norvegicus, Bos taurus
F1189LKDGVFTTYSD1Homo sapiens
F1189LKDGKFDSKSD1Caenorhabditis elegans
F1189LRDGVYSSASD1Drosophila melanogaster
G1006MSRELGQGSFG2Homo sapiens, Bos taurus
G1006MNRELGQGSFG2Mus musculus, Rattus norvegicus
G1006LGQQCGEGSFG1Caenorhabditis elegans
G1006QLAPLGQGSFG1Drosophila melanogaster
G1008RELGQGSFGMV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G1008QQCGEGSFGKV1Caenorhabditis elegans
G1008APLGQGSFGMV1Drosophila melanogaster
G1085ELMTRGDLKSY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G1085EMMDLGNLRDY1Caenorhabditis elegans
G1085ELMKKGDLKSY1Drosophila melanogaster
G1152FTVKIGDFGMT4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G1152ETVKIGDFGMA1Caenorhabditis elegans
G1152LTVKIGDFGMT1Drosophila melanogaster
G1155KIGDFGMTRDI5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
G1155KIGDFGMARDL1Caenorhabditis elegans
G1170YYRKGGKGLLP4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G1170YYKPSGKRMMP1Caenorhabditis elegans
G1170YYRKGTKGLLP1Drosophila melanogaster
G1172RKGGKGLLPVR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
G1172KPSGKRMMPVR1Caenorhabditis elegans
G1172RKGTKGLLPVR1Drosophila melanogaster
G1187ESLKDGVFTTH3Mus musculus, Rattus norvegicus, Bos taurus
G1187ESLKDGVFTTY1Homo sapiens
G1187ESLKDGKFDSK1Caenorhabditis elegans
G1187ESLRDGVYSSA1Drosophila melanogaster
G1273EM-EPSFQEVS2Mus musculus, Rattus norvegicus
G1273EM-EPGFREVS1Homo sapiens
G1273EA-SPEFRDLS1Caenorhabditis elegans
G1273QCPNSQFKEVS1Drosophila melanogaster
G1273EM-EAGFREVS1Bos taurus
G315GFIRNSTQSMY2Mus musculus, Rattus norvegicus
G315GFIRNGSQSMY1Homo sapiens
G315GYQINPDDHRE1Caenorhabditis elegans
G315GYQK-SENKRM1Drosophila melanogaster
G315-----------1Bos taurus
H1133ANKFVHRDLAA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H1133SLKFCHRDLAA1Caenorhabditis elegans
H1133AKKFVHRDLAA1Drosophila melanogaster
H253CVACRHYYYKG2Mus musculus, Rattus norvegicus
H253CVACRHYYYAG1Homo sapiens
H253CHACKNVYHKG1Caenorhabditis elegans
H253CISCRNVSFNN1Drosophila melanogaster
H253-----------1Bos taurus
I1032--RVAIKTVNE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I1032FGPCAIKINVD1Caenorhabditis elegans
I1032--ECAIKTVNE1Drosophila melanogaster
I1151DFTVKIGDFGM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
I1151DETVKIGDFGM1Caenorhabditis elegans
I1151DLTVKIGDFGM1Drosophila melanogaster
I1160GMTRDIYETDY5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
I1160GMARDLFYHDY1Caenorhabditis elegans
I160IDWSLILDAVS2Mus musculus, Rattus norvegicus
I160VDWSLILDAVS1Homo sapiens
I160IDWKHLITSSI1Caenorhabditis elegans
I160IDWLEILAENE1Drosophila melanogaster
I160-----------1Bos taurus
K1033-RVAIKTVNEA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K1033GPCAIKINVDD1Caenorhabditis elegans
K1033-ECAIKTVNEN1Drosophila melanogaster
K1111PPSLSKMIQMA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K1111PR--DKFHEWA1Caenorhabditis elegans
K1111PPTYGRIYQMA1Drosophila melanogaster
K1168TDYYRKGGKGL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K1168HDYYKPSGKRM1Caenorhabditis elegans
K1168TDYYRKGTKGL1Drosophila melanogaster
K1171YRKGGKGLLPV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
K1171YKPSGKRMMPV1Caenorhabditis elegans
K1171YRKGTKGLLPV1Drosophila melanogaster
L1005TMSRELGQGSF2Homo sapiens, Bos taurus
