mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KLK3
Gene summary
Basic gene Info.Gene symbolKLK3
Gene namekallikrein-related peptidase 3
SynonymsAPS|KLK2A1|PSA|hK3
CytomapUCSC genome browser: 19q13.41
Type of geneprotein-coding
RefGenesNM_001030047.1,
NM_001030048.1,NM_001648.2,NM_001030049.1,NM_001030050.1,
DescriptionP-30 antigengamma-seminoproteinkallikrein-3prostate specific antigenprostate-specific antigensemenogelaseseminin
Modification date20141212
dbXrefs MIM : 176820
HGNC : HGNC
Ensembl : ENSG00000142515
HPRD : 01461
Vega : OTTHUMG00000182867
ProteinUniProt: P07288
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KLK3
BioGPS: 354
PathwayNCI Pathway Interaction Database: KLK3
KEGG: KLK3
REACTOME: KLK3
Pathway Commons: KLK3
ContextiHOP: KLK3
ligand binding site mutation search in PubMed: KLK3
UCL Cancer Institute: KLK3
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for KLK3
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
C209C209YBRCA1
Y101D102EPRAD1
G230G230DUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for KLK3
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
C209C209Y-1.1151022
G230G230D-0.90017262
Y101D102E-0.45810534
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KLK3 from PDB

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Differential gene expression and gene-gene network for KLK3
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KLK3 and the right PPI network was created from samples without mutations in the LBS of KLK3. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for KLK3
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0033578Prostatic Neoplasms72AlteredExpression, Biomarker, GeneticVariation
umls:C2937421Prostatic Hyperplasia5Biomarker, GeneticVariation
umls:C0242656Disease Progression1Biomarker
umls:C0027643Neoplasm Recurrence, Local1Biomarker
umls:C1334615Phyllodes Tumor of the Prostate1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for KLK3
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KLK3 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of KLK3
Multiple alignments for P07288 in multiple species
LBSAA sequence# speciesSpecies
C209GGKDTCKGDSG5Mus musculus, Mus musculus, Mus musculus, Mus musculus, Mus musculus
C209GGKDTCAGDSG4Mus musculus, Mus musculus, Mus musculus, Mus musculus
C209GGKSTCSGDSG2Homo sapiens, Macaca mulatta
C209GGSYTCEHDSG1Mus musculus
C209GGKDTCMGDSG1Mus musculus
C209EDKGPCVGDSG1Mus musculus
C209GGKNICKGDSG1Mus musculus
C209GGKGTCKGDSG1Mus musculus
E232TSWGPSPCGKP2Mus musculus, Mus musculus
E232TSWGSIPCAKP2Mus musculus, Mus musculus
E232TSWGSEPCALP1Homo sapiens
E232TSWGSQPCALP1Macaca mulatta
E232TSWGHTPCGEP1Mus musculus
E232TSWGYNPCGEP1Mus musculus
E232TSWGFTPCGEP1Mus musculus
E232TSWGPEPCGEP1Mus musculus
E232VSIGPDPCGIP1Mus musculus
E232TSTGPIPCGKP1Mus musculus
E232TSNGPEPCGKP1Mus musculus
