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mutLBSgeneDB |
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| Gene summary for KIF5B |
 Gene summary |
| Basic gene Info. | Gene symbol | KIF5B |
| Gene name | kinesin family member 5B | |
| Synonyms | HEL-S-61|KINH|KNS|KNS1|UKHC | |
| Cytomap | UCSC genome browser: 10p11.22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_004521.2, | |
| Description | conventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainkinesin-1 heavy chainubiquitous kinesin heavy chain | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602809 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000170759 | ||
| HPRD : 07214 | ||
| Vega : OTTHUMG00000017913 | ||
| Protein | UniProt: P33176 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KIF5B | |
| BioGPS: 3799 | ||
| Pathway | NCI Pathway Interaction Database: KIF5B | |
| KEGG: KIF5B | ||
| REACTOME: KIF5B | ||
| Pathway Commons: KIF5B | ||
| Context | iHOP: KIF5B | |
| ligand binding site mutation search in PubMed: KIF5B | ||
| UCL Cancer Institute: KIF5B | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID | GO:0042391 | regulation of membrane potential | 19675065 | GO:0043268 | positive regulation of potassium ion transport | 19675065 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane | 19675065 |
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| Ligand binding site mutations for KIF5B |
| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | M197 | M197I | BRCA | 1 | T87 | G85E | LUAD | 1 | K187 | S188F | SKCM | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for KIF5B |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | K187 | S188F | 0.30598184 | M197 | M197I | -0.60766432 | T87 | G85E | -0.11586658 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for KIF5B from PDB |
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| Differential gene expression and gene-gene network for KIF5B |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for KIF5B |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| umls:C0007131 | Carcinoma, Non-Small-Cell Lung | 7 | Biomarker |
| umls:C0011849 | Diabetes Mellitus | 1 | Biomarker |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for KIF5B |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of KIF5B go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | SO4 | SULFATE | 1mkj | A | K187 M197 | ADP | ADP | 1bg2 | A | T87 | ADP | ADP | 1mkj | A | T87 | ADP | ADP | 2p4n | K | T87 | ALF | TETRAFLUOROALUMINATE(1-) | 4hna | K | T87 | ATP | ATP | 3j8y | K | T87 |
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| Conservation information for LBS of KIF5B |
| Multiple alignments for P33176 in multiple species |
| LBS | AA sequence | # species | Species | A233 | YLVDLAGSEKV | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | A233 | FLVDLAGSEKV | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | G234 | LVDLAGSEKVS | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | G234 | LVDLAGSEKVG | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | G90 | GQTSSGKTHTM | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | G90 | GQTGAGKSYTM | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | H191 | GKSNRHVAVTN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H191 | GGNARAVAATN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | H191 | GKSNRMVAVTN | 1 | Caenorhabditis elegans | H191 | GKSNRHIAVTN | 1 | Drosophila melanogaster | H93 | SSGKTHTMEGK | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | H93 | SSGKTHTMEGV | 2 | Caenorhabditis elegans, Drosophila melanogaster | H93 | GAGKSYTMMGT | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | K187 | TIDEGKSNRHV | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | K187 | VMRRGGNARAV | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | K187 | AIEDGKSNRMV | 1 | Caenorhabditis elegans | K187 | VIEEGKSNRHI | 1 | Drosophila melanogaster | K91 | QTSSGKTHTME | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | K91 | QTGAGKSYTMM | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | M197 | VAVTNMNEHSS | 4 | Homo sapiens, Caenorhabditis elegans, Mus musculus, Rattus norvegicus | M197 | VAATNMNQESS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | M197 | IAVTNMNEHSS | 1 | Drosophila melanogaster | N198 | AVTNMNEHSSR | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | N198 | AATNMNQESSR | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | P17 | MCRFRPLNESE | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | P17 | VARFRPQNRVE | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | P17 | FCRIRPLNKTE | 1 | Caenorhabditis elegans | P17 | VCRFRPLNDSE | 1 | Drosophila melanogaster | R14 | IKVMCRFRPLN | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R14 | IKVVARFRPQN | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | R14 | VQVFCRIRPLN | 1 | Caenorhabditis elegans | R14 | IKVVCRFRPLN | 1 | Drosophila melanogaster | R16 | VMCRFRPLNES | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | R16 | VVARFRPQNRV | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | R16 | VFCRIRPLNKT | 1 | Caenorhabditis elegans | R16 | VVCRFRPLNDS | 1 | Drosophila melanogaster | S201 | NMNEHSSRSHS | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | S201 | NMNQESSRSHS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | S202 | MNEHSSRSHSI | 3 | Homo sapiens, Mus musculus, Rattus norvegicus | S202 | MNEHSSRSHSV | 2 | Caenorhabditis elegans, Drosophila melanogaster | S202 | MNQESSRSHSI | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | S88 | AYGQTSSGKTH | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | S88 | AYGQTGAGKSY | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | S89 | YGQTSSGKTHT | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | S89 | YGQTGAGKSYT | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | T87 | FAYGQTSSGKT | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | T87 | FAYGQTGAGKS | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | T92 | TSSGKTHTMEG | 5 | Homo sapiens, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Rattus norvegicus | T92 | TGAGKSYTMMG | 1 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) |
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