mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for IDO1
Gene summary
Basic gene Info.Gene symbolIDO1
Gene nameindoleamine 2,3-dioxygenase 1
SynonymsIDO|IDO-1|INDO
CytomapUCSC genome browser: 8p12-p11
Type of geneprotein-coding
RefGenesNM_002164.5,
Descriptionindolamine 2,3 dioxygenaseindole 2,3-dioxygenaseindoleamine-pyrrole 2,3-dioxygenase
Modification date20141222
dbXrefs MIM : 147435
HGNC : HGNC
HPRD : 00935
ProteinUniProt: P14902
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_IDO1
BioGPS: 3620
PathwayNCI Pathway Interaction Database: IDO1
KEGG: IDO1
REACTOME: IDO1
Pathway Commons: IDO1
ContextiHOP: IDO1
ligand binding site mutation search in PubMed: IDO1
UCL Cancer Institute: IDO1
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID


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Ligand binding site mutations for IDO1

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
A260E258KSKCM2
R231R231CCOAD1
H287H287YCOAD1
A260F259IGBM1
F270C272FLUAD1
G262G262DLUSC1
I354I356TSKCM1
F163G162ESKCM1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for IDO1
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
H287H287Y0.16808577
I354I356T-1.4599641
A260F259I-1.1101023
A260E258K-0.94411789
F270C272F-0.93554036
F163G162E-0.60501965
R231R231C-0.46989305
G262G262D-0.42517663
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for IDO1 from PDB
PDB IDPDB titlePDB structure
4PK5Crystal structure of the indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with Amg-1

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Differential gene expression and gene-gene network for IDO1
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of IDO1 and the right PPI network was created from samples without mutations in the LBS of IDO1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for IDO1
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C0021368Inflammation2Biomarker
umls:C0014175Endometriosis2Biomarker
umls:C0524851Neurodegenerative Diseases1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for IDO1
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of IDO1 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NHECHES2d0tAA260 G262
NHECHES2d0tBA260 G262
NHECHES2d0uBA260 G262
PIM4-PHENYLIMIDAZOLE4u74AF163
PIM4-PHENYLIMIDAZOLE4u74BF163
HEMHEME B4pk6AF163 F270
HEMHEME B4pk6BF163 F270
HEMHEME B5ek2AF163 F270
HEMHEME B2d0tAF163 F270 I354
HEMHEME B2d0tBF163 F270 I354
HEMHEME B2d0uAF163 F270 I354
HEMHEME B2d0uBF163 F270 I354
HEMHEME B4pk5AF163 F270 I354
HEMHEME B4pk5BF163 F270 I354
HEMHEME B4u72AF163 F270 I354
HEMHEME B4u72BF163 F270 I354
HEMHEME B4u74AF163 F270 I354
HEMHEME B4u74BF163 F270 I354
HEMHEME B5ek2BF163 F270 I354
HEMHEME B5ek3AF163 F270 I354
HEMHEME B5ek3BF163 F270 I354
HEMHEME B5ek4AF163 F270 I354
HEMHEME B5ek4BF163 F270 I354
PIM4-PHENYLIMIDAZOLE2d0tAF163 G262
PIM4-PHENYLIMIDAZOLE2d0tBF163 G262
PKLN-[2-(3-CHLOROPHENYL)ETHYL]-3-(4-METHYLPHENYL) IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBOXAMIDE4pk6AF163 G262
PIM4-PHENYLIMIDAZOLE4u72AF163 G262
PIM4-PHENYLIMIDAZOLE4u72BF163 G262
PKLN-[2-(3-CHLOROPHENYL)ETHYL]-3-(4-METHYLPHENYL) IMIDAZO[2,1-B][1,3]THIAZOLE-5-CARBOXAMIDE4pk6BF163 R231 G262
5PJ1-CYCLOHEXYL-2-[(5~{S})-6-FLUORANYL-5~{H}-IMIDAZO[1,5- B]ISOINDOL-5-YL]ETHANONE5ek2BF163 R231 G262
5PK(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-5~{H}-IMIDAZO[1,5- B]ISOINDOL-5-YL]ETHANOL5ek3BF163 R231 G262
PKJN-(1,3-BENZODIOXOL-5-YL)-2-{[5-(4-METHYLPHENYL)[1, 3]THIAZOLO[2,3-C][1,2,4]TRIAZOL-3- YL]SULFANYL}ACETAMIDE4pk5AF163 R231 G262 I354
PKJN-(1,3-BENZODIOXOL-5-YL)-2-{[5-(4-METHYLPHENYL)[1, 3]THIAZOLO[2,3-C][1,2,4]TRIAZOL-3- YL]SULFANYL}ACETAMIDE4pk5BF163 R231 G262 I354
5PJ1-CYCLOHEXYL-2-[(5~{S})-6-FLUORANYL-5~{H}-IMIDAZO[1,5- B]ISOINDOL-5-YL]ETHANONE5ek2AF163 R231 G262 I354
5PK(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-5~{H}-IMIDAZO[1,5- B]ISOINDOL-5-YL]ETHANOL5ek3AF163 R231 G262 I354
5PF(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-6-FLUORANYL-5~{H}- IMIDAZO[1,5-B]ISOINDOL-5-YL]ETHANOL5ek4AF163 R231 G262 I354
5PF(1~{R})-1-CYCLOHEXYL-2-[(5~{S})-6-FLUORANYL-5~{H}- IMIDAZO[1,5-B]ISOINDOL-5-YL]ETHANOL5ek4BF163 R231 G262 I354
NHECHES2d0uAG262
NHECHES2d0tBH287
NHECHES2d0tAI354
NHECHES2d0uAR231 H287
NHECHES2d0uBR231 H287