E232TSWGSTPCGEP1Mus musculus
E232TAWGPIPCGKP1Mus musculus
E232TSWGPVPCGKP1Mus musculus
F110LLNEHTPQPED3Mus musculus, Mus musculus, Mus musculus
F110LLKNRFLRPGD1Homo sapiens
F110LLKNRYLGPGD1Macaca mulatta
F110LMRKHIRFLEY1Mus musculus
F110LHRNRIQNPQD1Mus musculus
F110LHRNHIRHPEY1Mus musculus
F110LLTFEKLPPGA1Mus musculus
F110LLTLKEIPPGA1Mus musculus
F110LLMLQTTPPGA1Mus musculus
F110LL--QSVPTGA1Mus musculus
F110LLIIHNPEPED1Mus musculus
F110LLNDHIPHPED1Mus musculus
F110LMNDHTPHPED1Mus musculus
F110LLNDDIPQPKD1Mus musculus
G211KDTCKGDSGGP5Mus musculus, Mus musculus, Mus musculus, Mus musculus, Mus musculus
G211KDTCAGDSGGP4Mus musculus, Mus musculus, Mus musculus, Mus musculus
G211KSTCSGDSGGP2Homo sapiens, Macaca mulatta
G211SYTCEHDSGGP1Mus musculus
G211KDTCMGDSGGP1Mus musculus
G211KGPCVGDSGGP1Mus musculus
G211KNICKGDSGGP1Mus musculus
G211KGTCKGDSGGP1Mus musculus
G230GITSWGPSPCG2Mus musculus, Mus musculus
G230GITSWGSIPCA2Mus musculus, Mus musculus
G230GITSWGSEPCA1Homo sapiens
G230GITSWGSQPCA1Macaca mulatta
G230GITSWGHTPCG1Mus musculus
G230GLTSWGYNPCG1Mus musculus
G230GITSWGFTPCG1Mus musculus
G230GITSWGPEPCG1Mus musculus
G230GTVSIGPDPCG1Mus musculus
G230GITSTGPIPCG1Mus musculus
G230GTTSNGPEPCG1Mus musculus
G230GITSWGSTPCG1Mus musculus
G230GITAWGPIPCG1Mus musculus
G230GITSWGPVPCG1Mus musculus
H188DCAKAHIEKVT2Mus musculus, Mus musculus
H188VCAQVHPQKVT1Homo sapiens
H188VCAQVHSQKVT1Macaca mulatta
H188DCDKAYVQKVT1Mus musculus
H188DCGKAHIEKVT1Mus musculus
H188DCDKAHEMKVT1Mus musculus
H188DCVKAHIEKVT1Mus musculus
H188NCAKAYLLKVT1Mus musculus
H188NCIENHNVKVT1Mus musculus
H188NCAKVYLQKVT1Mus musculus
H188VCVKAHILKVT1Mus musculus
H188VCVKNHNQKVT1Mus musculus
H188NCAKAYVHKVT1Mus musculus
H188NCAKAYIHKVT1Mus musculus
H188NCTKPYLHKVT1Mus musculus
H65VLTAAHCYVD-3Mus musculus, Mus musculus, Mus musculus
H65VLTAAHCYYE-2Mus musculus, Mus musculus
H65VLTAAHCHND-2Mus musculus, Mus musculus
H65VLTAAHCIRN-1Homo sapiens
H65VLTAAHCIRS-1Macaca mulatta
H65VLTAAHCYDD-1Mus musculus
H65VLTAAHCYND-1Mus musculus
H65VLTAAHCYED-1Mus musculus
H65VLTAAHCHVS-1Mus musculus
H65VLTAAHCYGND1Mus musculus
H65VLTAAHCYGN-1Mus musculus
H65VLTAAHCYGNA1Mus musculus
K107NMSLLNEHTPQ3Mus musculus, Mus musculus, Mus musculus
K107DMSLLKNRFLR1Homo sapiens
K107NMSLLKNRYLG1Macaca mulatta
K107NMSLMRKHIRF1Mus musculus
K107NMSLHRNRIQN1Mus musculus
K107NRSLHRNHIRH1Mus musculus
K107NMTLLTFEKLP1Mus musculus
K107NMSLLTLKEIP1Mus musculus
K107NMSLLMLQTTP1Mus musculus
K107NMSLL--QSVP1Mus musculus
K107NMSLLIIHNPE1Mus musculus
K107NMSLLNDHIPH1Mus musculus
K107NMSLMNDHTPH1Mus musculus
K107NMSLLNDDIPQ1Mus musculus
L111LNEHTPQPEDD3Mus musculus, Mus musculus, Mus musculus
L111LKNRFLRPGDD1Homo sapiens
L111LKNRYLGPGDD1Macaca mulatta
L111MRKHIRFLEYD1Mus musculus
L111HRNRIQNPQDD1Mus musculus
L111HRNHIRHPEYD1Mus musculus
L111LTFEKLPPGAD1Mus musculus
L111LTLKEIPPGAD1Mus musculus
L111LMLQTTPPGAD1Mus musculus
