mutLBSgeneDB |
Gene summary for ING1 |
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Basic gene Info. | Gene symbol | ING1 |
Gene name | inhibitor of growth family, member 1 | |
Synonyms | p24ING1c|p33|p33ING1|p33ING1b|p47|p47ING1a | |
Cytomap | UCSC genome browser: 13q34 | |
Type of gene | protein-coding | |
RefGenes | NM_001267728.1, NM_005537.5,NM_198217.2,NM_198218.2,NM_198219.2, | |
Description | growth inhibitor ING1growth inhibitory protein ING1inhibitor of growth protein 1tumor suppressor ING1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601566 | |
HGNC : HGNC | ||
Ensembl : ENSG00000153487 | ||
HPRD : 03337 | ||
Vega : OTTHUMG00000017346 | ||
Protein | UniProt: Q9UK53 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ING1 | |
BioGPS: 3621 | ||
Pathway | NCI Pathway Interaction Database: ING1 | |
KEGG: ING1 | ||
REACTOME: ING1 | ||
Pathway Commons: ING1 | ||
Context | iHOP: ING1 | |
ligand binding site mutation search in PubMed: ING1 | ||
UCL Cancer Institute: ING1 | ||
Assigned class in mutLBSgeneDB | B: This gene belongs to targetable_mutLBSgenes. |
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GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ING1 |
![]() We represented ligand binding site mutations only. (You can see big image via clicking.) ![]() |
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LBS | AAchange of nsSNV | Cancer type | # samples | W378 | W378R | COAD | 2 | D370 | D370Y | COAD | 1 | E377 | E377K | COAD | 1 | W378 | W378C | OV | 1 | C358 | C358Y | STAD | 1 | D370 | D370Y | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ING1 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D370 | D370Y | 0.10766016 | E377 | E377K | -1.4667243 | W378 | W378C | -1.1993326 | W378 | W378R | -1.0898827 | C358 | C358Y | -0.7133892 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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PDB ID | PDB title | PDB structure | 2QIC | Crystal Structure of the ING1 PHD Finger in complex with a Histone H3K4ME3 peptide | ![]() |
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Differential gene expression and gene-gene network for ING1 |
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Phenotype information for ING1 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C1168401 | Carcinoma, squamous cell of head and neck | 2 | Biomarker, GeneticVariation |
umls:C0242656 | Disease Progression | 1 | Biomarker |
umls:C0038356 | Stomach Neoplasms | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ING1 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ING1 |
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LBS | AA sequence | # species | Species |
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