mutLBSgeneDB |
Gene summary for IL2 |
Gene summary |
Basic gene Info. | Gene symbol | IL2 |
Gene name | interleukin 2 | |
Synonyms | IL-2|TCGF|lymphokine | |
Cytomap | UCSC genome browser: 4q26-q27 | |
Type of gene | protein-coding | |
RefGenes | NM_000586.3, | |
Description | T cell growth factoraldesleukininterleukin-2involved in regulation of T-cell clonal expansion | |
Modification date | 20141222 | |
dbXrefs | MIM : 147680 | |
HGNC : HGNC | ||
HPRD : 00979 | ||
Protein | UniProt: P60568 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL2 | |
BioGPS: 3558 | ||
Pathway | NCI Pathway Interaction Database: IL2 | |
KEGG: IL2 | ||
REACTOME: IL2 | ||
Pathway Commons: IL2 | ||
Context | iHOP: IL2 | |
ligand binding site mutation search in PubMed: IL2 | ||
UCL Cancer Institute: IL2 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0002903 | negative regulation of B cell apoptotic process | 9184696 | GO:0030890 | positive regulation of B cell proliferation | 9184696 | GO:0032740 | positive regulation of interleukin-17 production | 16482511 | GO:0042104 | positive regulation of activated T cell proliferation | 10072077 | GO:0042523 | positive regulation of tyrosine phosphorylation of Stat5 protein | 19088061 |
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Ligand binding site mutations for IL2 |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | E82 | E82K | COAD | 2 | P102 | R103M | LUAD | 2 | E82 | E80G | BRCA | 1 | A93 | A93V | COAD | 1 | N49 | N49K | LUAD | 1 | T131 | T131K | LUAD | 1 | D40 | Q42K | LUAD | 1 | N49 | G47E | SKCM | 1 | H36 | H36N | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL2 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | E82 | E82K | -1.5016655 | T131 | T131K | -1.2376733 | D40 | Q42K | -1.1408186 | H36 | H36N | -0.89789183 | P102 | R103M | -0.88088922 | E82 | E80G | -0.81064052 | N49 | G47E | -0.54528936 | N49 | N49K | -0.3563303 | A93 | A93V | -0.24046231 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for IL2 from PDB |
PDB ID | PDB title | PDB structure | 1M47 | Crystal Structure of Human Interleukin-2 |
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Differential gene expression and gene-gene network for IL2 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for IL2 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0025202 | Melanoma | 117 | Biomarker, GeneticVariation, Therapeutic |
umls:C0019693 | HIV Infections | 113 | Biomarker, GeneticVariation |
umls:C0023493 | Leukemia-Lymphoma, Adult T-Cell | 79 | Biomarker |
umls:C0023418 | Leukemia | 35 | AlteredExpression, Biomarker, Therapeutic |
umls:C0027627 | Neoplasm Metastasis | 26 | Biomarker, Therapeutic |
umls:C0023903 | Liver Neoplasms | 10 | Biomarker, GeneticVariation, Therapeutic |
umls:C0027651 | Neoplasms | 9 | Biomarker, GeneticVariation, Therapeutic |
umls:C0017636 | Glioblastoma | 6 | Biomarker, Therapeutic |
umls:C0024121 | Lung Neoplasms | 6 | Biomarker, Therapeutic |
umls:C0001175 | Acquired Immunodeficiency Syndrome | 5 | Biomarker, Therapeutic |
umls:C0006118 | Brain Neoplasms | 5 | Biomarker |
umls:C0022665 | Kidney Neoplasms | 5 | Biomarker, Therapeutic |
umls:C0017658 | Glomerulonephritis | 4 | Biomarker |
umls:C0005695 | Urinary Bladder Neoplasms | 4 | Biomarker, Therapeutic |
umls:C0242596 | Neoplasm, Residual | 3 | Biomarker, Therapeutic |
umls:C0027659 | Neoplasms, Experimental | 3 | Therapeutic |
umls:C0033578 | Prostatic Neoplasms | 2 | Biomarker, GeneticVariation |
umls:C1269683 | Depressive Disorder, Major | 2 | Biomarker |
umls:C0027726 | Nephrotic Syndrome | 2 | Biomarker |
