mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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	Gene Summary
	Ligand Binding Site Mutation Information
	Protein Structure Related Information
	Gene Expression and Gene-Gene Network
	Phenotype Information
	Pharmacological Information
	Conservation Information for LBS

Gene summary for ARG1

Gene summary

Basic gene Info.	Gene symbol	ARG1
	Gene name	arginase 1
	Synonyms	-
	Cytomap	UCSC genome browser: 6q23
	Type of gene	protein-coding
	RefGenes	NM_000045.3, NM_001244438.1,
	Description	arginase, liverarginase-1liver-type arginasetype I arginase
	Modification date	20141219
dbXrefs	MIM : 608313
	HGNC : HGNC
	Ensembl : ENSG00000118520
	HPRD : 01947
	Vega : OTTHUMG00000015566
Protein	UniProt: P05089 go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_ARG1
	BioGPS: 383
Pathway	NCI Pathway Interaction Database: ARG1
	KEGG: ARG1
	REACTOME: ARG1
	Pathway Commons: ARG1
Context	iHOP: ARG1
	ligand binding site mutation search in PubMed: ARG1
	UCL Cancer Institute: ARG1
Assigned class in mutLBSgeneDB	B: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO Term

PubMed ID

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Ligand binding site mutations for ARG1

Cancer type specific mutLBS sorted by frequency

LBS	AAchange of nsSNV	Cancer type	# samples
G142	P144L	LUSC	1
D234	G235R	STAD	1

cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.

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Protein structure related information for ARG1

Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
(ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)

: nsSNV at non-LBS

: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.

LBS	AAchange of nsSNV	Relative stability change
D234	G235R	-0.55612291
G142	P144L	-0.18975718

(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for ARG1 from PDB

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Differential gene expression and gene-gene network for ARG1

Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)

* Left PPI network was created from samples with mutations in the LBS of ARG1 and the right PPI network was created from samples without mutations in the LBS of ARG1. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.

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Phenotype information for ARG1

Gene level disease information (DisGeNet)

Disease ID	Disease name	# PubMed	Association type
umls:C0268548	Hyperargininemia	12	Biomarker, GeneticVariation
umls:C0004096	Asthma	12	Biomarker, GeneticVariation
umls:C0037116	Silicosis	2	Biomarker
umls:C0032927	Precancerous Conditions	2	Biomarker, GeneticVariation
umls:C0002514	Amino Acid Metabolism, Inborn Errors	1	Biomarker
umls:C0860207	Drug-Induced Liver Injury	1	Biomarker
umls:C0018500	Hair Diseases	1	Biomarker
umls:C0021053	Immune System Diseases	1	Biomarker
umls:C0023281	Leishmaniasis	1	Biomarker
umls:C0026848	Muscular Diseases	1	Biomarker

Mutation level pathogenic information (ClinVar annotation)

Allele ID

AA change

Clinical significance

Origin

Phenotype IDs

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Pharmacological information for ARG1

Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network

Drug information targeting mutLBSgene (Approved drugs only)

Drug status	DrugBank ID	Name	Type	Drug structure
Approved\|nutraceutical	DB00129	L-Ornithine	Small molecule
Experimental	DB01983	2(S)-Amino-6-Boronohexanoic Acid	Small molecule
Experimental	DB02381	Nor-N-Omega-Hydroxy-L-Arginine	Small molecule
Experimental	DB02499	Dinor-N(Omega)-Hydroxy-L-Arginine	Small molecule
Experimental	DB02689	S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine	Small molecule
Experimental	DB03144	N-Omega-Hydroxy-L-Arginine	Small molecule
Experimental	DB03731	S-2-(Boronoethyl)-L-Cysteine	Small molecule
Approved	DB03904	Urea	Small molecule
Experimental	DB04197	Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine	Small molecule
Experimental	DB04530	S,S-(2-Hydroxyethyl)Thiocysteine	Small molecule
Experimental	DB04585	DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID	Small molecule
Experimental	DB04648	S-propylamine-L-cysteine	Small molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of ARG1 go to BioLip

