mutated Ligand Binding Site gene DataBase





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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IL2
Gene summary
Basic gene Info.Gene symbolIL2
Gene nameinterleukin 2
CytomapUCSC genome browser: 4q26-q27
Type of geneprotein-coding
DescriptionT cell growth factoraldesleukininterleukin-2involved in regulation of T-cell clonal expansion
Modification date20141222
dbXrefs MIM : 147680
HPRD : 00979
ProteinUniProt: P60568
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL2
BioGPS: 3558
PathwayNCI Pathway Interaction Database: IL2
Pathway Commons: IL2
ContextiHOP: IL2
ligand binding site mutation search in PubMed: IL2
UCL Cancer Institute: IL2
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO:0002903negative regulation of B cell apoptotic process9184696
GO:0030890positive regulation of B cell proliferation9184696
GO:0032740positive regulation of interleukin-17 production16482511
GO:0042104positive regulation of activated T cell proliferation10072077
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 protein19088061

Ligand binding site mutations for IL2
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Protein structure related information for IL2
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IL2 from PDB
PDB IDPDB titlePDB structure
1M47Crystal Structure of Human Interleukin-2

Differential gene expression and gene-gene network for IL2
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IL2 and the right PPI network was created from samples without mutations in the LBS of IL2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


Phenotype information for IL2
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0025202Melanoma117Biomarker, GeneticVariation, Therapeutic
umls:C0019693HIV Infections113Biomarker, GeneticVariation
umls:C0023493Leukemia-Lymphoma, Adult T-Cell79Biomarker
umls:C0023418Leukemia35AlteredExpression, Biomarker, Therapeutic
umls:C0027627Neoplasm Metastasis26Biomarker, Therapeutic
umls:C0023903Liver Neoplasms10Biomarker, GeneticVariation, Therapeutic
umls:C0027651Neoplasms9Biomarker, GeneticVariation, Therapeutic
umls:C0017636Glioblastoma6Biomarker, Therapeutic
umls:C0024121Lung Neoplasms6Biomarker, Therapeutic
umls:C0001175Acquired Immunodeficiency Syndrome5Biomarker, Therapeutic
umls:C0006118Brain Neoplasms5Biomarker
umls:C0022665Kidney Neoplasms5Biomarker, Therapeutic
umls:C0005695Urinary Bladder Neoplasms4Biomarker, Therapeutic
umls:C0242596Neoplasm, Residual3Biomarker, Therapeutic
umls:C0027659Neoplasms, Experimental3Therapeutic
umls:C0033578Prostatic Neoplasms2Biomarker, GeneticVariation
umls:C1269683Depressive Disorder, Major2Biomarker
umls:C0027726Nephrotic Syndrome2Biomarker
umls:C0004352Autistic Disorder2Biomarker
umls:C0270611Brain Injuries1Biomarker
umls:C0162820Dermatitis, Allergic Contact1Biomarker
umls:C0241910Hepatitis, Autoimmune1Biomarker
umls:C0031117Peripheral Nervous System Diseases1Biomarker
umls:C0042258Vaginal Neoplasms1Therapeutic

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

Pharmacological information for IL2
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ApprovedDB00852PseudoephedrineSmall molecule
ExperimentalDB02555SP4160Small molecule
ExperimentalDB025815-[2,3-Dichloro-4-(5-{1-[2-(2-Guanidino-4-Methyl-Pentanoylamino)-Acetyl]-Piperidin-4-Yl}-1-Methyl-1h-Pyrazol-3-Yl)-Phenoxymethyl]-Furan-2-Carboxylic AcidSmall molecule
ExperimentalDB033723-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-OneSmall molecule
ExperimentalDB03453(R)—N[2-[1-(aminoiminomethyl)-3-piperidinyl]-1-oxoethyl]-4-(phenylethynyl)-l-phenylalanine methylesterSmall molecule
ExperimentalDB03455(1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acidSmall molecule
ExperimentalDB03957SP2456Small molecule
ExperimentalDB042782-[2-(2-Cyclohexyl-2-Guanidino-Acetylamino)-Acetylamino]-N-(3-Mercapto-Propyl)-PropionamideSmall molecule
InvestigationalDB05299keyhole limpet hemocyaninBiotech
InvestigationalDB05304WX-G250Small molecule
Approved|investigationalDB05676ApremilastSmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IL2 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS