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Conservation information for LBS of IDO1
Multiple alignments for P14902 in multiple species
LBSAA sequence# speciesSpecies
A260DPKEFAGGSAG1Homo sapiens
A260--RIFSGGSNA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
A260TPKMFSGGSAG1Mus musculus
A260TPKKFSGGSAG1Rattus norvegicus
A264FSGGSAGQSSI2Mus musculus, Rattus norvegicus
A264FAGGSAGQSSV1Homo sapiens
A264FSGGSNAQSSL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
C129LSYADCVLANW2Mus musculus, Rattus norvegicus
C129LVYADCVLANW1Homo sapiens
C129ATYSSLVLWNF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F163DCDKGFFLVSL2Mus musculus, Rattus norvegicus
F163DCSKGFFLVSL1Homo sapiens
F163VDESWFYLVSV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F164CSKGFFLVSLL1Homo sapiens
F164DESWFYLVSVR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F164CDKGFFLVSLL1Mus musculus
F164CDKGFFLVSLM1Rattus norvegicus
F214KAKEIFKRMRD2Mus musculus, Rattus norvegicus
F214KALQVFHQIHD1Homo sapiens
F214RLSKALMEMEL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F226VDPDTFFHVLR2Mus musculus, Rattus norvegicus
F226VNPKAFFSVLR1Homo sapiens
F226CEPNVFYFKIR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F227DPDTFFHVLRI2Mus musculus, Rattus norvegicus
F227NPKAFFSVLRI1Homo sapiens
F227EPNVFYFKIRP1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F270GQSSIFQSLDV2Mus musculus, Rattus norvegicus
F270GQSSVFQCFDV1Homo sapiens
F270AQSSLIQTLDI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F291-----FLQEMR2Mus musculus, Rattus norvegicus
F291-----FLQDMR1Homo sapiens
F291DSKINYLDEMK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F387TDLMNFLKTVR1Homo sapiens
F387TRLMPFLKQCR1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
F387TNPMTFLRSVK1Mus musculus
F387TDVMNFLRSVK1Rattus norvegicus
G236RIYLSGWKGNP2Homo sapiens, Rattus norvegicus
G236RPFLAGWTNMS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G236RIYLSGWKCSS1Mus musculus
G261PKEFAGGSAGQ1Homo sapiens
G261-RIFSGGSNAQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G261PKMFSGGSAGQ1Mus musculus
G261PKKFSGGSAGQ1Rattus norvegicus
G262KEFAGGSAGQS1Homo sapiens
G262RIFSGGSNAQS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G262KMFSGGSAGQS1Mus musculus
G262KKFSGGSAGQS1Rattus norvegicus
G265SGGSAGQSSIF2Mus musculus, Rattus norvegicus
G265AGGSAGQSSVF1Homo sapiens
G265SGGSNAQSSLI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H287TAGGGHAAQ--1Homo sapiens
H287TANAAHSSQGD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H287EAGKESPAE--1Mus musculus
H287DVGEGSAAE--1Rattus norvegicus
H346SLRSYHLQIVT1Homo sapiens
H346IFRDNHIQIVT1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H346SVRKFHLAIVD1Mus musculus
H346SLRMFHLSIVD1Rattus norvegicus
I217EIFKRMRDFVD2Mus musculus, Rattus norvegicus
I217QVFHQIHDHVN1Homo sapiens
I217KALMEMELKCE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I349SYHLQIVTKYI1Homo sapiens
I349DNHIQIVTKYI1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I349KFHLAIVDTYI1Mus musculus
