mutLBSgeneDB |
Gene summary for IL2RB |
Gene summary |
Basic gene Info. | Gene symbol | IL2RB |
Gene name | interleukin 2 receptor, beta | |
Synonyms | CD122|IL15RB|P70-75 | |
Cytomap | UCSC genome browser: 22q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_000878.3, | |
Description | CD122 antigenIL-2 receptor subunit betaIL-2R subunit betaIL-2RBhigh affinity IL-2 receptor beta subunithigh affinity IL-2 receptor subunit betainterleukin 15 receptor, betainterleukin-2 receptor subunit betap75 | |
Modification date | 20141207 | |
dbXrefs | MIM : 146710 | |
HGNC : HGNC | ||
Ensembl : ENSG00000100385 | ||
HPRD : 00896 | ||
Vega : OTTHUMG00000150534 | ||
Protein | UniProt: P14784 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL2RB | |
BioGPS: 3560 | ||
Pathway | NCI Pathway Interaction Database: IL2RB | |
KEGG: IL2RB | ||
REACTOME: IL2RB | ||
Pathway Commons: IL2RB | ||
Context | iHOP: IL2RB | |
ligand binding site mutation search in PubMed: IL2RB | ||
UCL Cancer Institute: IL2RB | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0019221 | cytokine-mediated signaling pathway | 7736574 | GO:0038110 | interleukin-2-mediated signaling pathway | 7736574 | GO:0043066 | negative regulation of apoptotic process | 7736574 |
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Ligand binding site mutations for IL2RB |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | N39 | R41T | HNSC | 1 | S45 | C46G | LUSC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL2RB |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S45 | C46G | -1.2643715 | N39 | R41T | -1.2213797 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for IL2RB from PDB |
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Differential gene expression and gene-gene network for IL2RB |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for IL2RB |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0003873 | Arthritis, Rheumatoid | 10 | Biomarker, GeneticVariation |
umls:C0020517 | Hypersensitivity | 1 | Biomarker |
umls:C0032285 | Pneumonia | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL2RB |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Approved|investigational | DB00004 | Denileukin diftitox | Biotech | |
Approved | DB00041 | Aldesleukin | Biotech | |
Approved|investigational | DB00074 | Basiliximab | Biotech | |
Approved|investigational | DB00111 | Daclizumab | Biotech |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of IL2RB go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of IL2RB |
Multiple alignments for P14784 in multiple species |
LBS | AA sequence | # species | Species | F37 | SQFTCFYNSRA | 2 | Homo sapiens, Pan troglodytes | F37 | SHLECFYNSRA | 1 | Mus musculus | F37 | SHLKCFYNSRA | 1 | Rattus norvegicus | H62 | TSCQVHAWPDR | 2 | Homo sapiens, Pan troglodytes | H62 | TTCHVHAKSNL | 1 | Mus musculus | H62 | TSCHIHAKSDM | 1 | Rattus norvegicus | L132 | FENLRLMAPIS | 2 | Homo sapiens, Pan troglodytes | L132 | FDNLRLVAPHS | 1 | Mus musculus | L132 | FDNLRLIAPHS | 1 | Rattus norvegicus | M133 | ENLRLMAPISL | 2 | Homo sapiens, Pan troglodytes | M133 | DNLRLVAPHSL | 1 | Mus musculus | M133 | DNLRLIAPHSL | 1 | Rattus norvegicus | N39 | FTCFYNSRANI | 2 | Homo sapiens, Pan troglodytes | N39 | LECFYNSRANV | 1 | Mus musculus | N39 | LKCFYNSRANV | 1 | Rattus norvegicus | P222 | FTTWSPWSQPL | 2 | Homo sapiens, Pan troglodytes | P222 | TGTWSPWSQPL | 1 | Mus musculus | P222 | TRTWSPWSQPM | 1 | Rattus norvegicus | R107 | DIVTLRVLCRE | 2 | Homo sapiens, Pan troglodytes | R107 | DLLDINVVCWE | 1 | Mus musculus | R107 | DLLSLSVVCWE | 1 | Rattus norvegicus | R131 | PFENLRLMAPI | 2 | Homo sapiens, Pan troglodytes | R131 | PFDNLRLVAPH | 1 | Mus musculus | R131 | PFDNLRLIAPH | 1 | Rattus norvegicus | S45 | SRANISCVWSQ | 2 | Homo sapiens, Pan troglodytes | S45 | SRANVSCMWSH | 1 | Mus musculus | S45 | SRANVSCMWSP | 1 | Rattus norvegicus | W116 | REGVRWRVMAI | 2 | Homo sapiens, Pan troglodytes | W116 | WEEKGWRRVKT | 2 | Mus musculus, Rattus norvegicus |
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