L1005TMNRELGQGSF2Mus musculus, Rattus norvegicus
L1005VLGQQCGEGSF1Caenorhabditis elegans
L1005IQLAPLGQGSF1Drosophila melanogaster
L1081LVIMELMTRGD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L1081MVVMEMMDLGN1Caenorhabditis elegans
L1081LVVMELMKKGD1Drosophila melanogaster
L1126DGMAYLNANKF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L1126DGMAYLESLKF1Caenorhabditis elegans
L1126DGMAYLAAKKF1Drosophila melanogaster
L1173KGGKGLLPVRW4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L1173PSGKRMMPVRW1Caenorhabditis elegans
L1173KGTKGLLPVRW1Drosophila melanogaster
L1174GGKGLLPVRWM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L1174SGKRMMPVRWM1Caenorhabditis elegans
L1174GTKGLLPVRWM1Drosophila melanogaster
L1184MSPESLKDGVF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
L1184MSPESLKDGKF1Caenorhabditis elegans
L1184MPPESLRDGVY1Drosophila melanogaster
L159TIDWSLILDAV2Mus musculus, Rattus norvegicus
L159TVDWSLILDAV1Homo sapiens
L159TIDWKHLITSS1Caenorhabditis elegans
L159TIDWLEILAEN1Drosophila melanogaster
L159-----------1Bos taurus
L161DWSLILDAVSN3Homo sapiens, Mus musculus, Rattus norvegicus
L161DWKHLITSSIN1Caenorhabditis elegans
L161DWLEILAENET1Drosophila melanogaster
L161-----------1Bos taurus
L236CHPECLGSCH-2Mus musculus, Rattus norvegicus
L236CHPECLGSCS-1Homo sapiens
L236CHDQCVGGCE-1Caenorhabditis elegans
L236CSQDCLGGCVI1Drosophila melanogaster
L236-----------1Bos taurus
M1054NEASVMKEFNC4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M1054MEANIMKNFKT1Caenorhabditis elegans
M1054SEASVMKEFDT1Drosophila melanogaster
M1079PTLVIMELMTR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M1079PAMVVMEMMDL1Caenorhabditis elegans
M1079PALVVMELMKK1Drosophila melanogaster
M1082VIMELMTRGDL4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M1082VVMEMMDLGNL1Caenorhabditis elegans
M1082VVMELMKKGDL1Drosophila melanogaster
M1115SKMIQMAGEIA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M1115DKFHEWAAQIC1Caenorhabditis elegans
M1115GRIYQMAIEIA1Drosophila melanogaster
M1142AARNCMVAEDF4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
M1142AARNCMINRDE1Caenorhabditis elegans
M1142AARNCMVADDL1Drosophila melanogaster
M1156IGDFGMTRDIY5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
M1156IGDFGMARDLF1Caenorhabditis elegans
N1140DLAARNCMVAE4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N1140DLAARNCMINR1Caenorhabditis elegans
N1140DLAARNCMVAD1Drosophila melanogaster
N1218YQGLSNEQVLR5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
N1218YIGLSNDEVLN1Caenorhabditis elegans
N135LYNLRNITRGA3Homo sapiens, Mus musculus, Rattus norvegicus
N135LDKLSVIRNGG1Caenorhabditis elegans
N135LHKLRSITRGG1Drosophila melanogaster
N135-----------1Bos taurus
N314SGFIRNSTQSM2Mus musculus, Rattus norvegicus
N314SGFIRNGSQSM1Homo sapiens
N314DGYQINPDDHR1Caenorhabditis elegans
N314TGYQK-SENKR1Drosophila melanogaster
N314-----------1Bos taurus
P1175GKGLLPVRWMS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
P1175GKRMMPVRWMS1Caenorhabditis elegans
P1175TKGLLPVRWMP1Drosophila melanogaster
P1272DEM-EPSFQEV2Mus musculus, Rattus norvegicus
P1272EEM-EPGFREV1Homo sapiens
P1272AEA-SPEFRDL1Caenorhabditis elegans
P1272PQCPNSQFKEV1Drosophila melanogaster
P1272DEM-EAGFREV1Bos taurus
Q1007SRELGQGSFGM2Homo sapiens, Bos taurus
Q1007NRELGQGSFGM2Mus musculus, Rattus norvegicus
