mutLBSgeneDB |
Gene summary for ITGB3 |
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Basic gene Info. | Gene symbol | ITGB3 |
Gene name | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | |
Synonyms | BDPLT16|BDPLT2|CD61|GP3A|GPIIIa|GT | |
Cytomap | UCSC genome browser: 17q21.32 | |
Type of gene | protein-coding | |
RefGenes | NM_000212.2, | |
Description | integrin beta-3platelet membrane glycoprotein IIIa | |
Modification date | 20141222 | |
dbXrefs | MIM : 173470 | |
HGNC : HGNC | ||
Ensembl : ENSG00000259207 | ||
HPRD : 01428 | ||
Vega : OTTHUMG00000171956 | ||
Protein | UniProt: P05106 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITGB3 | |
BioGPS: 3690 | ||
Pathway | NCI Pathway Interaction Database: ITGB3 | |
KEGG: ITGB3 | ||
REACTOME: ITGB3 | ||
Pathway Commons: ITGB3 | ||
Context | iHOP: ITGB3 | |
ligand binding site mutation search in PubMed: ITGB3 | ||
UCL Cancer Institute: ITGB3 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
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GO ID | GO Term | PubMed ID | GO:0006457 | protein folding | 12204115 | GO:0007160 | cell-matrix adhesion | 22505472 | GO:0007229 | integrin-mediated signaling pathway | 23382103 | GO:0034446 | substrate adhesion-dependent cell spreading | 24658351 |
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Ligand binding site mutations for ITGB3 |
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LBS | AAchange of nsSNV | Cancer type | # samples | K774 | Y773H | BLCA | 1 | S703 | K702T | COAD | 1 | E752 | A754T | COAD | 1 | S379 | R378G | COAD | 1 | A776 | A776V | GBM | 1 | M361 | D362Y | HNSC | 1 | K380 | E382G | LUAD | 1 | D145 | M144I | LUAD | 1 | M361 | S363T | LUSC | 1 | D749 | D749N | SKCM | 1 | M206 | D205A | STAD | 1 | E664 | E664K | UCEC | 1 | D749 | R750Q | UCEC | 1 | S379 | R378C | UCEC | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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Protein structure related information for ITGB3 |
![]() Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
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![]() Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | S379 | R378G | -1.7304142 | K774 | Y773H | -1.3667032 | S379 | R378C | -1.3129824 | M206 | D205A | -1.3086455 | E664 | E664K | -1.2949879 | D749 | R750Q | -1.273372 | K380 | E382G | -1.1976907 | E752 | A754T | -1.0920673 | M361 | S363T | -0.99880474 | D749 | D749N | -0.88205183 | S703 | K702T | -0.64007164 | M361 | D362Y | -0.56534305 | A776 | A776V | -0.5300642 | D145 | M144I | -0.48244421 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
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Differential gene expression and gene-gene network for ITGB3 |
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Phenotype information for ITGB3 |
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Disease ID | Disease name | # PubMed | Association type |
umls:C0027051 | Myocardial Infarction | 43 | Biomarker, GeneticVariation |
umls:C0040015 | Thrombasthenia | 35 | AlteredExpression, Biomarker, GeneticVariation |
umls:C0038454 | Stroke | 26 | Biomarker, GeneticVariation |
umls:C0010072 | Coronary Thrombosis | 11 | Biomarker, GeneticVariation |
umls:C0948089 | Acute Coronary Syndrome | 9 | Biomarker, GeneticVariation |
umls:C0004352 | Autistic Disorder | 8 | AlteredExpression, Biomarker, GeneticVariation |
umls:C0033578 | Prostatic Neoplasms | 7 | AlteredExpression, Biomarker |
umls:C0473780 | Thrombocytopenia, Neonatal Alloimmune | 5 | Biomarker, GeneticVariation |
umls:C0040034 | Thrombocytopenia | 5 | Biomarker, GeneticVariation |
umls:C0019080 | Hemorrhage | 2 | Biomarker, GeneticVariation |
umls:C0031117 | Peripheral Nervous System Diseases | 2 | Biomarker, GeneticVariation |
umls:C0007274 | Carotid Artery Thrombosis | 1 | Biomarker |
umls:C2937358 | Cerebral Hemorrhage | 1 | Biomarker |
umls:C0008074 | Child Development Disorders, Pervasive | 1 | Biomarker |
umls:C0017639 | Gliosis | 1 | Biomarker |
umls:C0019557 | Hip Fractures | 1 | Biomarker |
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Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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Pharmacological information for ITGB3 |
![]() Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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Drug status | DrugBank ID | Name | Type | Drug structure |
Approved | DB00054 | Abciximab | Biotech | ![]() |
Approved|investigational | DB00063 | Eptifibatide | Biotech | ![]() |
Approved | DB00098 | Anti-thymocyte Globulin (Rabbit) | Biotech | ![]() |
Approved | DB00775 | Tirofiban | Small molecule | ![]() |
Investigational | DB04863 | Lefradafiban | Small molecule | ![]() |
Investigational | DB05787 | LM-609 | Biotech | ![]() |
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Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
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Conservation information for LBS of ITGB3 |
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LBS | AA sequence | # species | Species |
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