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mutLBSgeneDB |
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| Gene summary for GSTK1 |
 Gene summary |
| Basic gene Info. | Gene symbol | GSTK1 |
| Gene name | glutathione S-transferase kappa 1 | |
| Synonyms | GST|GST 13-13|GST13|GST13-13|GSTK1-1|hGSTK1 | |
| Cytomap | UCSC genome browser: 7q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001143679.1, NM_001143680.1,NM_001143681.1,NM_015917.2, | |
| Description | GST class-kappaglutathione S-transferase k1glutathione S-transferase subunit 13 homolog | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602321 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197448 | ||
| Vega : OTTHUMG00000152637 | ||
| Protein | UniProt: Q9Y2Q3 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GSTK1 | |
| BioGPS: 373156 | ||
| Pathway | NCI Pathway Interaction Database: GSTK1 | |
| KEGG: GSTK1 | ||
| REACTOME: GSTK1 | ||
| Pathway Commons: GSTK1 | ||
| Context | iHOP: GSTK1 | |
| ligand binding site mutation search in PubMed: GSTK1 | ||
| UCL Cancer Institute: GSTK1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0055114 | oxidation-reduction process | 14742434 |
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| Ligand binding site mutations for GSTK1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | L92 | E93Q | BRCA | 1 | M48 | M48I | HNSC | 1 | K62 | R61S | LUAD | 1 | W126 | V125I | STAD | 1 | W126 | R124C | UCEC | 1 | L70 | L72F | UCEC | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for GSTK1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | L92 | E93Q | -1.559063 | K62 | R61S | -1.4413709 | W126 | R124C | -1.0433873 | L70 | L72F | -0.80115054 | M48 | M48I | -0.77040974 | W126 | V125I | -0.53703519 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for GSTK1 from PDB |
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| Differential gene expression and gene-gene network for GSTK1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for GSTK1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0029408 | Osteoarthritis | 1 | Biomarker |
| umls:C0033578 | Prostatic Neoplasms | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for GSTK1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Gene-centered drug-gene interaction network |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Approved|nutraceutical | DB00143 | Glutathione | Small molecule |  |
| Experimental | DB04700 | GLUTATHIONE SULFINATE | Small molecule |  |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of GSTK1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | GSF | GLUTATHIONE SULFINATE | 1yzx | A | K62 | GSF | GLUTATHIONE SULFINATE | 1yzx | B | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | A | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | B | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | C | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | D | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | E | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | F | K62 | GTX | S-HEXYLGLUTATHIONE | 3rpn | D | L70 | GTX | S-HEXYLGLUTATHIONE | 3rpn | B | L92 | GTX | S-HEXYLGLUTATHIONE | 3rpn | C | L92 | GSF | GLUTATHIONE SULFINATE | 1yzx | A | M48 | GSF | GLUTATHIONE SULFINATE | 1yzx | B | M48 | GTX | S-HEXYLGLUTATHIONE | 3rpn | F | W126 |
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| Conservation information for LBS of GSTK1 |
| Multiple alignments for Q9Y2Q3 in multiple species |
