mutLBSgeneDB |
Gene summary for IL12B |
Gene summary |
Basic gene Info. | Gene symbol | IL12B |
Gene name | interleukin 12B | |
Synonyms | CLMF|CLMF2|IL-12B|IMD28|IMD29|NKSF|NKSF2 | |
Cytomap | UCSC genome browser: 5q31.1-q33.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002187.2, | |
Description | CLMF p40IL-12 subunit p40IL12, subunit p40NK cell stimulatory factor chain 2cytotoxic lymphocyte maturation factor 40 kDa subunitinterleukin 12, p40interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, | |
Modification date | 20141221 | |
dbXrefs | MIM : 161561 | |
HGNC : HGNC | ||
Ensembl : ENSG00000113302 | ||
HPRD : 01194 | ||
Vega : OTTHUMG00000130307 | ||
Protein | UniProt: P29460 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL12B | |
BioGPS: 3593 | ||
Pathway | NCI Pathway Interaction Database: IL12B | |
KEGG: IL12B | ||
REACTOME: IL12B | ||
Pathway Commons: IL12B | ||
Context | iHOP: IL12B | |
ligand binding site mutation search in PubMed: IL12B | ||
UCL Cancer Institute: IL12B | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID | GO:0002230 | positive regulation of defense response to virus by host | 12421946 | GO:0002827 | positive regulation of T-helper 1 type immune response | 15114670 | GO:0002860 | positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target | 7903063 | GO:0007050 | cell cycle arrest | 16942485 | GO:0010224 | response to UV-B | 8992506 | GO:0010535 | positive regulation of activation of JAK2 kinase activity | 12023369 | GO:0016477 | cell migration | 7903063 | GO:0030101 | natural killer cell activation | 1673147 | GO:0032700 | negative regulation of interleukin-17 production | 16482511 | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production | 20027291 | GO:0032729 | positive regulation of interferon-gamma production | 11114383 | GO:0032733 | positive regulation of interleukin-10 production | 15265908 | GO:0032735 | positive regulation of interleukin-12 production | 20027291 | GO:0032740 | positive regulation of interleukin-17 production | 16482511 | GO:0032816 | positive regulation of natural killer cell activation | 1674604 | GO:0032819 | positive regulation of natural killer cell proliferation | 19088061 | GO:0034393 | positive regulation of smooth muscle cell apoptotic process | 16942485 | GO:0042093 | T-helper cell differentiation | 1673147 | GO:0042102 | positive regulation of T cell proliferation | 12023369 | GO:0042104 | positive regulation of activated T cell proliferation | 11114383 | GO:0042510 | regulation of tyrosine phosphorylation of Stat1 protein | 12023369 | GO:0042517 | positive regulation of tyrosine phosphorylation of Stat3 protein | 12023369 | GO:0042520 | positive regulation of tyrosine phosphorylation of Stat4 protein | 11114383 | GO:0042523 | positive regulation of tyrosine phosphorylation of Stat5 protein | 12023369 | GO:0045672 | positive regulation of osteoclast differentiation | 17888176 | GO:0045785 | positive regulation of cell adhesion | 7903063 | GO:0048662 | negative regulation of smooth muscle cell proliferation | 16942485 | GO:0050671 | positive regulation of lymphocyte proliferation | 1674604 | GO:0050829 | defense response to Gram-negative bacterium | 15114670 | GO:0051135 | positive regulation of NK T cell activation | 19088061 | GO:0051142 | positive regulation of NK T cell proliferation | 19088061 |
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Ligand binding site mutations for IL12B |
Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.) : non-synonymous mutation on LBS, Circle size denotes number of samples. |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | R309 | R309W | GBM | 1 | R309 | V308M | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for IL12B |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | R309 | R309W | -0.73893153 | R309 | V308M | -0.4673651 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for IL12B from PDB |
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Differential gene expression and gene-gene network for IL12B |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for IL12B |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0033860 | Psoriasis | 36 | Biomarker, GeneticVariation |
umls:C0010346 | Crohn Disease | 19 | Biomarker, GeneticVariation |
umls:C0004096 | Asthma | 17 | Biomarker, GeneticVariation |
umls:C0009324 | Colitis, Ulcerative | 11 | Biomarker, GeneticVariation |
umls:C0003872 | Arthritis, Psoriatic | 10 | Biomarker, GeneticVariation |
umls:C0024141 | Lupus Erythematosus, Systemic | 5 | Biomarker, GeneticVariation |
umls:C0038013 | Spondylitis, Ankylosing | 3 | Biomarker, GeneticVariation |
umls:C0017638 | Glioma | 2 | GeneticVariation, Therapeutic |
umls:C0000786 | Abortion, Spontaneous | 1 | Biomarker |
umls:C0020672 | Hypothermia | 1 | Biomarker |
umls:C0023892 | Liver Cirrhosis, Biliary | 1 | Biomarker |
umls:C0023903 | Liver Neoplasms | 1 | Therapeutic |
umls:C0027659 | Neoplasms, Experimental | 1 | Therapeutic |
umls:C0034069 | Pulmonary Fibrosis | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for IL12B |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Experimental | DB02763 | 5-Mercapto-2-Nitro-Benzoic Acid | Small molecule | |
Investigational | DB05459 | Briakinumab | Biotech | |
Approved|investigational | DB05679 | Ustekinumab | Biotech | |
Investigational | DB05848 | humanized SMART Anti-IL-12 Antibody | Biotech |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of IL12B go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of IL12B |
Multiple alignments for P29460 in multiple species |
LBS | AA sequence | # species | Species | A304 | ICRKNASISVR | 1 | Homo sapiens | A304 | ICRKNASFSVQ | 1 | Macaca mulatta | A304 | VCHKDAKIRVQ | 1 | Canis lupus familiaris | A304 | TCHKDANVRVQ | 1 | Bos taurus | C274 | FSLTFCVQVQG | 2 | Homo sapiens, Bos taurus | C274 | FSLTFCIQVQG | 1 | Macaca mulatta | C274 | FSLTFCVQAQG | 1 | Canis lupus familiaris | N303 | VICRKNASISV | 1 | Homo sapiens | N303 | VICRKNASFSV | 1 | Macaca mulatta | N303 | VVCHKDAKIRV | 1 | Canis lupus familiaris | N303 | VTCHKDANVRV | 1 | Bos taurus | Q276 | LTFCVQVQGKS | 1 | Homo sapiens | Q276 | LTFCIQVQGKS | 1 | Macaca mulatta | Q276 | LTFCVQAQGKN | 1 | Canis lupus familiaris | Q276 | LTFCVQVQGKN | 1 | Bos taurus | R288 | REKKDRVFTDK | 1 | Homo sapiens | R288 | REKKDRIFTDK | 1 | Macaca mulatta | R288 | REKKDRLCVDK | 1 | Canis lupus familiaris | R288 | REKK--LFMDQ | 1 | Bos taurus | R301 | ATVICRKNASI | 1 | Homo sapiens | R301 | ATVICRKNASF | 1 | Macaca mulatta | R301 | AKVVCHKDAKI | 1 | Canis lupus familiaris | R301 | AKVTCHKDANV | 1 | Bos taurus | R309 | ASISVRAQDRY | 1 | Homo sapiens | R309 | ASFSVQAQDRY | 1 | Macaca mulatta | R309 | AKIRVQARDRY | 1 | Canis lupus familiaris | R309 | ANVRVQARDRY | 1 | Bos taurus | W319 | YYSSSWSEWAS | 2 | Homo sapiens, Macaca mulatta | W319 | YYSSSWSDWAS | 1 | Canis lupus familiaris | W319 | YYSSFWSEWAS | 1 | Bos taurus | W322 | SSWSEWASVPC | 2 | Homo sapiens, Macaca mulatta | W322 | SSWSDWASVSC | 1 | Canis lupus familiaris | W322 | SFWSEWASVSC | 1 | Bos taurus |
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