mutLBSgeneDB |
Gene summary for ITGB7 |
Gene summary |
Basic gene Info. | Gene symbol | ITGB7 |
Gene name | integrin, beta 7 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 12q13.13 | |
Type of gene | protein-coding | |
RefGenes | NM_000889.2, NR_104181.1, | |
Description | gut homing receptor beta subunitintegrin beta 7 subunitintegrin beta-7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 147559 | |
HGNC : HGNC | ||
Ensembl : ENSG00000139626 | ||
HPRD : 00948 | ||
Vega : OTTHUMG00000169775 | ||
Protein | UniProt: P26010 go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ITGB7 | |
BioGPS: 3695 | ||
Pathway | NCI Pathway Interaction Database: ITGB7 | |
KEGG: ITGB7 | ||
REACTOME: ITGB7 | ||
Pathway Commons: ITGB7 | ||
Context | iHOP: ITGB7 | |
ligand binding site mutation search in PubMed: ITGB7 | ||
UCL Cancer Institute: ITGB7 | ||
Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO Term | PubMed ID |
Top |
Ligand binding site mutations for ITGB7 |
Cancer type specific mutLBS sorted by frequency |
LBS | AAchange of nsSNV | Cancer type | # samples | P217 | R219Q | GBM | 1 | D290 | T291A | STAD | 1 |
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
Top |
Protein structure related information for ITGB7 |
Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
: nsSNV at non-LBS: nsSNV at LBS |
nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
LBS | AAchange of nsSNV | Relative stability change | D290 | T291A | -1.5539502 | P217 | R219Q | -1.2792484 |
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
Structure image for ITGB7 from PDB |
Top |
Differential gene expression and gene-gene network for ITGB7 |
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
Top |
Top |
Phenotype information for ITGB7 |
Gene level disease information (DisGeNet) |
Disease ID | Disease name | # PubMed | Association type |
Mutation level pathogenic information (ClinVar annotation) |
Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
Top |
Pharmacological information for ITGB7 |
Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
Gene-centered drug-gene interaction network |
Drug information targeting mutLBSgene (Approved drugs only) |
Drug status | DrugBank ID | Name | Type | Drug structure |
Investigational | DB05122 | R1295 | Small molecule | |
Investigational | DB05802 | MLN-02 | Small molecule | |
Approved | DB09033 | Vedolizumab | Biotech |
Gene-centered ligand-gene interaction network |
Ligands binding to mutated ligand binding site of ITGB7 go to BioLip |
Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS |
Top |
Conservation information for LBS of ITGB7 |
Multiple alignments for P26010 in multiple species |
LBS | AA sequence | # species | Species |
Copyright © 2016-Present - The University of Texas Health Science Center at Houston |