| LBS | AA sequence | # species | Species | D201 | MLFGSDRMELL | 2 | Homo sapiens, Rattus norvegicus | D201 | SFFGSDRFHLI | 1 | Caenorhabditis elegans | D201 | MLFGSDRLELL | 1 | Mus musculus | F181 | CKYGAFGLP-T | 2 | Mus musculus, Rattus norvegicus | F181 | CRYGAFGLP-I | 1 | Homo sapiens | F181 | VDLMAYGAPWI | 1 | Caenorhabditis elegans | F198 | QTHMLFGSDRM | 1 | Homo sapiens | F198 | SEHSFFGSDRF | 1 | Caenorhabditis elegans | F198 | KTYMLFGSDRL | 1 | Mus musculus | F198 | KTYMLFGSDRM | 1 | Rattus norvegicus | G182 | KYGAFGLP-TT | 2 | Mus musculus, Rattus norvegicus | G182 | RYGAFGLP-IT | 1 | Homo sapiens | G182 | DLMAYGAPWIN | 1 | Caenorhabditis elegans | G199 | THMLFGSDRME | 1 | Homo sapiens | G199 | EHSFFGSDRFH | 1 | Caenorhabditis elegans | G199 | TYMLFGSDRLE | 1 | Mus musculus | G199 | TYMLFGSDRME | 1 | Rattus norvegicus | I44 | LRPSLITGIMK | 1 | Homo sapiens | I44 | YIPFFLGAVMK | 1 | Caenorhabditis elegans | I44 | LRPTLIAGIMK | 1 | Mus musculus | I44 | LRPALLAGIMK | 1 | Rattus norvegicus | K62 | GLLPRKGLYMA | 1 | Homo sapiens | K62 | AMLPARSIMMM | 1 | Caenorhabditis elegans | K62 | AMVPRKGQYIF | 1 | Mus musculus | K62 | AMVPHKGQYIL | 1 | Rattus norvegicus | L15 | LFYDVLSPYSW | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | L15 | FYFDVISPYSY | 1 | Caenorhabditis elegans | L183 | YGAFGLP-TTV | 2 | Mus musculus, Rattus norvegicus | L183 | YGAFGLP-ITV | 1 | Homo sapiens | L183 | LMAYGAPWINV | 1 | Caenorhabditis elegans | L70 | YMANDLKLLRH | 1 | Homo sapiens | L70 | MMMTDLKRTAK | 1 | Caenorhabditis elegans | L70 | YIFKEIPLLKQ | 1 | Mus musculus | L70 | YILKEIPLLKQ | 1 | Rattus norvegicus | L88 | FPKDFLSVMLE | 1 | Homo sapiens | L88 | PPPLFMEWIKK | 1 | Caenorhabditis elegans | L88 | IPKDFFGETVK | 1 | Mus musculus | L88 | VPKDFFGEHVK | 1 | Rattus norvegicus | L92 | FLSVMLEKGSL | 1 | Homo sapiens | L92 | FMEWIKKYRTT | 1 | Caenorhabditis elegans | L92 | FFGETVKKGSI | 1 | Mus musculus | L92 | FFGEHVKKGTV | 1 | Rattus norvegicus | M48 | LITGIMKDSGN | 1 | Homo sapiens | M48 | FLGAVMKESGN | 1 | Caenorhabditis elegans | M48 | LIAGIMKDSGN | 1 | Mus musculus | M48 | LLAGIMKDSGN | 1 | Rattus norvegicus | M66 | RKGLYMANDLK | 1 | Homo sapiens | M66 | ARSIMMMTDLK | 1 | Caenorhabditis elegans | M66 | RKGQYIFKEIP | 1 | Mus musculus | M66 | HKGQYILKEIP | 1 | Rattus norvegicus | M91 | DFLSVMLEKGS | 1 | Homo sapiens | M91 | LFMEWIKKYRT | 1 | Caenorhabditis elegans | M91 | DFFGETVKKGS | 1 | Mus musculus | M91 | DFFGEHVKKGT | 1 | Rattus norvegicus | N53 | MKDSGNQPPAM | 2 | Mus musculus, Rattus norvegicus | N53 | MKDSGNKPPGL | 1 | Homo sapiens | N53 | MKESGNRPPAM | 1 | Caenorhabditis elegans | P17 | YDVLSPYSWLG | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P17 | FDVISPYSYIA | 1 | Caenorhabditis elegans | P56 | SGNKPPGLLPR | 1 | Homo sapiens | P56 | SGNRPPAMLPA | 1 | Caenorhabditis elegans | P56 | SGNQPPAMVPR | 1 | Mus musculus | P56 | SGNQPPAMVPH | 1 | Rattus norvegicus | R202 | LFGSDRMELLA | 2 | Homo sapiens, Rattus norvegicus | R202 | FFGSDRFHLIA | 1 | Caenorhabditis elegans | R202 | LFGSDRLELLA | 1 | Mus musculus | S16 | FYDVLSPYSWL | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S16 | YFDVISPYSYI | 1 | Caenorhabditis elegans | S200 | HMLFGSDRMEL | 1 | Homo sapiens | S200 | HSFFGSDRFHL | 1 | Caenorhabditis elegans | S200 | YMLFGSDRLEL | 1 | Mus musculus | S200 | YMLFGSDRMEL | 1 | Rattus norvegicus | W126 | LWMRVWSRNED | 1 | Homo sapiens | W126 | MWVRLWSRSEK | 1 | Caenorhabditis elegans | W126 | IWMRVWSRDED | 1 | Mus musculus | W126 | LWMRIWSRDED | 1 | Rattus norvegicus | Y18 | DVLSPYSWLGF | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | Y18 | DVISPYSYIAF | 1 | Caenorhabditis elegans |
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