L111L--QSVPTGAD1Mus musculus
L111LIIHNPEPEDD1Mus musculus
L111LNDHIPHPEDK1Mus musculus
L111MNDHTPHPEDD1Mus musculus
L111LNDDIPQPKDK1Mus musculus
N108MSLLNEHTPQP3Mus musculus, Mus musculus, Mus musculus
N108MSLLKNRFLRP1Homo sapiens
N108MSLLKNRYLGP1Macaca mulatta
N108MSLMRKHIRFL1Mus musculus
N108MSLHRNRIQNP1Mus musculus
N108RSLHRNHIRHP1Mus musculus
N108MTLLTFEKLPP1Mus musculus
N108MSLLTLKEIPP1Mus musculus
N108MSLLMLQTTPP1Mus musculus
N108MSLL--QSVPT1Mus musculus
N108MSLLIIHNPEP1Mus musculus
N108MSLLNDHIPHP1Mus musculus
N108MSLMNDHTPHP1Mus musculus
N108MSLLNDDIPQP1Mus musculus
P189CAKAHIEKVTD2Mus musculus, Mus musculus
P189CAQVHPQKVTK1Homo sapiens
P189CAQVHSQKVTK1Macaca mulatta
P189CDKAYVQKVTD1Mus musculus
P189CGKAHIEKVTD1Mus musculus
P189CDKAHEMKVTD1Mus musculus
P189CVKAHIEKVTD1Mus musculus
P189CAKAYLLKVTD1Mus musculus
P189CIENHNVKVTD1Mus musculus
P189CAKVYLQKVTD1Mus musculus
P189CVKAHILKVTD1Mus musculus
P189CVKNHNQKVTD1Mus musculus
P189CAKAYVHKVTD1Mus musculus
P189CAKAYIHKVTD1Mus musculus
P189CTKPYLHKVTD1Mus musculus
Q186NEDCAKAHIEK2Mus musculus, Mus musculus
Q186NDVCAQVHPQK1Homo sapiens
Q186NDVCAQVHSQK1Macaca mulatta
Q186NEDCDKAYVQK1Mus musculus
Q186NEDCGKAHIEK1Mus musculus
Q186NEDCDKAHEMK1Mus musculus
Q186NEDCVKAHIEK1Mus musculus
Q186NENCAKAYLLK1Mus musculus
Q186IKNCIENHNVK1Mus musculus
Q186NENCAKVYLQK1Mus musculus
Q186NEVCVKAHILK1Mus musculus
Q186NEVCVKNHNQK1Mus musculus
Q186NENCAKAYVHK1Mus musculus
Q186NENCAKAYIHK1Mus musculus
Q186NENCTKPYLHK1Mus musculus
Q190AQVHPQKVTKF1Homo sapiens
Q190AQVHSQKVTKF1Macaca mulatta
Q190AKAHIEKVTDA1Mus musculus
Q190DKAYVQKVTDV1Mus musculus
Q190GKAHIEKVTDV1Mus musculus
Q190DKAHEMKVTDA1Mus musculus
Q190AKAHIEKVTDD1Mus musculus
Q190VKAHIEKVTDV1Mus musculus
Q190AKAYLLKVTDV1Mus musculus
Q190IENHNVKVTDV1Mus musculus
Q190AKVYLQKVTDV1Mus musculus
Q190VKAHILKVTDV1Mus musculus
Q190VKNHNQKVTDV1Mus musculus
Q190AKAYVHKVTDV1Mus musculus
Q190AKAYIHKVTDV1Mus musculus
Q190TKPYLHKVTDV1Mus musculus
R239CGEPKKPGVYT2Mus musculus, Mus musculus
R239CGKPNVPGIYT2Mus musculus, Mus musculus
R239CALPERPSLYT1Homo sapiens
R239CALPRRPSLYT1Macaca mulatta
R239CGEPDMPGVYT1Mus musculus
R239CGEPTEPSVYT1Mus musculus
R239CGIPGVSAIYT1Mus musculus
R239CGKPGVPAMYT1Mus musculus
R239CGKPGVPAIYT1Mus musculus
R239CGEPNAPAIYT1Mus musculus
R239CGKPNTPGVYT1Mus musculus
R239CAKPNAPGVFT1Mus musculus
R239CAKPNAPAIYT1Mus musculus
R239CGKPNAPAIYT1Mus musculus
S210GKDTCKGDSGG5Mus musculus, Mus musculus, Mus musculus, Mus musculus, Mus musculus
S210GKDTCAGDSGG4Mus musculus, Mus musculus, Mus musculus, Mus musculus
S210GKSTCSGDSGG2Homo sapiens, Macaca mulatta
S210GSYTCEHDSGG1Mus musculus
S210GKDTCMGDSGG1Mus musculus
S210DKGPCVGDSGG1Mus musculus
S210GKNICKGDSGG1Mus musculus
S210GKGTCKGDSGG1Mus musculus
S213TCKGDSGGPLI6Mus musculus, Mus musculus, Mus musculus, Mus musculus, Mus musculus, Mus musculus
S213TCAGDSGGPLI4Mus musculus, Mus musculus, Mus musculus, Mus musculus