Ligand ID	Ligand short name	Ligand long name	PDB ID	PDB name	mutLBS
MN		MANGANESE(2+)	1wva	A	D234
S2C		S-2-(BORONOETHYL)-L-CYSTEINE	1wva	A	D234
MN		MANGANESE(2+)	1wva	B	D234
S2C		S-2-(BORONOETHYL)-L-CYSTEINE	1wva	B	D234
MN		MANGANESE(2+)	1wvb	A	D234
S2C		S-2-(BORONOETHYL)-L-CYSTEINE	1wvb	A	D234
MN		MANGANESE(2+)	1wvb	B	D234
S2C		S-2-(BORONOETHYL)-L-CYSTEINE	1wvb	B	D234
MN		MANGANESE(2+)	2aeb	A	D234
MN		MANGANESE(2+)	2aeb	B	D234
MN		MANGANESE(2+)	2pha	A	D234
MN		MANGANESE(2+)	2pha	B	D234
MN		MANGANESE(2+)	2pho	A	D234
MN		MANGANESE(2+)	2pho	B	D234
MN		MANGANESE(2+)	2pll	A	D234
MN		MANGANESE(2+)	2pll	B	D234
MN		MANGANESE(2+)	2zav	A	D234
MN		MANGANESE(2+)	2zav	B	D234
MN		MANGANESE(2+)	3dj8	A	D234
MN		MANGANESE(2+)	3dj8	B	D234
MN		MANGANESE(2+)	3e6k	A	D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3e6k	A	D234
MN		MANGANESE(2+)	3e6k	B	D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3e6k	B	D234
MN		MANGANESE(2+)	3e6v	A	D234
MN		MANGANESE(2+)	3e6v	B	D234
MN		MANGANESE(2+)	3f80	A	D234
MN		MANGANESE(2+)	3f80	B	D234
MN		MANGANESE(2+)	3gmz	A	D234
MN		MANGANESE(2+)	3gmz	B	D234
MN		MANGANESE(2+)	3gn0	A	D234
MN		MANGANESE(2+)	3gn0	B	D234
MN		MANGANESE(2+)	3kv2	A	D234
MN		MANGANESE(2+)	3kv2	B	D234
MN		MANGANESE(2+)	3lp4	A	D234
MN		MANGANESE(2+)	3lp4	B	D234
MN		MANGANESE(2+)	3lp7	A	D234
MN		MANGANESE(2+)	3lp7	B	D234
MN		MANGANESE(2+)	3mfv	A	D234
MN		MANGANESE(2+)	3mfv	B	D234
SO4		SULFATE	3mfw	A	D234
MN		MANGANESE(2+)	3mfw	A	D234
SO4		SULFATE	3mfw	B	D234
MN		MANGANESE(2+)	3mfw	B	D234
MN		MANGANESE(2+)	3mjl	A	D234
MN		MANGANESE(2+)	3mjl	B	D234
MN		MANGANESE(2+)	3sjt	A	D234
MN		MANGANESE(2+)	3sjt	B	D234
5AB		[(5S)-5-AMINO-5-CARBOXYHEXYL](TRIHYDROXY)BORATE	3sjt	B	D234
MN		MANGANESE(2+)	3skk	A	D234
4U7		[(5S)-5-AMINO-5-CARBOXY-6,6-DIFLUOROHEXYL](TRIHYDROXY)BORATE(1-)	3skk	A	D234
MN		MANGANESE(2+)	3skk	B	D234
CO		COBALT(2+)	3th7	A	D234
CO		COBALT(2+)	3th7	B	D234
CO		COBALT(2+)	3the	A	D234
CO		COBALT(2+)	3the	B	D234
CO		COBALT(2+)	3thh	A	D234
CO		COBALT(2+)	3thh	B	D234
CO		COBALT(2+)	3thj	A	D234
CO		COBALT(2+)	3thj	B	D234
MN		MANGANESE(2+)	4fci	A	D234
MN		MANGANESE(2+)	4fci	B	D234
CO		COBALT(2+)	4fck	A	D234
CO		COBALT(2+)	4fck	B	D234
ZN		ZINC(2+)	4gsz	A	D234
ZN		ZINC(2+)	4gsz	B	D234
MN		MANGANESE(2+)	4gwc	A	D234
MN		MANGANESE(2+)	4gwc	B	D234
MN		MANGANESE(2+)	4gwd	A	D234
MN		MANGANESE(2+)	4gwd	B	D234
MN		MANGANESE(2+)	4hww	A	D234
MN		MANGANESE(2+)	4hww	B	D234
MN		MANGANESE(2+)	4hxq	A	D234
MN		MANGANESE(2+)	4hxq	B	D234