umls:C0004352 | Autistic Disorder | 2 | Biomarker |
umls:C0002622 | Amnesia | 1 | Biomarker |
umls:C0002871 | Anemia | 1 | Therapeutic |
umls:C0003123 | Anorexia | 1 | Biomarker |
umls:C0004093 | Asthenia | 1 | Biomarker |
umls:C0270611 | Brain Injuries | 1 | Biomarker |
umls:C0162820 | Dermatitis, Allergic Contact | 1 | Biomarker |
umls:C0014324 | Entamoebiasis | 1 | Biomarker |
umls:C0015967 | Fever | 1 | Biomarker |
umls:C0241910 | Hepatitis, Autoimmune | 1 | Biomarker |
umls:C0424295 | Hyperkinesis | 1 | Biomarker |
umls:C0020649 | Hypotension | 1 | Biomarker |
umls:C0023530 | Leukopenia | 1 | Therapeutic |
umls:C0030193 | Pain | 1 | Therapeutic |
umls:C0031117 | Peripheral Nervous System Diseases | 1 | Biomarker |
umls:C0042258 | Vaginal Neoplasms | 1 | Therapeutic |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL2 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00852 | Pseudoephedrine | Small molecule | |
Experimental | DB02555 | SP4160 | Small molecule | |
Experimental | DB02581 | 5-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic Acid | Small molecule | |
Experimental | DB03372 | 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One | Small molecule | |
Experimental | DB03453 | (R)—N[2-[1-(aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-l-phenylalanine methylester | Small molecule | |
Experimental | DB03455 | (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid | Small molecule | |
Experimental | DB03957 | SP2456 | Small molecule | |
Experimental | DB04278 | 2-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-Propionamide | Small molecule | |
Investigational | DB05299 | keyhole limpet hemocyanin | Biotech | |
Investigational | DB05304 | WX-G250 | Small molecule | |
Approved|investigational | DB05676 | Apremilast | Small molecule |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of IL2 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of IL2 |
Multiple alignments for P60568 in multiple species |
LBS | AA sequence | # species | Species | A93 | EVLNLAQSKNF | 2 | Homo sapiens, Macaca mulatta | A93 | HVLDLTQSKSF | 1 | Mus musculus | A93 | RVLDLTQSKSF | 1 | Rattus norvegicus | A93 | EVLGLPQSKNV | 1 | Canis lupus familiaris | D40 | EHLLLDLQMIL | 2 | Homo sapiens, Macaca mulatta | D40 | EQLLMDLQELL | 1 | Mus musculus | D40 | EQLLLDLQVLL | 1 | Rattus norvegicus | D40 | EQLLLDLQLLL | 1 | Canis lupus familiaris | E136 | TATIVEFLNRW | 2 | Homo sapiens, Macaca mulatta | E136 | SATVVDFLRRW | 1 | Mus musculus | E136 | PATVVEFLRRW | 1 | Rattus norvegicus | E136 | TATITEFLNKW | 1 | Canis lupus familiaris | E82 | QCLEEELKPLE | 2 | Homo sapiens, Macaca mulatta | E82 | QCLEDELGPLR | 1 | Mus musculus | E82 | QCLENELGALQ | 1 | Rattus norvegicus | E82 | QCLAEELKNLE | 1 | Canis lupus familiaris | F62 | TRMLTFKFYMP | 2 | Homo sapiens, Macaca mulatta | F62 | PRMLTFKFYLP | 1 | Mus musculus | F62 | PMMLTFKFYLP | 1 | Rattus norvegicus | F62 | SRMLTFKFYTP | 1 | Canis lupus familiaris | F64 | MLTFKFYMPKK | 2 | Homo sapiens, Macaca mulatta | F64 | MLTFKFYLPKQ | 2 | Mus musculus, Rattus norvegicus | F64 | MLTFKFYTPKK | 1 | Canis lupus familiaris | F98 | AQSKNFHLR-P | 1 | Homo sapiens | F98 | TQSKSFQLEDA | 1 | Mus musculus | F98 | TQSKSFHLEDA | 1 | Rattus norvegicus | F98 | PQSKNVHLTDT | 1 | Canis lupus familiaris | F98 | AQSKNFHLRDT | 1 | Macaca mulatta | H36 | QLQLEHLLLDL | 2 | Homo sapiens, Macaca mulatta | H36 | QQHLEQLLMDL | 1 | Mus musculus | H36 | QQHLEQLLLDL | 1 | Rattus norvegicus | H36 | EQQMEQLLLDL | 1 | Canis lupus familiaris | K52 | GINNYKNPKLT | 2 | Homo sapiens, Macaca mulatta | K52 | RMENYRNLKLP | 1 | Mus musculus | K52 | GIDNYKNLKLP | 1 | Rattus norvegicus | K52 | GVNNYENPQLS | 1 | Canis lupus familiaris | K55 | NYKNPKLTRML | 2 | Homo sapiens, Macaca mulatta | K55 | NYRNLKLPRML | 1 | Mus musculus | K55 | NYKNLKLPMML | 1 | Rattus norvegicus | K55 | NYENPQLSRML | 1 | Canis lupus familiaris | K63 | RMLTFKFYMPK | 2 | Homo sapiens, Macaca mulatta | K63 | RMLTFKFYLPK | 1 | Mus musculus | K63 | MMLTFKFYLPK | 1 | Rattus norvegicus | K63 | RMLTFKFYTPK | 1 | Canis lupus familiaris | L105 | R-PRDLISNIN | 1 | Homo sapiens | L105 | EDAENFISNIR | 1 | Mus musculus | L105 | EDAGNFISNIR | 1 | Rattus norvegicus | L105 | TDTKELISNMN | 1 | Canis lupus familiaris | L105 | RDTKDLISNIN | 1 | Macaca mulatta | L56 | YKNPKLTRMLT | 2 | Homo sapiens, Macaca mulatta | L56 | YRNLKLPRMLT | 1 | Mus musculus | L56 | YKNLKLPMMLT | 1 | Rattus norvegicus | L56 | YENPQLSRMLT | 1 | Canis lupus familiaris | L60 | KLTRMLTFKFY | 2 | Homo sapiens, Macaca mulatta | L60 | KLPRMLTFKFY | 1 | Mus musculus | L60 | KLPMMLTFKFY | 1 | Rattus norvegicus | L60 | QLSRMLTFKFY | 1 | Canis lupus familiaris | L90 | PLEEVLNLAQS | 2 | Homo sapiens, Macaca mulatta | L90 | PLRHVLDLTQS | 1 | Mus musculus | L90 | ALQRVLDLTQS | 1 | Rattus norvegicus | L90 | NLEEVLGLPQS | 1 | Canis lupus familiaris | L92 | EEVLNLAQSKN | 2 | Homo sapiens, Macaca mulatta | L92 | RHVLDLTQSKS | 1 | Mus musculus | L92 | QRVLDLTQSKS | 1 | Rattus norvegicus | L92 | EEVLGLPQSKN | 1 | Canis lupus familiaris | M59 | PKLTRMLTFKF | 2 | Homo sapiens, Macaca mulatta | M59 | LKLPRMLTFKF | 1 | Mus musculus | M59 | LKLPMMLTFKF | 1 | Rattus norvegicus | M59 | PQLSRMLTFKF | 1 | Canis lupus familiaris | N49 | ILNGINNYKNP | 2 | Homo sapiens, Macaca mulatta | N49 | LLSRMENYRNL | 1 | Mus musculus | N49 | LLRGIDNYKNL | 1 | Rattus norvegicus | N49 | LLNGVNNYENP | 1 | Canis lupus familiaris | P102 | FHLR-PRDLIS | 1 | Homo sapiens | P102 | FQLEDAENFIS | 1 | Mus musculus | P102 | FHLEDAGNFIS | 1 | Rattus norvegicus | P102 | VHLTDTKELIS | 1 | Canis lupus familiaris | P102 | FHLRDTKDLIS | 1 | Macaca mulatta | P54 | NNYKNPKLTRM | 2 | Homo sapiens, Macaca mulatta | P54 | ENYRNLKLPRM | 1 | Mus musculus | P54 | DNYKNLKLPMM | 1 | Rattus norvegicus | P54 | NNYENPQLSRM | 1 | Canis lupus familiaris | P85 | EEELKPLEEVL | 2 | Homo sapiens, Macaca mulatta | P85 | EDELGPLRHVL | 1 | Mus musculus | P85 | ENELGALQRVL | 1 | Rattus norvegicus | P85 | AEELKNLEEVL | 1 | Canis lupus familiaris | R58 | NPKLTRMLTFK | 2 | Homo sapiens, Macaca mulatta | R58 | NLKLPRMLTFK | 1 | Mus musculus | R58 | NLKLPMMLTFK | 1 | Rattus norvegicus | R58 | NPQLSRMLTFK | 1 | Canis lupus familiaris | T131 | EYADETATIVE | 2 | Homo sapiens, Macaca mulatta | T131 | QFDDESATVVD | 1 | Mus musculus | T131 | QFDDEPATVVE | 1 | Rattus norvegicus | T131 | EYDDETATITE | 1 | Canis lupus familiaris | T133 | ADETATIVEFL | 2 | Homo sapiens, Macaca mulatta | T133 | DDESATVVDFL | 1 | Mus musculus | T133 | DDEPATVVEFL | 1 | Rattus norvegicus | T133 | DDETATITEFL | 1 | Canis lupus familiaris | T61 | LTRMLTFKFYM | 2 | Homo sapiens, Macaca mulatta | T61 | LPRMLTFKFYL | 1 | Mus musculus | T61 | LPMMLTFKFYL | 1 | Rattus norvegicus | T61 | LSRMLTFKFYT | 1 | Canis lupus familiaris | V89 | KPLEEVLNLAQ | 2 | Homo sapiens, Macaca mulatta | V89 | GPLRHVLDLTQ | 1 | Mus musculus | V89 | GALQRVLDLTQ | 1 | Rattus norvegicus | V89 | KNLEEVLGLPQ | 1 | Canis lupus familiaris | Y65 | LTFKFYMPKKA | 2 | Homo sapiens, Macaca mulatta | Y65 | LTFKFYLPKQA | 2 | Mus musculus, Rattus norvegicus | Y65 | LTFKFYTPKKA | 1 | Canis lupus familiaris |
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