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mutLBSgeneDB |
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| Gene summary for KIFC1 |
 Gene summary |
| Basic gene Info. | Gene symbol | KIFC1 |
| Gene name | kinesin family member C1 | |
| Synonyms | HSET|KNSL2 | |
| Cytomap | UCSC genome browser: 6p21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002263.3, | |
| Description | kinesin-like 2kinesin-like protein 2kinesin-like protein KIFC1kinesin-related protein HSET | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 603763 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000237649 | ||
| Vega : OTTHUMG00000031209 | ||
| Protein | UniProt: Q9BW19 go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KIFC1 | |
| BioGPS: 3833 | ||
| Pathway | NCI Pathway Interaction Database: KIFC1 | |
| KEGG: KIFC1 | ||
| REACTOME: KIFC1 | ||
| Pathway Commons: KIFC1 | ||
| Context | iHOP: KIFC1 | |
| ligand binding site mutation search in PubMed: KIFC1 | ||
| UCL Cancer Institute: KIFC1 | ||
| Assigned class in mutLBSgeneDB | C: This gene just belongs to mutLBSgenes. | |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO Term | PubMed ID |
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| Ligand binding site mutations for KIFC1 |
| Lollipop-style diagram of mutations at LBS in amino-acid sequence. We represented ligand binding site mutations only. (You can see big image via clicking.)  : non-synonymous mutation on LBS, Circle size denotes number of samples. |
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| Cancer type specific mutLBS sorted by frequency |
| LBS | AAchange of nsSNV | Cancer type | # samples | P319 | P319S | BRCA | 1 |
| cf) Cancer type abbreviation. BLCA: Bladder urothelial carcinoma, BRCA: Breast invasive carcinoma, CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma, COAD: Colon adenocarcinoma, GBM: Glioblastoma multiforme, LGG: Brain lower grade glioma, HNSC: Head and neck squamous cell carcinoma, KICH: Kidney chromophobe, KIRC: Kidney renal clear cell carcinoma, KIRP: Kidney renal papillary cell carcinoma, LAML: Acute myeloid leukemia, LUAD: Lung adenocarcinoma, LUSC: Lung squamous cell carcinoma, OV: Ovarian serous cystadenocarcinoma, PAAD: Pancreatic adenocarcinoma, PRAD: Prostate adenocarcinoma, SKCM: Skin cutaneous melanoma, STAD: Stomach adenocarcinoma, THCA: Thyroid carcinoma, UCEC: Uterine corpus endometrial carcinoma. |
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| Protein structure related information for KIFC1 |
| Relative protein structure stability change (ΔΔE) using Mupro 1.1 Mupro score denotes assessment of the effect of mutations on thermodynamic stability. (ΔΔE<0: mutation decreases stability, ΔΔE>0: mutation increases stability) |
 : nsSNV at non-LBS : nsSNV at LBS |
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| nsSNVs sorted by the relative stability change of protein structure by each mutation Blue: mutations of positive stability change. and red : the most recurrent mutation for this gene. |
| LBS | AAchange of nsSNV | Relative stability change | P319 | P319S | -0.56720968 |
| (MuPro1.1: Jianlin Cheng et al., Prediction of Protein Stability Changes for Single-Site Mutations Using Support Vector Machines, PROTEINS: Structure, Function, and Bioinformatics. 2006, 62:1125-1132) |
| Structure image for KIFC1 from PDB |
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| Differential gene expression and gene-gene network for KIFC1 |
| Differential gene expression between mutated and non-mutated LBS samples in all 16 major cancer types |
| Differential co-expressed gene network based on protein-protein interaction data (CePIN) |
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| Phenotype information for KIFC1 |
| Gene level disease information (DisGeNet) |
| Disease ID | Disease name | # PubMed | Association type |
| Mutation level pathogenic information (ClinVar annotation) |
| Allele ID | AA change | Clinical significance | Origin | Phenotype IDs |
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| Pharmacological information for KIFC1 |
| Gene expression profile of anticancer drug treated cell-lines (CCLE) Heatmap showing the correlation between gene expression and drug response across all the cell-lines. We chose the top 20 among 138 drugs.We used Pearson's correlation coefficient. |
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| Drug information targeting mutLBSgene (Approved drugs only) |
| Drug status | DrugBank ID | Name | Type | Drug structure |
| Gene-centered ligand-gene interaction network |
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| Ligands binding to mutated ligand binding site of KIFC1 go to BioLip |
| Ligand ID | Ligand short name | Ligand long name | PDB ID | PDB name | mutLBS | ADP | ADP | 2rep | A | P319 |
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| Conservation information for LBS of KIFC1 |
| Multiple alignments for Q9BW19 in multiple species |
| LBS | AA sequence | # species | Species | F418 | GSGKTFTMEGG | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | F418 | GSGKTYTMMGR | 4 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | F418 | GSGKTYTMDGV | 1 | Drosophila melanogaster | G413 | AYGQTGSGKTY | 5 | Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | G413 | AYGQTGSGKTF | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | G415 | GQTGSGKTYTM | 5 | Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | G415 | GQTGSGKTFTM | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | K416 | QTGSGKTFTME | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | K416 | QTGSGKTYTMM | 4 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | K416 | QTGSGKTYTMD | 1 | Drosophila melanogaster | L321 | RVRPVLEGE-S | 3 | Mus musculus, Mus musculus, Rattus norvegicus | L321 | RVRPLLPDDGG | 2 | Arabidopsis thaliana, Arabidopsis thaliana | L321 | RVRPVLPGE-P | 1 | Homo sapiens | L321 | RIRPPLESE-E | 1 | Drosophila melanogaster | L321 | RVRPLLPGENN | 1 | Arabidopsis thaliana | L321 | RVRPLLSGENS | 1 | Arabidopsis thaliana | P319 | FCRVRPVLEGE | 3 | Mus musculus, Mus musculus, Rattus norvegicus | P319 | FCRVRPLLPDD | 2 | Arabidopsis thaliana, Arabidopsis thaliana | P319 | FCRVRPVLPGE | 1 | Homo sapiens | P319 | FCRIRPPLESE | 1 | Drosophila melanogaster | P319 | FCRVRPLLPGE | 1 | Arabidopsis thaliana | P319 | FCRVRPLLSGE | 1 | Arabidopsis thaliana | R316 | IRVFCRVRPVL | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | R316 | IRVFCRVRPLL | 4 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | R316 | IRVFCRIRPPL | 1 | Drosophila melanogaster | R318 | VFCRVRPVLEG | 3 | Mus musculus, Mus musculus, Rattus norvegicus | R318 | VFCRVRPLLPD | 2 | Arabidopsis thaliana, Arabidopsis thaliana | R318 | VFCRVRPVLPG | 1 | Homo sapiens | R318 | VFCRIRPPLES | 1 | Drosophila melanogaster | R318 | VFCRVRPLLPG | 1 | Arabidopsis thaliana | R318 | VFCRVRPLLSG | 1 | Arabidopsis thaliana | S414 | YGQTGSGKTYT | 5 | Drosophila melanogaster, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | S414 | YGQTGSGKTFT | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | T412 | FAYGQTGSGKT | 9 | Homo sapiens, Drosophila melanogaster, Mus musculus, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | T417 | TGSGKTFTMEG | 4 | Homo sapiens, Mus musculus, Mus musculus, Rattus norvegicus | T417 | TGSGKTYTMMG | 4 | Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana, Arabidopsis thaliana | T417 | TGSGKTYTMDG | 1 | Drosophila melanogaster |
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