mutLBSgeneDB

mutLBSgeneDB
mutated Ligand Binding Site gene DataBase

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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

Gene Summary

Ligand Binding Site Mutation Information

Protein Structure Related Information

Gene Expression and Gene-Gene Network

Phenotype Information

Pharmacological Information

Conservation Information for LBS

Gene summary for KIF11
Gene summary
Basic gene Info.Gene symbolKIF11
Gene namekinesin family member 11
SynonymsEG5|HKSP|KNSL1|MCLMR|TRIP5
CytomapUCSC genome browser: 10q24.1
Type of geneprotein-coding
RefGenesNM_004523.3,
DescriptionTR-interacting protein 5TRIP-5kinesin-like protein 1kinesin-like protein KIF11kinesin-like spindle protein HKSPkinesin-related motor protein Eg5thyroid receptor-interacting protein 5
Modification date20141207
dbXrefs MIM : 148760
HGNC : HGNC
Ensembl : ENSG00000138160
HPRD : 01023
Vega : OTTHUMG00000018761
ProteinUniProt: P52732
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_KIF11
BioGPS: 3832
PathwayNCI Pathway Interaction Database: KIF11
KEGG: KIF11
REACTOME: KIF11
Pathway Commons: KIF11
ContextiHOP: KIF11
ligand binding site mutation search in PubMed: KIF11
UCL Cancer Institute: KIF11
Assigned class in mutLBSgeneDBB: This gene belongs to targetable_mutLBSgenes.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO TermPubMed ID
GO:0090307spindle assembly involved in mitosis19001501


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Ligand binding site mutations for KIF11
Lollipop-style diagram of mutations at LBS in amino-acid sequence.
We represented ligand binding site mutations only. (You can see big image via clicking.)
 : non-synonymous mutation on LBS, Circle size denotes number of samples.

Cancer type specific mutLBS sorted by frequency
LBSAAchange of nsSNVCancer type# samples
L171L172VBLCA1
E145F144ICOAD1
D130P131LLUAD1
P338P338SSKCM1
D149G151CSKCM1
K207N206SUCEC1
cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma.


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Protein structure related information for KIF11
Relative protein structure stability change (ΔΔE) using Mupro 1.1
Mupro score denotes assessment of the effect of mutations on thermodynamic stability.
  (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability)
: nsSNV at non-LBS: nsSNV at LBS

nsSNVs sorted by the relative stability change of protein structure by each mutation
Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene.
LBSAAchange of nsSNVRelative stability change
L171L172V-1.1884407
K207N206S-0.73895347
P338P338S-0.64310063
D130P131L-0.621092
D149G151C-0.60544779
E145F144I-0.31757885
(MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132)

Structure image for KIF11 from PDB

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Differential gene expression and gene-gene network for KIF11
Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types

Differential co-expressed gene network based on protein-protein interaction data (CePIN)
* Left PPI network was created from samples with mutations in the LBS of KIF11 and the right PPI network was created from samples without mutations in the LBS of KIF11. Only genes with p-value < 0.05 are shown.
Red circle: input gene. Orange circle: LBSgene. Blue circle: other gene.


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Phenotype information for KIF11
Gene level disease information (DisGeNet)
Disease IDDisease name# PubMedAssociation type
umls:C1835265Lymphedema, microcephaly and chorioretinopathy syndrome2Biomarker, GeneticVariation
umls:C0002938Aneuploidy1Biomarker
umls:C1257806Chromosomal Instability1Biomarker
umls:C0017661Glomerulonephritis, IGA1Biomarker
umls:C0027659Neoplasms, Experimental1Biomarker

Mutation level pathogenic information (ClinVar annotation)
Allele IDAA changeClinical significanceOriginPhenotype IDs

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Pharmacological information for KIF11
Gene expression profile of anticancer drug treated cell-lines (CCLE)
Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient.

