mutLBSgeneDB |
Gene summary for ITGAX |
Gene summary |
Basic gene Info. | Gene symbol | ITGAX |
Gene name | integrin, alpha X (complement component 3 receptor 4 subunit) | |
Synonyms | CD11C|SLEB6 | |
Cytomap | UCSC genome browser: 16p11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_000887.4, NM_001286375.1, | |
Description | CD11 antigen-like family member Cintegrin alpha-Xintegrin, alpha X (antigen CD11C (p150), alpha polypeptide)leu M5, alpha subunitleukocyte adhesion glycoprotein p150,95 alpha chainleukocyte adhesion receptor p150,95leukocyte surface antigen p150,95, | |
Modification date | 20141207 | |
dbXrefs | MIM : 151510 | |
HGNC : HGNC | ||
Ensembl : ENSG00000140678 | ||
HPRD : 01051 | ||
Vega : OTTHUMG00000132465 | ||
Protein | UniProt: P20702 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITGAX | |
BioGPS: 3687 | ||
Pathway | NCI Pathway Interaction Database: ITGAX | |
KEGG: ITGAX | ||
REACTOME: ITGAX | ||
Pathway Commons: ITGAX | ||
Context | iHOP: ITGAX | |
ligand binding site mutation search in PubMed: ITGAX | ||
UCL Cancer Institute: ITGAX | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
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Ligand binding site mutations for ITGAX |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | D530 | G529W | LUAD | 1 | D530 | L528Q | LUAD | 1 | D593 | G591V | LUAD | 1 | K535 | K535Q | OV | 1 | D466 | S464F | SKCM | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ITGAX |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D530 | L528Q | -1.1985133 | K535 | K535Q | -0.9145622 | D530 | G529W | -0.83906695 | D466 | S464F | -0.59965923 | D593 | G591V | -0.3979873 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ITGAX from PDB |
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Differential gene expression and gene-gene network for ITGAX |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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Phenotype information for ITGAX |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
umls:C0024141 | Lupus Erythematosus, Systemic | 2 | Biomarker, GeneticVariation |
umls:C0023487 | Leukemia, Promyelocytic, Acute | 2 | AlteredExpression, Biomarker |
umls:C0017661 | Glomerulonephritis, IGA | 1 | Biomarker |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ITGAX |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ITGAX go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ITGAX |
Multiple alignments for P20702 in multiple species |
LBS | AA sequence | # species | Species |
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