S213TCSGDSGGPLV2Homo sapiens, Macaca mulatta
S213TCEHDSGGPLI1Mus musculus
S213TCMGDSGGPLI1Mus musculus
S213PCVGDSGGPLI1Mus musculus
S213ICKGDSGGPLI1Mus musculus
S228LQGITSWGSEP1Homo sapiens
S228LQGITSWGSQP1Macaca mulatta
S228LQGITSWGHTP1Mus musculus
S228LQGLTSWGYNP1Mus musculus
S228LQGITSWGFTP1Mus musculus
S228LQGITSWGPEP1Mus musculus
S228LQGITSWGPSP1Mus musculus
S228LHGITSWGPSP1Mus musculus
S228LQGTVSIGPDP1Mus musculus
S228LQGITSTGPIP1Mus musculus
S228LQGTTSNGPEP1Mus musculus
S228LQGITSWGSTP1Mus musculus
S228LHGITAWGPIP1Mus musculus
S228LHGITSWGSIP1Mus musculus
S228LQGITSWGSIP1Mus musculus
S228LHGITSWGPVP1Mus musculus
S231ITSWGPSPCGK2Mus musculus, Mus musculus
S231ITSWGSIPCAK2Mus musculus, Mus musculus
S231ITSWGSEPCAL1Homo sapiens
S231ITSWGSQPCAL1Macaca mulatta
S231ITSWGHTPCGE1Mus musculus
S231LTSWGYNPCGE1Mus musculus
S231ITSWGFTPCGE1Mus musculus
S231ITSWGPEPCGE1Mus musculus
S231TVSIGPDPCGI1Mus musculus
S231ITSTGPIPCGK1Mus musculus
S231TTSNGPEPCGK1Mus musculus
S231ITSWGSTPCGE1Mus musculus
S231ITAWGPIPCGK1Mus musculus
S231ITSWGPVPCGK1Mus musculus
T208GGGKDTCAGDS3Mus musculus, Mus musculus, Mus musculus
T208DGGKDTCKGDS2Mus musculus, Mus musculus
T208GGGKDTCKGDS2Mus musculus, Mus musculus
T208TGGKSTCSGDS1Homo sapiens
T208MGGKSTCSGDS1Macaca mulatta
T208DGGSYTCEHDS1Mus musculus
T208DGGKDTCAGDS1Mus musculus
T208DGGKDTCMGDS1Mus musculus
T208GEDKGPCVGDS1Mus musculus
T208SGGKNICKGDS1Mus musculus
T208NGGKDTCKGDS1Mus musculus
T208GGGKGTCKGDS1Mus musculus
V187EDCAKAHIEKV2Mus musculus, Mus musculus
V187DVCAQVHPQKV1Homo sapiens
V187DVCAQVHSQKV1Macaca mulatta
V187EDCDKAYVQKV1Mus musculus
V187EDCGKAHIEKV1Mus musculus
V187EDCDKAHEMKV1Mus musculus
V187EDCVKAHIEKV1Mus musculus
V187ENCAKAYLLKV1Mus musculus
V187KNCIENHNVKV1Mus musculus
V187ENCAKVYLQKV1Mus musculus
V187EVCVKAHILKV1Mus musculus
V187EVCVKNHNQKV1Mus musculus
V187ENCAKAYVHKV1Mus musculus
V187ENCAKAYIHKV1Mus musculus
V187ENCTKPYLHKV1Mus musculus
W229QGITSWGSEPC1Homo sapiens
W229QGITSWGSQPC1Macaca mulatta
W229QGITSWGHTPC1Mus musculus
W229QGLTSWGYNPC1Mus musculus
W229QGITSWGFTPC1Mus musculus
W229QGITSWGPEPC1Mus musculus
W229QGITSWGPSPC1Mus musculus
W229HGITSWGPSPC1Mus musculus
W229QGTVSIGPDPC1Mus musculus
W229QGITSTGPIPC1Mus musculus
W229QGTTSNGPEPC1Mus musculus
W229QGITSWGSTPC1Mus musculus
W229HGITAWGPIPC1Mus musculus
W229HGITSWGSIPC1Mus musculus
W229QGITSWGSIPC1Mus musculus
W229HGITSWGPVPC1Mus musculus
Y101IPHPDFNMSLL3Mus musculus, Mus musculus, Mus musculus
Y101FPHPDYNMSLL3Mus musculus, Mus musculus, Mus musculus
Y101FPHPGFNMSLL2Mus musculus, Mus musculus
Y101FPHPLYDMSLL1Homo sapiens
Y101FPHPLYNMSLL1Macaca mulatta
Y101IPHPGFNMSLM1Mus musculus
Y101FLHPCYNMSLH1Mus musculus
Y101FLHPGYNRSLH1Mus musculus
Y101FPHPGFNMTLL1Mus musculus
Y101FPHPDFNMSLL1Mus musculus
Y101FPHPDYNMSLM1Mus musculus


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