Gene-centered drug-gene interaction network
Drug information targeting mutLBSgene (Approved drugs only)
Drug statusDrugBank IDNameTypeDrug structure
ExperimentalDB039963-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]PhenolSmall molecule
ExperimentalDB04331MonastrolSmall molecule
ExperimentalDB07064(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDESmall molecule
ExperimentalDB08032N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall molecule
ExperimentalDB08033(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDESmall molecule
ExperimentalDB08037(2S)-4-(2,5-difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamideSmall molecule
ExperimentalDB08198[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONESmall molecule
ExperimentalDB08239(2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall molecule
ExperimentalDB08244(1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINESmall molecule
ExperimentalDB08246(2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDESmall molecule
ExperimentalDB08250(5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDESmall molecule

Gene-centered ligand-gene interaction network

Ligands binding to mutated ligand binding site of KIF11 go to BioLip
Ligand IDLigand short nameLigand long namePDB IDPDB namemutLBS
NATS-MENASTROL1q0bAD130
NATS-MENASTROL1q0bBD130
NATS-MENASTROL1x88AD130
NATS-MENASTROL1x88BD130
L473-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL1yrsAD130
L473-[(5S)-1-ACETYL-3-(2-CHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-5-YL]PHENOL1yrsBD130
3QC(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE2fmeAD130
3QC(4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE2fmeBD130
2AZN-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE2gm1AD130
2AZN-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE2gm1BD130
2AZN-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE2gm1DD130
2AZN-(3-AMINOPROPYL)-N-[(R)-(3-BENZYL-5-CHLORO-4-OXO-3,4-DIHYDROPYRROLO[2,1-F][1,2,4]TRIAZIN-2-YL)(CYCLOPROPYL)METHYL]-4-METHYLBENZAMIDE2gm1ED130
MOY[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE2iehAD130
MOY[(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE2iehBD130
K01N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE2pg2AD130
K02(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE2uyiAD130
K02(5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE2uyiBD130
K03N,N-DIETHYL-5,5-DIMETHYL-2-(THIOPHENE-2-CARBOXAMIDO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXAMIDE2uymAD130
K03N,N-DIETHYL-5,5-DIMETHYL-2-(THIOPHENE-2-CARBOXAMIDO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXAMIDE2uymBD130
KZ9(4S)-4-(3-HYDROXYPHENYL)-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE2x7cAD130
KZ9(4S)-4-(3-HYDROXYPHENYL)-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE2x7cBD130
EGB(4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE2x7dAD130
EGB(4S)-4-(3-HYDROXYPHENYL)-7,7-DIMETHYL-2-THIOXO-2,3,4,6,7,8-HEXAHYDROQUINAZOLIN-5(1H)-ONE2x7dBD130
X7E(R)-(3,4-DIFLUOROPHENYL)(4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)2x7eAD130
X7E(R)-(3,4-DIFLUOROPHENYL)(4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)2x7eBD130
L313-[(1R)-2-ACETYL-6-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-1-YL]PHENOL3k3bAD130
L313-[(1R)-2-ACETYL-6-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLIN-1-YL]PHENOL3k3bBD130
K5E(4S,5R)-5-HYDROXY-4-(3-HYDROXYPHENYL)-3,4,5,6,7,8-HEXAHYDROQUINAZOLINE-2(1H)-THIONE3k5eAD130
K5E(4S,5R)-5-HYDROXY-4-(3-HYDROXYPHENYL)-3,4,5,6,7,8-HEXAHYDROQUINAZOLINE-2(1H)-THIONE3k5eBD130
G7XISPINESIB MESILATE4a5yBD130
G7XISPINESIB MESILATE4a5yCD130
G7XISPINESIB MESILATE4ap0BD130
G7XISPINESIB MESILATE4ap0CD130
G7XISPINESIB MESILATE4ap0DD130
6LXN-(3-AMINOPROPYL)-N-[(1R)-1-(3-BENZYL-7- CHLORO-4-OXO-4H-CHROMEN-2-YL)-2-METHYLPROPYL]-4- METHYLBENZAMIDE4as7AD130
MJQN-(3-AZANYLPROPYL)-N-[(1R)-1-[7-CHLORANYL-4- OXIDANYLIDENE-3-(PHENYLMETHYL)CHROMEN-2-YL]-2- METHYL-PROPYL]-4-METHYL-BENZAMIDE4bxnAD130
G7XISPINESIB MESILATE4ap0AD130 L171
COCOBALT(2+)4b7bAE145 D149
COCOBALT(2+)4b7bAE145 K207
4A2(2E)-2-(3-FLUORANYL-4-METHOXY-PHENYL)IMINO-1- [[2-(TRIFLUOROMETHYL)PHENYL]METHYL]-3H- BENZIMIDAZOLE-5-CARBOXYLIC ACID3zcwAL171
CACALCIUM(2+)4b7bAP338


