mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

Home

	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for FOXK2

Gene summary

Basic gene Info.	Gene symbol	FOXK2
	Gene name	forkhead box K2
	Synonyms	ILF\|ILF-1\|ILF1
	Cytomap	UCSC genome browser: 17q25
	Type of gene	protein-coding
	RefGenes	NM_004514.3, NM_181430.1,NM_181431.1,
	Description	FOXK1cellular transcription factor ILF-1forkhead box protein K2interleukin enhancer binding factor 1interleukin enhancer-binding factor 1
	Modification date	20141207
dbXrefs	MIM : 147685
	HGNC : HGNC
	Ensembl : ENSG00000141568
	HPRD : 00982
	Vega : OTTHUMG00000140374
Protein	UniProt: Q01167 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_FOXK2
	BioGPS: 3607
Pathway	NCI Pathway Interaction Database: FOXK2
	KEGG: FOXK2
	REACTOME: FOXK2
	Pathway Commons: FOXK2
Context	iHOP: FOXK2
	ligand binding site mutation search in PubMed: FOXK2
	UCL Cancer Institute: FOXK2
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO Term	PubMed ID
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	9065434

Top

Ligand binding site mutations for FOXK2

Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)

: non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
N313	R314C	COAD	1
R307	R307H	HNSC	1
R307	R307C	SKCM	1
K258	P259L	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

Top

Protein structure related information for FOXK2

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
R307	R307H	-1.6865718
N313	R314C	-1.5020562
R307	R307C	-1.3858994
K258	P259L	-0.55208295

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for FOXK2 from PDB

Top

Differential gene expression and gene-gene network for FOXK2

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of FOXK2 and the right PPI network was created from samples without mutations in the LBS of FOXK2. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

Top

Phenotype information for FOXK2

Gene level disease information (DisGeNet)

Disease ID

Disease name

# PubMed

Association type

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

Top

Pharmacological information for FOXK2

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.