mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IL10
Gene summary
Basic gene Info.Gene symbolIL10
Gene nameinterleukin 10
SynonymsCSIF|GVHDS|IL-10|IL10A|TGIF
CytomapUCSC genome browser: 1q31-q32
Type of geneprotein-coding
RefGenesNM_000572.2,
DescriptionT-cell growth inhibitory factorcytokine synthesis inhibitory factorinterleukin-10
Modification date20141222
dbXrefs MIM : 124092
HGNC : HGNC
Ensembl : ENSG00000136634
HPRD : 00495
Vega : OTTHUMG00000036386
ProteinUniProt: P22301
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IL10
BioGPS: 3586
PathwayNCI Pathway Interaction Database: IL10
KEGG: IL10
REACTOME: IL10
Pathway Commons: IL10
ContextiHOP: IL10
ligand binding site mutation search in PubMed: IL10
UCL Cancer Institute: IL10
Assigned class in mutLBSgeneDBC: This gene just belongs to mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0002237response to molecule of bacterial origin17449476
GO:0002740negative regulation of cytokine secretion involved in immune response10443688
GO:0002904positive regulation of B cell apoptotic process9184696
GO:0006954inflammatory response10443688
GO:0010468regulation of gene expression9184696
GO:0030889negative regulation of B cell proliferation9184696
GO:0032715negative regulation of interleukin-6 production10443688
GO:0032800receptor biosynthetic process10443688
GO:0045893positive regulation of transcription, DNA-templated7749983
GO:0050715positive regulation of cytokine secretion10443688
GO:0051045negative regulation of membrane protein ectodomain proteolysis18383040
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activity7749983
GO:0051384response to glucocorticoid10443688


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Ligand binding site mutations for IL10
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
R124R125CCOAD2
R124C126RLUSC1
R124R125CUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for IL10
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
R124R125C-0.87608358
R124C126R-0.84811054
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IL10 from PDB
PDB IDPDB titlePDB structure
1INRCYTOKINE SYNTHESIS

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Differential gene expression and gene-gene network for IL10
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IL10 and the right PPI network was created from samples without mutations in the LBS of IL10. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IL10
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0024141Lupus Erythematosus, Systemic93AlteredExpression, Biomarker, GeneticVariation
umls:C0003873Arthritis, Rheumatoid84Biomarker, GeneticVariation
umls:C0019693HIV Infections80AlteredExpression, Biomarker, GeneticVariation
umls:C0009319Colitis65Biomarker, Therapeutic
umls:C0021390Inflammatory Bowel Diseases58Biomarker, GeneticVariation
umls:C0010346Crohn Disease47Biomarker, GeneticVariation
umls:C0243026Sepsis45Biomarker, GeneticVariation, Therapeutic
umls:C0009324Colitis, Ulcerative44Biomarker, GeneticVariation
umls:C0021368Inflammation32AlteredExpression, Biomarker, GeneticVariation
umls:C0011854Diabetes Mellitus, Type 131Biomarker, GeneticVariation
umls:C0011615Dermatitis, Atopic24Biomarker, GeneticVariation
umls:C0027051Myocardial Infarction16AlteredExpression, Biomarker, GeneticVariation
umls:C0022104Irritable Bowel Syndrome15Biomarker, GeneticVariation
umls:C0024121Lung Neoplasms11AlteredExpression, Biomarker, GeneticVariation
umls:C0004943Behcet Syndrome11Biomarker, GeneticVariation
umls:C0007131Carcinoma, Non-Small-Cell Lung11Biomarker
umls:C0023893Liver Cirrhosis, Experimental10Therapeutic
umls:C0023290Leishmaniasis, Visceral9Biomarker
umls:C0023283Leishmaniasis, Cutaneous9Biomarker, GeneticVariation
umls:C0993582Arthritis, Experimental7Biomarker, Therapeutic
umls:C0017658Glomerulonephritis7Biomarker, GeneticVariation
umls:C0035126Reperfusion Injury6AlteredExpression, Biomarker, GeneticVariation
umls:C0014356Enterocolitis6Biomarker
umls:C0023281Leishmaniasis5AlteredExpression, Biomarker
umls:C0023493Leukemia-Lymphoma, Adult T-Cell5Biomarker
umls:C0020429Hyperalgesia4Biomarker, Therapeutic
umls:C0013182Drug Hypersensitivity4Biomarker, GeneticVariation
umls:C0026766Multiple Organ Failure4GeneticVariation, Therapeutic
umls:C0241910Hepatitis, Autoimmune4Biomarker, GeneticVariation
umls:C0033581Prostatitis3Biomarker, GeneticVariation
umls:C0270611Brain Injuries3Biomarker, Therapeutic
umls:C0006434Burns3Biomarker, GeneticVariation
umls:C0033578Prostatic Neoplasms3Biomarker, GeneticVariation
umls:C0162820Dermatitis, Allergic Contact3Biomarker
umls:C0020523Hypersensitivity, Immediate2Biomarker, GeneticVariation
umls:C2609414Acute Kidney Injury1Biomarker
umls:C0003615Appendicitis1Biomarker
umls:C0004352Autistic Disorder1Biomarker
umls:C0014324Entamoebiasis1Biomarker
umls:C0314657Genetic Predisposition to Disease1Biomarker
umls:C0018843Heat Stroke1Biomarker
umls:C0024668Mammary Neoplasms, Experimental1Biomarker
umls:C0333355Mucositis1Biomarker
umls:C0032231Pleurisy1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IL10
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
InvestigationalDB05066AV411Small molecule
InvestigationalDB05744CRx-139Small molecule
InvestigationalDB05771LLL-3348Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IL10 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS


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Conservation information for LBS of IL10
Multiple alignments for P22301 in multiple species
LBSAA sequence# speciesSpecies
C30QSENSCTHFPG1Homo sapiens
C30CLEPTCLHFSE1Gallus gallus
C30REDNNCTHFPV1Mus musculus
C30RGDNNCTHFPV1Rattus norvegicus
C30LSDSSCIHLPT1Bos taurus
C30LLEDDCTHFPA1Canis lupus familiaris
C30QSENSCTRFPG1Macaca mulatta
K135LPCENKSKAVE6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
K135FTCEKRSKAIK1Gallus gallus
N134FLPCENKSKAV6Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus, Canis lupus familiaris, Macaca mulatta
N134FFTCEKRSKAI1Gallus gallus
R122--LRLRLRRCH3Homo sapiens, Bos taurus, Macaca mulatta
R122--LKATMRRCH1Gallus gallus
R122--LRMRLRRCH1Mus musculus
R122--LWIQLRRCH1Rattus norvegicus
R122LRLRLRLRRCH1Canis lupus familiaris
R124LRLRLRRCHRF4Homo sapiens, Bos taurus, Canis lupus familiaris, Macaca mulatta
R124LKATMRRCHRF1Gallus gallus
R124LRMRLRRCHRF1Mus musculus
R124LWIQLRRCHRF1Rattus norvegicus
T24SPGQGTQSENS2Homo sapiens, Macaca mulatta
T24CTLPAHCLEPT1Gallus gallus
T24SRGQYSREDNN1Mus musculus
T24SKGHSIRGDNN1Rattus norvegicus
T24SRDASTLSDSS1Bos taurus
T24SRHQSTLLEDD1Canis lupus familiaris
T31SENSCTHFPGN1Homo sapiens
T31LEPTCLHFSEL1Gallus gallus
T31EDNNCTHFPVG1Mus musculus
T31GDNNCTHFPVS1Rattus norvegicus
T31SDSSCIHLPTS1Bos taurus
T31LEDDCTHFPAS1Canis lupus familiaris
T31SENSCTRFPGN1Macaca mulatta


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