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Conservation information for LBS of KIF11
Multiple alignments for P52732 in multiple species
LBSAA sequence# speciesSpecies
A133EEDPLAGIIPR2Homo sapiens, Mus musculus
A133EDDSDIGIIPR1Drosophila melanogaster
A133EQDPLAGIIPR1Xenopus tropicalis
A218ILEKGAAKRTT2Homo sapiens, Mus musculus
A218LLEKGKERRKT1Drosophila melanogaster
A218ILERGAARRKT1Xenopus tropicalis
A219LEKGAAKRTTA2Homo sapiens, Mus musculus
A219LEKGKERRKTA1Drosophila melanogaster
A219LERGAARRKTA1Xenopus tropicalis
A224AKRTTAATLMN2Homo sapiens, Mus musculus
A224ERRKTATTLMN1Drosophila melanogaster
A224ARRKTASTLMN1Xenopus tropicalis
A267NLVDLAGSENI3Homo sapiens, Xenopus tropicalis, Mus musculus
A267NLVDLAGSENV1Drosophila melanogaster
A334RTSIIATISPA2Homo sapiens, Mus musculus
A334KTSIIATISPG1Drosophila melanogaster
A334KTSIIATVSPA1Xenopus tropicalis
A353STLEYAHRAKN3Homo sapiens, Drosophila melanogaster, Mus musculus
A353STLEYANRAKN1Xenopus tropicalis
A74DMVFGASTKQI2Homo sapiens, Mus musculus
A74DRSFGPESKQC1Drosophila melanogaster
A74DMVFGPAAKQI1Xenopus tropicalis
C43HSIVECDPVRK1Homo sapiens
C43AEVVDVVGPRE1Drosophila melanogaster
C43HSVLECDAPRK1Xenopus tropicalis
C43HSVVECDHARK1Mus musculus
C87YRSVVCPILDE3Homo sapiens, Xenopus tropicalis, Mus musculus
C87YSVVVSPLIEE1Drosophila melanogaster
D130YTWEEDPLAGI2Homo sapiens, Mus musculus
D130SSWEDDSDIGI1Drosophila melanogaster
D130FTWEQDPLAGI1Xenopus tropicalis
D149FEKLTDNGTEF2Homo sapiens, Mus musculus
D149FDELRMMEVEY1Drosophila melanogaster
D149FEKLSENGTEF1Xenopus tropicalis
D265KLNLVDLAGSE4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
D91VCPILDEVIMG3Homo sapiens, Xenopus tropicalis, Mus musculus
D91VSPLIEEVLNG1Drosophila melanogaster
E116KTFTMEGERSP2Homo sapiens, Mus musculus
E116KTHTMVGNETA1Drosophila melanogaster
E116KTFTMEGERSA1Xenopus tropicalis
E118FTMEGERSPNE2Homo sapiens, Mus musculus
E118HTMVGNETAEL1Drosophila melanogaster
E118FTMEGERSADE1Xenopus tropicalis
E145LHQIFEKLTDN2Homo sapiens, Mus musculus
E145LSHLFDELRMM1Drosophila melanogaster
E145LHQIFEKLSEN1Xenopus tropicalis
E166LEIYNEELFDL3Homo sapiens, Xenopus tropicalis, Mus musculus
E166LELYNEELCDL1Drosophila melanogaster
E215VYQILEKGAAK2Homo sapiens, Mus musculus
E215VYKLLEKGKER1Drosophila melanogaster
E215VYHILERGAAR1Xenopus tropicalis
F113GTGKTFTMEGE3Homo sapiens, Xenopus tropicalis, Mus musculus
F113GTGKTHTMVGN1Drosophila melanogaster
F239RSHSVFSVTIH3Homo sapiens, Xenopus tropicalis, Mus musculus
F239RSHTVFSIVVH1Drosophila melanogaster
F28VRCRPFNLAER2Homo sapiens, Mus musculus
F28VRVRPLNSRER1Drosophila melanogaster
F28VRCRPFNQLER1Xenopus tropicalis
G105TIFAYGQTGTG2Homo sapiens, Mus musculus
G105TVFAYGQTGTG2Drosophila melanogaster, Xenopus tropicalis
G108AYGQTGTGKTF3Homo sapiens, Xenopus tropicalis, Mus musculus