I349MFHLSIVDTYI1Rattus norvegicus
I354IVTKYILIPAS1Homo sapiens
I354IVTKYIILPSN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
I354IVDTYIMKPSK1Mus musculus
I354IVDTYIVKPSK1Rattus norvegicus
L230TFFHVLRIYLS2Mus musculus, Rattus norvegicus
L230AFFSVLRIYLS1Homo sapiens
L230VFYFKIRPFLA1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L234VLRIYLSGWKG2Homo sapiens, Rattus norvegicus
L234KIRPFLAGWTN1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L234VLRIYLSGWKC1Mus musculus
L384TGGTDLMNFLK1Homo sapiens
L384TGGTRLMPFLK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L384TGGTNPMTFLR1Mus musculus
L384TGGTDVMNFLR1Rattus norvegicus
L388DLMNFLKTVRS1Homo sapiens
L388RLMPFLKQCRD1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
L388NPMTFLRSVKD1Mus musculus
L388DVMNFLRSVKD1Rattus norvegicus
R231FFHVLRIYLSG2Mus musculus, Rattus norvegicus
R231FFSVLRIYLSG1Homo sapiens
R231FYFKIRPFLAG1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R343ALVSLRSYHLQ1Homo sapiens
R343MLKIFRDNHIQ1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
R343GLVSVRKFHLA1Mus musculus
R343GLVSLRMFHLS1Rattus norvegicus
S167GFFLVSLLVEI2Homo sapiens, Mus musculus
S167WFYLVSVRFEK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S167GFFLVSLMVEI1Rattus norvegicus
S235LRIYLSGWKGN2Homo sapiens, Rattus norvegicus
S235IRPFLAGWTNM1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S235LRIYLSGWKCS1Mus musculus
S263EFAGGSAGQSS1Homo sapiens
S263IFSGGSNAQSS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S263MFSGGSAGQSS1Mus musculus
S263KFSGGSAGQSS1Rattus norvegicus
V125LPPILSYADCV2Mus musculus, Rattus norvegicus
V125LPPILVYADCV1Homo sapiens
V125VPPLATYSSLV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V130SYADCVLANWK2Mus musculus, Rattus norvegicus
V130VYADCVLANWK1Homo sapiens
V130TYSSLVLWNFK1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V166KGFFLVSLLVE2Homo sapiens, Mus musculus
V166SWFYLVSVRFE1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V166KGFFLVSLMVE1Rattus norvegicus
V170LVSLLVEIAAA1Homo sapiens
V170LVSVRFEKIGS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V170LVSLLVEIAAS1Mus musculus
V170LVSLMVEIAAS1Rattus norvegicus
V221RMRDFVDPDTF2Mus musculus, Rattus norvegicus
V221QIHDHVNPKAF1Homo sapiens
V221EMELKCEPNVF1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V350YHLQIVTKYIL1Homo sapiens
V350NHIQIVTKYII1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V350FHLAIVDTYIM1Mus musculus
V350FHLSIVDTYIV1Rattus norvegicus
V391NFLKTVRSTT-1Homo sapiens
V391PFLKQCRDETV1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
V391TFLRSVKDTT-1Mus musculus
V391NFLRSVKDTT-1Rattus norvegicus
Y126PPILSYADCVL2Mus musculus, Rattus norvegicus
Y126PPILVYADCVL1Homo sapiens
Y126PPLATYSSLVL1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y353QIVTKYILIPA1Homo sapiens
Y353QIVTKYIILPS1Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Y353AIVDTYIMKPS1Mus musculus
Y353SIVDTYIVKPS1Rattus norvegicus


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