MN		MANGANESE(2+)	4ie1	A	D234
MN		MANGANESE(2+)	4ie1	B	D234
EXY		(2S)-2-AMINO-7,8-EPOXY OCTANOIC ACID	3dj8	A	G142
6HN		6-NITRO-L-NORLEUCINE	3f80	A	G142
ORN		L-ORNITHINE	3gmz	A	G142
ORN		L-ORNITHINE	3gmz	B	G142
DMO		2-(DIFLUOROMETHYL)ORNITHINE	3gn0	A	G142
LYS		LYSINE	3lp4	B	G142
Z70		2-AMINOHOMOHISTIDINE	3mfv	A	G142
B3U		2-AMINO-L-HISTIDINE	3mfw	A	G142
B3U		2-AMINO-L-HISTIDINE	3mfw	B	G142
2AI		P-IODOCLONIDINE	3mjl	A	G142
ORN		L-ORNITHINE	3thj	A	G142
ORN		L-ORNITHINE	3thj	B	G142
GPA		2-AMINO-3-GUANIDINO-PROPIONIC ACID	4fci	A	G142
GPA		2-AMINO-3-GUANIDINO-PROPIONIC ACID	4fck	B	G142
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	2aeb	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	2aeb	B	G142 D234
TSZ		HYDRAZINECARBOTHIOAMIDE	2pho	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	2pll	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	2pll	B	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3e6v	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3e6v	B	G142 D234
NNH		NOR-N-OMEGA-HYDROXY-L-ARGININE	3kv2	A	G142 D234
NNH		NOR-N-OMEGA-HYDROXY-L-ARGININE	3kv2	B	G142 D234
HAR		N(5)-[(HYDROXYAMINO)(IMINO)METHYL]-L-ORNITHINE	3lp7	B	G142 D234
Z70		2-AMINOHOMOHISTIDINE	3mfv	B	G142 D234
5AB		[(5S)-5-AMINO-5-CARBOXYHEXYL](TRIHYDROXY)BORATE	3sjt	A	G142 D234
4U7		[(5S)-5-AMINO-5-CARBOXY-6,6-DIFLUOROHEXYL](TRIHYDROXY)BORATE(1-)	3skk	B	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3thh	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	3thh	B	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gsv	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gsv	B	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gsz	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gsz	B	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gwd	A	G142 D234
ABH		(S)-2-AMINO-6-BORONOHEXANOIC ACID	4gwd	B	G142 D234
X7A		[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL) HEPTYL](TRIHYDROXY)BORATE(1-)	4hww	A	G142 D234
X7A		[(5R)-5-AMINO-5-CARBOXY-7-(PIPERIDIN-1-YL) HEPTYL](TRIHYDROXY)BORATE(1-)	4hww	B	G142 D234
X8A		[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL) HEPTYL](TRIHYDROXY)BORATE(1-)	4hxq	A	G142 D234
X8A		[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL) HEPTYL](TRIHYDROXY)BORATE(1-)	4hxq	B	G142 D234
1EC		[(5R)-5-AMINO-5-CARBOXY-8-HYDROXYOCTYL](TRIHYDROXY) BORATE(1-)	4ie1	A	G142 D234
1EC		[(5R)-5-AMINO-5-CARBOXY-8-HYDROXYOCTYL](TRIHYDROXY) BORATE(1-)	4ie1	B	G142 D234