G108AYGQTGTGKTH1Drosophila melanogaster
G110GQTGTGKTFTM3Homo sapiens, Xenopus tropicalis, Mus musculus
G110GQTGTGKTHTM1Drosophila melanogaster
G117TFTMEGERSPN2Homo sapiens, Mus musculus
G117THTMVGNETAE1Drosophila melanogaster
G117TFTMEGERSAD1Xenopus tropicalis
G217QILEKGAAKRT2Homo sapiens, Mus musculus
G217KLLEKGKERRK1Drosophila melanogaster
G217HILERGAARRK1Xenopus tropicalis
G268LVDLAGSENIG3Homo sapiens, Xenopus tropicalis, Mus musculus
G268LVDLAGSENVS1Drosophila melanogaster
G296SLLTLGRVITA4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
G73FDMVFGASTKQ2Homo sapiens, Mus musculus
G73FDRSFGPESKQ1Drosophila melanogaster
G73FDMVFGPAAKQ1Xenopus tropicalis
I136PLAGIIPRTLH3Homo sapiens, Xenopus tropicalis, Mus musculus
I136SDIGIIPRALS1Drosophila melanogaster
I163VSLLEIYNEEL3Homo sapiens, Xenopus tropicalis, Mus musculus
I163ISYLELYNEEL1Drosophila melanogaster
I213DEVYQILEKGA2Homo sapiens, Mus musculus
I213DDVYKLLEKGK1Drosophila melanogaster
I213DEVYHILERGA1Xenopus tropicalis
I288REAGNINQSLL3Homo sapiens, Xenopus tropicalis, Mus musculus
I288RETVNINQSLL1Drosophila melanogaster
I299TLGRVITALVE3Homo sapiens, Xenopus tropicalis, Mus musculus
I299TLGRVITALVD1Drosophila melanogaster
I332RTRTSIIATIS2Homo sapiens, Mus musculus
I332RTKTSIIATIS1Drosophila melanogaster
I332RTKTSIIATVS1Xenopus tropicalis
K111QTGTGKTFTME3Homo sapiens, Xenopus tropicalis, Mus musculus
K111QTGTGKTHTMV1Drosophila melanogaster
K146HQIFEKLTDNG2Homo sapiens, Mus musculus
K146SHLFDELRMME1Drosophila melanogaster
K146HQIFEKLSENG1Xenopus tropicalis
K207ITVHNKDEVYQ2Homo sapiens, Mus musculus
K207IPVHSKDDVYK1Drosophila melanogaster
K207VSVHNKDEVYH1Xenopus tropicalis
K216YQILEKGAAKR2Homo sapiens, Mus musculus
K216YKLLEKGKERR1Drosophila melanogaster
K216YHILERGAARR1Xenopus tropicalis
K220EKGAAKRTTAA2Homo sapiens, Mus musculus
K220EKGKERRKTAT1Drosophila melanogaster
K220ERGAARRKTAS1Xenopus tropicalis
L160SVKVSLLEIYN3Homo sapiens, Xenopus tropicalis, Mus musculus
L160TMRISYLELYN1Drosophila melanogaster
L171EELFDLLNPSS1Homo sapiens
L171EELCDLL--ST1Drosophila melanogaster
L171EELFDLLSPSP1Xenopus tropicalis
L171EELFDLLSPSS1Mus musculus
L214EVYQILEKGAA2Homo sapiens, Mus musculus
L214DVYKLLEKGKE1Drosophila melanogaster
L214EVYHILERGAA1Xenopus tropicalis
L266LNLVDLAGSEN4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
L292NINQSLLTLGR4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
L293INQSLLTLGRV4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
L295QSLLTLGRVIT4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
M228TAATLMNAYSS2Homo sapiens, Mus musculus
M228TATTLMNAQSS1Drosophila melanogaster
M228TASTLMNAYSS1Xenopus tropicalis
N229AATLMNAYSSR2Homo sapiens, Mus musculus
N229ATTLMNAQSSR1Drosophila melanogaster
N229ASTLMNAYSSR1Xenopus tropicalis
N287AREAGNINQSL3Homo sapiens, Xenopus tropicalis, Mus musculus