Q1007GQQCGEGSFGK1Caenorhabditis elegans
Q1007LAPLGQGSFGM1Drosophila melanogaster
Q1114LSKMIQMAGEI4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Q1114-DKFHEWAAQI1Caenorhabditis elegans
Q1114YGRIYQMAIEI1Drosophila melanogaster
R1084MELMTRGDLKS4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R1084MEMMDLGNLRD1Caenorhabditis elegans
R1084MELMKKGDLKS1Drosophila melanogaster
R1134NKFVHRDLAAR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
R1134LKFCHRDLAAR1Caenorhabditis elegans
R1134KKFVHRDLAAR1Drosophila melanogaster
R1139RDLAARNCMVA5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
R1139RDLAARNCMIN1Caenorhabditis elegans
R1158DFGMTRDIYET5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
R1158DFGMARDLFYH1Caenorhabditis elegans
R252TCVACRHYYYK2Mus musculus, Rattus norvegicus
R252ACVACRHYYYA1Homo sapiens
R252ACHACKNVYHK1Caenorhabditis elegans
R252SCISCRNVSFN1Drosophila melanogaster
R252-----------1Bos taurus
S1009ELGQGSFGMVY4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S1009QCGEGSFGKVY1Caenorhabditis elegans
S1009PLGQGSFGMVY1Drosophila melanogaster
S1183WMSPESLKDGV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
S1183WMSPESLKDGK1Caenorhabditis elegans
S1183WMPPESLRDGV1Drosophila melanogaster
S158STIDWSLILDA2Mus musculus, Rattus norvegicus
S158STVDWSLILDA1Homo sapiens
S158KTIDWKHLITS1Caenorhabditis elegans
S158RTIDWLEILAE1Drosophila melanogaster
S158-----------1Bos taurus
T1083IMELMTRGDLK4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T1083VMEMMDLGNLR1Caenorhabditis elegans
T1083VMELMKKGDLK1Drosophila melanogaster
T1148VAEDFTVKIGD4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
T1148INRDETVKIGD1Caenorhabditis elegans
T1148VADDLTVKIGD1Drosophila melanogaster
T1157GDFGMTRDIYE5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
T1157GDFGMARDLFY1Caenorhabditis elegans
T137NLRNITRGAIR3Homo sapiens, Mus musculus, Rattus norvegicus
T137KLSVIRNGGVR1Caenorhabditis elegans
T137KLRSITRGGVR1Drosophila melanogaster
T137-----------1Bos taurus
V1013GSFGMVYEGVA4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V1013GSFGKVYLGTG1Caenorhabditis elegans
V1013GSFGMVYEGIL1Drosophila melanogaster
V1062FNCHHVVRLLG4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V1062FKTNFIVKLYG1Caenorhabditis elegans
V1062FDTYHVVRLLG1Drosophila melanogaster
V1063NCHHVVRLLGV4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V1063KTNFIVKLYGV1Caenorhabditis elegans
V1063DTYHVVRLLGV1Drosophila melanogaster
V1077GQPTLVIMELM4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
V1077VQPAMVVMEMM1Caenorhabditis elegans
V1077GQPALVVMELM1Drosophila melanogaster
W1178LLPVRWMSPES4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
W1178MMPVRWMSPES1Caenorhabditis elegans
W1178LLPVRWMPPES1Drosophila melanogaster
Y1090GDLKSYLRSLR4Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
Y1090GNLRDYLRSKR1Caenorhabditis elegans
Y1090GDLKSYLRAHR1Drosophila melanogaster
Y1161MTRDIYETDYY5Homo sapiens, Drosophila melanogaster, Mus musculus, Rattus norvegicus, Bos taurus
Y1161MARDLFYHDYY1Caenorhabditis elegans
Y320STQSMYCIPCE2Mus musculus, Rattus norvegicus
Y320GSQSMYCIPCE1Homo sapiens
Y320PDDHRECRKCV1Caenorhabditis elegans
Y320SENKRMCEPCP1Drosophila melanogaster
Y320-----------1Bos taurus


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