Conservation information for LBS of IL2
Multiple alignments for P60568 in multiple species
LBSAA sequence# speciesSpecies
A93EVLNLAQSKNF2Homo sapiens, Macaca mulatta
A93HVLDLTQSKSF1Mus musculus
A93RVLDLTQSKSF1Rattus norvegicus
A93EVLGLPQSKNV1Canis lupus familiaris
D40EHLLLDLQMIL2Homo sapiens, Macaca mulatta
D40EQLLMDLQELL1Mus musculus
D40EQLLLDLQVLL1Rattus norvegicus
D40EQLLLDLQLLL1Canis lupus familiaris
E136TATIVEFLNRW2Homo sapiens, Macaca mulatta
E136SATVVDFLRRW1Mus musculus
E136PATVVEFLRRW1Rattus norvegicus
E136TATITEFLNKW1Canis lupus familiaris
E82QCLEEELKPLE2Homo sapiens, Macaca mulatta
E82QCLEDELGPLR1Mus musculus
E82QCLENELGALQ1Rattus norvegicus
E82QCLAEELKNLE1Canis lupus familiaris
F62TRMLTFKFYMP2Homo sapiens, Macaca mulatta
F62PRMLTFKFYLP1Mus musculus
F62PMMLTFKFYLP1Rattus norvegicus
F62SRMLTFKFYTP1Canis lupus familiaris
F64MLTFKFYMPKK2Homo sapiens, Macaca mulatta
F64MLTFKFYLPKQ2Mus musculus, Rattus norvegicus
F64MLTFKFYTPKK1Canis lupus familiaris
F98AQSKNFHLR-P1Homo sapiens
F98TQSKSFQLEDA1Mus musculus
F98TQSKSFHLEDA1Rattus norvegicus
F98PQSKNVHLTDT1Canis lupus familiaris
F98AQSKNFHLRDT1Macaca mulatta
H36QLQLEHLLLDL2Homo sapiens, Macaca mulatta
H36QQHLEQLLMDL1Mus musculus
H36QQHLEQLLLDL1Rattus norvegicus
H36EQQMEQLLLDL1Canis lupus familiaris
K52GINNYKNPKLT2Homo sapiens, Macaca mulatta
K52RMENYRNLKLP1Mus musculus
K52GIDNYKNLKLP1Rattus norvegicus
K52GVNNYENPQLS1Canis lupus familiaris
K55NYKNPKLTRML2Homo sapiens, Macaca mulatta
K55NYRNLKLPRML1Mus musculus
K55NYKNLKLPMML1Rattus norvegicus
K55NYENPQLSRML1Canis lupus familiaris
K63RMLTFKFYMPK2Homo sapiens, Macaca mulatta
K63RMLTFKFYLPK1Mus musculus
K63MMLTFKFYLPK1Rattus norvegicus
K63RMLTFKFYTPK1Canis lupus familiaris
L105R-PRDLISNIN1Homo sapiens
L105EDAENFISNIR1Mus musculus
L105EDAGNFISNIR1Rattus norvegicus
L105TDTKELISNMN1Canis lupus familiaris
L105RDTKDLISNIN1Macaca mulatta
L56YKNPKLTRMLT2Homo sapiens, Macaca mulatta
L56YRNLKLPRMLT1Mus musculus
L56YKNLKLPMMLT1Rattus norvegicus
L56YENPQLSRMLT1Canis lupus familiaris
L60KLTRMLTFKFY2Homo sapiens, Macaca mulatta
L60KLPRMLTFKFY1Mus musculus
L60KLPMMLTFKFY1Rattus norvegicus
L60QLSRMLTFKFY1Canis lupus familiaris
L90PLEEVLNLAQS2Homo sapiens, Macaca mulatta
L90PLRHVLDLTQS1Mus musculus
L90ALQRVLDLTQS1Rattus norvegicus
L90NLEEVLGLPQS1Canis lupus familiaris
L92EEVLNLAQSKN2Homo sapiens, Macaca mulatta
L92RHVLDLTQSKS1Mus musculus
L92QRVLDLTQSKS1Rattus norvegicus
L92EEVLGLPQSKN1Canis lupus familiaris
M59PKLTRMLTFKF2Homo sapiens, Macaca mulatta
M59LKLPRMLTFKF1Mus musculus
M59LKLPMMLTFKF1Rattus norvegicus
M59PQLSRMLTFKF1Canis lupus familiaris
N49ILNGINNYKNP2Homo sapiens, Macaca mulatta
N49LLSRMENYRNL1Mus musculus
N49LLRGIDNYKNL1Rattus norvegicus
N49LLNGVNNYENP1Canis lupus familiaris
P102FHLR-PRDLIS1Homo sapiens
P102FQLEDAENFIS1Mus musculus
P102FHLEDAGNFIS1Rattus norvegicus
P102VHLTDTKELIS1Canis lupus familiaris
P102FHLRDTKDLIS1Macaca mulatta
P54NNYKNPKLTRM2Homo sapiens, Macaca mulatta
P54ENYRNLKLPRM1Mus musculus
P54DNYKNLKLPMM1Rattus norvegicus
P54NNYENPQLSRM1Canis lupus familiaris
P85EEELKPLEEVL2Homo sapiens, Macaca mulatta
P85EDELGPLRHVL1Mus musculus
P85ENELGALQRVL1Rattus norvegicus
P85AEELKNLEEVL1Canis lupus familiaris
R58NPKLTRMLTFK2Homo sapiens, Macaca mulatta
R58NLKLPRMLTFK1Mus musculus
R58NLKLPMMLTFK1Rattus norvegicus
R58NPQLSRMLTFK1Canis lupus familiaris
T131EYADETATIVE2Homo sapiens, Macaca mulatta
T131QFDDESATVVD1Mus musculus
T131QFDDEPATVVE1Rattus norvegicus
T131EYDDETATITE1Canis lupus familiaris
T133ADETATIVEFL2Homo sapiens, Macaca mulatta
T133DDESATVVDFL1Mus musculus
T133DDEPATVVEFL1Rattus norvegicus
T133DDETATITEFL1Canis lupus familiaris
T61LTRMLTFKFYM2Homo sapiens, Macaca mulatta
T61LPRMLTFKFYL1Mus musculus
T61LPMMLTFKFYL1Rattus norvegicus
T61LSRMLTFKFYT1Canis lupus familiaris
V89KPLEEVLNLAQ2Homo sapiens, Macaca mulatta
V89GPLRHVLDLTQ1Mus musculus
V89GALQRVLDLTQ1Rattus norvegicus
V89KNLEEVLGLPQ1Canis lupus familiaris
Y65LTFKFYMPKKA2Homo sapiens, Macaca mulatta
Y65LTFKFYLPKQA2Mus musculus, Rattus norvegicus
Y65LTFKFYTPKKA1Canis lupus familiaris

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