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mutLBSgeneDB |
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| Gene summary for ITGAM |
 Gene summary |
| Basic gene Info. | Gene symbol | ITGAM |
| Gene name | integrin, alpha M (complement component 3 receptor 3 subunit) | |
| Synonyms | CD11B|CR3A|MAC-1|MAC1A|MO1A|SLEB6 | |
| Cytomap | UCSC genome browser: 16p11.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000632.3, NM_001145808.1, | |
| Description | CD11 antigen-like family member BCR-3 alpha chainantigen CD11b (p170)cell surface glycoprotein MAC-1 subunit alphaintegrin alpha-Mleukocyte adhesion receptor MO1macrophage antigen alpha polypeptideneutrophil adherence receptor alpha-M subunit | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 120980 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169896 | ||
| HPRD : 00411 | ||
| Vega : OTTHUMG00000176612 | ||
| Protein | UniProt: P11215 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ITGAM | |
| BioGPS: 3684 | ||
| Pathway | NCI Pathway Interaction Database: ITGAM | |
| KEGG: ITGAM | ||
| REACTOME: ITGAM | ||
| Pathway Commons: ITGAM | ||
| Context | iHOP: ITGAM | |
| ligand binding site mutation search in PubMed: ITGAM | ||
| UCL Cancer Institute: ITGAM | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for ITGAM |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L189 | S188C | BLCA | 1 | T225 | R224Q | COAD | 1 | T225 | T225A | KICH | 1 | I218 | T219M | KIRC | 1 | T225 | G223W | LUAD | 1 | I155 | L154F | LUAD | 1 | L189 | L189F | LUSC | 1 | D258 | D258N | SKCM | 1 | T225 | R224Q | THCA | 1 | S158 | S158Y | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for ITGAM |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | T225 | R224Q | -1.3131134 | L189 | L189F | -1.2167049 | T225 | G223W | -0.72952933 | I155 | L154F | -0.65727474 | T225 | T225A | -0.64487738 | L189 | S188C | -0.57260708 | S158 | S158Y | -0.56349026 | D258 | D258N | -0.50926404 | I218 | T219M | -0.15611899 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for ITGAM from PDB |
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| Differential gene expression and gene-gene network for ITGAM |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for ITGAM |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0024141 | Lupus Erythematosus, Systemic | 29 | Biomarker, GeneticVariation |
| umls:C0023487 | Leukemia, Promyelocytic, Acute | 6 | AlteredExpression, Biomarker, PostTranslationalModification |
| umls:C0017661 | Glomerulonephritis, IGA | 2 | Biomarker, GeneticVariation |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | Biomarker |
| umls:C0020877 | Ileitis | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for ITGAM |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of ITGAM go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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| Conservation information for LBS of ITGAM |
| Multiple alignments for P11215 in multiple species |
| LBS | AA sequence | # species | Species |
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