N287VRETVNINQSL1Drosophila melanogaster
N289EAGNINQSLLT3Homo sapiens, Xenopus tropicalis, Mus musculus
N289ETVNINQSLLT1Drosophila melanogaster
P137LAGIIPRTLHQ3Homo sapiens, Xenopus tropicalis, Mus musculus
P137DIGIIPRALSH1Drosophila melanogaster
P27VVRCRPFNLAE2Homo sapiens, Mus musculus
P27YVRVRPLNSRE1Drosophila melanogaster
P27VVRCRPFNQLE1Xenopus tropicalis
P338IATISPASLNL1Homo sapiens
P338IATISPGHKDI1Drosophila melanogaster
P338IATVSPASINL1Xenopus tropicalis
P338IATISPASFNL1Mus musculus
Q106IFAYGQTGTGK2Homo sapiens, Mus musculus
Q106VFAYGQTGTGK2Drosophila melanogaster, Xenopus tropicalis
R119TMEGERSPNEE1Homo sapiens
R119TMVGNETAELK1Drosophila melanogaster
R119TMEGERSADEE1Xenopus tropicalis
R119TMEGERSPNEV1Mus musculus
R221KGAAKRTTAAT2Homo sapiens, Mus musculus
R221KGKERRKTATT1Drosophila melanogaster
R221RGAARRKTAST1Xenopus tropicalis
R24IQVVVRCRPFN3Homo sapiens, Xenopus tropicalis, Mus musculus
R24IQVYVRVRPLN1Drosophila melanogaster
R26VVVRCRPFNLA2Homo sapiens, Mus musculus
R26VYVRVRPLNSR1Drosophila melanogaster
R26VVVRCRPFNQL1Xenopus tropicalis
R297LLTLGRVITAL4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
R355LEYAHRAKNIL1Homo sapiens
R355LEYAHRAKNIQ1Drosophila melanogaster
R355LEYANRAKNIM1Xenopus tropicalis
R355LEYAHRAKNIM1Mus musculus
S232LMNAYSSRSHS3Homo sapiens, Xenopus tropicalis, Mus musculus
S232LMNAQSSRSHT1Drosophila melanogaster
S233MNAYSSRSHSV3Homo sapiens, Xenopus tropicalis, Mus musculus
S233MNAQSSRSHTV1Drosophila melanogaster
S235AYSSRSHSVFS3Homo sapiens, Xenopus tropicalis, Mus musculus
S235AQSSRSHTVFS1Drosophila melanogaster
S291GNINQSLLTLG3Homo sapiens, Xenopus tropicalis, Mus musculus
S291VNINQSLLTLG1Drosophila melanogaster
T107FAYGQTGTGKT4Homo sapiens, Drosophila melanogaster, Xenopus tropicalis, Mus musculus
T109YGQTGTGKTFT3Homo sapiens, Xenopus tropicalis, Mus musculus
T109YGQTGTGKTHT1Drosophila melanogaster
T112TGTGKTFTMEG3Homo sapiens, Xenopus tropicalis, Mus musculus
T112TGTGKTHTMVG1Drosophila melanogaster
T114TGKTFTMEGER3Homo sapiens, Xenopus tropicalis, Mus musculus
T114TGKTHTMVGNE1Drosophila melanogaster
T300LGRVITALVER3Homo sapiens, Xenopus tropicalis, Mus musculus
T300LGRVITALVDR1Drosophila melanogaster
V210HNKDEVYQILE2Homo sapiens, Mus musculus
V210HSKDDVYKLLE1Drosophila melanogaster
V210HNKDEVYHILE1Xenopus tropicalis
W127NEEYTWEEDPL1Homo sapiens
W127ELKSSWEDDSD1Drosophila melanogaster
W127DEEFTWEQDPL1Xenopus tropicalis
W127NEVYTWEEDPL1Mus musculus
Y104CTIFAYGQTGT2Homo sapiens, Mus musculus
Y104CTVFAYGQTGT2Drosophila melanogaster, Xenopus tropicalis
Y211NKDEVYQILEK2Homo sapiens, Mus musculus
Y211SKDDVYKLLEK1Drosophila melanogaster
Y211NKDEVYHILER1Xenopus tropicalis
Y352LSTLEYAHRAK3Homo sapiens, Drosophila melanogaster, Mus musculus
Y352VSTLEYANRAK1Xenopus tropicalis


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