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Conservation information for LBS of ARG1

Multiple alignments for P05089 in multiple species

LBS	AA sequence	# species	Species
A125	VIWVDAHTDIN	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
A125	VLWIDAHADIN	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
A125	LLWIDAHADIN	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
A125	LLWVDAHADIN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D117	ARVHPDLCVIW	3	Mus musculus, Rattus norvegicus, Bos taurus
D117	QAVYDDACVLW	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D117	ARVHPDLGVIW	1	Homo sapiens
D117	LDKYPDAGLLW	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D117	LDKYPNAGLLW	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D117	LDRYPDAGLLW	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D124	CVIWVDAHTDI	3	Mus musculus, Rattus norvegicus, Bos taurus
D124	CVLWIDAHADI	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D124	GLLWIDAHADI	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D124	GVIWVDAHTDI	1	Homo sapiens
D124	GLLWVDAHADI	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D128	VDAHTDINTPL	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D128	IDAHADINTPD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D128	IDAHADINTPE	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D128	IDAHADINTIE	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D128	IDAHADINTCS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D128	VDAHADINTLA	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D183	GLRDVDPGEHY	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D183	GLRDLDPMERA	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D183	GLRDVDAGEKK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D183	GLRDVDAAERK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D183	GLRDVDPEEKE	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D232	IHLSFDVDGLD	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
D232	IHLSFDVDACD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D232	VHLSFDVDACD	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D232	IMCSYDVDGVD	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D232	IMVSYDVDAID	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D232	VMVSYDVDAID	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
D234	LSFDVDGLDPS	2	Homo sapiens, Bos taurus
D234	LSFDVDACDPI	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
D234	LSFDVDGLDPA	1	Mus musculus
D234	LSFDVDGLDPV	1	Rattus norvegicus
D234	CSYDVDGVDPL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
D234	VSYDVDAIDPL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
D234	VSYDVDAIDPM	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E186	DVDPGEHYILK	2	Homo sapiens, Bos taurus
E186	DVDPGEHYIIK	2	Mus musculus, Rattus norvegicus
E186	DLDPMERAFLR	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E186	DVDAGEKKILK	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
E186	DVDAAERKILK	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
E186	DVDPEEKEILR	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E277	GLDIMEVNPSL	2	Homo sapiens, Bos taurus
E277	GLDIMEVNPTL	2	Mus musculus, Rattus norvegicus
E277	AVDVMEVNPLL	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
E277	ALDVVECNPEL	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
E277	ALDVVECNPDL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
G142	SGNLHGQPVSF	2	Homo sapiens, Mus musculus
G142	SKNLHGCPLSF	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
G142	SGNLHGCPVSF	2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
G142	SGNLHGQPVAF	1	Rattus norvegicus
G142	TGNLHGQPVSF	1	Bos taurus
G142	SGNIHGCPVSF	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H101	TLGGDHSIAIG	3	Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H101	VLGGDHSLAIG	2	Homo sapiens, Bos taurus
H101	NIGGDHSLAIG	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H101	VLGGDHSLAVG	1	Mus musculus
H101	VLGGDHSMAIG	1	Rattus norvegicus
H115	GHARVHPDLCV	3	Mus musculus, Rattus norvegicus, Bos taurus
H115	GVQAVYDDACV	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H115	GHARVHPDLGV	1	Homo sapiens
H115	AVLDKYPDAGL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H115	GVLDKYPNAGL	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H115	GVLDRYPDAGL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H126	IWVDAHTDINT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
H126	LWIDAHADINT	4	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843), Saccharomyces cerevisiae (strain ATCC 204508 / S288c), Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37
H126	LWVDAHADINT	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
H141	PSKNLHGCPLS	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
H141	TSGNLHGQPVS	1	Homo sapiens
H141	SSGNLHGQPVS	1	Mus musculus
H141	SSGNLHGQPVA	1	Rattus norvegicus
H141	KTGNLHGQPVS	1	Bos taurus
H141	PSGNLHGCPVS	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
H141	ESGNIHGCPVS	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
H141	ESGNLHGCPVS	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
N130	AHTDINTPLTT	4	Homo sapiens, Mus musculus, Rattus norvegicus, Bos taurus
N130	AHADINTPDSS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N130	AHADINTPESS	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
N130	AHADINTIEST	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
N130	AHADINTCSTT	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
N130	AHADINTLAST	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
S137	PLTTSSGNLHG	2	Mus musculus, Rattus norvegicus
S137	PLTTTSGNLHG	1	Homo sapiens
S137	PLTTKTGNLHG	1	Bos taurus
S137	PDSSPSKNLHG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S137	PESSPSKNLHG	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
S137	IESTPSGNLHG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
S137	CSTTESGNIHG	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
S137	LASTESGNLHG	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T134	INTPLTTSSGN	2	Mus musculus, Rattus norvegicus
T134	INTPLTTTSGN	1	Homo sapiens
T134	INTPLTTKTGN	1	Bos taurus
T134	INTPDSSPSKN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T134	INTPESSPSKN	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T134	INTIESTPSGN	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T134	INTCSTTESGN	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T134	INTLASTESGN	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T135	NTPLTTSSGNL	2	Mus musculus, Rattus norvegicus
T135	NTPLTTTSGNL	1	Homo sapiens
T135	NTPLTTKTGNL	1	Bos taurus
T135	NTPDSSPSKNL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T135	NTPESSPSKNL	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T135	NTIESTPSGNL	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T135	NTCSTTESGNI	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T135	NTLASTESGNL	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T136	TPLTTSSGNLH	2	Mus musculus, Rattus norvegicus
T136	TPLTTTSGNLH	1	Homo sapiens
T136	TPLTTKTGNLH	1	Bos taurus
T136	TPDSSPSKNLH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T136	TPESSPSKNLH	1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T136	TIESTPSGNLH	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
T136	TCSTTESGNIH	1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
T136	TLASTESGNLH	1	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T246	TPATGTPVVGG	2	Homo sapiens, Rattus norvegicus
T246	APATGTRVPGG	2	Schizosaccharomyces pombe (strain 972 / ATCC 24843), Schizosaccharomyces pombe (strain 972 / ATCC 24843)
T246	VPATGTPVRGG	2	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37), Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
T246	TPATGTPVLGG	1	Mus musculus
T246	TPATGTPVQGG	1	Bos taurus
T246	IPATGTPVRGG	1	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)