mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IGFBP1
Gene summary
Basic gene Info.Gene symbolIGFBP1
Gene nameinsulin-like growth factor binding protein 1
CytomapUCSC genome browser: 7p12.3
Type of geneprotein-coding
DescriptionIBP-1IGF-binding protein 1IGFBP-1alpha-pregnancy-associated endometrial globulinamniotic fluid binding proteinbinding protein-25binding protein-26binding protein-28growth hormone independent-binding proteininsulin-like growth factor-binding prote
Modification date20141222
dbXrefs MIM : 146730
Ensembl : ENSG00000146678
HPRD : 00897
Vega : OTTHUMG00000152343
ProteinUniProt: P08833
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IGFBP1
BioGPS: 3484
PathwayNCI Pathway Interaction Database: IGFBP1
Pathway Commons: IGFBP1
ContextiHOP: IGFBP1
ligand binding site mutation search in PubMed: IGFBP1
UCL Cancer Institute: IGFBP1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

Ligand binding site mutations for IGFBP1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for IGFBP1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IGFBP1 from PDB
PDB IDPDB titlePDB structure
1ZT3C-terminal domain of Insulin-like Growth Factor Binding Protein-1 isolated from human amniotic fluid

Differential gene expression and gene-gene network for IGFBP1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IGFBP1 and the right PPI network was created from samples without mutations in the LBS of IGFBP1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for IGFBP1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0014175Endometriosis7AlteredExpression, Biomarker
umls:C0017661Glomerulonephritis, IGA2Biomarker
umls:C0000786Abortion, Spontaneous1Biomarker
umls:C2609414Acute Kidney Injury1Therapeutic
umls:C0009375Colonic Neoplasms1Biomarker
umls:C3658338Drug-Related Side Effects and Adverse Reactions1Biomarker
umls:C0023892Liver Cirrhosis, Biliary1Biomarker
umls:C0023893Liver Cirrhosis, Experimental1Biomarker
umls:C0032927Precancerous Conditions1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for IGFBP1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IGFBP1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of IGFBP1
Multiple alignments for P08833 in multiple species
LBSAA sequence# speciesSpecies
C206FYLPNCNKNGF4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
C217YHSKQCETSLD2Mus musculus, Rattus norvegicus
C217YHSRQCETSMD1Homo sapiens
C217YHSKQCETSLE1Bos taurus
E224TSLDGEAGLCW2Mus musculus, Rattus norvegicus
E224TSMDGEAGLCW1Homo sapiens
E224TSLEGEPGLCW1Bos taurus
F201DEIYKFYLPNC2Mus musculus, Rattus norvegicus
F201EEISKFYLPNC1Homo sapiens
F201DKLYKFYLPNC1Bos taurus
G210NCNKNGFYHSK3Bos taurus, Mus musculus, Rattus norvegicus
G210NCNKNGFYHSR1Homo sapiens
H213KNGFYHSKQCE3Bos taurus, Mus musculus, Rattus norvegicus
H213KNGFYHSRQCE1Homo sapiens
K208LPNCNKNGFYH4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
L180PCQRELYKVLE2Mus musculus, Rattus norvegicus
L180PCRIELYRVVE1Homo sapiens
L180PCQRELYKVLD1Bos taurus
L203IYKFYLPNCNK2Mus musculus, Rattus norvegicus
L203ISKFYLPNCNK1Homo sapiens
L203LYKFYLPNCNK1Bos taurus
N205KFYLPNCNKNG4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
N207YLPNCNKNGFY4Homo sapiens, Bos taurus, Mus musculus, Rattus norvegicus
P204YKFYLPNCNKN3Bos taurus, Mus musculus, Rattus norvegicus
P204SKFYLPNCNKN1Homo sapiens
R177WKEPCQRELYK3Bos taurus, Mus musculus, Rattus norvegicus
R177WKEPCRIELYR1Homo sapiens
R215GFYHSKQCETS3Bos taurus, Mus musculus, Rattus norvegicus
R215GFYHSRQCETS1Homo sapiens
S214NGFYHSKQCET3Bos taurus, Mus musculus, Rattus norvegicus
S214NGFYHSRQCET1Homo sapiens
Y181CQRELYKVLER2Mus musculus, Rattus norvegicus
Y181CRIELYRVVES1Homo sapiens
Y181CQRELYKVLDR1Bos taurus

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