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mutLBSgeneDB |
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| Gene summary for IKBKB |
 Gene summary |
| Basic gene Info. | Gene symbol | IKBKB |
| Gene name | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | |
| Synonyms | IKK-beta|IKK2|IKKB|IMD15|NFKBIKB | |
| Cytomap | UCSC genome browser: 8p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001190720.2, NM_001242778.1,NM_001556.2,NR_033818.1,NR_033819.1, NR_040009.1,NM_001190721.1,NM_001190722.1, | |
| Description | I-kappa-B kinase 2I-kappa-B-kinase betaIKK-Binhibitor of nuclear factor kappa-B kinase subunit betanuclear factor NF-kappa-B inhibitor kinase beta | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603258 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000104365 | ||
| HPRD : 04462 | ||
| Vega : OTTHUMG00000164092 | ||
| Protein | UniProt: O14920 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_IKBKB | |
| BioGPS: 3551 | ||
| Pathway | NCI Pathway Interaction Database: IKBKB | |
| KEGG: IKBKB | ||
| REACTOME: IKBKB | ||
| Pathway Commons: IKBKB | ||
| Context | iHOP: IKBKB | |
| ligand binding site mutation search in PubMed: IKBKB | ||
| UCL Cancer Institute: IKBKB | ||
| Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0006468 | protein phosphorylation | 20434986 | GO:0042501 | serine phosphorylation of STAT protein | 21399639 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 23091055 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 15790681 | GO:0071356 | cellular response to tumor necrosis factor | 23091055 |
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| Ligand binding site mutations for IKBKB |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | D166 | D166H | LUAD | 1 | M96 | A95V | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for IKBKB |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | D166 | D166H | -1.3846826 | M96 | A95V | -0.66323999 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for IKBKB from PDB |
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| Differential gene expression and gene-gene network for IKBKB |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for IKBKB |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for IKBKB |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved | DB00244 | Mesalazine | Small molecule |  |
| Approved | DB00795 | Sulfasalazine | Small molecule |  |
| Approved|vet_approved | DB00945 | Acetylsalicylic acid | Small molecule |  |
| Approved | DB00995 | Auranofin | Small molecule |  |
| Approved|investigational | DB01169 | Arsenic trioxide | Small molecule |  |
| Investigational | DB05183 | MLN0415 | Small molecule |  |
| Approved | DB06151 | Acetylcysteine | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of IKBKB go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | KSA | K-252A | 4kik | A | M96 D166 | KSA | K-252A | 4kik | B | M96 D166 |
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| Conservation information for LBS of IKBKB |
| Multiple alignments for O14920 in multiple species |
| LBS | AA sequence | # species | Species | A42 | TGEQIAIKQCR | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | C99 | LAMEYCQGGDL | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | D166 | IHKIIDLGYAK | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E149 | RDLKPENIVLQ | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | E97 | PLLAMEYCQGG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | G102 | EYCQGGDLRKY | 2 | Homo sapiens, Bos taurus | G102 | EYCQGGDLRRY | 1 | Rattus norvegicus | G22 | MKERLGTGGFG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | I165 | LIHKIIDLGYA | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | K44 | EQIAIKQCRQE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | L21 | EMKERLGTGGF | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | M96 | LPLLAMEYCQG | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V152 | KPENIVLQQGE | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | V29 | GGFGNVIRWHN | 3 | Homo sapiens, Rattus norvegicus, Bos taurus | Y98 | LLAMEYCQGGD | 3 | Homo sapiens, Rattus norvegicus, Bos taurus |
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